LOCUS       NM_001113415            4859 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus early B cell factor 3 (Ebf3), transcript variant 1,
            mRNA.
ACCESSION   NM_001113415
VERSION     NM_001113415.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4859)
  AUTHORS   Argiro,L., Chevalier,C., Choquet,C., Nandkishore,N., Ghata,A.,
            Baudot,A., Zaffran,S. and Lescroart,F.
  TITLE     Gastruloids are competent to specify both cardiac and skeletal
            muscle lineages
  JOURNAL   Nat Commun 15 (1), 10172 (2024)
   PUBMED   39580459
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4859)
  AUTHORS   Kc,R., Lopez de Boer,R., Lin,M., Vagnozzi,A.N., Jeannotte,L. and
            Philippidou,P.
  TITLE     Multimodal Hox5 activity generates motor neuron diversity
  JOURNAL   Commun Biol 7 (1), 1166 (2024)
   PUBMED   39289460
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4859)
  AUTHORS   Hu,W., Wang,M., Sun,G., Zhang,L. and Lu,H.
  TITLE     Early B Cell Factor 3 (EBF3) attenuates Parkinson's disease through
            directly regulating contactin-associated protein-like 4 (CNTNAP4)
            transcription: An experimental study
  JOURNAL   Cell Signal 118, 111139 (2024)
   PUBMED   38479556
  REMARK    GeneRIF: Early B Cell Factor 3 (EBF3) attenuates Parkinson's
            disease through directly regulating contactin-associated
            protein-like 4 (CNTNAP4) transcription: An experimental study.
REFERENCE   4  (bases 1 to 4859)
  AUTHORS   Chen,Z., Snetkova,V., Bower,G., Jacinto,S., Clock,B., Dizehchi,A.,
            Barozzi,I., Mannion,B.J., Alcaina-Caro,A., Lopez-Rios,J.,
            Dickel,D.E., Visel,A., Pennacchio,L.A. and Kvon,E.Z.
  TITLE     Increased enhancer-promoter interactions during developmental
            enhancer activation in mammals
  JOURNAL   Nat Genet 56 (4), 675-685 (2024)
   PUBMED   38509385
REFERENCE   5  (bases 1 to 4859)
  AUTHORS   Sivori,M., Dempsey,B., Chettouh,Z., Boismoreau,F., Ayerdi,M.,
            Eymael,A., Baulande,S., Lameiras,S., Coulpier,F., Delattre,O.,
            Rohrer,H., Mirabeau,O. and Brunet,J.F.
  TITLE     The pelvic organs receive no parasympathetic innervation
  JOURNAL   Elife 12, 91576 (2024)
   PUBMED   38488657
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4859)
  AUTHORS   Erkman,L., Yates,P.A., McLaughlin,T., McEvilly,R.J., Whisenhunt,T.,
            O'Connell,S.M., Krones,A.I., Kirby,M.A., Rapaport,D.H.,
            Bermingham,J.R., O'Leary,D.D. and Rosenfeld,M.G.
  TITLE     A POU domain transcription factor-dependent program regulates axon
            pathfinding in the vertebrate visual system
  JOURNAL   Neuron 28 (3), 779-792 (2000)
   PUBMED   11163266
REFERENCE   7  (bases 1 to 4859)
  AUTHORS   Garel,S., Garcia-Dominguez,M. and Charnay,P.
  TITLE     Control of the migratory pathway of facial branchiomotor neurones
  JOURNAL   Development 127 (24), 5297-5307 (2000)
   PUBMED   11076752
REFERENCE   8  (bases 1 to 4859)
  AUTHORS   Pattyn,A., Hirsch,M., Goridis,C. and Brunet,J.F.
  TITLE     Control of hindbrain motor neuron differentiation by the homeobox
            gene Phox2b
  JOURNAL   Development 127 (7), 1349-1358 (2000)
   PUBMED   10704382
REFERENCE   9  (bases 1 to 4859)
  AUTHORS   Garel,S., Marin,F., Mattei,M.G., Vesque,C., Vincent,A. and
            Charnay,P.
