LOCUS       NM_001012324            3596 bp    mRNA    linear   ROD 11-NOV-2023
DEFINITION  Mus musculus extracellular matrix protein 2, female organ and
            adipocyte specific (Ecm2), mRNA.
ACCESSION   NM_001012324 XM_484254
VERSION     NM_001012324.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3596)
  AUTHORS   Zhang X, Wang D, Dongye M, Zhu Y, Chen C, Wang R, Long E, Liu Z, Wu
            X, Lin D, Chen J, Lin Z, Wang J, Li W, Li Y, Li D and Lin H.
  TITLE     Loss-of-function mutations in FREM2 disrupt eye morphogenesis
  JOURNAL   Exp Eye Res 181, 302-312 (2019)
   PUBMED   30802441
REFERENCE   2  (bases 1 to 3596)
  AUTHORS   Vezzali R, Weise SC, Hellbach N, Machado V, Heidrich S and Vogel T.
  TITLE     The FOXG1/FOXO/SMAD network balances proliferation and
            differentiation of cortical progenitors and activates Kcnh3
            expression in mature neurons
  JOURNAL   Oncotarget 7 (25), 37436-37455 (2016)
   PUBMED   27224923
REFERENCE   3  (bases 1 to 3596)
  AUTHORS   Manabe R, Tsutsui K, Yamada T, Kimura M, Nakano I, Shimono C,
            Sanzen N, Furutani Y, Fukuda T, Oguri Y, Shimamoto K, Kiyozumi D,
            Sato Y, Sado Y, Senoo H, Yamashina S, Fukuda S, Kawai J, Sugiura N,
            Kimata K, Hayashizaki Y and Sekiguchi K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
REFERENCE   4  (bases 1 to 3596)
  AUTHORS   Dmitriev RI, Korneenko TV, Bessonov AA, Shakhparonov MI, Modyanov
            NN and Pestov NB.
  TITLE     Characterization of hampin/MSL1 as a node in the nuclear
            interactome
  JOURNAL   Biochem Biophys Res Commun 355 (4), 1051-1057 (2007)
   PUBMED   17335777
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123954.4.
            
            [WARNING] On Jan 9, 2024 this sequence was replaced by
            NM_001012324.4.
            
            On Aug 23, 2018 this sequence version replaced NM_001012324.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089559.1, AK040995.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               AC123954.4         49900-50095         c
            197-502             AC123954.4         39806-40111         c
            503-691             AC123954.4         36415-36603         c
            692-1192            AC123954.4         33833-34333         c
            1193-1308           AC123954.4         32014-32129         c
            1309-1444           AC123954.4         30447-30582         c
            1445-1602           AC123954.4         27138-27295         c
            1603-1742           AC123954.4         25892-26031         c
            1743-2069           AC123954.4         24514-24840         c
            2070-3596           AC123954.4         22116-23642         c
FEATURES             Location/Qualifiers
     source          1..3596
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 25.29 cM"
     gene            1..3596
                     /gene="Ecm2"
                     /gene_synonym="9030618O22Rik; tenonectin"
                     /note="extracellular matrix protein 2, female organ and
                     adipocyte specific"
                     /db_xref="GeneID:407800"
                     /db_xref="MGI:MGI:3039578"
     exon            1..196
                     /gene="Ecm2"
                     /gene_synonym="9030618O22Rik; tenonectin"
                     /inference="alignment:Splign:2.1.0"
     exon            197..502
                     /gene="Ecm2"
                     /gene_synonym="9030618O22Rik; tenonectin"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..2238
