LOCUS       NM_025855               3048 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus enoyl Coenzyme A hydratase domain containing 1
            (Echdc1), transcript variant 1, mRNA.
ACCESSION   NM_025855
VERSION     NM_025855.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3048)
  AUTHORS   Votava,J.A., John,S.V., Li,Z., Chen,S., Fan,J. and Parks,B.W.
  TITLE     Mining cholesterol genes from thousands of mouse livers identifies
            aldolase C as a regulator of cholesterol biosynthesis
  JOURNAL   J Lipid Res 65 (3), 100525 (2024)
   PUBMED   38417553
REFERENCE   2  (bases 1 to 3048)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3048)
  AUTHORS   Dewulf,J.P., Paquay,S., Marbaix,E., Achouri,Y., Van Schaftingen,E.
            and Bommer,G.T.
  TITLE     ECHDC1 knockout mice accumulate ethyl-branched lipids and excrete
            abnormal intermediates of branched-chain fatty acid metabolism
  JOURNAL   J Biol Chem 297 (4), 101083 (2021)
   PUBMED   34419447
  REMARK    GeneRIF: ECHDC1 knockout mice accumulate ethyl-branched lipids and
            excrete abnormal intermediates of branched-chain fatty acid
            metabolism.
REFERENCE   4  (bases 1 to 3048)
  AUTHORS   Linster,C.L., Noel,G., Stroobant,V., Vertommen,D., Vincent,M.F.,
            Bommer,G.T., Veiga-da-Cunha,M. and Van Schaftingen,E.
  TITLE     Ethylmalonyl-CoA decarboxylase, a new enzyme involved in metabolite
            proofreading
  JOURNAL   J Biol Chem 286 (50), 42992-43003 (2011)
   PUBMED   22016388
REFERENCE   5  (bases 1 to 3048)
  AUTHORS   Taher,L., Collette,N.M., Murugesh,D., Maxwell,E., Ovcharenko,I. and
            Loots,G.G.
  TITLE     Global gene expression analysis of murine limb development
  JOURNAL   PLoS One 6 (12), e28358 (2011)
   PUBMED   22174793
REFERENCE   6  (bases 1 to 3048)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ051963.1, AK006444.1 and AK028775.1.
            
            On Oct 30, 2007 this sequence version replaced NM_025855.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028775.1, AK166589.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               CJ051963.1         2-125
            125-2044            AK006444.1         2-1921
            2045-3048           AK028775.1         1942-2945
FEATURES             Location/Qualifiers
     source          1..3048
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 16.59 cM"
     gene            1..3048
                     /gene="Echdc1"
                     /gene_synonym="1700028A24Rik; D10Ertd667e; MMCD"
                     /note="enoyl Coenzyme A hydratase domain containing 1"
                     /db_xref="GeneID:52665"
                     /db_xref="MGI:MGI:1277169"
     exon            1..234
                     /gene="Echdc1"
                     /gene_synonym="1700028A24Rik; D10Ertd667e; MMCD"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..1136
                     /gene="Echdc1"
                     /gene_synonym="1700028A24Rik; D10Ertd667e; MMCD"
                     /EC_number="4.1.1.94"
                     /note="isoform a is encoded by transcript variant 1;
                     enoyl-CoA hydratase domain-containing protein 1;
                     methylmalonyl-CoA decarboxylase; ethylmalonyl-CoA
                     decarboxylase"
                     /codon_start=1
                     /product="ethylmalonyl-CoA decarboxylase isoform a"
                     /protein_id="NP_080131.4"
                     /db_xref="CCDS:CCDS23760.1"
                     /db_xref="GeneID:52665"
                     /db_xref="MGI:MGI:1277169"
                     /translation="MRRCEVNSKPISEYFGIPCENREMAKCLLTSSLSVRTKLLQTGV
                     SLYNTSHGFHEEEVKKILEQFPGGSIDLLKKQNGIGILTLNNPNKMNAFSGVMMLQLL
                     ERVIELENWTEGKGLIIHGAKNTFCSGSDLNAVKALSTPESGVALSMFMQNTLTRFMR
                     LPLISVALVQGWAMGGGAELTTACDFRLMTEESVIRFVHKEMGIVPSWGGTSRLVEII
                     GSRQALKVLSGTLKLDSKEALNIGLTDEVLQPSDETTALEQAQEWLEKFVSGPPQVIR
                     GLKKSVCSARELYIEEALQNERDVLETLWGGPANLEAIAKKGKHTK"
     exon            235..450
                     /gene="Echdc1"
                     /gene_synonym="1700028A24Rik; D10Ertd667e; MMCD"
                     /inference="alignment:Splign:2.1.0"
     exon            451..593
                     /gene="Echdc1"
                     /gene_synonym="1700028A24Rik; D10Ertd667e; MMCD"
                     /inference="alignment:Splign:2.1.0"
     exon            594..646
                     /gene="Echdc1"
                     /gene_synonym="1700028A24Rik; D10Ertd667e; MMCD"
                     /inference="alignment:Splign:2.1.0"
