LOCUS       NM_001369179            4686 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus endothelin converting enzyme 1 (Ece1), transcript
            variant 4, mRNA.
ACCESSION   NM_001369179 XM_006538767
VERSION     NM_001369179.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4686)
  AUTHORS   Chen,L., Lu,Y., Zhao,M., Xu,J., Wang,Y., Xu,Q., Cao,Y. and Liu,H.
  TITLE     A non-canonical role of endothelin converting enzyme 1 (ECE1) in
            promoting lung cancer development via directly targeting protein
            kinase B (AKT)
  JOURNAL   J Gene Med 26 (1), e3612 (2024)
   PUBMED   37897251
  REMARK    GeneRIF: A non-canonical role of endothelin converting enzyme 1
            (ECE1) in promoting lung cancer development via directly targeting
            protein kinase B (AKT).
REFERENCE   2  (bases 1 to 4686)
  AUTHORS   Eckman,E.A., Clausen,D.M., Sole-Domenech,S., Lee,C.W.,
            Sinobas-Pereira,C., Domalewski,R.J., Nichols,M.R. and
            Pacheco-Quinto,J.
  TITLE     Nascent Abeta42 Fibrillization in Synaptic Endosomes Precedes
            Plaque Formation in a Mouse Model of Alzheimer's-like
            beta-Amyloidosis
  JOURNAL   J Neurosci 43 (50), 8812-8824 (2023)
   PUBMED   37884349
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4686)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   4  (bases 1 to 4686)
  AUTHORS   Arfian,N., Suzuki,Y., Hartopo,A.B., Anggorowati,N.,
            Nugrahaningsih,D.A.A. and Emoto,N.
  TITLE     Endothelin converting enzyme-1 (ECE-1) deletion in association with
            Endothelin-1 downregulation ameliorates kidney fibrosis in mice
  JOURNAL   Life Sci 258, 118223 (2020)
   PUBMED   32768584
  REMARK    GeneRIF: Endothelin converting enzyme-1 (ECE-1) deletion in
            association with Endothelin-1 downregulation ameliorates kidney
            fibrosis in mice.
REFERENCE   5  (bases 1 to 4686)
  AUTHORS   Poltavski,D.M., Colombier,P., Hu,J., Duron,A., Black,B.L. and
            Makita,T.
  TITLE     Venous endothelin modulates responsiveness of cardiac sympathetic
            axons to arterial semaphorin
  JOURNAL   Elife 8, e42528 (2019)
   PUBMED   30735130
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4686)
  AUTHORS   Kuwaki,T., Ling,G.Y., Onodera,M., Ishii,T., Nakamura,A., Ju,K.H.,
            Cao,W.H., Kumada,M., Kurihara,H., Kurihara,Y., Yazaki,Y.,
            Ohuchi,T., Yanagisawa,M. and Fukuda,Y.
  TITLE     Endothelin in the central control of cardiovascular and respiratory
            functions
  JOURNAL   Clin Exp Pharmacol Physiol 26 (12), 989-994 (1999)
   PUBMED   10626068
  REMARK    Review article
REFERENCE   7  (bases 1 to 4686)
  AUTHORS   Yanagisawa,H., Hammer,R.E., Richardson,J.A., Williams,S.C.,
            Clouthier,D.E. and Yanagisawa,M.
  TITLE     Role of Endothelin-1/Endothelin-A receptor-mediated signaling
            pathway in the aortic arch patterning in mice
  JOURNAL   J Clin Invest 102 (1), 22-33 (1998)
   PUBMED   9649553
REFERENCE   8  (bases 1 to 4686)
  AUTHORS   Yanagisawa,H., Yanagisawa,M., Kapur,R.P., Richardson,J.A.,
            Williams,S.C., Clouthier,D.E., de Wit,D., Emoto,N. and Hammer,R.E.
  TITLE     Dual genetic pathways of endothelin-mediated intercellular
            signaling revealed by targeted disruption of endothelin converting
            enzyme-1 gene
  JOURNAL   Development 125 (5), 825-836 (1998)
   PUBMED   9449665
REFERENCE   9  (bases 1 to 4686)
  AUTHORS   Hanania,E.G., Au,W.W., Ullrich,R.L. and Papaconstantinou,J.