                     /gene="Ecm2"
                     /gene_synonym="9030618O22Rik; tenonectin"
                     /codon_start=1
                     /product="extracellular matrix protein 2 precursor"
                     /protein_id="NP_001012324.1"
                     /db_xref="CCDS:CCDS26502.1"
                     /db_xref="GeneID:407800"
                     /db_xref="MGI:MGI:3039578"
                     /translation="MKLAVLFCFILLIVLQTDCERGTRRQRRRMHQRRLRKSSSFHLR
                     ANRQLEVQQTTAAPDARLPTANSDYSVEENIESLLSNLGVESSYSVLPGKKGYCFVKG
                     MIMYNKAVWSPEPCTTCLCSNGRVLCDETECHPKACPYTIKPEGECCPICSDAEQESI
                     NKLHKQVPPPQMEMDQVAIKEALQSEEDEEIAEGHKEHKKETSVPTKIHGDGERTERK
                     LRPEKEGRSAHQPLYHGRREEEESKEETEREGEEEEEEEEEEEEDAIRGDVFRMSSRV
                     IPGTPRGRPRLPRSCSLSYRTISCVHADFTEIPPITAPEVTNLELVGNSIISIPDEAF
                     NGLPNLERLDLSRNNITSSGIGPKAFKSLKKLMRLNMDGNNLVHIPSDLPSTLEELKI
                     NDNNLQAIDEKSLSDLNQLVTLELEGNNLSEINVDPLAFQSLESLSYLRLGRNKFRII
                     PQGLPASTEELYLENNQIEEITEICFNHTRKITMIILRYNKIEESRIAPLAWINQENL
                     ESIDLSYNKLYHVPSYLPKSLLHLVLIGNQIDRIPGYVFGHMQPGLEYLYLSFNRLSD
                     DGVDLVSFYGAYHSLRELFLDHNDFKSIPPGIQDMKALHFLRLNNNKIRNIHPEQICN
                     AEEDEDSALEHLHLENNYIRTREISSYAFSCIRLYSSIVLKPQHIK"
     exon            503..691
                     /gene="Ecm2"
                     /gene_synonym="9030618O22Rik; tenonectin"
                     /inference="alignment:Splign:2.1.0"
     exon            692..1192
                     /gene="Ecm2"
                     /gene_synonym="9030618O22Rik; tenonectin"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1308
                     /gene="Ecm2"
                     /gene_synonym="9030618O22Rik; tenonectin"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1444
                     /gene="Ecm2"
                     /gene_synonym="9030618O22Rik; tenonectin"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1602
                     /gene="Ecm2"
                     /gene_synonym="9030618O22Rik; tenonectin"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1742
                     /gene="Ecm2"
                     /gene_synonym="9030618O22Rik; tenonectin"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..2069
                     /gene="Ecm2"
                     /gene_synonym="9030618O22Rik; tenonectin"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..3596
                     /gene="Ecm2"
                     /gene_synonym="9030618O22Rik; tenonectin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctgatttt ccacacaaag aactgaaagg cgtttatccc aagggaagca gttcttttag
       61 attttactaa gaagtcagct aacacttttc aacattccct tctcttcttt gtttttaaag
      121 aaagttctgg ttttgtttca ctttcatcgg gagacttaaa tgacaccaag caaagctact
      181 tagtttagat ttccagaagt tcttggtgga aaaaaaaaat caagcatgaa gctagcagtg
      241 ttgttttgtt tcattctgct tattgttctt caaactgatt gtgaacgagg tactaggagg
      301 caaaggagaa ggatgcatca gagaagactc aggaaaagct cttcattcca cctcagagcc
      361 aacaggcagc ttgaagttca gcaaaccact gctgctccag atgctagact acccactgcc
      421 aactctgatt acagtgtgga agaaaacata gaatcgcttc taagtaatct tggagtagaa
      481 tcaagttaca gtgttttacc aggaaagaaa ggatactgct ttgtaaaggg catgatcatg
      541 tacaacaaag ctgtctggtc tcctgagccc tgcaccacct gcctctgctc aaatggaaga
      601 gtgctttgtg atgaaaccga gtgccacccc aaggcgtgcc cctataccat taaaccggaa
      661 ggagagtgct gccccatctg ctctgatgct gaacaagaat ccattaacaa acttcacaag
      721 caagtgccac ctcctcagat ggaaatggac caagtagcca taaaagaagc tcttcaatct
