LOCUS       NP_001012324             670 aa            linear   ROD 01-MAY-2025
DEFINITION  extracellular matrix protein 2 precursor [Mus musculus].
ACCESSION   NP_001012324 XP_484254
VERSION     NP_001012324.1
DBSOURCE    REFSEQ: accession NM_001012324.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 670)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 670)
  AUTHORS   Zhang,X., Wang,D., Dongye,M., Zhu,Y., Chen,C., Wang,R., Long,E.,
            Liu,Z., Wu,X., Lin,D., Chen,J., Lin,Z., Wang,J., Li,W., Li,Y.,
            Li,D. and Lin,H.
  TITLE     Loss-of-function mutations in FREM2 disrupt eye morphogenesis
  JOURNAL   Exp Eye Res 181, 302-312 (2019)
   PUBMED   30802441
REFERENCE   3  (residues 1 to 670)
  AUTHORS   Vezzali,R., Weise,S.C., Hellbach,N., Machado,V., Heidrich,S. and
            Vogel,T.
  TITLE     The FOXG1/FOXO/SMAD network balances proliferation and
            differentiation of cortical progenitors and activates Kcnh3
            expression in mature neurons
  JOURNAL   Oncotarget 7 (25), 37436-37455 (2016)
   PUBMED   27224923
REFERENCE   4  (residues 1 to 670)
  AUTHORS   Manabe,R., Tsutsui,K., Yamada,T., Kimura,M., Nakano,I., Shimono,C.,
            Sanzen,N., Furutani,Y., Fukuda,T., Oguri,Y., Shimamoto,K.,
            Kiyozumi,D., Sato,Y., Sado,Y., Senoo,H., Yamashina,S., Fukuda,S.,
            Kawai,J., Sugiura,N., Kimata,K., Hayashizaki,Y. and Sekiguchi,K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
REFERENCE   5  (residues 1 to 670)
  AUTHORS   Dmitriev,R.I., Korneenko,T.V., Bessonov,A.A., Shakhparonov,M.I.,
            Modyanov,N.N. and Pestov,N.B.
  TITLE     Characterization of hampin/MSL1 as a node in the nuclear
            interactome
  JOURNAL   Biochem Biophys Res Commun 355 (4), 1051-1057 (2007)
   PUBMED   17335777
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123954.4.
            
            On Feb 17, 2005 this sequence version replaced XP_484254.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089559.1, AK040995.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..670
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 25.29 cM"
     Protein         1..670
                     /product="extracellular matrix protein 2 precursor"
                     /calculated_mol_wt=74510
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2184
     mat_peptide     20..670
                     /product="Extracellular matrix protein 2.
                     /id=PRO_0000287728"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5FW85.1)"
                     /calculated_mol_wt=74510
     Region          98..152
                     /region_name="VWC"
                     /note="von Willebrand factor type C domain; pfam00093"
                     /db_xref="CDD:278520"
     Region          185..270
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5FW85.1)"
     Region          266..268
                     /region_name="Cell attachment site. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5FW85.1)"
     Region          287..315
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          315..642
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          316..339
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          339..359
                     /region_name="LRR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5FW85.1)"
     Region          340..365
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            349
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FW85.1)"
     Region          365..386
                     /region_name="LRR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5FW85.1)"
     Region          366..410
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          387..407
                     /region_name="LRR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5FW85.1)"
     Region          410..430
                     /region_name="LRR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5FW85.1)"
     Region          411..436
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            420
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FW85.1)"
     Region          436..456
                     /region_name="LRR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5FW85.1)"
     Region          437..457
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          457..478
                     /region_name="LRR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5FW85.1)"
     Region          458..507
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            477
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FW85.1)"
     Region          481..501
                     /region_name="LRR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5FW85.1)"
     Region          507..528
                     /region_name="LRR 8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5FW85.1)"
     Region          508..553
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          529..549
                     /region_name="LRR 9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5FW85.1)"
     Region          530..549
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          553..573
                     /region_name="LRR 10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5FW85.1)"
     Region          554..580
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          580..601
                     /region_name="LRR 11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5FW85.1)"
     Region          581..603
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          603..624
                     /region_name="LRR 12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5FW85.1)"
     Region          604..624
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          632..655
                     /region_name="LRR 13"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5FW85.1)"
     Region          633..655
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..670
                     /gene="Ecm2"
                     /gene_synonym="9030618O22Rik; tenonectin"
                     /coded_by="NM_001012324.4:177..2189"
                     /db_xref="CCDS:CCDS26502.1"
                     /db_xref="GeneID:407800"
                     /db_xref="MGI:MGI:3039578"
ORIGIN      
        1 mklavlfcfi llivlqtdce rgtrrqrrrm hqrrlrksss fhlranrqle vqqttaapda
       61 rlptansdys veenieslls nlgvessysv lpgkkgycfv kgmimynkav wspepcttcl
      121 csngrvlcde techpkacpy tikpegeccp icsdaeqesi nklhkqvppp qmemdqvaik
      181 ealqseedee iaeghkehkk etsvptkihg dgerterklr pekegrsahq plyhgrreee
      241 eskeetereg eeeeeeeeee eedairgdvf rmssrvipgt prgrprlprs cslsyrtisc
      301 vhadfteipp itapevtnle lvgnsiisip deafnglpnl erldlsrnni tssgigpkaf
      361 kslkklmrln mdgnnlvhip sdlpstleel kindnnlqai dekslsdlnq lvtlelegnn
      421 lseinvdpla fqsleslsyl rlgrnkfrii pqglpastee lylennqiee iteicfnhtr
      481 kitmiilryn kieesriapl awinqenles idlsynklyh vpsylpksll hlvlignqid
      541 ripgyvfghm qpgleylyls fnrlsddgvd lvsfygayhs lrelfldhnd fksippgiqd
      601 mkalhflrln nnkirnihpe qicnaeeded salehlhlen nyirtreiss yafscirlys
      661 sivlkpqhik
//
