LOCUS       NM_001110513            2687 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus early B cell factor 4 (Ebf4), transcript variant 2,
            mRNA.
ACCESSION   NM_001110513
VERSION     NM_001110513.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2687)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2687)
  AUTHORS   Kuriki,M., Sato,F., Arai,H.N., Sogabe,M., Kaneko,M., Kiyonari,H.,
            Kawakami,K., Yoshimoto,Y., Shukunami,C. and Sehara-Fujisawa,A.
  TITLE     Transient and lineage-restricted requirement of Ebf3 for sternum
            ossification
  JOURNAL   Development 147 (9) (2020)
   PUBMED   32398354
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2687)
  AUTHORS   Catela,C., Correa,E., Wen,K., Aburas,J., Croci,L., Consalez,G.G.
            and Kratsios,P.
  TITLE     An ancient role for collier/Olf/Ebf (COE)-type transcription
            factors in axial motor neuron development
  JOURNAL   Neural Dev 14 (1), 2 (2019)
   PUBMED   30658714
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2687)
  AUTHORS   Memic,F., Knoflach,V., Morarach,K., Sadler,R., Laranjeira,C.,
            Hjerling-Leffler,J., Sundstrom,E., Pachnis,V. and Marklund,U.
  TITLE     Transcription and Signaling Regulators in Developing Neuronal
            Subtypes of Mouse and Human Enteric Nervous System
  JOURNAL   Gastroenterology 154 (3), 624-636 (2018)
   PUBMED   29031500
REFERENCE   5  (bases 1 to 2687)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 2687)
  AUTHORS   Quina,L.A., Wang,S., Ng,L. and Turner,E.E.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
REFERENCE   7  (bases 1 to 2687)
  AUTHORS   Willnow,T., Antignac,C., Brandli,A., Christensen,E., Cox,R.,
            Davidson,D., Davies,J., Devuyst,O., Eichele,G., Hastie,N.,
            Verroust,P., Schedl,A. and Meij,I.
  TITLE     The European renal genome project: an integrated approach towards
            understanding the genetics of kidney development and disease
  JOURNAL   Organogenesis 2 (2), 42-47 (2005)
   PUBMED   19521566
REFERENCE   8  (bases 1 to 2687)
  AUTHORS   Mella,S., Soula,C., Morello,D., Crozatier,M. and Vincent,A.
  TITLE     Expression patterns of the coe/ebf transcription factor genes
            during chicken and mouse limb development
  JOURNAL   Gene Expr Patterns 4 (5), 537-542 (2004)
   PUBMED   15261831
REFERENCE   9  (bases 1 to 2687)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 2687)
  AUTHORS   Wang,S.S., Betz,A.G. and Reed,R.R.
  TITLE     Cloning of a novel Olf-1/EBF-like gene, O/E-4, by degenerate
            oligo-based direct selection
  JOURNAL   Mol Cell Neurosci 20 (3), 404-414 (2002)
   PUBMED   12139918
  REMARK    GeneRIF: The fourth member of the Olf-1/Ebf-like gene family,
            O/E-4, is expressed in the neuronal and basal cell layers of
            olfactory epithelium and may interact with other O/E family members
            to regulate gene expression in the olfactory sensory neurons.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF387633.1 and BE944141.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF387633.1, BC138119.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2648              AF387633.1         1-2648
            2649-2687           BE944141.1         1-39                c
FEATURES             Location/Qualifiers
     source          1..2687
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.21 cM"
     gene            1..2687
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /note="early B cell factor 4"
                     /db_xref="GeneID:228598"
                     /db_xref="MGI:MGI:2385972"
     exon            1..211
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1874
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     transcription factor COE4; early B-cell factor 3; OE-4;
                     EBF-4; Olf-1/EBF-like 4"
                     /codon_start=1
                     /product="transcription factor COE4 isoform 2"
                     /protein_id="NP_001103983.1"
                     /db_xref="CCDS:CCDS50709.1"
                     /db_xref="GeneID:228598"
                     /db_xref="MGI:MGI:2385972"
                     /translation="MFPAQDALPRGGLHLKEEPLLPSSLGSVRSWMQSAGILDSNTAA
                     QSGVGLARAHFEKQPPSNLRKSNFFHFVLAMYDRQGQPVEVERTAFIDFVEKDREPGT
                     EKTNNGIHYRLRLVYNNGLRTEQDLYVRLIDSMSKQAIIYEGQDKNPEMCRVLLTHEI
                     MCSRCCDRKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVST
                     TVSVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEAATPCIKAISPGEGWTTGGATVII
                     IGDNFFDGLQVVFGNVLLWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPG
                     RFVYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVLLKRAADLAEALYGVPSSNQE
                     LLLKRAADVAEALYSAPRAPAPLGPLAPSHPHPAVVGINAFSSPLAIAVGDTTPEPGY
