LOCUS       NM_001277925            2906 bp    mRNA    linear   ROD 18-DEC-2022
DEFINITION  Mus musculus endothelin converting enzyme-like 1 (Ecel1),
            transcript variant 1, mRNA.
ACCESSION   NM_001277925
VERSION     NM_001277925.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2906)
  AUTHORS   Puelles L, Diaz C, Stuhmer T, Ferran JL, Martinez-de la Torre M and
            Rubenstein JLR.
  TITLE     LacZ-reporter mapping of Dlx5/6 expression and genoarchitectural
            analysis of the postnatal mouse prethalamus
  JOURNAL   J Comp Neurol 529 (2), 367-420 (2021)
   PUBMED   32420617
REFERENCE   2  (bases 1 to 2906)
  AUTHORS   Kiryu-Seo S, Nagata K, Saido TC and Kiyama H.
  TITLE     New Insights of a Neuronal Peptidase DINE/ECEL1: Nerve Development,
            Nerve Regeneration and Neurogenic Pathogenesis
  JOURNAL   Neurochem Res 44 (6), 1279-1288 (2019)
   PUBMED   30357652
  REMARK    Review article
REFERENCE   3  (bases 1 to 2906)
  AUTHORS   Loo L, Simon JM, Xing L, McCoy ES, Niehaus JK, Guo J, Anton ES and
            Zylka MJ.
  TITLE     Single-cell transcriptomic analysis of mouse neocortical
            development
  JOURNAL   Nat Commun 10 (1), 134 (2019)
   PUBMED   30635555
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2906)
  AUTHORS   Lindstrom NO, Guo J, Kim AD, Tran T, Guo Q, De Sena Brandine G,
            Ransick A, Parvez RK, Thornton ME, Baskin L, Grubbs B, McMahon JA,
            Smith AD and McMahon AP.
  TITLE     Conserved and Divergent Features of Mesenchymal Progenitor Cell
            Types within the Cortical Nephrogenic Niche of the Human and Mouse
            Kidney
  JOURNAL   J Am Soc Nephrol 29 (3), 806-824 (2018)
   PUBMED   29449449
REFERENCE   5  (bases 1 to 2906)
  AUTHORS   Zhang Q, Huang R, Ye Y, Guo X, Lu J, Zhu F, Gong X, Zhang Q, Yan J,
            Luo L, Zhuang S, Chen Y, Zhao X, Evans SM, Jiang C, Liang X and Sun
            Y.
  TITLE     Temporal requirements for ISL1 in sympathetic neuron proliferation,
            differentiation, and diversification
  JOURNAL   Cell Death Dis 9 (2), 247 (2018)
   PUBMED   29445148
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2906)
  AUTHORS   Harrow JL, Steward CA, Frankish A, Gilbert JG, Gonzalez JM,
            Loveland JE, Mudge J, Sheppard D, Thomas M, Trevanion S and Wilming
            LG.
  TITLE     The Vertebrate Genome Annotation browser 10 years on
  JOURNAL   Nucleic Acids Res 42 (Database issue), D771-D779 (2014)
   PUBMED   24316575
REFERENCE   7  (bases 1 to 2906)
  AUTHORS   Nagata K, Kiryu-Seo S, Maeda M, Yoshida K, Morita T and Kiyama H.
  TITLE     Damage-induced neuronal endopeptidase is critical for presynaptic
            formation of neuromuscular junctions
  JOURNAL   J Neurosci 30 (20), 6954-6962 (2010)
   PUBMED   20484637
  REMARK    GeneRIF: The data of this study suggested that DINE is a crucial
            molecule in distal axonal arborization into muscle to establish
            neuromuscular junctions.
REFERENCE   8  (bases 1 to 2906)
  AUTHORS   Kiryu-Seo S, Kato R, Ogawa T, Nakagomi S, Nagata K and Kiyama H.
  TITLE     Neuronal injury-inducible gene is synergistically regulated by
            ATF3, c-Jun, and STAT3 through the interaction with Sp1 in damaged
            neurons
  JOURNAL   J Biol Chem 283 (11), 6988-6996 (2008)
   PUBMED   18192274
  REMARK    GeneRIF: Sp1 recruits ATF3, c-Jun, and STAT3 to obtain the
            requisite synergistic effect in neuronal injury through DINE
            neuronal injury-inducible gene
REFERENCE   9  (bases 1 to 2906)
  AUTHORS   Kiryu-Seo S, Sasaki M, Yokohama H, Nakagomi S, Hirayama T, Aoki S,
            Wada K and Kiyama H.
