LOCUS       NM_010023               1091 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus enoyl-Coenzyme A delta isomerase 1 (Eci1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_010023
VERSION     NM_010023.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1091)
  AUTHORS   Xu,Y. and Xie,J.
  TITLE     Etomoxir regulates the differentiation of male germ cells by
            specifically reducing H3K27ac level
  JOURNAL   BMC Dev Biol 21 (1), 5 (2021)
   PUBMED   33517883
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1091)
  AUTHORS   Zurkirchen,L., Varum,S., Giger,S., Klug,A., Hausel,J., Bossart,R.,
            Zemke,M., Cantu,C., Atak,Z.K., Zamboni,N., Basler,K. and Sommer,L.
  TITLE     Yin Yang 1 sustains biosynthetic demands during brain development
            in a stage-specific manner
  JOURNAL   Nat Commun 10 (1), 2192 (2019)
   PUBMED   31097699
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1091)
  AUTHORS   Menendez-Montes,I., Escobar,B., Palacios,B., Gomez,M.J.,
            Izquierdo-Garcia,J.L., Flores,L., Jimenez-Borreguero,L.J.,
            Aragones,J., Ruiz-Cabello,J., Torres,M. and Martin-Puig,S.
  TITLE     Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch
            Essential for Cardiac Maturation
  JOURNAL   Dev Cell 39 (6), 724-739 (2016)
   PUBMED   27997827
REFERENCE   4  (bases 1 to 1091)
  AUTHORS   Justus,J. and Weigand,E.
  TITLE     The effect of a moderate zinc deficiency and dietary fat source on
            the activity and expression of the Delta(3)Delta (2)-enoyl-CoA
            isomerase in the liver of growing rats
  JOURNAL   Biol Trace Elem Res 158 (3), 365-375 (2014)
   PUBMED   24682920
  REMARK    GeneRIF: Data indicate that diets enriched with safflower oil
            induce markedly increased hepatic Delta(3)Delta(2)-enoyl-CoA
            isomerase (ECI)activities in the liver.
REFERENCE   5  (bases 1 to 1091)
  AUTHORS   van Weeghel,M., te Brinke,H., van Lenthe,H., Kulik,W.,
            Minkler,P.E., Stoll,M.S., Sass,J.O., Janssen,U., Stoffel,W.,
            Schwab,K.O., Wanders,R.J., Hoppel,C.L. and Houten,S.M.
  TITLE     Functional redundancy of mitochondrial enoyl-CoA isomerases in the
            oxidation of unsaturated fatty acids
  JOURNAL   FASEB J 26 (10), 4316-4326 (2012)
   PUBMED   22782973
  REMARK    GeneRIF: Data conclude that Eci2 compensates for Eci1 deficiency
            explaining the mild phenotype of Eci1-deficient mice.
REFERENCE   6  (bases 1 to 1091)
  AUTHORS   Yu,W., Chu,X., Deng,G., Liu,X., Chen,G. and Li,D.
  TITLE     Mutation of Lys242 allows Delta3-Delta2-enoyl-CoA isomerase to
            acquire enoyl-CoA hydratase activity
  JOURNAL   Biochim Biophys Acta 1760 (12), 1874-1883 (2006)
   PUBMED   16952422
REFERENCE   7  (bases 1 to 1091)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 1091)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   9  (bases 1 to 1091)
  AUTHORS   Janssen,U. and Stoffel,W.
  TITLE     Disruption of mitochondrial beta -oxidation of unsaturated fatty
            acids in the 3,2-trans-enoyl-CoA isomerase-deficient mouse
  JOURNAL   J Biol Chem 277 (22), 19579-19584 (2002)
   PUBMED   11916962
REFERENCE   10 (bases 1 to 1091)
  AUTHORS   Stoffel,W., Duker,M. and Hofmann,K.
  TITLE     Molecular cloning and gene organization of the mouse mitochondrial
            3,2-trans-enoyl-CoA isomerase
  JOURNAL   FEBS Lett 333 (1-2), 119-122 (1993)
   PUBMED   8224148
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154237.1.
