LOCUS       NM_001360202            5049 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus early B cell factor 2 (Ebf2), transcript variant 3,
            mRNA.
ACCESSION   NM_001360202 XM_011244945
VERSION     NM_001360202.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5049)
  AUTHORS   Kc,R., Lopez de Boer,R., Lin,M., Vagnozzi,A.N., Jeannotte,L. and
            Philippidou,P.
  TITLE     Multimodal Hox5 activity generates motor neuron diversity
  JOURNAL   Commun Biol 7 (1), 1166 (2024)
   PUBMED   39289460
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5049)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5049)
  AUTHORS   Jun,S., Angueira,A.R., Fein,E.C., Tan,J.M.E., Weller,A.H.,
            Cheng,L., Batmanov,K., Ishibashi,J., Sakers,A.P., Stine,R.R. and
            Seale,P.
  TITLE     Control of murine brown adipocyte development by GATA6
  JOURNAL   Dev Cell 58 (21), 2195-2205 (2023)
   PUBMED   37647897
REFERENCE   4  (bases 1 to 5049)
  AUTHORS   Rao,J., Djeffal,Y., Chal,J., Marchiano,F., Wang,C.H., Al
            Tanoury,Z., Gapon,S., Mayeuf-Louchart,A., Glass,I., Sefton,E.M.,
            Habermann,B., Kardon,G., Watt,F.M., Tseng,Y.H. and Pourquie,O.
  TITLE     Reconstructing human brown fat developmental trajectory in vitro
  JOURNAL   Dev Cell 58 (21), 2359-2375 (2023)
   PUBMED   37647896
REFERENCE   5  (bases 1 to 5049)
  AUTHORS   Jacob,T., Annusver,K., Czarnewski,P., Dalessandri,T., Kalk,C.,
            Levra Levron,C., Campama Sanz,N., Kastriti,M.E., Mikkola,M.L.,
            Rendl,M., Lichtenberger,B.M., Donati,G., Bjorklund,A.K. and
            Kasper,M.
  TITLE     Molecular and spatial landmarks of early mouse skin development
  JOURNAL   Dev Cell 58 (20), 2140-2162 (2023)
   PUBMED   37591247
REFERENCE   6  (bases 1 to 5049)
  AUTHORS   Garel,S., Marin,F., Mattei,M.G., Vesque,C., Vincent,A. and
            Charnay,P.
  TITLE     Family of Ebf/Olf-1-related genes potentially involved in neuronal
            differentiation and regional specification in the central nervous
            system
  JOURNAL   Dev Dyn 210 (3), 191-205 (1997)
   PUBMED   9389446
REFERENCE   7  (bases 1 to 5049)
  AUTHORS   Cornwall,G.A. and Hsia,N.
  TITLE     ADAM7, a member of the ADAM (a disintegrin and metalloprotease)
            gene family is specifically expressed in the mouse anterior
            pituitary and epididymis
  JOURNAL   Endocrinology 138 (10), 4262-4272 (1997)
   PUBMED   9322939
REFERENCE   8  (bases 1 to 5049)
  AUTHORS   Malgaretti,N., Pozzoli,O., Bosetti,A., Corradi,A., Ciarmatori,S.,
            Panigada,M., Bianchi,M.E., Martinez,S. and Consalez,G.G.
  TITLE     Mmot1, a new helix-loop-helix transcription factor gene displaying
            a sharp expression boundary in the embryonic mouse brain
  JOURNAL   J Biol Chem 272 (28), 17632-17639 (1997)
   PUBMED   9211912
REFERENCE   9  (bases 1 to 5049)
  AUTHORS   Wang,S.S., Tsai,R.Y. and Reed,R.R.
  TITLE     The characterization of the Olf-1/EBF-like HLH transcription factor
            family: implications in olfactory gene regulation and neuronal
            development
  JOURNAL   J Neurosci 17 (11), 4149-4158 (1997)
   PUBMED   9151732
REFERENCE   10 (bases 1 to 5049)
  AUTHORS   Shang,J., Luo,Y. and Clayton,D.A.
  TITLE     Backfoot is a novel homeobox gene expressed in the mesenchyme of
            developing hind limb
  JOURNAL   Dev Dyn 209 (2), 242-253 (1997)
   PUBMED   9186059
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC050922.1, CT010493.12 and BM932499.1.
            
            On Jan 30, 2018 this sequence version replaced XM_011244945.2.