  TITLE     Damage-induced neuronal endopeptidase (DINE) is a unique
            metallopeptidase expressed in response to neuronal damage and
            activates superoxide scavengers
  JOURNAL   Proc Natl Acad Sci U S A 97 (8), 4345-4350 (2000)
   PUBMED   10759559
REFERENCE   10 (bases 1 to 2906)
  AUTHORS   Schweizer A, Valdenaire O, Koster A, Lang Y, Schmitt G, Lenz B,
            Bluethmann H and Rohrer J.
  TITLE     Neonatal lethality in mice deficient in XCE, a novel member of the
            endothelin-converting enzyme and neutral endopeptidase family
  JOURNAL   J Biol Chem 274 (29), 20450-20456 (1999)
   PUBMED   10400672
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK159365.1 and BC057569.1.
            
            [WARNING] On Apr 26, 2023 this sequence was replaced by
            NM_001277925.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159365.1, SRR7974084.20508.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-548               AK159365.1         3-550
            549-2906            BC057569.1         371-2728
FEATURES             Location/Qualifiers
     source          1..2906
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..2906
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /note="endothelin converting enzyme-like 1"
                     /db_xref="GeneID:13599"
                     /db_xref="MGI:MGI:1343461"
     exon            1..117
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            118..1002
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..2544
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /EC_number="3.4.24.11"
                     /note="damage-induced neuronal endopeptidase"
                     /codon_start=1
                     /product="endothelin-converting enzyme-like 1"
                     /protein_id="NP_001264854.1"
                     /db_xref="CCDS:CCDS15128.1"
                     /db_xref="GeneID:13599"
                     /db_xref="MGI:MGI:1343461"
                     /translation="MEAPYSMTAHYDEFQEVKYVSRCGTGGARGTSLPPGFPRGSGRS
                     ASGSRSGLPRWNRREVCLLSGLVFAAGLCAILAAMLALKYLGPGAAGGGGACPEGCPE
                     RKAFARAARFLSANLDASIDPCQDFYSFACGGWLRRHAIPDDKLTYGTIAAIGEQNEE
                     RLRRLLARPTGGPGGAAQRKVRAFFRSCLDMREIERLGPRPMLEVIEDCGGWDLGGAA
                     DRPGAARWDLNRLLYKAQGVYSAAALFSLTVSLDDRNSSRYVIRIDQDGLTLPERTLY
                     LAQDEESEKILAAYRVFMQRLLRLLGADAVEQKAQEILQLEQRLANISVSEYDDLRRD
                     VSSAYNKVTLGQLQKIIPHLQWKWLLDQIFQEDFSEEEEVVLLATDYMQQVSQLIRST
                     PRRILHNYLVWRVVVVLSEHLSSPFREALHELAKEMEGNDKPQELARVCLGQANRHFG
                     MALGALFVHEHFSAASKAKVQQLVEDIKYILGQRLEELDWMDAQTKAAARAKLQYMMV
                     MVGYPDFLLKPEAVDKEYEFEVHEKTYFKNILNSIRFSIQLSVKKIRQEVDKSSWLLP
                     PQALNAYYLPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQ
                     YDRSGNLLHWWTETSYSHFLRKAECIVRLYDNFTVYNQRVNGKHTLGENIADMGGLKL
                     AYYAYQKWVREHGPEHPLHRLKYTHNQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPE
                     HYRVLGSVSQFEEFGRAFHCPKDSPMNPVHKCSVW"
     exon            1003..1071
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1182
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1275
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1400
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1623
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1722
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1797
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1901
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..1960
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2012
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2080
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2205
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2271
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2367