                     ARSCGSASPRFAPSPGSQQSSYGSGLGAGLGSYGAPGVTGLGVPGSPSFLNGSTATSP
                     FAIMPSSPPLAAASSMSLPAAAPTTSVFSFSPVNMICAVKQRSAFAPVLRPPSSPSQA
                     CPRAHREGLPDQPFEDTDKFHSAARGLQGLAYS"
     exon            212..368
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            369..432
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            433..488
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            489..562
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            563..631
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            632..713
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            714..831
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            832..965
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1092
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1181
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1247
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1419
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1605
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1803
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1879
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2670
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2629..2634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /note="hexamer: AATAAA"
     polyA_site      2656
                     /gene="Ebf4"
                     /gene_synonym="Ebf3; O/E-4; Olf-1"
                     /note="major polyA site"
ORIGIN      
        1 tgagctgaga cgcccacagc ctcggcggga cgggatccct ggcagttggg ggcgcccacg
       61 aactgcgggt ccttatgttc cccgcacagg acgctctgcc ccgcggtggg ctccatctga
      121 aagaggagcc gctgctgccc tccagcctgg gctcggtgcg ctcctggatg cagagcgcgg
      181 gcatcctgga ctccaacacc gcggcgcaga gtggcgtggg cctggcaaga gcacattttg
      241 aaaagcagcc cccctccaac ctcaggaagt ccaacttctt ccacttcgtg ctggccatgt
      301 acgaccggca ggggcagccc gtggaggtgg agcgcacagc cttcatcgac ttcgtggaaa
      361 aggatcgaga gcctgggacg gaaaagacaa acaacgggat ccattaccgc cttcggctgg
      421 tgtataataa tggacttcgg acagagcaag acctctacgt gcgccttatt gactccatgt
      481 cgaagcaggc tatcatctat gagggacagg acaagaatcc tgagatgtgc cgagtgctgc
      541 tcactcatga gatcatgtgc agccggtgct gtgaccgcaa gagctgtggt aaccggaatg
      601 agacgccttc tgatccagtc attattgaca ggttcttcct caaattcttt ctcaaatgca
      661 accagaactg cttgaagaat gccgggaatc cccgagacat gcgccgcttc caggtggtgg
      721 tgtccacgac cgtgagtgtg gatggccatg tgctggctgt gtcggacaac atgtttgtgc
      781 acaacaactc caagcatgga cgcagagccc gacgcctgga cccttctgaa gctgccaccc
      841 cctgcatcaa ggccatcagc ccaggggagg gctggaccac gggaggcgcc accgtcatta
      901 tcatcggaga caacttcttc gacgggttgc aggtcgtgtt tggcaacgtg ctcctgtgga
      961 gcgagctcat cactccccat gctatccggg tgcagacacc accccgacac atccctgggg
     1021 tagtagaagt gaccctctcc tacaagtcca agcagttctg taaaggagcc cctggccgct
     1081 ttgtctacac agccctgaat gaacccacca ttgactacgg attccagagg ctccagaaag
     1141 ttattcccag acaccccgga gaccctgaga ggctacccaa ggaagtgctg ctgaaaaggg
     1201 cggctgactt ggcggaggcc ctgtacggag tgcccagcag taaccaggag ctcctcctga
     1261 aacgtgcggc ggacgtggcc gaggctctgt acagcgcccc gcgcgcgcct gcaccactcg
     1321 gacccctggc ccccagccac ccgcaccccg ccgtcgtggg tatcaatgcc ttcagcagcc
     1381 ctctggccat cgccgtcggg gataccacac cggagccggg ctatgcccgt agctgcggca
     1441 gcgcgtctcc ccggttcgcg cccagccccg gctctcagca gagcagctat ggcagtggcc
     1501 ttggagccgg cctcggtagc tatggcgcgc ctggtgtgac tggccttggc gtgcccgggt
     1561 cccctagctt cctcaatggc tccaccgcaa cctcaccttt cgccatcatg ccctctagcc
     1621 ccccgctggc ggctgcctcc tccatgtccc ttccggccgc cgcccccacc accagcgtct
     1681 tctccttctc gcctgtcaac atgatctgcg ctgtcaagca gaggagcgcc ttcgcccctg
     1741 tgctgcgccc acccagttcc ccatcgcagg cctgccccag agcccacaga gaggggcttc
     1801 cagaccagcc ttttgaagat actgacaagt tccactctgc agcccgggga ctccagggct
     1861 tggcatactc ctaattatgg tccgcaggtg ctgtccccaa cagggctgga ctggaggtct
     1921 ttctggactc acgttcgtgg ccggatggca gggcttcggg tggacctcga cccctgggat
     1981 acacagggag aggccttcac ctctgtgctg gaggcccctc acacccacag accctcatac
     2041 ttacctctct ttctcgggac acattagaac ctcagcactg tgaggacgct cttggcagga
     2101 gagcatcgta gggaggaggt gttgggatgt cgggccttac tactggatca attcctctat
     2161 aagaggaatt ttgtgcagac cagggatgtt ggtaagatga gcaagaactg agaactgtgg
     2221 gaaagaggac agctcaggga gaggtcatct agagaggccc tgtttgcatc tgaccaatca
     2281 tacctgacct aatagccgcc ttctctcctg ccagcaaggt gtctagcagt ctcaggaggc
     2341 ccattcaggc tcccatggag ctgcccacga gccactggac cccattggct gccttcactt
     2401 cctcctctga gagtagcaca ttcatgctga tcatatccca cctccctttg ggggttttag
     2461 gcatggaaga tgcacagaag ggcctcctgg attttgactc tgaccccaat agatgtttca
     2521 tgaaatttgt ccccctacca ccacacaccc agctctagct ggccccaaag aacagcctgg
     2581 ccatgccttg gtggcctcac actctgatga gtttggacaa aatggaacaa taaaaccaga
     2641 tgcaggtggc cacgtggcct cttgtgcctg aaaaaaaaaa aaaaaaa
//