  TITLE     Family of Ebf/Olf-1-related genes potentially involved in neuronal
            differentiation and regional specification in the central nervous
            system
  JOURNAL   Dev Dyn 210 (3), 191-205 (1997)
   PUBMED   9389446
REFERENCE   10 (bases 1 to 4859)
  AUTHORS   Wang,S.S., Tsai,R.Y. and Reed,R.R.
  TITLE     The characterization of the Olf-1/EBF-like HLH transcription factor
            family: implications in olfactory gene regulation and neuronal
            development
  JOURNAL   J Neurosci 17 (11), 4149-4158 (1997)
   PUBMED   9151732
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135639.4.
            
            On Jan 6, 2023 this sequence version replaced NM_001113415.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U92702.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-502               AC135639.4         15568-16069
            503-659             AC135639.4         16175-16331
            660-723             AC135639.4         16693-16756
            724-779             AC135639.4         17445-17500
            780-853             AC135639.4         20477-20550
            854-922             AC135639.4         22296-22364
            923-1004            AC135639.4         93861-93942
            1005-1149           AC135639.4         98541-98685
            1150-1280           AC135639.4         103963-104093
            1281-1407           AC135639.4         104580-104706
            1408-1496           AC135639.4         123576-123664
            1497-1562           AC135639.4         128658-128723
            1563-1740           AC135639.4         129289-129466
            1741-1929           AC135639.4         130567-130755
            1930-2127           AC135639.4         131160-131357
            2128-4859           AC135639.4         133447-136178
FEATURES             Location/Qualifiers
     source          1..4859
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 82.26 cM"
     gene            1..4859
                     /gene="Ebf3"
                     /gene_synonym="3110018A08Rik; mKIAA4201; O/E-2"
                     /note="early B cell factor 3"
                     /db_xref="GeneID:13593"
                     /db_xref="MGI:MGI:894289"
     exon            1..502
                     /gene="Ebf3"
                     /gene_synonym="3110018A08Rik; mKIAA4201; O/E-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             369..2159
                     /gene="Ebf3"
                     /gene_synonym="3110018A08Rik; mKIAA4201; O/E-2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor COE3; OE-2; EBF-3; Olf-1/EBF-like 2"
                     /codon_start=1
                     /product="transcription factor COE3 isoform 1"
                     /protein_id="NP_001106886.1"
                     /db_xref="CCDS:CCDS52422.1"
                     /db_xref="GeneID:13593"
                     /db_xref="MGI:MGI:894289"
                     /translation="MFGIQENIPRGGTTMKEEPLGSGMNPVRSWMHTAGVVDANTAAQ
                     SGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVDFVEKEKEPNNE
                     KTNNGIHYKLQLLYSNGVRTEQDLYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIM
                     CSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTT
                     VNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEGTAPSYLENATPCIKAISPSEGWTT
                     GGATVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQ
                     FCKGAPGRFVYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVLLKRAADLVEALYG
                     MPHNNQEIILKRAADIAEALYSVPRNHNQIPTLGNTPAHTGMMGVNSFSSQLAVNVSE
                     TSQANDQVGYSRNTSSVSPRGYVPSSTPQQSNYNTVSTSMNGYGSGAMANLGVPGSPG
                     FLNGSSANSPYGIVPSSPTMAASSVTLPSNCSSTHGIFSFSPANVISAVKQKSAFAPV
                     VRPQASPPPSCTSANGNGLQAMSGLVVPPM"
     exon            503..659
                     /gene="Ebf3"
                     /gene_synonym="3110018A08Rik; mKIAA4201; O/E-2"
                     /inference="alignment:Splign:2.1.0"
     exon            660..723
                     /gene="Ebf3"
                     /gene_synonym="3110018A08Rik; mKIAA4201; O/E-2"
                     /inference="alignment:Splign:2.1.0"
     exon            724..779
                     /gene="Ebf3"
                     /gene_synonym="3110018A08Rik; mKIAA4201; O/E-2"
                     /inference="alignment:Splign:2.1.0"
     exon            780..853
                     /gene="Ebf3"
                     /gene_synonym="3110018A08Rik; mKIAA4201; O/E-2"
                     /inference="alignment:Splign:2.1.0"
     exon            854..922
                     /gene="Ebf3"
                     /gene_synonym="3110018A08Rik; mKIAA4201; O/E-2"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1004
                     /gene="Ebf3"
                     /gene_synonym="3110018A08Rik; mKIAA4201; O/E-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1149
                     /gene="Ebf3"
                     /gene_synonym="3110018A08Rik; mKIAA4201; O/E-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1280
                     /gene="Ebf3"
                     /gene_synonym="3110018A08Rik; mKIAA4201; O/E-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1407
                     /gene="Ebf3"
                     /gene_synonym="3110018A08Rik; mKIAA4201; O/E-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1496
                     /gene="Ebf3"
                     /gene_synonym="3110018A08Rik; mKIAA4201; O/E-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1562
                     /gene="Ebf3"
                     /gene_synonym="3110018A08Rik; mKIAA4201; O/E-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1740
                     /gene="Ebf3"
                     /gene_synonym="3110018A08Rik; mKIAA4201; O/E-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1929
                     /gene="Ebf3"
                     /gene_synonym="3110018A08Rik; mKIAA4201; O/E-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2127
                     /gene="Ebf3"
                     /gene_synonym="3110018A08Rik; mKIAA4201; O/E-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..4859
                     /gene="Ebf3"
                     /gene_synonym="3110018A08Rik; mKIAA4201; O/E-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3805..3810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ebf3"
                     /gene_synonym="3110018A08Rik; mKIAA4201; O/E-2"
                     /note="hexamer: AATAAA"
     regulatory      3830..3835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ebf3"
                     /gene_synonym="3110018A08Rik; mKIAA4201; O/E-2"
                     /note="hexamer: ATTACA"
     polyA_site      3837
                     /gene="Ebf3"
                     /gene_synonym="3110018A08Rik; mKIAA4201; O/E-2"
                     /note="major polyA site"