  TITLE     Regulation of retinoblastoma gene expression in a mouse mammary
            tumor model
  JOURNAL   Cancer Gene Ther 2 (4), 251-261 (1995)
   PUBMED   8548579
REFERENCE   10 (bases 1 to 4686)
  AUTHORS   Xu,D., Emoto,N., Giaid,A., Slaughter,C., Kaw,S., deWit,D. and
            Yanagisawa,M.
  TITLE     ECE-1: a membrane-bound metalloprotease that catalyzes the
            proteolytic activation of big endothelin-1
  JOURNAL   Cell 78 (3), 473-485 (1994)
   PUBMED   8062389
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807764.9.
            
            On Mar 22, 2019 this sequence version replaced XM_006538767.3.
            
            Transcript Variant: This variant (4), as well as variant 3, encodes
            isoform c.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5286961.44991.1,
                                           SRR9219379.14050.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               AL807764.9         115362-115463
            103-189             AL807764.9         166850-166936
            190-331             AL807764.9         174103-174244
            332-544             AL807764.9         179301-179513
            545-666             AL807764.9         188343-188464
            667-813             AL807764.9         189740-189886
            814-879             AL807764.9         190421-190486
            880-1071            AL807764.9         191706-191897
            1072-1214           AL807764.9         198099-198241
            1215-1329           AL807764.9         199337-199451
            1330-1440           AL807764.9         201626-201736
            1441-1539           AL807764.9         202529-202627
            1540-1617           AL807764.9         203238-203315
            1618-1721           AL807764.9         204580-204683
            1722-1832           AL807764.9         209540-209650
            1833-1900           AL807764.9         210217-210284
            1901-2091           AL807764.9         211081-211271
            2092-2187           AL807764.9         214725-214820
            2188-4686           AL807764.9         215812-218310
FEATURES             Location/Qualifiers
     source          1..4686
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 70.02 cM"
     gene            1..4686
                     /gene="Ece1"
                     /gene_synonym="ECE-1; ECE-1a; ECE-1b; ECE-1c1; ECE-1d"
                     /note="endothelin converting enzyme 1"
                     /db_xref="GeneID:230857"
                     /db_xref="MGI:MGI:1101357"
     exon            1..102
                     /gene="Ece1"
                     /gene_synonym="ECE-1; ECE-1a; ECE-1b; ECE-1c1; ECE-1d"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..2364
                     /gene="Ece1"
                     /gene_synonym="ECE-1; ECE-1a; ECE-1b; ECE-1c1; ECE-1d"
                     /EC_number="3.4.24.71"
                     /note="isoform c is encoded by transcript variant 4;
                     endothelin-converting enzyme-1b; endothelin-converting
                     enzyme-1d; endothelin-converting enzyme-1a;
                     endothelin-converting enzyme-1c1"
                     /codon_start=1
                     /product="endothelin-converting enzyme 1 isoform c"
                     /protein_id="NP_001356108.1"
                     /db_xref="CCDS:CCDS18822.1"
                     /db_xref="GeneID:230857"
