LOCUS       NM_016772               1138 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus enoyl coenzyme A hydratase 1, peroxisomal (Ech1),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_016772
VERSION     NM_016772.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1138)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1138)
  AUTHORS   Liu,B., Yi,W., Mao,X., Yang,L. and Rao,C.
  TITLE     Enoyl coenzyme A hydratase 1 alleviates nonalcoholic
            steatohepatitis in mice by suppressing hepatic ferroptosis
  JOURNAL   Am J Physiol Endocrinol Metab 320 (5), E925-E937 (2021)
   PUBMED   33813878
  REMARK    GeneRIF: Enoyl coenzyme A hydratase 1 alleviates nonalcoholic
            steatohepatitis in mice by suppressing hepatic ferroptosis.
REFERENCE   3  (bases 1 to 1138)
  AUTHORS   Mao,X., Huang,D., Rao,C., Du,M., Liang,M., Li,F., Liu,B. and
            Huang,K.
  TITLE     Enoyl coenzyme A hydratase 1 combats obesity and related metabolic
            disorders by promoting adipose tissue browning
  JOURNAL   Am J Physiol Endocrinol Metab 318 (3), E318-E329 (2020)
   PUBMED   31961704
  REMARK    GeneRIF: ECH1 regulated the thermogenic program by inhibiting
            mammalian target of rapamycin signaling, which may partially
            explain the potential mechanism for ECH1 regulating adipose
            browning
REFERENCE   4  (bases 1 to 1138)
  AUTHORS   Zurkirchen,L., Varum,S., Giger,S., Klug,A., Hausel,J., Bossart,R.,
            Zemke,M., Cantu,C., Atak,Z.K., Zamboni,N., Basler,K. and Sommer,L.
  TITLE     Yin Yang 1 sustains biosynthetic demands during brain development
            in a stage-specific manner
  JOURNAL   Nat Commun 10 (1), 2192 (2019)
   PUBMED   31097699
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1138)
  AUTHORS   Varum,S., Baggiolini,A., Zurkirchen,L., Atak,Z.K., Cantu,C.,
            Marzorati,E., Bossart,R., Wouters,J., Hausel,J., Tuncer,E.,
            Zingg,D., Veen,D., John,N., Balz,M., Levesque,M.P., Basler,K.,
            Aerts,S., Zamboni,N., Dummer,R. and Sommer,L.
  TITLE     Yin Yang 1 Orchestrates a Metabolic Program Required for Both
            Neural Crest Development and Melanoma Formation
  JOURNAL   Cell Stem Cell 24 (4), 637-653 (2019)
   PUBMED   30951662
REFERENCE   6  (bases 1 to 1138)
  AUTHORS   Zhang,J., Tang,J.W., Song,M.Y., Wang,B., Li,R.K., Hou,L.,
            Huang,Y.H., Wang,M., Song,B. and Jin,Y.L.
  TITLE     [Expression of enoyl CoA hydratase 1 reduces cell proliferation and
            migration in mouse hepatocarcinoma cells]
  JOURNAL   Zhonghua Bing Li Xue Za Zhi 40 (12), 830-833 (2011)
   PUBMED   22336209
  REMARK    GeneRIF: Down-regulation of ECH1 could inhibit the cell
            proliferation and migration of Hca-F hepatocarcinoma cells.
REFERENCE   7  (bases 1 to 1138)
  AUTHORS   Zhang,J., Song,M., Wang,J., Sun,M., Wang,B., Li,R., Huang,Y.,
            Hou,L., Jin,Y., Wang,M. and Tang,J.
  TITLE     Enoyl coenzyme A hydratase 1 is an important factor in the
            lymphatic metastasis of tumors
  JOURNAL   Biomed Pharmacother 65 (3), 157-162 (2011)
   PUBMED   21616630
  REMARK    GeneRIF: The downregulation of Ech1 inhibited proliferation of the
            Hca-F cells, increased the ratio of Hca-F cells in S phase to G(1)
            phase and decreased the adhesion and migration capacities of Hca-F
            cells.
REFERENCE   8  (bases 1 to 1138)
  AUTHORS   Lin,Q., Donahue,S.L., Moore-Jarrett,T., Cao,S., Osipovich,A.B. and
            Ruley,H.E.
  TITLE     Mutagenesis of diploid mammalian genes by gene entrapment
  JOURNAL   Nucleic Acids Res 34 (20), e139 (2006)
   PUBMED   17062627
REFERENCE   9  (bases 1 to 1138)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (bases 1 to 1138)
  AUTHORS   Jia,Y., Qi,C., Zhang,Z., Hashimoto,T., Rao,M.S., Huyghe,S.,
            Suzuki,Y., Van Veldhoven,P.P., Baes,M. and Reddy,J.K.