     polyA_site      3852
                     /gene="Ebf3"
                     /gene_synonym="3110018A08Rik; mKIAA4201; O/E-2"
     regulatory      4782..4787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ebf3"
                     /gene_synonym="3110018A08Rik; mKIAA4201; O/E-2"
                     /note="hexamer: ATTAAA"
     polyA_site      4805
                     /gene="Ebf3"
                     /gene_synonym="3110018A08Rik; mKIAA4201; O/E-2"
     regulatory      4838..4843
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ebf3"
                     /gene_synonym="3110018A08Rik; mKIAA4201; O/E-2"
                     /note="hexamer: ATTAAA"
     polyA_site      4859
                     /gene="Ebf3"
                     /gene_synonym="3110018A08Rik; mKIAA4201; O/E-2"
ORIGIN      
        1 agaagcgggc gatcccgcag tgtcctgcag ccgcggacgc cgcctggcta ggatgacacc
       61 acgttgagcg cgcctgcaaa caacaacaac aacaagcgcc gccgcggcca ccgcgtccac
      121 cgcgccctgc tcctccgaag cgtcgcgtcg ccaccggtgc agcccgcccg cgtccccggc
      181 cgtccgcagc gcccggccgc cggtgtatgc ggcgcctgcc cgggacgggc tgaagccggc
      241 ggcgggccgc accgcaggcg ccgagcaggg ccagggcggc cagggcagcc tcctgccgcc
      301 gagccccgag cgccgccgac cgcggacgcg ctttcggccg ggagtcgcgg ccgccgccag
      361 cagtgttcat gtttgggatt caggagaata ttccgcgcgg ggggacgacc atgaaggagg
      421 agccgctggg cagcggcatg aacccggtgc gctcgtggat gcacacggca ggcgtggtgg
      481 acgccaacac ggccgcccag agcggcgtgg ggctggcgcg ggcgcacttc gagaagcagc
      541 ctccttccaa cctccggaaa tccaatttct tccacttcgt gctggcgctc tacgacaggc
      601 aggggcagcc ggtggagatc gaaaggaccg cttttgtgga ctttgtggag aaagagaaag
      661 agccgaacaa cgagaaaacc aacaacggca ttcactacaa gctgcagcta ctgtacagca
      721 atggcgtcag aacagagcaa gatctgtatg tccgcctcat agattcaatg accaaacagg
      781 ccatcgtgta tgaaggccag gacaagaatc cggagatgtg ccgcgtgctg ctgacccacg
      841 agatcatgtg cagccggtgc tgtgacaaga agagttgtgg caatagaaac gagacaccct
      901 cagaccctgt aatcattgac agattctttc taaagttctt cctcaagtgc aatcagaact
      961 gcctgaagaa tgcgggcaac cctcgggaca tgcggaggtt ccaggtcgtt gtatcgacaa
     1021 cagtcaacgt ggacggccac gtgctggccg tgtctgacaa catgtttgtg cacaacaatt
     1081 ccaaacacgg gaggcgggcc cgccgcctag acccgtcaga aggtacggcc ccttcttatc
     1141 tggaaaatgc cactccgtgt atcaaggcta tcagccccag tgaaggctgg accacggggg
     1201 gtgccactgt gatcataatc ggggacaact tctttgacgg tctacaagtt gtgttcggaa
     1261 ctatgttggt gtggagtgag ctgataaccc cccacgccat ccgagtgcag acgccgcctc
     1321 gacacatccc tggagttgtt gaagtgaccc tctcctacaa gtctaagcag ttctgcaaag
     1381 gcgctcctgg acgctttgtc tacactgccc ttaatgagcc aaccatagat tacggcttcc
     1441 agaggttgca gaaagtgata cccagacatc caggtgaccc cgaaaggtta cccaaggaag
     1501 tgttactgaa gagggcagca gaccttgtgg aagccttgta tgggatgcct cacaataacc
     1561 aggagatcat cctgaagaga gcggccgaca ttgctgaggc gttgtacagc gttccccgca
     1621 atcacaacca gatccccacc ctgggcaaca ccccagcaca cactggcatg atgggtgtga
     1681 actccttcag cagccagcta gccgttaatg tgtcagagac ctcacaagcc aatgaccaag
     1741 tcggctacag tcgcaataca agcagcgtgt ccccgcgagg ctacgtcccc agcagtactc
     1801 cccagcagtc caattacaac acagtcagca ctagcatgaa tggatatgga agtggcgcca
     1861 tggccaatct aggggtccct ggctcgcctg gatttcttaa tggctcctcc gctaactctc
     1921 cctacggcat agtgccgtcc agccccacca tggcagcctc ttcggtcacc ctcccttcaa
     1981 actgtagcag cacacacggc attttctcat tctcacctgc caatgtcatc tccgcagtga
     2041 aacagaagag cgcttttgcg cccgtggtcc ggccccaagc ctcgcctcct ccttcctgca
