LOCUS       NM_015766               1187 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus Epstein-Barr virus induced gene 3 (Ebi3), mRNA.
ACCESSION   NM_015766
VERSION     NM_015766.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1187)
  AUTHORS   Pagano,G., Botana,I.F., Wierz,M., Roessner,P.M., Ioannou,N.,
            Zhou,X., Al-Hity,G., Borne,C., Gargiulo,E., Gonder,S., Qu,B.,
            Stamatopoulos,B., Ramsay,A.G., Seiffert,M., Largeot,A., Moussay,E.
            and Paggetti,J.
  TITLE     Interleukin-27 potentiates CD8+ T-cell-mediated antitumor immunity
            in chronic lymphocytic leukemia
  JOURNAL   Haematologica 108 (11), 3011-3024 (2023)
   PUBMED   37345470
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1187)
  AUTHORS   Goto,H., Kikuchi,T., Takayanagi,Y., Kamiya,Y., Suzuki,Y.,
            Kawamura,S., Sawada,N., Hayashi,J.I. and Mitani,A.
  TITLE     Ebi3 knockout aggravates experimental periodontitis via Th17
            polarization
  JOURNAL   J Clin Periodontol 50 (10), 1406-1418 (2023)
   PUBMED   37534736
  REMARK    GeneRIF: Ebi3 knockout aggravates experimental periodontitis via
            Th17 polarization.
REFERENCE   3  (bases 1 to 1187)
  AUTHORS   Li,S., Mirlekar,B., Johnson,B.M., Brickey,W.J., Wrobel,J.A.,
            Yang,N., Song,D., Entwistle,S., Tan,X., Deng,M., Cui,Y., Li,W.,
            Vincent,B.G., Gale,M. Jr., Pylayeva-Gupta,Y. and Ting,J.P.
  TITLE     STING-induced regulatory B cells compromise NK function in cancer
            immunity
  JOURNAL   Nature 610 (7931), 373-380 (2022)
   PUBMED   36198789
REFERENCE   4  (bases 1 to 1187)
  AUTHORS   Michaud,D., Mirlekar,B., Steward,C., Bishop,G. and
            Pylayeva-Gupta,Y.
  TITLE     B Cell Receptor Signaling and Protein Kinase D2 Support Regulatory
            B Cell Function in Pancreatic Cancer
  JOURNAL   Front Immunol 12, 745873 (2022)
   PUBMED   35046933
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1187)
  AUTHORS   Wang,Q., Li,D., Cao,G., Shi,Q., Zhu,J., Zhang,M., Cheng,H., Wen,Q.,
            Xu,H., Zhu,L., Zhang,H., Perry,R.J., Spadaro,O., Yang,Y., He,S.,
            Chen,Y., Wang,B., Li,G., Liu,Z., Yang,C., Wu,X., Zhou,L., Zhou,Q.,
            Ju,Z., Lu,H., Xin,Y., Yang,X., Wang,C., Liu,Y., Shulman,G.I.,
            Dixit,V.D., Lu,L., Yang,H., Flavell,R.A. and Yin,Z.
  TITLE     IL-27 signalling promotes adipocyte thermogenesis and energy
            expenditure
  JOURNAL   Nature 600 (7888), 314-318 (2021)
   PUBMED   34819664
REFERENCE   6  (bases 1 to 1187)
  AUTHORS   Takahashi,H., Hatakeyama,S., Saitoh,H. and Nakayama,K.I.
  TITLE     Noncovalent SUMO-1 binding activity of thymine DNA glycosylase
            (TDG) is required for its SUMO-1 modification and colocalization
            with the promyelocytic leukemia protein
  JOURNAL   J Biol Chem 280 (7), 5611-5621 (2005)
   PUBMED   15569683
REFERENCE   7  (bases 1 to 1187)
  AUTHORS   Lucas,S., Ghilardi,N., Li,J. and de Sauvage,F.J.
  TITLE     IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through
            Stat1-dependent and -independent mechanisms
  JOURNAL   Proc Natl Acad Sci U S A 100 (25), 15047-15052 (2003)
   PUBMED   14657353
REFERENCE   8  (bases 1 to 1187)
  AUTHORS   Zhang,J.H., He,H., Borzychowski,A.M., Takeda,K., Akira,S. and
            Croy,B.A.
  TITLE     Analysis of cytokine regulators inducing interferon production by
            mouse uterine natural killer cells
  JOURNAL   Biol Reprod 69 (2), 404-411 (2003)
   PUBMED   12646495
REFERENCE   9  (bases 1 to 1187)
  AUTHORS   Nieuwenhuis,E.E., Neurath,M.F., Corazza,N., Iijima,H.,
            Trgovcich,J., Wirtz,S., Glickman,J., Bailey,D., Yoshida,M.,
            Galle,P.R., Kronenberg,M., Birkenbach,M. and Blumberg,R.S.
  TITLE     Disruption of T helper 2-immune responses in Epstein-Barr
            virus-induced gene 3-deficient mice
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16951-16956 (2002)
   PUBMED   12482940
  REMARK    GeneRIF: EBI3 plays a critical regulatory role in the induction of
            Th2-type immune responses and the development of Th2-mediated
            tissue inflammation in vivo.