                     /db_xref="MGI:MGI:1101357"
                     /translation="MSTYKRATLDEEDLVDSLSEGDVYPNGLQVNFRSSRSGQRCWAA
                     RTSVEKRLVVLVTLLAAGLVACLAALGIQYQTRTPPVCLTEACVSVTSSILNSMDPTV
                     DPCQDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAVIKHLLENATASVSEAERK
                     AQVYYRACMNETRIEELRAKPLMELIEKLGGWNITGPWAKDNFQDTLQVVTAHYRTSP
                     FFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLG
                     GGDEDAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPF
                     LNTIFYPVEINESEPIVVYDKEYLRQVSTLINNTDKCLLNNYMMWNLVRKTSSFLDQR
                     FQDADEKFMEVMYGTKKTCIPRWKFCVSDTENNLGFALGPMFVKATFAEDSKNIASEI
                     IMEIKKAFEESLSTLKWMDEETRRSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTA
                     VPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGIL
                     QAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQ
                     TECMVQQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEQTLPTLG
                     LTSNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPP
                     GSPMNPHHKCEVW"
     exon            103..189
                     /gene="Ece1"
                     /gene_synonym="ECE-1; ECE-1a; ECE-1b; ECE-1c1; ECE-1d"
                     /inference="alignment:Splign:2.1.0"
     exon            190..331
                     /gene="Ece1"
                     /gene_synonym="ECE-1; ECE-1a; ECE-1b; ECE-1c1; ECE-1d"
                     /inference="alignment:Splign:2.1.0"
     exon            332..544
                     /gene="Ece1"
                     /gene_synonym="ECE-1; ECE-1a; ECE-1b; ECE-1c1; ECE-1d"
                     /inference="alignment:Splign:2.1.0"
     exon            545..666
                     /gene="Ece1"
                     /gene_synonym="ECE-1; ECE-1a; ECE-1b; ECE-1c1; ECE-1d"
                     /inference="alignment:Splign:2.1.0"
     exon            667..813
                     /gene="Ece1"
                     /gene_synonym="ECE-1; ECE-1a; ECE-1b; ECE-1c1; ECE-1d"
                     /inference="alignment:Splign:2.1.0"
     exon            814..879
                     /gene="Ece1"
                     /gene_synonym="ECE-1; ECE-1a; ECE-1b; ECE-1c1; ECE-1d"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1071
                     /gene="Ece1"
                     /gene_synonym="ECE-1; ECE-1a; ECE-1b; ECE-1c1; ECE-1d"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1214
                     /gene="Ece1"
                     /gene_synonym="ECE-1; ECE-1a; ECE-1b; ECE-1c1; ECE-1d"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1329
                     /gene="Ece1"
                     /gene_synonym="ECE-1; ECE-1a; ECE-1b; ECE-1c1; ECE-1d"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1440
                     /gene="Ece1"
                     /gene_synonym="ECE-1; ECE-1a; ECE-1b; ECE-1c1; ECE-1d"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1539
                     /gene="Ece1"
                     /gene_synonym="ECE-1; ECE-1a; ECE-1b; ECE-1c1; ECE-1d"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1617
                     /gene="Ece1"
                     /gene_synonym="ECE-1; ECE-1a; ECE-1b; ECE-1c1; ECE-1d"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1721
                     /gene="Ece1"
