LOCUS       NM_001415846            2983 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus early B cell factor 4 (Ebf4), transcript variant 1,
            mRNA.
ACCESSION   NM_001415846 XM_006499279
VERSION     NM_001415846.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2983)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2983)
  AUTHORS   Kuriki,M., Sato,F., Arai,H.N., Sogabe,M., Kaneko,M., Kiyonari,H.,
            Kawakami,K., Yoshimoto,Y., Shukunami,C. and Sehara-Fujisawa,A.
  TITLE     Transient and lineage-restricted requirement of Ebf3 for sternum
            ossification
  JOURNAL   Development 147 (9) (2020)
   PUBMED   32398354
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2983)
  AUTHORS   Catela,C., Correa,E., Wen,K., Aburas,J., Croci,L., Consalez,G.G.
            and Kratsios,P.
  TITLE     An ancient role for collier/Olf/Ebf (COE)-type transcription
            factors in axial motor neuron development
  JOURNAL   Neural Dev 14 (1), 2 (2019)
   PUBMED   30658714
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2983)
  AUTHORS   Memic,F., Knoflach,V., Morarach,K., Sadler,R., Laranjeira,C.,
            Hjerling-Leffler,J., Sundstrom,E., Pachnis,V. and Marklund,U.
  TITLE     Transcription and Signaling Regulators in Developing Neuronal
            Subtypes of Mouse and Human Enteric Nervous System
  JOURNAL   Gastroenterology 154 (3), 624-636 (2018)
   PUBMED   29031500
REFERENCE   5  (bases 1 to 2983)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 2983)
  AUTHORS   Quina,L.A., Wang,S., Ng,L. and Turner,E.E.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
REFERENCE   7  (bases 1 to 2983)
  AUTHORS   Willnow,T., Antignac,C., Brandli,A., Christensen,E., Cox,R.,
            Davidson,D., Davies,J., Devuyst,O., Eichele,G., Hastie,N.,
            Verroust,P., Schedl,A. and Meij,I.
  TITLE     The European renal genome project: an integrated approach towards
            understanding the genetics of kidney development and disease
  JOURNAL   Organogenesis 2 (2), 42-47 (2005)
   PUBMED   19521566
REFERENCE   8  (bases 1 to 2983)
  AUTHORS   Mella,S., Soula,C., Morello,D., Crozatier,M. and Vincent,A.
  TITLE     Expression patterns of the coe/ebf transcription factor genes
            during chicken and mouse limb development
  JOURNAL   Gene Expr Patterns 4 (5), 537-542 (2004)
   PUBMED   15261831
REFERENCE   9  (bases 1 to 2983)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 2983)
  AUTHORS   Wang,S.S., Betz,A.G. and Reed,R.R.
  TITLE     Cloning of a novel Olf-1/EBF-like gene, O/E-4, by degenerate
            oligo-based direct selection
  JOURNAL   Mol Cell Neurosci 20 (3), 404-414 (2002)
   PUBMED   12139918
  REMARK    GeneRIF: The fourth member of the Olf-1/Ebf-like gene family,
            O/E-4, is expressed in the neuronal and basal cell layers of
            olfactory epithelium and may interact with other O/E family members
            to regulate gene expression in the olfactory sensory neurons.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX936285.5 and BX890605.4.