     2101 ccagcgccaa cgggaacgga ctgcaagcta tgtctgggct ggtagtcccg cccatgtgag
     2161 gggctctgtt tgccttcgca gcacccagca tccaaggacg gacttcaggg gacacgtgta
     2221 gtgtgttaag atgtgctgat ggaaacacta tcttcaaaac taaaaatcag ccacagttga
     2281 atgctacaaa agacatttaa agattttatt taaactgtta agaatcaagc cgcgaacaag
     2341 cccactcctt catgaacaat tccactttat tgactgaact cttctcatac cttcacattt
     2401 ctcagtcctg aagattaagg aaacaaagca ccgcctattt tgtataaagt ttctgattcc
     2461 gtcttggctg tctagtgcgt gctatctgtg tggggagaag cttcgtgaat atgcaccgtt
     2521 ttgatgccca tgcaacagtg aggaagaaaa accctcgaga cattttttct gtactcatat
     2581 ttagattcac aatggttgtg tatctctata atgtgaaata tttttttgtg gtgaataaaa
     2641 gggggccaag gaggtatgag ccattaactg gaacagacga ggatatgact aggtgaattt
     2701 ggggtggcag ggagggaggg agggtttatc attgcttaac ttcatcttaa tgaaatgaaa
     2761 ctttgtaact tattgtagtt agaaattgta actttgatat cgaatctctt gccttcaaca
     2821 agcacactga cagagaaaaa aaaatatgct actgtctgtt ggttccaata ttctcccacc
     2881 tagagcttcc tgttaaagca agtgcgatca gcaacatttt tcaactttcg cgcactgtaa
     2941 acctattgca ttcttaggct actgtgaggt ctatgtttct tgtacctgaa attgtccttt
     3001 ggactcctag acccttcttc cccgatgtgt tttgtatgtg gttataaaat tgtagacttt
     3061 tgtgattttg ccaaagttgt agctaaatat ttatacactt gtcttgaatt tttttcagat
     3121 ccacttaaaa tatttagaaa aacgagtttt attccttatg ggtcttatag gggataaaat
     3181 gctcttcttc catgcgacac ttcctttccc atgaacactt gcagttgcta agggacttta
     3241 ttttgtaaca tattaattat aaatattgta tttatctttg aaattttgta cattgctttc
     3301 cctgccttct tttttcacgt ctgttttggt gtttgatccc tgcccagtgt tgtcgcacag
     3361 gggaagggca gataccaaga cctgtctgtt ggatctgttt tgttgagata aactgatgtc
     3421 cttacatttc atttgtacct aaaccatttg ctatcgttta gactttccac cccccacccc
     3481 ttttttttat gttgaggaaa agtcaaattc attgtttatt tttatattat ttttaagtta
     3541 tctgaacaaa tacttttgaa aagaaaagtt tgttgtatag tcaaaagaaa acggtgtcag
     3601 cggccgagac aaattctggt aggttctgtg catgtgaagc ggccgtgaag gggccacatc
     3661 gtccgggctg tgtccttatt taatttttaa tttttaattt tttcgtagaa tgtaaaaaaa
     3721 aaaaagtcat tttagctgcc acctatgact ttgccacata gctgaactgt gtttactgga
     3781 aaaattcaga ggcctaaagt ttaaaataaa atttacttcc gacgttttaa ttacaaatgt
     3841 ttgccacatt aacttctctg atgccttaaa agtggacttc tttgaagaac ttctgtgcta
     3901 ttttatcaca ggctcatacc acaattgtta atatctggag atggatgatg aacacacaca
     3961 cacacacaca cacacacaca cacacacaca caccaaaagc acaaacctcc agtccgccag
     4021 tcacttcttc ctgggtctgt ctgctgctct cggtcctcta agctcccctt ggagttggag
     4081 aggtatcggg gacactgctg gttagtacgt tttgatttta aacaggacct ttgtgtggtc
     4141 agatcccaca gcactgcctg tccttttttt tttaactgga aagacctcct tcagacactc
     4201 tgcctcttag tgccaaaccc accgtcagac caagagtcag gacttcagga ctctgtcctt
     4261 ccttcccact catcgccctt gcagacagcg tgtgctttgc gaacagcagc agaagtcaca
     4321 tttagaacaa aaaggagggg attataaaaa aactagacac acaccttcac aaagagacaa
     4381 catagagctt agaaagcgtt cattcaaggg actcagtaag agaaacggaa tgtccccaag
     4441 ggtcagtggg ccacactctg gctttgtggc tgctgacagg gcttagctac acgaacagcc
     4501 tgagaagtca ctttggaact aaattgcctc gatttatttt gtgtaagtaa gggtttgacc
     4561 taaaaagagc tcacgtgcac attagcaagt gtcctcatgc ccgcacccgg tttgtgttgt
     4621 agatcaacta gccaacgccc tcattgcttc attgtgtcaa aaaaccgaga gcttcactaa
     4681 atggtagatt ttgctgtcag agaccctaca ataagattgt tttatctgta cattttttca
     4741 gatatttaac tgtataaaat gttcatttta cacaatattt aattaaagta tttcttgtct
     4801 gtgaatttca cttttggtag ttttatctgt tttgactatt aaaatgactg acaaatgaa
//