                     /gene_synonym="ECE-1; ECE-1a; ECE-1b; ECE-1c1; ECE-1d"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1832
                     /gene="Ece1"
                     /gene_synonym="ECE-1; ECE-1a; ECE-1b; ECE-1c1; ECE-1d"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1900
                     /gene="Ece1"
                     /gene_synonym="ECE-1; ECE-1a; ECE-1b; ECE-1c1; ECE-1d"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2091
                     /gene="Ece1"
                     /gene_synonym="ECE-1; ECE-1a; ECE-1b; ECE-1c1; ECE-1d"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2187
                     /gene="Ece1"
                     /gene_synonym="ECE-1; ECE-1a; ECE-1b; ECE-1c1; ECE-1d"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..4686
                     /gene="Ece1"
                     /gene_synonym="ECE-1; ECE-1a; ECE-1b; ECE-1c1; ECE-1d"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccctgagg ttcgagcgta gagctcagcc cagcgcactt ggagctggag ccttagcggg
       61 aggtgcatcc taagcccggc cgttcggagc ccgggagcga cgatgtcaac ctacaagcgg
      121 gccacgctgg acgaagagga tctggtggac tcactctccg agggcgatgt gtaccccaat
      181 ggcctacagg tgaacttccg cagctcccgg agcggccaga ggtgctgggc agctcggacc
      241 tcggtggaga agcggctggt ggtgctggtg acgcttctgg cggcagggtt ggtggcctgc
      301 ctggcagccc tgggcatcca gtaccagaca agaacgcctc cggtatgtct gacggaggcc
      361 tgtgtctcag tgaccagctc tatcctaaac tccatggacc ccacagtaga cccgtgccag
      421 gacttcttca gctacgcctg cgggggctgg atcaaggcca accccgtgcc cgatggccac
      481 tcacgctggg gaaccttcag caacctctgg gaacacaacc aagctgtcat caagcatcta
      541 ctggaaaatg ccacggccag tgtgagcgag gcagagagaa aagcccaagt gtactaccgt
      601 gcgtgcatga acgaaactag gattgaggag cttcgggcca agcccctgat ggagctgatt
      661 gagaagctgg gaggctggaa tatcacagga ccctgggcca aggacaactt ccaggacaca
      721 ctgcaggtgg tcacagctca ctaccgcacc tcacccttct tctctgttta tgtcagcgcg
      781 gactccaaga attccaacag caatgtgatc caggtggacc agtccggcct tggcttgccc
      841 tccagagact attacctgaa caagacagag aatgaaaagg tcctgactgg atacctgaac
      901 tacatggtcc agctggggaa gctcctgggc ggtggggacg aggatgccat ccggccacag
      961 atgcagcaga tcctggattt tgagacggcg ctggccaaca tcaccatccc ccaggagaag
     1021 cgcagggatg aagaactcat ctaccacaaa gtcacggctg ccgagctgca gaccttggca
     1081 cctgccatca actggttacc ctttctgaac accatttttt acccagtgga gatcaatgag
     1141 tctgagccaa tcgtggtcta cgacaaggaa tacttgagac aagtctccac cctcatcaac
     1201 aacaccgaca aatgtctgct caacaactac atgatgtgga acctggtacg caaaacaagc
     1261 tccttcctgg accagcgctt tcaggacgcc gacgagaagt tcatggaggt tatgtatggg
     1321 acgaagaaga cctgtattcc ccgctggaag ttttgtgtga gtgacacgga aaacaacctg
     1381 ggctttgccc tgggacccat gtttgtgaaa gcaacctttg cagaagacag taagaatata
     1441 gccagtgaga tcatcatgga gatcaagaag gcgtttgagg agagtctgag cactctgaaa
     1501 tggatggatg aagagactcg gagatcagcc aaggagaagg cggatgctat ctacaacatg
     1561 ataggctacc ccaacttcat catggacccc aaggagctgg acaaagtctt caatgactac
     1621 acagcagttc ctgatctcta ctttgagaac gccatgcgct ttttcaactt ctcatggagg
     1681 gtcacagctg accagctcag aaaagctccc aacagagatc agtggagtat gacgccgccc
     1741 atggtgaacg cttactactc gcccaccaag aacgagatcg tgtttccagc tggaatactg
     1801 caggcgccat tttatacccg ctcttcaccc aacgccttga acttcggtgg cattggtgtc
     1861 gtagtgggcc acgagctgac tcacgctttc gatgatcaag gtcgggagta cgacaaggat
     1921 gggaaccttc gaccctggtg gaagaactcg tccgtggagg cgttcaagca gcagacggag