     exon            647..727
                     /gene="Echdc1"
                     /gene_synonym="1700028A24Rik; D10Ertd667e; MMCD"
                     /inference="alignment:Splign:2.1.0"
     exon            728..3048
                     /gene="Echdc1"
                     /gene_synonym="1700028A24Rik; D10Ertd667e; MMCD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2306..2311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Echdc1"
                     /gene_synonym="1700028A24Rik; D10Ertd667e; MMCD"
                     /note="hexamer: AATAAA"
     polyA_site      2338
                     /gene="Echdc1"
                     /gene_synonym="1700028A24Rik; D10Ertd667e; MMCD"
                     /note="major polyA site"
ORIGIN      
        1 gcggctgcgc acacgctcac cgcgcaggcg cactgccctc tgctggctct gcaccgcagc
       61 gcaggcgccg ccgcgcaggt gggctcgtga gttcctgcag gtctctggga aatcctgagg
      121 cgttgcagag aacgtgggaa aatccgctaa attggcagtt tcaaaggatg agaaggtgtg
      181 aggtcaattc taagccgatt tctgaatatt ttggaatccc ttgtgagaac cgagaaatgg
      241 caaaatgtct tttgacttca tctctgtctg taagaacaaa actcttacaa acaggagtgt
      301 cgctttataa tacgagtcat ggcttccacg aggaggaagt gaagaagata ctggagcagt
      361 ttcctggtgg atccattgac ctcctaaaga agcagaacgg cattggcatt ctgacgctaa
      421 acaaccccaa taaaatgaat gccttctcag gtgtcatgat gctacaactt ttggaaaggg
      481 taattgaatt agaaaattgg acagaaggga aaggcctcat tatccatgga gcaaaaaata
      541 ctttctgctc aggatctgat ctgaatgctg tgaaggcact ctccactcca gaaagtggag
      601 tggccttatc tatgttcatg caaaacacgt taacaagatt tatgagacta ccgttaataa
      661 gtgttgctct ggttcaaggc tgggcaatgg gtggaggagc agaacttact acagcatgtg
      721 atttcaggtt gatgactgag gaaagtgtga tcagatttgt ccacaaggag atgggtatag
      781 ttccaagctg gggtggtacc agccgtctgg ttgaaatcat tggcagcaga caagctctca
      841 aagtgttaag tgggactctc aaactggatt ccaaggaagc tttaaatata ggcttgactg
      901 atgaggtctt acagccctca gatgaaacta cggctctaga acaggcacaa gagtggctgg
      961 agaaatttgt cagtgggcct ccacaagtca ttaggggttt aaaaaaatct gtctgctctg
     1021 cccgagaact gtatatagag gaggcgttac agaatgaacg agacgttttg gaaacactgt
     1081 ggggtggacc tgcaaattta gaggctattg ctaagaaagg aaagcatact aaatagcctt
     1141 taaaatgagt gtagtacagg tgaagctgca ggggaacatg catggaggtg agatgattag
     1201 aaatgagctg cggaagtcat tcaaagggga ctgctaatct gcgtagttgg ctcggggggc
     1261 cttctccata ttgtaattca gtgctctgtt gtctttctta tcatttaaca tataccaatt
     1321 tctacattcc tgtagtaatt cttagcccag gcttatgctt tgtaacatac taacttttaa
     1381 gagagggtct taaacttgct atgtagcgcc aagggtagac gtgaattcct gacactcctg
     1441 ctaccgcctc ccaaacactt gttaatactg ctgtttctgg ctgttttggt ctttcttaag
     1501 tcgaaataat ttacaaaagc aaagttaaac aaaatttaaa ataacttaat atatccttca
     1561 taggaagcaa aaggcaggga gagactagag aggcatgtaa gaaatattag ttattttcgt
     1621 gtgtgtgttc tgtatacata ggatactgat gtgaaatggt tcttcattta aagaaaaaaa
     1681 aggcccctct gtcatgggag tttttgttgg ccttttcaac catctgtctt ctatttcaaa
     1741 agacctacta aacagtgaaa gccattctac tggctataca aagtagcaga gcattggtct
     1801 ctgagatttt catgttaata gtaaagcagt agtattgatt taaagactca tgaagcatcc
     1861 ttttcatttt caccagattt ttgagcaata cctaactttt tgtgtggcta tcttttaata
     1921 actaaattta atagaaacac ataacccaaa ctttatgtcc attccagaat ttacttgttc
     1981 cataaaaact gtataagaat taacttctaa ccagtctcaa caagaggtaa aagacactca
     2041 aaataatcac ctttttgttg tttgttttcg cactctgtta acgtgataat tcgaatacag
     2101 ggaatttaga agtgtgtaaa tacaggaccc cactttttaa aggaaacaca ggcagatgtg
     2161 ttttctccgg gacaaattct caattctgtg ttcgccagta tttcctccct tgtcaatcca
     2221 tataaagtgg gcttattggt tctataacac tatgcttgta gcccagacag aaataccact
     2281 gatggagcct ggtaaagtaa atgtaaataa atgatattag ctgcttgaga aatttaaatc
     2341 tcacgaccta tggatctttt tccacatttg tttattccaa acacagcgcc cattgatagc
     2401 ttctctttcc ttattctctt ctgaagaaat cagacttact tcttgagtaa ggaacagttt
     2461 gaatagaatg caatcaattc aaacctcacc tttaaaaaag ctctttagcc acaaatacca
     2521 aagtgtcccc atcccttttc cagactcaaa caaattattt ctgataaact ctagtattta
     2581 ttaaattata aagttttttt aatcaaaaag aaaaatgcag actaagagaa acctccaagt
     2641 acaaggacaa gacagcaaat cttatggaag ggaacaccat gaagtgcgtt acagattctg
     2701 aaacttatta gctgcagctt tacatttcta tctcaagaag accaactata gttgttaatc
     2761 atctatttta aaatcccaaa ttcacatcaa gcttcctgct cataatgata tcaaatatct
     2821 cacaggtgcc aaattttatt gaagatttta taccaatcca tgcagaaaaa ataagtagtg
     2881 caagagtcag atgaggacca ttaatgcaca gggacacact agccaaaaga actaaaaact
     2941 taaaaaaata cactataaac agatgtcaag aaaactgtgt tatactgaac agctctcaac
     3001 tatcaacacc ccagttcctc acattaaata aatttcagca gagacatg
//