REFERENCE   10 (bases 1 to 1187)
  AUTHORS   Puttagunta,R., Gordon,L.A., Meyer,G.E., Kapfhamer,D.,
            Lamerdin,J.E., Kantheti,P., Portman,K.M., Chung,W.K., Jenne,D.E.,
            Olsen,A.S. and Burmeister,M.
  TITLE     Comparative maps of human 19p13.3 and mouse chromosome 10 allow
            identification of sequences at evolutionary breakpoints
  JOURNAL   Genome Res 10 (9), 1369-1380 (2000)
   PUBMED   10984455
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY134465.1, CX240802.1, BI134394.1 and AW495532.1.
            
            On Jul 15, 2005 this sequence version replaced NM_015766.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008209.1, AF013114.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-363               BY134465.1         2-364
            364-697             CX240802.1         311-644
            698-1167            BI134394.1         22-491              c
            1168-1187           AW495532.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..1187
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.08 cM"
     gene            1..1187
                     /gene="Ebi3"
                     /gene_synonym="EBI-3; IL-27"
                     /note="Epstein-Barr virus induced gene 3"
                     /db_xref="GeneID:50498"
                     /db_xref="MGI:MGI:1354171"
     exon            1..306
                     /gene="Ebi3"
                     /gene_synonym="EBI-3; IL-27"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..926
                     /gene="Ebi3"
                     /gene_synonym="EBI-3; IL-27"
                     /note="interleukin-27 subunit beta; IL-27B; IL-27 subunit
                     beta; epstein-Barr virus-induced gene 3 protein homolog"
                     /codon_start=1
                     /product="interleukin-27 subunit beta precursor"
                     /protein_id="NP_056581.1"
                     /db_xref="CCDS:CCDS28888.1"
                     /db_xref="GeneID:50498"
                     /db_xref="MGI:MGI:1354171"
                     /translation="MSKLLFLSLALWASRSPGYTETALVALSQPRVQCHASRYPVAVD
                     CSWTPLQAPNSTRSTSFIATYRLGVATQQQSQPCLQRSPQASRCTIPDVHLFSTVPYM
                     LNVTAVHPGGASSSLLAFVAERIIKPDPPEGVRLRTAGQRLQVLWHPPASWPFPDIFS
                     LKYRLRYRRRGASHFRQVGPIEATTFTLRNSKPHAKYCIQVSAQDLTDYGKPSDWSLP
                     GQVESAPHKP"
     exon            307..436
                     /gene="Ebi3"
                     /gene_synonym="EBI-3; IL-27"
                     /inference="alignment:Splign:2.1.0"
     exon            437..615
                     /gene="Ebi3"
                     /gene_synonym="EBI-3; IL-27"
                     /inference="alignment:Splign:2.1.0"
     exon            616..770
                     /gene="Ebi3"
                     /gene_synonym="EBI-3; IL-27"
                     /inference="alignment:Splign:2.1.0"
     exon            771..1171
                     /gene="Ebi3"
                     /gene_synonym="EBI-3; IL-27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1151..1156
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ebi3"
                     /gene_synonym="EBI-3; IL-27"
                     /note="hexamer: ATTAAA"
     polyA_site      1171
                     /gene="Ebi3"
                     /gene_synonym="EBI-3; IL-27"
                     /note="major polyA site"
ORIGIN      
        1 gacttctccc ttttggggcc ctccttctac ctcaaggcct ttccccacac atacacacag
       61 cagctggtga cagaatcagg gttcccgtca ccatcatcat ctcctgcccc atacactgga
      121 caactgagcc acactgggca ggtccttccc tggggccagg ttccctgtgt gagtcccctg
      181 tccttcaccc tctctctgat gggtcactaa ctcggatcca aggaacagag ccacagagca
      241 tgtccaagct gctcttcctg tcacttgccc tctgggccag ccgctcccct ggttacactg
      301 aaacagctct cgtggctcta agccagccca gagtgcaatg ccatgcttct cggtatcccg
      361 tggccgtgga ctgctcctgg actcctctcc aggctcccaa ctccaccaga tccacgtcct
      421 tcattgccac ttacaggctc ggtgtggcca cccagcagca gagccagccc tgcctacaac
      481 ggagccccca ggcctcccga tgcaccatcc ccgacgtgca cctgttctcc acggtgccct
      541 acatgctaaa tgtcactgca gtgcacccag gcggcgccag cagcagcctc ctagcctttg
      601 tggctgagcg aatcatcaag ccggaccctc cggaaggcgt gcgcctgcgc acagcgggac
      661 agcgcctgca ggtgctctgg catccccctg cttcctggcc cttcccggac atcttctctc
      721 tcaagtaccg actccgctac cggcgccgag gagcctctca cttccgccag gtgggaccca
      781 ttgaagccac gactttcacc ctcaggaact cgaaacccca tgccaagtat tgcatccagg
      841 tgtcagctca ggacctcaca gattatggga aaccaagtga ctggagcctc cctgggcaag
      901 tagaaagtgc accccataag ccctgaagag ggactggatc cttgatatca gaccctgatg
      961 tcgtctactt gagggtggca gggtggcctg tcctgagtct gaatactgac tttccatgta
     1021 ctgggctgct ccgaagcact ggataattca cttgacttct tcagacctca atttccaacc
     1081 ctgtgggatg atctttcttc ttctgccggt gcggggcttt gtgaactttg tgatttaatt
     1141 agaaagacgg attaaataag aatcatcatc aaaaaaaaaa aaaaaaa
//