     1981 tgcatggtgc agcaatacag caactacagc gtgaacgggg agcccgtgaa cggtcgacac
     2041 accctcgggg agaacattgc cgacaacggg ggactcaagg cggcctaccg ggcgtaccag
     2101 aactgggtaa agaagaacgg agctgagcag acgctgccca ccctgggtct caccagcaac
     2161 cagctcttct tcctaggatt tgcacaggtc tggtgctctg tccgcacacc tgagagctcc
     2221 cacgaaggcc tcatcacgga tccgcacagc ccctctcgct tccgggtcat cggctcgctc
     2281 tccaactcca aggagttctc agaacacttt cgctgcccgc ctggctctcc catgaaccct
     2341 catcacaagt gcgaagtctg gtaagggcta aagcgcagag agcacggaca gaaaaaggga
     2401 aggagctgca gctagctccc agcggagcca tgttgccacc ctcctcccag cccctcggcc
     2461 tagggcccct tccccactct ggagagtatg cagccatcct aagcctaaga tggatggagc
     2521 ctcaccactc gaagccaaga tttgaccccc tgtgaagctc cggcatcctg gacaccggtg
     2581 cgtgatgcta ggcgggcctt tggatgtgtc aagctggtgg cttgccagcc ctgggcctca
     2641 cactgacaat ggcagtggga catggccccc tgcccacatc caatgccaga tacaccacaa
     2701 taccactgtg tcaaatgctt taaagatata tttttgggga gactattttt taagcattat
     2761 ggaatacact ggaaatcttc agggaaaata catttaaaac actttttttt taaaaaaaga
     2821 aaagaaaaga ttagtatatt tattatgttc tcttttttct aaacaacctg tggacaaagg
     2881 aaaccccact aatttacccc ctgggaaccc caggctgtgg agaaggctgc cagtttgagc
     2941 gagcactact ttagcccatt gctggtgtaa ttacttctat agtcaccggt gcagtcagga
     3001 gatgtagggg cccaggcaga gggggtgagc agctgaaggg cctggttatg ggcgtgacct
     3061 tctcagctta cctgtcctgt cgctggagtc caaccatggg aagcccaaca aggatgggtt
     3121 gatacccaag tgatagttga ggcagcacaa aggcagagta atgaccttca tatcacgtgg
     3181 cacccgaaca ctctagacta gaacatagga gcctgttgga gctgagaacc cacaccccac
     3241 cagatgcacc ctgttgtcca aagatgtctt tttttttttt ttttttttgg tcccacctct
     3301 tctggccctg agacccgttg cctctctgta gcaattctga catcctgaag tggtcagctt
     3361 cactgatcct ctgtgcagag ggaaagggga aaaaaaactc agcccagttc tccctccaag
     3421 ctctgtagcc tgtagttgcc ctggcctggc tcctgggacc cccttctcta gtgccttacc
     3481 ccaggctgca gaccctgagc cccactagga ggcagcattt ggcttgcttt cccagtggag
     3541 cccccaagtg tcctgactag aagccaacac catagcccca ttcccagaag ccccagggta
     3601 ccaccccaac ctgcctacag gacagccatt ccagatagac gtccagtgtc aggagctgct
     3661 gacctctcag gctttcagcc acccgtggca cgcacattga atcaattcag tccttgtaga
     3721 tagagggatt cccctcaccc cctccccctc tctgtttttt tggaggtgga tgctgtagcc
     3781 agagcaggcc aagactggaa tgttcccagc cccattgggc tccagggaat ggcagaaagt
     3841 catccaccca cagcatcacg tagtagatat gtgggctccc actaggtggc gctcaccgca
     3901 gttctcatga ctcctgcagg gagcaagctc ttgtgatatg tgtgggagaa gcctagtagt
     3961 gcccattaca gcccctggca ggccatgctc ccacaccaca cagcacggcg tgcgctcaca
     4021 cacacacaca cacacacaca cacacacaca cacacacaca cacacacaca cacacacacc
     4081 tggaagccgg agtcctcctt gaccaagacg cagagacaat atggtctcgg ccccgcttgc
     4141 taggatggga actacaagca ggcacctggc aaggttcttg gtccctgtaa acacattcga
     4201 ggtctcggct cttcggggga aaggtaacat aagaaggcag gaaggtgctg gagccgtgcc
     4261 ctgccacaca aagggggacc ttctgggtct ggatcatctg ccctttctat cccgtcgcct
     4321 tgcctctcca tagagtggca gtcctggata ctggtatcta gaagcggggt cctgaactgg
     4381 gttcagccat atggacattg ctcagggtgt gcagggagcc aaggcaggaa gacgcagact
     4441 ggttagggat ggatgggcac aaaagcagaa ccccaagccc cgcccctcca gagatttgag
     4501 aagggcggta gcgggaaggg catctgccct cagaaagacc ccttctctca agcccggagt
     4561 ttccctgcag gcacaaggac atggggtttg gagctgggga ctcttatttt tttgtattat
     4621 tgtgttttgt gctactgtag ttttggtgtg gcactattat aattaaaata aagtacttat
     4681 accaag
//
