LOCUS       NP_001264854             775 aa            linear   ROD 23-JUL-2024
DEFINITION  endothelin-converting enzyme-like 1 [Mus musculus].
ACCESSION   NP_001264854
VERSION     NP_001264854.1
DBSOURCE    REFSEQ: accession NM_001277925.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 775)
  AUTHORS   Huang,Y., Mai,Y., Ye,W., Lv,S., Zhou,Y., Wu,P., Zhou,L., Li,Y. and
            Zhong,K.
  TITLE     Brachial Plexus Root Avulsion Injury-Induced Endothelin-Converting
            Enzyme-Like 1 Overexpression Is Associated with Injured Motor
            Neurons Survival
  JOURNAL   Mol Neurobiol 61 (8), 5194-5205 (2024)
   PUBMED   38170441
  REMARK    GeneRIF: Brachial Plexus Root Avulsion Injury-Induced
            Endothelin-Converting Enzyme-Like 1 Overexpression Is Associated
            with Injured Motor Neurons Survival.
REFERENCE   2  (residues 1 to 775)
  AUTHORS   Yao,S.Q., Wang,M., Liang,J.J., Ng,T.K. and Cen,L.P.
  TITLE     Retinal transcriptome of neonatal mice after optic nerve injury
  JOURNAL   PLoS One 18 (5), e0286344 (2023)
   PUBMED   37252932
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 775)
  AUTHORS   Kiral,F.R., Cakir,B., Tanaka,Y., Kim,J., Yang,W.S., Wehbe,F.,
            Kang,Y.J., Zhong,M., Sancer,G., Lee,S.H., Xiang,Y. and Park,I.H.
  TITLE     Generation of ventralized human thalamic organoids with thalamic
            reticular nucleus
  JOURNAL   Cell Stem Cell 30 (5), 677-688 (2023)
   PUBMED   37019105
REFERENCE   4  (residues 1 to 775)
  AUTHORS   Puelles,L., Diaz,C., Stuhmer,T., Ferran,J.L., Martinez-de la
            Torre,M. and Rubenstein,J.L.R.
  TITLE     LacZ-reporter mapping of Dlx5/6 expression and genoarchitectural
            analysis of the postnatal mouse prethalamus
  JOURNAL   J Comp Neurol 529 (2), 367-420 (2021)
   PUBMED   32420617
REFERENCE   5  (residues 1 to 775)
  AUTHORS   Loo,L., Simon,J.M., Xing,L., McCoy,E.S., Niehaus,J.K., Guo,J.,
            Anton,E.S. and Zylka,M.J.
  TITLE     Single-cell transcriptomic analysis of mouse neocortical
            development
  JOURNAL   Nat Commun 10 (1), 134 (2019)
   PUBMED   30635555
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 775)
  AUTHORS   Harrow,J.L., Steward,C.A., Frankish,A., Gilbert,J.G.,
            Gonzalez,J.M., Loveland,J.E., Mudge,J., Sheppard,D., Thomas,M.,
            Trevanion,S. and Wilming,L.G.
  TITLE     The Vertebrate Genome Annotation browser 10 years on
  JOURNAL   Nucleic Acids Res 42 (Database issue), D771-D779 (2014)
   PUBMED   24316575
REFERENCE   7  (residues 1 to 775)
  AUTHORS   Nagata,K., Kiryu-Seo,S., Maeda,M., Yoshida,K., Morita,T. and
            Kiyama,H.
  TITLE     Damage-induced neuronal endopeptidase is critical for presynaptic
            formation of neuromuscular junctions
  JOURNAL   J Neurosci 30 (20), 6954-6962 (2010)
   PUBMED   20484637
  REMARK    GeneRIF: The data of this study suggested that DINE is a crucial
            molecule in distal axonal arborization into muscle to establish
            neuromuscular junctions.
REFERENCE   8  (residues 1 to 775)
  AUTHORS   Kiryu-Seo,S., Kato,R., Ogawa,T., Nakagomi,S., Nagata,K. and
            Kiyama,H.
