LOCUS       NM_001110331            1442 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus enoyl-Coenzyme A delta isomerase 2 (Eci2), transcript
            variant 1, mRNA.
ACCESSION   NM_001110331
VERSION     NM_001110331.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1442)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1442)
  AUTHORS   van Weeghel,M., Ofman,R., Argmann,C.A., Ruiter,J.P., Claessen,N.,
            Oussoren,S.V., Wanders,R.J., Aten,J. and Houten,S.M.
  TITLE     Identification and characterization of Eci3, a murine
            kidney-specific Delta3,Delta2-enoyl-CoA isomerase
  JOURNAL   FASEB J 28 (3), 1365-1374 (2014)
   PUBMED   24344334
REFERENCE   3  (bases 1 to 1442)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 1442)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   5  (bases 1 to 1442)
  AUTHORS   Willnow,T., Antignac,C., Brandli,A., Christensen,E., Cox,R.,
            Davidson,D., Davies,J., Devuyst,O., Eichele,G., Hastie,N.,
            Verroust,P., Schedl,A. and Meij,I.
  TITLE     The European renal genome project: an integrated approach towards
            understanding the genetics of kidney development and disease
  JOURNAL   Organogenesis 2 (2), 42-47 (2005)
   PUBMED   19521566
REFERENCE   6  (bases 1 to 1442)
  AUTHORS   Kikuchi,M., Hatano,N., Yokota,S., Shimozawa,N., Imanaka,T. and
            Taniguchi,H.
  TITLE     Proteomic analysis of rat liver peroxisome: presence of
            peroxisome-specific isozyme of Lon protease
  JOURNAL   J Biol Chem 279 (1), 421-428 (2004)
   PUBMED   14561759
REFERENCE   7  (bases 1 to 1442)
  AUTHORS   Geisbrecht,B.V., Zhang,D., Schulz,H. and Gould,S.J.
  TITLE     Characterization of PECI, a novel monofunctional Delta(3),
            Delta(2)-enoyl-CoA isomerase of mammalian peroxisomes
  JOURNAL   J Biol Chem 274 (31), 21797-21803 (1999)
   PUBMED   10419495
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY037058.1, AK009478.1 and BQ176032.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001983.1, AK009478.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               BY037058.1         1-191
            192-1419            AK009478.1         176-1403
            1420-1442           BQ176032.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..1442
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 14.23 cM"
     gene            1..1442
                     /gene="Eci2"
                     /gene_synonym="Acbd2; Drs1; Hca88; Peci"
                     /note="enoyl-Coenzyme A delta isomerase 2"
                     /db_xref="GeneID:23986"
                     /db_xref="MGI:MGI:1346064"
     exon            1..131
                     /gene="Eci2"
                     /gene_synonym="Acbd2; Drs1; Hca88; Peci"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1263
                     /gene="Eci2"
                     /gene_synonym="Acbd2; Drs1; Hca88; Peci"
                     /EC_number="5.3.3.8"
                     /note="isoform a is encoded by transcript variant 1;
                     peroxisomal 3,2-trans-enoyl-CoA isomerase; enoyl-CoA delta
                     isomerase 2, mitochondrial; dodecenoyl-CoA isomerase;
                     D3,D2-enoyl-CoA isomerase; delta(3),delta(2)-enoyl-CoA
                     isomerase; peroxisomal delta3, delta2-enoyl-Coenzyme A
                     isomerase"
                     /codon_start=1
                     /product="enoyl-CoA delta isomerase 2 isoform a"
                     /protein_id="NP_001103801.1"
                     /db_xref="CCDS:CCDS49234.1"
                     /db_xref="GeneID:23986"
                     /db_xref="MGI:MGI:1346064"
                     /translation="MAAVTWSRARCWCPSVLQVFRLQVAKLHLGRPTMRASQQDFENA
                     LNQVKLLKKDPGNEVKLRLYALYKQATEGPCNMPKPGMLDFVNKAKWDAWNALGSLPK
                     ETARQNYVDLVSSLSSSSEAPSQGKRGADEKARESKDILVTSEDGITKITFNRPTKKN
                     AISFQMYRDIILALKNASTDNTVMAVFTGTGDYYCSGNDLTNFTSATGGIEEAASNGA