            
            Transcript Variant: This variant (3) differs in 5' UTR, compared to
            variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050922.1, U92703.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2767              BC050922.1         1-2767
            2768-5038           CT010493.12        188419-190689
            5039-5047           BM932499.1         28-36               c
            5048-5049           CT010493.12        190699-190700
FEATURES             Location/Qualifiers
     source          1..5049
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 34.63 cM"
     gene            1..5049
                     /gene="Ebf2"
                     /gene_synonym="D14Ggc1e; EBF-2; Mmot1; O/E-3; OE-3"
                     /note="early B cell factor 2"
                     /db_xref="GeneID:13592"
                     /db_xref="MGI:MGI:894332"
     exon            1..622
                     /gene="Ebf2"
                     /gene_synonym="D14Ggc1e; EBF-2; Mmot1; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             492..2219
                     /gene="Ebf2"
                     /gene_synonym="D14Ggc1e; EBF-2; Mmot1; O/E-3; OE-3"
                     /note="MET-mesencephalon-olfactory TF1;
                     MET-mesencephalon-olfactory transcription factor 1;
                     Olf-1/EBF-like 3; metencephalon-mesencephalon-olfactory
                     transcription factor 1"
                     /codon_start=1
                     /product="transcription factor COE2"
                     /protein_id="NP_001347131.1"
                     /db_xref="CCDS:CCDS27228.1"
                     /db_xref="GeneID:13592"
                     /db_xref="MGI:MGI:894332"
                     /translation="MFGIQDTLGRGPALKDKSLGAEMDSVRSWVRNVGVVDANVAAQS
                     GVALSRAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVDFVENDKEQGNEK
                     TNNGTHYKLQLLYSNGVRTEQDLYVRLIDSVTKQPIAYEGQNKNPEMCRVLLTHEVMC
                     SRCCEKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKTAGNPRDMRRFQVVLSTTV
                     NVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEATPCIKAISPSEGWTTGGAMVIIIGD
                     NFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRFI
                     YTALNEPTIDYGFQRLQKVIPRHPGDPERLAKEMLLKRAADLVEALYGTPHNNQDIIL
                     KRAADIAEALYSVPRNPSQIPALSSSPAHSGMMGINSYGSQLGVSISESTQGNNQGYI
                     RNTSSISPRGYSSSSTPQQSNYSTSSNSMNGYSNVPMANLGVPGSPGFLNGSPTGSPY
                     GIMSSSPTVGSSSTSSILPFSSSVFPAVKQKSAFAPVIRPQGSPSPACSSGNGNGFRA
                     MTGLVVPPM"
     exon            623..779
                     /gene="Ebf2"
                     /gene_synonym="D14Ggc1e; EBF-2; Mmot1; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     exon            780..843
                     /gene="Ebf2"
                     /gene_synonym="D14Ggc1e; EBF-2; Mmot1; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     exon            844..899
                     /gene="Ebf2"
                     /gene_synonym="D14Ggc1e; EBF-2; Mmot1; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     exon            900..973
                     /gene="Ebf2"
                     /gene_synonym="D14Ggc1e; EBF-2; Mmot1; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1042
                     /gene="Ebf2"
                     /gene_synonym="D14Ggc1e; EBF-2; Mmot1; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1124
                     /gene="Ebf2"
                     /gene_synonym="D14Ggc1e; EBF-2; Mmot1; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1242
                     /gene="Ebf2"
                     /gene_synonym="D14Ggc1e; EBF-2; Mmot1; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1373
                     /gene="Ebf2"
                     /gene_synonym="D14Ggc1e; EBF-2; Mmot1; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1500