      781 gaggaggatg aagagatagc tgaaggacac aaggagcaca agaaagagac ctcagtgcct
      841 actaagatcc atggcgatgg ggaaagaact gagagaaaac tgaggccgga gaaagaaggg
      901 aggtcagcac atcaaccact ctaccatgga agaagggagg aagaggagag caaggaggag
      961 actgagaggg aaggagagga ggaagaggag gaggaggaag aagaagaaga ggatgctata
     1021 agaggagatg tgttcagaat gtcctcccgg gtaattcctg gaaccccaag aggcaggcca
     1081 cgtctgccca gaagctgttc cctgtcctac aggactatca gctgcgttca tgcagacttc
     1141 actgagatcc caccaataac agcaccagaa gtaacgaacc tggagttggt tgggaattcg
     1201 atcatctcca ttccggatga agcatttaat ggattaccaa atttggaaag acttgatctg
     1261 agcagaaata atatcacttc ttcgggcata ggtccaaaag cattcaagtc tttgaagaag
     1321 ttaatgcgtc tgaacatgga tggaaataat ttggtacata ttccttcaga cttaccatct
     1381 acactagaag aacttaaaat aaatgacaac aatctccagg ctatcgatga gaaaagttta
     1441 tcagacttaa atcaacttgt cactttagaa ttggaaggaa acaatctcag tgaaatcaat
     1501 gtcgaccctc tagctttcca atctttggaa agtctatcgt atctacgtct gggaagaaac
     1561 aaatttagaa tcataccaca aggtcttcct gcttctactg aggagttata cctagaaaat
     1621 aatcaaattg aagaaataac tgaaatttgt ttcaatcata ccagaaagat aactatgatc
     1681 attctacgtt acaataaaat agaagaaagt cggattgctc ctttagcatg gataaatcaa
     1741 gaaaatcttg aatctattga cctgtcctat aacaagctct accacgtccc ctcctaccta
     1801 cccaaatctc ttctgcacct tgtcctaatt gggaaccaaa tcgatcggat ccctggctat
     1861 gtgtttggcc acatgcaacc aggcctggag tacttgtacc tgtcatttaa cagactttct
     1921 gatgatggtg tggacctagt ctcgttctat ggagcatatc attctctgag agaattattt
     1981 ctggatcaca atgacttcaa atctatacca cctggaatac aagacatgaa agcactgcat
     2041 tttctgaggc tgaacaacaa taagattcgg aatattcatc ctgagcaaat ctgcaatgct
     2101 gaagaggatg aggactcagc tctcgagcat cttcatcttg aaaacaatta tattagaact
     2161 agagagatat catcctatgc attttcatgc ataagactgt attcaagtat tgttcttaaa
     2221 ccacaacaca tcaagtgatt tcaagcttcc ttctgccatt attgtttttt gtttgtttgt
     2281 tttctgagac agggtttctc tgtgtagctc tggctgtcct ggaactcact ttgtagacca
     2341 gactggcctc gaactcagaa atccacctgt ttttgcctcc caagtgctag gattaaaggc
     2401 gtgcgccacc accgcccggc accttctgcc atttataaat tttactgaag cattaacaaa
     2461 attacgtctc ttttattgtg tgtgtgtgtt tctgtatgtg tttgtgcaca tgagttctgt
     2521 gctctcagta accagaagaa ggtgttggtt gccctggagc tggagttaca agtggttctg
     2581 agccagttga taagtgtgct gtaaaatgaa cttgggtatg tggtaagagc agtacatgtt
     2641 cttaactgct tgatccatgt ctccagtctc caaaacacca ttctaatgct aatttcttgg
     2701 tttaaataat tttacagtgg ttacatatac acactggtaa tggtaaggaa agctagcaga
     2761 agggcataca aaaattctac actataagtc tagaattagt tttcaaagtt aaaataaagc
     2821 catttcaaga ctgctttcat tctgcagcaa gataaaaaaa ttagaaaaag taaactgagc
     2881 atggtggcac atgcctttaa ccccagcgct gtgagacaga ggccaaagga tctcagtgag
     2941 tatgaggcca gccgggtcta tatagtgaga tccaggacag cctgaactat gtaaagaccc
     3001 tatctcaaaa aaagactaca aaatgtaagc actcttctaa aaatacaaat tactgttaat
     3061 tataagctga cataaatgta aatacaactc attcctacac tagttatata gttagcaacc
     3121 atctcttttg ccagttacta aaatatactt tttatcagtt taatgaacaa agtagcactc
     3181 attacacact gacttgtaat gatttctttt aatgtaaacc tgatcgatcg atcgatcgat
     3241 cgatctatct atctatctat ctatctatct atctacctac ctacctacct acctacctac
     3301 ctacctacct gtctgtctat gatctagcta ttaagagaga ctcttactgt atagctctgg
     3361 ctggcctggc acttaaccag gtgcaaggat taaaggcatg tgcaatcttt gatctctgta
     3421 tttatacaaa attttatata atatatatag aaactctgtt gatttctttt attaactctt
     3481 aaattattgt tctgaagaaa tactagtgtc atgacttaag ctctagcttt gggatctacc
     3541 ttagtttctt ttcctgttac tgtgataaaa atacctcaat aaaagctaac tcaaag
//