  TITLE     Overexpression of peroxisome proliferator-activated receptor-alpha
            (PPARalpha)-regulated genes in liver in the absence of peroxisome
            proliferation in mice deficient in both L- and D-forms of enoyl-CoA
            hydratase/dehydrogenase enzymes of peroxisomal beta-oxidation
            system
  JOURNAL   J Biol Chem 278 (47), 47232-47239 (2003)
   PUBMED   14500732
  REMARK    GeneRIF: disruption of peroxisomal fatty acid beta-oxidation at the
            level of enoyl-CoA hydratase/L-3-hydroxyacyl-CoA dehydrogenase
            (L-PBE) in mice leads to the induction of many of the PPARalpha
            target genes independently of peroxisome proliferation in
            hepatocytes
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF030343.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF030343.1, BC068112.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1138
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 16.94 cM"
     gene            1..1138
                     /gene="Ech1"
                     /note="enoyl coenzyme A hydratase 1, peroxisomal"
                     /db_xref="GeneID:51798"
                     /db_xref="MGI:MGI:1858208"
     exon            1..75
                     /gene="Ech1"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1007
                     /gene="Ech1"
                     /note="peroxisomal/mitochondrial dienoyl-CoA isomerase;
                     delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase,
                     mitochondrial"
                     /codon_start=1
                     /product="delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase,
                     mitochondrial precursor"
                     /protein_id="NP_058052.1"
                     /db_xref="CCDS:CCDS21057.1"
                     /db_xref="GeneID:51798"
                     /db_xref="MGI:MGI:1858208"
                     /translation="MATAMTVSSKLRGLLMQQLRGTSQLYFNISLRSLSSSAQEASKR
                     APEEVSDHNYESIQVTSAQKHVLHVQLNRPEKRNAMNRAFWRELVECFQKISKDSDCR
                     AVVVSGAGKMFTSGIDLMDMASELMQPSGDDAARIAWYLRDLISKYQKTFTVIEKCPK
                     PVIAAIHGGCIGGGVDLVSACDIRYCTQDAFFQIKEVDMGLAADVGTLQRLPKVIGNQ
                     SLVNELTFSARKMMADEALDSGLVSRVFQDKDAMLNAAFALAADISSKSPVAVQGSKI
                     NLIYSRDHSVDESLDYMATWNMSMLQTQDIIKSVQAAMEKRDTKSITFSKL"
     exon            76..280
                     /gene="Ech1"
                     /inference="alignment:Splign:2.1.0"
     exon            281..369
                     /gene="Ech1"
                     /inference="alignment:Splign:2.1.0"
     exon            370..494
                     /gene="Ech1"
                     /inference="alignment:Splign:2.1.0"
     exon            495..543
                     /gene="Ech1"
                     /inference="alignment:Splign:2.1.0"
     exon            544..608
                     /gene="Ech1"
                     /inference="alignment:Splign:2.1.0"
     exon            609..679
                     /gene="Ech1"
                     /inference="alignment:Splign:2.1.0"
     exon            680..751
                     /gene="Ech1"
                     /inference="alignment:Splign:2.1.0"
     exon            752..902
                     /gene="Ech1"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1138
                     /gene="Ech1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcacagctc cggagctcca gaaatggcta ccgcgatgac agtttccagt aaactccgcg
       61 gcctgctgat gcagcagctg agaggtacca gccagctgta cttcaacatc agccttcgat
      121 ctctgagctc ctctgcacaa gaggcctcca agagagcccc cgaggaagtc tcagaccaca
      181 actatgagtc tattcaagtc acaagtgccc agaagcatgt tctccacgtg cagctaaacc
      241 ggccagagaa gaggaatgcc atgaacaggg ctttctggag ggagttggtg gaatgcttcc
      301 aaaagatatc caaagactcg gactgccggg ctgttgtagt ctccggtgca ggaaagatgt
      361 tcacttcagg tattgacctc atggacatgg cctccgaact catgcagccc tcaggagatg
      421 atgcggcccg catagcctgg tacctccgtg acctcatcag caagtaccag aagaccttca
      481 ctgtcattga gaagtgcccc aagccagtga ttgctgccat tcacggaggc tgcattggcg
      541 gaggtgtgga cctcgtttct gcctgtgaca ttcgctactg cactcaggat gcttttttcc
      601 agatcaagga ggtagatatg ggcttggctg ctgatgtagg aacactgcag agactgccca
      661 aggtcatcgg gaaccagagc ctggtcaacg agctgacctt ctctgcccgc aagatgatgg
      721 ctgacgaggc cctggacagt gggctggtca gccgcgtgtt ccaagataag gacgccatgc
      781 tgaatgcagc ctttgccctg gcggctgata tttccagcaa gagccctgtg gctgtgcagg
      841 ggtcaaaaat caatctcatc tactcccgag accattctgt ggacgagagc cttgactaca
      901 tggccacctg gaacatgagc atgctgcaga cccaggacat catcaaatca gtccaggcag
      961 ccatggagaa gagggacaca aaaagcatca ccttctccaa gctctgaatg tcttccggac
     1021 cctgagagag gaggactcca cggagccagg cctcctccca tggggtgtcc cagtgtataa
     1081 ctttatgact tagttcttca tttcctgggg ccttatcttc actgtgaaca ataaagtt
//