                     /gene="Ebf2"
                     /gene_synonym="D14Ggc1e; EBF-2; Mmot1; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1589
                     /gene="Ebf2"
                     /gene_synonym="D14Ggc1e; EBF-2; Mmot1; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1655
                     /gene="Ebf2"
                     /gene_synonym="D14Ggc1e; EBF-2; Mmot1; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1833
                     /gene="Ebf2"
                     /gene_synonym="D14Ggc1e; EBF-2; Mmot1; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..2019
                     /gene="Ebf2"
                     /gene_synonym="D14Ggc1e; EBF-2; Mmot1; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2187
                     /gene="Ebf2"
                     /gene_synonym="D14Ggc1e; EBF-2; Mmot1; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..5049
                     /gene="Ebf2"
                     /gene_synonym="D14Ggc1e; EBF-2; Mmot1; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5024..5029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ebf2"
                     /gene_synonym="D14Ggc1e; EBF-2; Mmot1; O/E-3; OE-3"
                     /note="hexamer: AATAAA"
     polyA_site      5047
                     /gene="Ebf2"
                     /gene_synonym="D14Ggc1e; EBF-2; Mmot1; O/E-3; OE-3"
                     /note="major polyA site"
ORIGIN      
        1 ctgcggcgct ctcagccacc gcctcctccc cgctccgggt cttccccttc ctcttacaac
       61 tgatcctgtt ggggattttt tttttttttc ctatatcgga acggtgggga ggagcaggga
      121 ggggggaaca aggaggaagg ggagagatca ggcagctatc tatctcctcc tgtttttccc
      181 agaacaggtg atgcttccaa attgtggcca ctttctggag aacgttctgc agctggaagg
      241 atgcgggcga cctagagtgg aagccccgag gcggcagatc tgaagccacc gaggataaaa
      301 aacgcaaact ttgcattgtg cgtggaggaa cgggctggct atttctttcc aagagggccc
      361 ccaaacttcg gcccttgccg cctttctcgg attgcttttg gagaacacca tttgctggca
      421 gcattggaga gtgaggacgg tgttgttgta aagtcacttt taaggcgaca gtagaggacc
      481 agacttttta aatgtttggg attcaagata cgctaggaag aggaccagct ctgaaagaca
      541 agtcgctggg tgccgagatg gattcggtca ggtcctgggt ccggaatgtc ggcgtggtgg
      601 acgccaatgt cgcggctcag agcggagttg ctctgtcccg ggcccatttt gaaaagcaac
      661 ctccttcaaa cttgaggaaa tccaacttct ttcattttgt cctggcgctc tacgacaggc
      721 agggacagcc ggtggagatt gagcgcacag ccttcgtgga ctttgtggag aatgacaaag
      781 agcaaggcaa tgagaagacc aacaatggta ctcactacaa gttacagctc ctttacagca
      841 acggtgtccg cacggagcag gacctgtatg tcaggctcat cgactctgtc accaaacagc
      901 ccatagccta tgagggacag aataagaatc ccgaaatgtg cagagttctg ctgacacacg
      961 aggtgatgtg cagtcgatgc tgtgagaaga agagctgcgg gaaccggaac gagacccctt
     1021 cagacccggt catcatcgac agattctttt taaaattttt cctgaagtgc aatcagaatt
     1081 gtttgaaaac agcgggaaac ccaagggaca tgaggcggtt ccaggtcgtg ttgtccacaa
     1141 cagtaaatgt ggatggacat gtgctggctg tttctgacaa catgtttgtt cataacaatt
     1201 ctaagcatgg aaggagagca agaaggcttg acccatctga agctacaccc tgcatcaaag
     1261 ccatcagccc aagtgaaggc tggaccacag gaggggccat ggtcatcatc attggtgaca
     1321 acttttttga tggtctccag gttgtgtttg gtaccatgct tgtatggagt gagctcataa
     1381 cccctcatgc catcagagta cagacccctc cccggcatat ccctggagtt gtggaagtga
     1441 cactatctta taaatccaaa cagttctgca aaggagcccc gggcaggttc atctacacag
     1501 ccttaaatga acccaccata gactatggct tccaaagatt gcagaaagtc atcccaaggc
     1561 acccaggtga ccctgagagg ctagctaagg aaatgctgtt gaaaagagct gcggacctgg
     1621 tggaagccct ctacggcaca ccacacaata atcaggacat cattttaaag cgtgctgcag
     1681 acattgctga agccctgtac agtgtcccca ggaaccccag ccagattcca gctctttcca
     1741 gctccccagc tcacagcggt atgatgggta tcaactctta cggcagccag ctcggcgtca
     1801 gcatttcaga gtccacacaa ggaaataacc aaggatacat ccgcaacaca agcagcatct
     1861 ccccgcgggg atactcctcc agctccacgc ctcagcaatc taattacagc acctccagca
     1921 acagcatgaa cggctacagc aatgttccta tggccaacct gggtgtgcca ggatccccgg