            
            On Dec 3, 2008 this sequence version replaced NM_010023.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077386.1, AK029481.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AC154237.1         86762-86821
            61-147              AC154237.1         86932-87018
            148-275             AC154237.1         93212-93339
            276-422             AC154237.1         96257-96403
            423-544             AC154237.1         97299-97420
            545-723             AC154237.1         97511-97689
            724-1091            AC154237.1         99028-99395
FEATURES             Location/Qualifiers
     source          1..1091
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.39 cM"
     gene            1..1091
                     /gene="Eci1"
                     /gene_synonym="Dci; eci"
                     /note="enoyl-Coenzyme A delta isomerase 1"
                     /db_xref="GeneID:13177"
                     /db_xref="MGI:MGI:94871"
     exon            1..60
                     /gene="Eci1"
                     /gene_synonym="Dci; eci"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..890
                     /gene="Eci1"
                     /gene_synonym="Dci; eci"
                     /EC_number="5.3.3.8"
                     /note="3,2-trans-enoyl-CoA isomerase, mitochondrial; 3,2
                     trans-enoyl-Coenyme A isomerase; enoyl-CoA delta isomerase
                     1, mitochondrial; dodecenoyl-CoA isomerase;
                     D3,D2-enoyl-CoA isomerase; delta(3),Delta(2)-enoyl-CoA
                     isomerase; dodecenoyl-Coenzyme A delta isomerase (3,2
                     trans-enoyl-Coenyme A isomerase)"
                     /codon_start=1
                     /product="enoyl-CoA delta isomerase 1, mitochondrial
                     precursor"
                     /protein_id="NP_034153.2"
                     /db_xref="CCDS:CCDS28480.1"
                     /db_xref="GeneID:13177"
                     /db_xref="MGI:MGI:94871"
                     /translation="MALAAARRLLLHAGSRLGRREAVDGARRFANKRVLVETEGPAGV
                     AVMKLRNPPVNSLSLECLTEFTISLEKLENDKSIRGVILTSECPGIFSAGLDLLEMYG
                     RNPAHYAEYWKNVQELWLRLYTSNMILVSAINGASPAGGCLLALCCDYRVMADNPKYT
                     IGLNESLLGIVAPFWFKDMYVNTIGHREAERALQLGTLFSPAEALKVGVVDEVVPEDQ
                     VHSKARSVMTKWLAIPDHSRQLTKNMMRKATADNLIKQREADIQNFTSFISKDSIQKS
                     LHMYLEKLKQKKG"
     exon            61..147
                     /gene="Eci1"
                     /gene_synonym="Dci; eci"
                     /inference="alignment:Splign:2.1.0"
     exon            148..275
                     /gene="Eci1"
                     /gene_synonym="Dci; eci"
                     /inference="alignment:Splign:2.1.0"
     exon            276..422
                     /gene="Eci1"
                     /gene_synonym="Dci; eci"
                     /inference="alignment:Splign:2.1.0"
     exon            423..544
                     /gene="Eci1"
                     /gene_synonym="Dci; eci"
                     /inference="alignment:Splign:2.1.0"
     exon            545..723
                     /gene="Eci1"
                     /gene_synonym="Dci; eci"
                     /inference="alignment:Splign:2.1.0"
     exon            724..1091
                     /gene="Eci1"
                     /gene_synonym="Dci; eci"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccccact gatatccaag atggcgctgg ctgctgcgcg tcgccttctg ctgcacgcgg
       61 gatcccgcct cgggcgcagg gaagcggtgg acggcgcgcg gcgcttcgct aacaagcggg
      121 tgctggtgga gacggagggc ccggcagggg ttgcagtgat gaagttaagg aaccctcccg
      181 tgaattccct cagcttggag tgtctcacag agttcaccat cagcctggag aagctggaaa
      241 atgacaagag catccgaggt gtcatcctca cgtcggaatg cccgggtatc ttctcagctg
      301 gcctggactt gctggagatg tatggccgga acccagccca ctatgctgag tactggaaga
      361 acgtgcagga gctgtggctg agactctaca cgtccaacat gatcttagtg tctgccatca
      421 atggagcctc tccagctgga gggtgcctct tggctctctg ctgtgactac agggttatgg
      481 ctgacaaccc caaatatact ataggattga atgagagcct gctgggcatt gttgccccct
      541 tctggtttaa agacatgtat gtgaacacca tcgggcaccg ggaggcggag cgtgcccttc
      601 agctggggac ccttttctca ccagcagagg ccctcaaggt gggagtggtg gatgaggtgg
      661 tacctgagga tcaggtacac agcaaggctc gctcagtgat gaccaagtgg ttagctatcc
      721 cagaccattc tcggcagctg acaaagaaca tgatgcgaaa ggccaccgca gacaacctga
      781 tcaagcagcg agaggctgac atccagaatt tcaccagttt catctccaaa gactccatcc
      841 agaagtccct acacatgtac ttggaaaagc tcaagcaaaa gaagggctaa cctaggtgga
      901 cttctgagtt cgaggccagc ctggtctaca gagtgagttc caggacagcc aggggtatac
      961 agagaaaccc tgttttgaaa aaaaataata aaaaaataaa aataagggct aacctacagc
     1021 tgccacatat gtgccttcta gggacccact ggtcccaaag attatatata aacaaggtat
     1081 tcttcaactt c
//