            
            On Jan 4, 2023 this sequence version replaced XM_006499279.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-416               BX936285.5         6832-7247
            417-538             BX936285.5         7706-7827
            539-695             BX936285.5         18086-18242
            696-759             BX936285.5         18479-18542
            760-815             BX936285.5         18677-18732
            816-889             BX890605.4         2434-2507
            890-958             BX890605.4         3554-3622
            959-1040            BX890605.4         52656-52737
            1041-1158           BX890605.4         53450-53567
            1159-1292           BX890605.4         53652-53785
            1293-1419           BX890605.4         53885-54011
            1420-1508           BX890605.4         55499-55587
            1509-1574           BX890605.4         55710-55775
            1575-1746           BX890605.4         55871-56042
            1747-1932           BX890605.4         56127-56312
            1933-2130           BX890605.4         59341-59538
            2131-2206           BX890605.4         63319-63394
            2207-2983           BX890605.4         63572-64348
FEATURES             Location/Qualifiers
     source          1..2983
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.21 cM"
     gene            1..2983
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /note="early B cell factor 4"
                     /db_xref="GeneID:228598"
                     /db_xref="MGI:MGI:2385972"
     exon            1..416
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..2201
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; transcription factor COE4; early B-cell factor
                     3; OE-4; EBF-4; Olf-1/EBF-like 4"
                     /codon_start=1
                     /product="transcription factor COE4 isoform 1 precursor"
                     /protein_id="NP_001402775.1"
                     /db_xref="GeneID:228598"
                     /db_xref="MGI:MGI:2385972"
                     /translation="MARARGQAPGSGGRRRPRRGGAGTGPRGDSAGLLLLLLQVLPPG
                     AAAGPGRRGTRGPGGGCVCWPGAGPAFPRDARLLLLLPPRPPPSPPPTSTAAASPSRM
                     DALPRGGLHLKEEPLLPSSLGSVRSWMQSAGILDSNTAAQSGVGLARAHFEKQPPSNL
                     RKSNFFHFVLAMYDRQGQPVEVERTAFIDFVEKDREPGTEKTNNGIHYRLRLVYNNGL
                     RTEQDLYVRLIDSMSKQAIIYEGQDKNPEMCRVLLTHEIMCSRCCDRKSCGNRNETPS
                     DPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHN
                     NSKHGRRARRLDPSEAATPCIKAISPGEGWTTGGATVIIIGDNFFDGLQVVFGNVLLW
                     SELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRFVYTALNEPTIDYGFQRL
                     QKVIPRHPGDPERLPKEVLLKRAADLAEALYGVPSSNQELLLKRAADVAEALYSAPRA
                     PAPLGPLAPSHPHPAVVGINAFSSPLAIAVGDTTPEPGYARSCGSASPRFAPSPGSQQ
                     SSYGSGLGAGLGSYGAPGVTGLGVPGSPSFLNGSTATSPFAIMPSSPPLAAASSMSLP
                     AAAPTTSVFSFSPVNMICAVKQRSAFAPVLRPPSSPSQACPRAHREGLPDQPFEDTDK
                     FHSAARGLQGLAYS"
     exon            417..538
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            539..695
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            696..759
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            760..815
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            816..889
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            890..958
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1040
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1158
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1292
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1419
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1508
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1574
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1746
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1932
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2130
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2206