     1981 gatttctgaa tggctcaccc acgggctccc catatggaat catgtcttca agccccaccg
     2041 tgggatcctc cagcacgtcc tccatcctcc cgttctcctc ttcagttttt cctgctgtca
     2101 aacagaagag tgcctttgcc cctgtcatca ggccccaagg ctccccatcg cctgcctgct
     2161 ccagcggcaa tgggaacgga ttcagagcca tgacaggact tgttgttccc ccgatgtaaa
     2221 gcggaagaag aactgctttc tcatagcaca aaactactta ttccgatgga ccaattatga
     2281 aggaagcact ctgagcttgt tggggagagt tgcgccccca agcggccatg ttggacagat
     2341 ttgggaaggc agagagccgc catcttggtc tcgtgttcct catgaagcat tgacagtcac
     2401 tacacaaact gacccttttg gagacaagag cagagaaatg tcattgacgt ggtcagtgct
     2461 aagagcagca attctttgtt atgaacatta caaaaaccac cttcctatgt ttgtaaaata
     2521 tttaagaaaa acattggcaa acattcatgc ttaatatttt ggatactatt tgtttttctt
     2581 tgtaggaaaa aaaagttgaa agtttctatt ttctatgaat cctttcagat accaatttag
     2641 tttatgcaga aaaaaattga acaaaacagg gtaccagcat ggaagacttt cttaaaatga
     2701 aacctgaatt gaatgaggaa atgttgtatg tgtgtttgct tatactttaa gctcttttaa
     2761 aaaaaaaggg aaaaaaattt aaaatgtttt acagttattt aaataaataa acgtgtaact
     2821 tattgtaagt agaggtagaa attaagacct tttttaagaa gagaagaatt tctcttcctg
     2881 atgtaaaatg aaattgacac acgtagtgac cagttttaaa ggtgtgttgt tattacagtt
     2941 gcttattaga ttcttatcct acatcccaca cccccctctt tttccatcac tttatcaacc
     3001 catgcacaag aatgtgtaac ttgtgcagat tcccacagaa tccaccacag aaaccagact
     3061 cagataaacg ccagcacacc aacacttcaa tccaccactc cattcccaga tctgctttct
     3121 agttcacaga tcccttatgg tgtccaatct tggtgaagcg ttttgaaaaa atacattcct
     3181 ccctgagcaa tgcagggagt ccccatgtta ccctctcagc tttgaacatc ctcaggcaag
     3241 aagtatctca cctctaagga gagtcaaagc cccatggcta cactgaccaa ggactcttca
     3301 gaatttctct ccaacagagc cccacagtcc ttcctctttg ggtactcgat tcaggcatgg
     3361 aggcaggaag ctccatagaa ctttggagaa agaacttggg gagcttggtt gtgtttcttg
     3421 gactcttaag actcagtctt tgactgtttc ctttctatgc agagtttttc ttttatgtta
     3481 gtaaactccc ttggaaaagc atgtatctca cctgacactg tttctgagat gagcagggtg
     3541 gggtgaagag gaacgaactc aaaaccccct aagtggctct cttattggga gattcgtggc
     3601 agctgtgttc caagcggtgc agttacccag cctgccctgg gagccttgtg ctacctacct
     3661 agttcttagc agggaaaacc ttgcagtagt tgctaacagt ggtagactct tgaaaatgtg
     3721 tgtggtcctg gagatgcatc tagacttgct tggcttgcca ataggatgtc atgattttcc
     3781 aggtgtcttc tctttgattc caatgactta gcttggggtt cttggttagg cttctagcat
     3841 tggaaattga tgtgtctttc acggaaaaaa aaaagaaaaa aaaaacaaaa ccatcattag
     3901 tacttctgag ccaattttag atgaccctct cattgcccga ctggcacatg tcctcatcca
     3961 accctcaact ggattatttg ccttcagttt gctagaatta cccactatga catttttttt
     4021 ctatgcacat gagaatccac aattttagaa acctggcatg cttataacca ctgctgacag
     4081 tccttcatag gcagggctca cagcgccaaa ctatacggaa atgcatgaga aaaacctccc
     4141 tggctaacaa cctggtacag ggaaagaacg tgtggaatac gagcattacc atcccacaat
     4201 ggaggcagaa tacaattaag catgtttaga cctggctttg agccaaccca acctaagaac
     4261 tttttctttc tttctctctc tctctctttc tttttttaaa aagtagcata gcttttagaa
     4321 cctgtgaatc tttctcttgc atgaggatta gtgcagttct gtctccagaa tgatcgtaga
     4381 atctgtcagt agctttacac cgaagactgt gtgtaactaa atactggaca tctttgacca
     4441 ttcactagga catcggcagc cacagatcta tttaattgta caaacgtgtg taagggttat
     4501 ttttagtgta ctaataaatt aaaaacaaag ccactctgtc ctctttagtc attgctatta
     4561 aatgattctg gtcccaggtt atttttatgc cacttggcag acaagtatct ctataggtaa
     4621 tgacaaaaat tctgttctat ttttgagagg agctgtgtaa gatttttttc atttaaaggt
     4681 acaacttact gcattatctc atttctttgg ttacagcatc gaaattcttc ccagtttttc
     4741 tttgcacatt tcaacatgca tggtttaaac accattacct ttaccttttg tacagtaagg
     4801 cctcatttcc aaactgtata gttttgggtt tttttttttg tttgtttgtt tgttttcttg
     4861 ctttgtcagt tacatacagt ataaagttgc tatgcacaga gctttttgta aagacagctt
     4921 tttttgttta ctgtttttaa tggtcttcct tatgaaagaa tatcttgttt gtaaaatgaa
     4981 tatgtctact tcagttttaa actttaaatt atcctaacaa aaaaataaaa tttttgtact
     5041 gtaaaaatt
//