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..2444
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2876
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaggcggcg ggcgcacgaa gagagccgca gccagcccag ctcctctccg gctgaggccg
       61 ggatttgctc ccgacccctc cctcggtcct cgcccggccc agacgcgcac ctgccggctg
      121 cgaccgaggg ccatgtgggc tccgaccaga aagcccgcag acagaagcag cctataatcg
      181 accaaacaag gggtctgcag ccaaagcctc ggcacaatgg aggccccgta ttccatgaca
      241 gcgcactacg acgagttcca ggaagtcaag tatgtgagcc ggtgtggcac cgggggcgct
      301 cgagggacct cactgcctcc aggcttcccg aggggctcag ggcgcagtgc tagcgggtcc
      361 aggtctgggc tgccccgctg gaatcgacgc gaggtgtgcc tgctgtcggg gttggtgttt
      421 gctgccggcc tctgcgccat cctggcggcc atgctggcgc tcaaatacct gggcccggga
      481 gcggcgggcg gtggcggagc ctgtcccgag ggctgccccg agcgcaaggc ctttgcacgc
      541 gccgcccgct ttctgtctgc caacctggac gccagcatcg acccgtgcca ggacttctac
      601 tcgttcgcgt gcggaggctg gctgcggcgc cacgctatcc ccgacgacaa gctcacctac
      661 ggcacgatcg cggccatcgg agagcagaac gaggagcgtc tgcggcgcct gctggcgaga
      721 cccaccggag gccccggcgg cgctgcgcag cgcaaggtgc gcgccttctt ccgctcgtgc
      781 ctcgacatgc gcgagatcga gaggctcggg ccgcggccca tgctcgaggt catcgaggac
      841 tgcggcggct gggacctggg cggcgcggcc gatcgccccg gggcggctcg ctgggacctc
      901 aaccgactgc tgtacaaggc acagggtgtg tacagcgcgg ccgcgctctt ctcgcttaca
      961 gtcagcctgg acgacaggaa ctcctcgcgc tacgtcatcc gcattgacca ggatgggctc
     1021 accctgccag agagaaccct gtacctagct caagacgagg agagtgagaa gatcttggct
     1081 gcatacaggg tgttcatgca gcgtctactc agactactgg gagcggacgc tgtggagcag
     1141 aaggcgcagg aaatccttca gctggaacag aggctggcca atatctctgt gtcagaatat
     1201 gatgatctcc gtcgtgatgt cagctccgcg tacaacaaag tgactctggg gcagctgcag
     1261 aagatcatcc cccatttgca gtggaagtgg ctgctggatc agatcttcca ggaagacttc
     1321 tcggaggagg aggaggtggt gctgctggcc acagactaca tgcagcaggt gtcccagctc
     1381 atccgctcca cacctcgaag gatcctgcac aactacctag tgtggcgtgt ggtggtggtt
     1441 ctgagtgagc acctgtcctc accattccga gaggcactgc atgagctggc caaagagatg
     1501 gagggcaatg acaagcccca ggagttggcc cgagtctgcc tgggccaggc caaccgccac
     1561 ttcggcatgg ctcttggtgc cctctttgta catgaacact tctcagctgc cagtaaagcc
     1621 aaggtgcagc agctagtgga agatatcaag tacatcttgg gccagcgcct ggaggagctg
     1681 gactggatgg atgcccagac caaggcagct gctcgggcca agctccagta catgatggtc
     1741 atggttggct atccagactt cctgctgaaa cctgaggctg tagacaaaga atatgagttc
     1801 gaggtccacg agaagaccta cttcaagaac attttgaaca gcatccgatt cagtatccag
     1861 ttgtccgtca aaaagattcg acaggaggtg gacaaatcct cgtggctcct cccaccacag
     1921 gcgctcaatg cctactatct gcccaacaag aatcaaatgg tcttcccagc tggcatcctg
     1981 cagcccaccc tgtatgaccc agacttccca cagtctctga actacggggg tattggcacc
     2041 atcattgggc acgaactgac ccatggctat gacgactggg ggggacagta tgaccgctca
     2101 ggaaacctgt tgcactggtg gactgagacc tcctacagcc actttctgcg caaggccgag
     2161 tgcatcgttc gcctctatga caacttcacc gtctacaacc agcgcgtgaa tgggaaacac
     2221 acacttggcg agaacatcgc agacatggga ggcctcaagc tggcctacta tgcctatcag
     2281 aagtgggtcc gggagcatgg cccggagcac ccgctgcacc ggctcaagta cacacacaac
     2341 cagcttttct tcattgcctt tgcacagaac tggtgcatca agcgacggtc acagtccatc
     2401 tacctgcagg tgctgacaga caagcatgca cctgagcact accgggtcct gggcagcgta
     2461 tcccagtttg aggaattcgg ccgggccttc cactgtccca aggactctcc catgaacccc
     2521 gtccataagt gctctgtgtg gtgagcctgg ccgtctgcct gtctacctgc acgtccccac
     2581 tgccctgcac ggatcacctc taccagctgt ggggcaacat gagccccatg cttcctgctc
     2641 cgggtctatc ttccttccca acctttatgt gattgtcttc ccgccccctg cagtccttca
     2701 cttaagcgag ggcctggagc aggggtaagg ctaggttctg ggggacactc gagggggaat
     2761 tatgaggtcc tcacacccgg ctctaggcag ctggaccccc ctaccggggc tggataggtc
     2821 ccactgatgt gttcttgctg attagtctgg tcaataaagc tgctgtacta tatataaaaa
     2881 aaaaaaaaaa aaaaaaaaaa aaaaaa
//