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2983
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2956..2961
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /note="hexamer: AATAAA"
     polyA_site      2983
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /note="major polyA site"
ORIGIN      
        1 gcctcccctg gccccgagtc ccctgggccc acccgcttgc gacagccctc ctcttgcccg
       61 tgctccctcc ctacggctcc cgctccccag ggagcggcgg cggcggcggg atggccaggg
      121 cccgcggcca ggccccgggg agcggcgggc ggcggcggcc gcggcgggga ggcgcgggga
      181 ccgggccccg gggggactcg gccggtctgc tgctgctcct gctgcaggtg ctgccgcccg
      241 gggcagcggc aggcccgggg cgccggggca ctcgggggcc tggcggcggc tgcgtctgct
      301 ggcccggcgc cggccctgct tttccacggg acgcgcgtct gctgctgttg ctgccgcccc
      361 ggccaccacc gtcgccgccg ccgacctcca cggccgcagc ctccccctct cggatggacg
      421 ctctgccccg cggtgggctc catctgaaag aggagccgct gctgccctcc agcctgggct
      481 cggtgcgctc ctggatgcag agcgcgggca tcctggactc caacaccgcg gcgcagagtg
      541 gcgtgggcct ggcaagagca cattttgaaa agcagccccc ctccaacctc aggaagtcca
      601 acttcttcca cttcgtgctg gccatgtacg accggcaggg gcagcccgtg gaggtggagc
      661 gcacagcctt catcgacttc gtggaaaagg atcgagagcc tgggacggaa aagacaaaca
      721 acgggatcca ttaccgcctt cggctggtgt ataataatgg acttcggaca gagcaagacc
      781 tctacgtgcg ccttattgac tccatgtcga agcaggctat catctatgag ggacaggaca
      841 agaatcctga gatgtgccga gtgctgctca ctcatgagat catgtgcagc cggtgctgtg
      901 accgcaagag ctgtggtaac cggaatgaga cgccttctga tccagtcatt attgacaggt
      961 tcttcctcaa attctttctc aaatgcaacc agaactgctt gaagaatgcc gggaatcccc
     1021 gagacatgcg ccgcttccag gtggtggtgt ccacgaccgt gagtgtggat ggccatgtgc
     1081 tggctgtgtc ggacaacatg tttgtgcaca acaactccaa gcatggacgc agagcccgac
     1141 gcctggaccc ttctgaagct gccaccccct gcatcaaggc catcagccca ggggagggct
     1201 ggaccacggg aggcgccacc gtcattatca tcggagacaa cttcttcgac gggttgcagg
     1261 tcgtgtttgg caacgtgctc ctgtggagcg agctcatcac tccccatgct atccgggtgc
     1321 agacaccacc ccgacacatc cctggggtag tagaagtgac cctctcctac aagtccaagc
     1381 agttctgtaa aggagcccct ggccgctttg tctacacagc cctgaatgaa cccaccattg
     1441 actacggatt ccagaggctc cagaaagtta ttcccagaca ccccggagac cctgagaggc
     1501 tacccaagga agtgctgctg aaaagggcgg ctgacttggc ggaggccctg tacggagtgc
     1561 ccagcagtaa ccaggagctc ctcctgaaac gtgcggcgga cgtggccgag gctctgtaca
     1621 gcgccccgcg cgcgcctgca ccactcggac ccctggcccc cagccacccg caccccgccg
     1681 tcgtgggtat caatgccttc agcagccctc tggccatcgc cgtcggggat accacaccgg
     1741 agccgggcta tgcccgtagc tgcggcagcg cgtctccccg gttcgcgccc agccccggct
     1801 ctcagcagag cagctatggc agtggccttg gagccggcct cggtagctat ggcgcgcctg
     1861 gtgtgactgg ccttggcgtg cccgggtccc ctagcttcct caatggctcc accgcaacct
     1921 cacctttcgc catcatgccc tctagccccc cgctggcggc tgcctcctcc atgtcccttc
     1981 cggccgccgc ccccaccacc agcgtcttct ccttctcgcc tgtcaacatg atctgcgctg
     2041 tcaagcagag gagcgccttc gcccctgtgc tgcgcccacc cagttcccca tcgcaggcct
     2101 gccccagagc ccacagagag gggcttccag accagccttt tgaagatact gacaagttcc
     2161 actctgcagc ccggggactc cagggcttgg catactccta attatggtcc gcaggtgctg
     2221 tccccaacag ggctggactg gaggtctttc tggactcacg ttcgtggccg gatggcaggg
     2281 cttcgggtgg acctcgaccc ctgggataca cagggagagg ccttcacctc tgtgctggag
     2341 gcccctcaca cccacagacc ctcatactta cctctctttc tcgggacaca ttagaacctc
     2401 agcactgtga ggacgctctt ggcaggagag catcgtaggg aggaggtgtt gggatgtcgg
     2461 gccttactac tggatcaatt cctctataag aggaattttg tgcagaccag ggatgttggt
     2521 aagatgagca agaactgaga actgtgggaa agaggacagc tcagggagag gtcatctaga
     2581 gaggccctgt ttgcatctga ccaatcatac ctgacctaat agccgccttc tctcctgcca
     2641 gcaaggtgtc tagcagtctc aggaggccca ttcaggctcc catggagctg cccacgagcc
     2701 actggacccc attggctgcc ttcacttcct cctctgagag tagcacattc atgctgatca
     2761 tatcccacct ccctttgggg gttttaggca tggaagatgc acagaagggc ctcctggatt
     2821 ttgactctga ccccaataga tgtttcatga aatttgtccc cctaccacca cacacccagc
     2881 tctagctggc cccaaagaac agcctggcca tgccttggtg gcctcacact ctgatgagtt
     2941 tggacaaaat ggaacaataa aaccagatgc aggtggccac gtg
//