                     VLLRDFVNSFIDFPKPLVAVVNGPAVGISVTLLGLFDAVFASDRATFHTPFSQLGQSP
                     EACSSYTFPKMMGSAKAAEMLLFGKKLTAREAWAQGLVTEVFPESTFETEVWTRLKTY
                     AKLPPNAMRISKELIRKNEKEKLYAVNAEECTTLQARWLSEECMNAIMSFVSRKPKL"
     exon            132..294
                     /gene="Eci2"
                     /gene_synonym="Acbd2; Drs1; Hca88; Peci"
                     /inference="alignment:Splign:2.1.0"
     exon            295..393
                     /gene="Eci2"
                     /gene_synonym="Acbd2; Drs1; Hca88; Peci"
                     /inference="alignment:Splign:2.1.0"
     exon            394..582
                     /gene="Eci2"
                     /gene_synonym="Acbd2; Drs1; Hca88; Peci"
                     /inference="alignment:Splign:2.1.0"
     exon            583..652
                     /gene="Eci2"
                     /gene_synonym="Acbd2; Drs1; Hca88; Peci"
                     /inference="alignment:Splign:2.1.0"
     exon            653..752
                     /gene="Eci2"
                     /gene_synonym="Acbd2; Drs1; Hca88; Peci"
                     /inference="alignment:Splign:2.1.0"
     exon            753..873
                     /gene="Eci2"
                     /gene_synonym="Acbd2; Drs1; Hca88; Peci"
                     /inference="alignment:Splign:2.1.0"
     exon            874..963
                     /gene="Eci2"
                     /gene_synonym="Acbd2; Drs1; Hca88; Peci"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1107
                     /gene="Eci2"
                     /gene_synonym="Acbd2; Drs1; Hca88; Peci"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1426
                     /gene="Eci2"
                     /gene_synonym="Acbd2; Drs1; Hca88; Peci"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1405..1410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eci2"
                     /gene_synonym="Acbd2; Drs1; Hca88; Peci"
                     /note="hexamer: AATAAA"
     polyA_site      1426
                     /gene="Eci2"
                     /gene_synonym="Acbd2; Drs1; Hca88; Peci"
                     /note="major polyA site"
ORIGIN      
        1 acctctggct ccgccccttc ccggtcttgc cctgcagttt ctgctgggcc taagcctccg
       61 ggctcagttt gaccacagta tctagctatg gcggcagtga cctggagtcg ggctcgatgc
      121 tggtgtccga gtgtcctgca ggtcttcaga ttacaagtgg ctaaactgca cttgggcaga
      181 ccaacaatga gagccagtca gcaggacttt gaaaatgcat tgaaccaggt gaaactcttg
      241 aagaaggacc cgggaaacga agtgaagcta agactctatg cactgtacaa gcaggccaca
      301 gaaggaccct gtaatatgcc taagcctggt atgcttgact ttgtcaacaa agccaagtgg
      361 gatgcatgga atgccctggg cagcctaccc aaggaaactg ccaggcagaa ctatgtggat
      421 ctcgtatcca gtttgagttc ctcatctgaa gccccgagcc agggaaagcg tggagctgat
      481 gagaaagccc gggagtccaa agacatcctg gtaacttctg aagatggtat cacgaagatc
      541 acgttcaatc ggcccaccaa aaagaatgcc atatccttcc agatgtatcg ggatattata
      601 ctcgcactta aaaatgccag cactgataac actgtcatgg ctgttttcac aggaactggt
      661 gactactact gcagtgggaa tgacctgact aacttcacta gtgccactgg ggggatagag
      721 gaggcagcta gcaacggtgc tgtgttactg agggactttg taaacagttt tatagacttt
      781 cccaagcctc tggttgcggt agtaaatggc ccagctgtgg gaatctctgt cacccttctg
      841 ggactatttg atgctgtctt tgcatcagac agggcaacgt ttcatactcc attcagccaa
      901 ctcggccaga gcccggaagc atgctcctct tacacgtttc cgaagatgat gggctcagca
      961 aaggcagctg agatgcttct ctttgggaag aagctgacag caagagaggc ctgggctcaa
     1021 ggccttgtca ctgaagtttt ccctgagagc acttttgaga cagaagtctg gaccaggctg
     1081 aaaacatatg cgaagctccc gccaaacgcc atgagaattt ccaaagagtt aatcagaaaa
     1141 aatgagaaag aaaagctcta cgcagtcaac gctgaagagt gcactactct gcaagcaagg
     1201 tggctgtcag aggagtgcat gaacgcaatc atgagcttcg tctccagaaa accaaagctg
     1261 tgaagaccac cacagcagct agactcctca tagggagcat gggctgggag gtccagtttc
     1321 gaggactcaa acgacacatg cttctctgtg ccttttcctt gattaacgta gcaattatga
     1381 tgagaattct tcacagtact gataaataaa acttttcata aatcaaaaaa aaaaaaaaaa
     1441 aa
//