  TITLE     Neuronal injury-inducible gene is synergistically regulated by
            ATF3, c-Jun, and STAT3 through the interaction with Sp1 in damaged
            neurons
  JOURNAL   J Biol Chem 283 (11), 6988-6996 (2008)
   PUBMED   18192274
  REMARK    GeneRIF: Sp1 recruits ATF3, c-Jun, and STAT3 to obtain the
            requisite synergistic effect in neuronal injury through DINE
            neuronal injury-inducible gene
REFERENCE   9  (residues 1 to 775)
  AUTHORS   Kiryu-Seo,S., Sasaki,M., Yokohama,H., Nakagomi,S., Hirayama,T.,
            Aoki,S., Wada,K. and Kiyama,H.
  TITLE     Damage-induced neuronal endopeptidase (DINE) is a unique
            metallopeptidase expressed in response to neuronal damage and
            activates superoxide scavengers
  JOURNAL   Proc Natl Acad Sci U S A 97 (8), 4345-4350 (2000)
   PUBMED   10759559
REFERENCE   10 (residues 1 to 775)
  AUTHORS   Schweizer,A., Valdenaire,O., Koster,A., Lang,Y., Schmitt,G.,
            Lenz,B., Bluethmann,H. and Rohrer,J.
  TITLE     Neonatal lethality in mice deficient in XCE, a novel member of the
            endothelin-converting enzyme and neutral endopeptidase family
  JOURNAL   J Biol Chem 274 (29), 20450-20456 (1999)
   PUBMED   10400672
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102611.10.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159365.1, SRR7974084.20508.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..775
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 44.06 cM"
     Protein         1..775
                     /product="endothelin-converting enzyme-like 1"
                     /EC_number="3.4.24.11"
                     /note="damage-induced neuronal endopeptidase"
                     /calculated_mol_wt=87863
     Region          30..52
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JMI0.2)"
     Site            62..82
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JMI0.2)"
     Region          121..773
                     /region_name="M13"
                     /note="Peptidase family M13 includes neprilysin and
                     endothelin-converting enzyme I; cd08662"
                     /db_xref="CDD:341056"
     Site            order(151,565,570..573,592,608..609,612..613,616,672,715,
                     718..719,736..737,743)
                     /site_type="active"
                     /db_xref="CDD:341056"
     Site            255
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JMI0.2)"
     Site            322
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JMI0.2)"
     Site            656
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JMI0.2)"
     CDS             1..775
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /coded_by="NM_001277925.2:217..2544"
                     /db_xref="CCDS:CCDS15128.1"
                     /db_xref="GeneID:13599"
                     /db_xref="MGI:MGI:1343461"
ORIGIN      
        1 meapysmtah ydefqevkyv srcgtggarg tslppgfprg sgrsasgsrs glprwnrrev
       61 cllsglvfaa glcailaaml alkylgpgaa ggggacpegc perkafaraa rflsanldas
      121 idpcqdfysf acggwlrrha ipddkltygt iaaigeqnee rlrrllarpt ggpggaaqrk
      181 vraffrscld mreierlgpr pmleviedcg gwdlggaadr pgaarwdlnr llykaqgvys
      241 aaalfsltvs lddrnssryv iridqdgltl pertlylaqd eesekilaay rvfmqrllrl
      301 lgadaveqka qeilqleqrl anisvseydd lrrdvssayn kvtlgqlqki iphlqwkwll
      361 dqifqedfse eeevvllatd ymqqvsqlir stprrilhny lvwrvvvvls ehlsspfrea
      421 lhelakemeg ndkpqelarv clgqanrhfg malgalfvhe hfsaaskakv qqlvedikyi
      481 lgqrleeldw mdaqtkaaar aklqymmvmv gypdfllkpe avdkeyefev hektyfknil
      541 nsirfsiqls vkkirqevdk sswllppqal nayylpnknq mvfpagilqp tlydpdfpqs
      601 lnyggigtii ghelthgydd wggqydrsgn llhwwtetsy shflrkaeci vrlydnftvy
      661 nqrvngkhtl geniadmggl klayyayqkw vrehgpehpl hrlkythnql ffiafaqnwc
      721 ikrrsqsiyl qvltdkhape hyrvlgsvsq feefgrafhc pkdspmnpvh kcsvw
//
