LOCUS       NM_007897               5203 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus early B cell factor 1 (Ebf1), transcript variant 2,
            mRNA.
ACCESSION   NM_007897 XM_977520
VERSION     NM_007897.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5203)
  AUTHORS   Thiruppathy,M., Teubner,L., Roberts,R.R., Lasser,M.C.,
            Moscatello,A., Chen,Y.W., Hochstim,C., Ruffins,S., Sarkar,A.,
            Tassey,J., Evseenko,D., Lozito,T.P., Willsey,H.R., Gillis,J.A. and
            Crump,J.G.
  TITLE     Repurposing of a gill gene regulatory program for outer-ear
            evolution
  JOURNAL   Nature (2025) In press
   PUBMED   39788155
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 5203)
  AUTHORS   Kc,R., Lopez de Boer,R., Lin,M., Vagnozzi,A.N., Jeannotte,L. and
            Philippidou,P.
  TITLE     Multimodal Hox5 activity generates motor neuron diversity
  JOURNAL   Commun Biol 7 (1), 1166 (2024)
   PUBMED   39289460
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5203)
  AUTHORS   Powers,K.G., Wilkerson,B.A., Beach,K.E., Seo,S.S., Rodriguez,J.S.,
            Baxter,A.N., Hunter,S.E. and Bermingham-McDonogh,O.
  TITLE     Deletion of the Ebf1, a mouse deafness gene, causes a dramatic
            increase in hair cells and support cells of the organ of Corti
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39037017
  REMARK    GeneRIF: Deletion of the Ebf1, a mouse deafness gene, causes a
            dramatic increase in hair cells and support cells of the organ of
            Corti.
REFERENCE   4  (bases 1 to 5203)
  AUTHORS   Wu,Y., Chen,S., Huang,G., Zhang,L., Zhong,L., Feng,Y., Wen,P. and
            Liu,J.
  TITLE     Transcriptome analysis reveals EBF1 ablation-induced injuries in
            cardiac system
  JOURNAL   Theranostics 14 (12), 4894-4915 (2024)
   PUBMED   39239522
  REMARK    GeneRIF: Transcriptome analysis reveals EBF1 ablation-induced
            injuries in cardiac system.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5203)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 5203)
  AUTHORS   Lin,H. and Grosschedl,R.
  TITLE     Failure of B-cell differentiation in mice lacking the transcription
            factor EBF
  JOURNAL   Nature 376 (6537), 263-267 (1995)
   PUBMED   7542362
REFERENCE   7  (bases 1 to 5203)
  AUTHORS   Milatovich,A., Qiu,R.G., Grosschedl,R. and Francke,U.
  TITLE     Gene for a tissue-specific transcriptional activator (EBF or
            Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory
            neurons, is located on human chromosome 5, band q34, and proximal
            mouse chromosome 11
  JOURNAL   Mamm Genome 5 (4), 211-215 (1994)
   PUBMED   8012110
REFERENCE   8  (bases 1 to 5203)
  AUTHORS   Yan,H., Grossman,A., Wang,H., D'Eustachio,P., Mossie,K.,
            Musacchio,J.M., Silvennoinen,O. and Schlessinger,J.
  TITLE     A novel receptor tyrosine phosphatase-sigma that is highly
            expressed in the nervous system
  JOURNAL   J Biol Chem 268 (33), 24880-24886 (1993)
   PUBMED   8227050
REFERENCE   9  (bases 1 to 5203)
  AUTHORS   Travis,A., Hagman,J., Hwang,L. and Grosschedl,R.
  TITLE     Purification of early-B-cell factor and characterization of its
            DNA-binding specificity
  JOURNAL   Mol Cell Biol 13 (6), 3392-3400 (1993)
   PUBMED   8497258
REFERENCE   10 (bases 1 to 5203)
  AUTHORS   Hagman,J., Belanger,C., Travis,A., Turck,C.W. and Grosschedl,R.
  TITLE     Cloning and functional characterization of early B-cell factor, a
            regulator of lymphocyte-specific gene expression
  JOURNAL   Genes Dev 7 (5), 760-773 (1993)
   PUBMED   8491377
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK141175.1, AK035781.1 and AL672013.9.
            
            On Mar 19, 2014 this sequence version replaced NM_007897.2.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the central coding region, compared to variant 1. The encoded
            isoform (2) is shorter, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK035781.1, L12147.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AK141175.1         1-118
            119-2651            AK035781.1         2-2534
            2652-5203           AL672013.9         64292-66843
FEATURES             Location/Qualifiers
     source          1..5203
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 26.45 cM"
     gene            1..5203
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /note="early B cell factor 1"
                     /db_xref="GeneID:13591"
                     /db_xref="MGI:MGI:95275"
     exon            1..213
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1855
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     transcription factor COE1; early B-cell factor"
                     /codon_start=1
                     /product="transcription factor COE1 isoform 2"
                     /protein_id="NP_031923.1"
                     /db_xref="CCDS:CCDS24566.1"
                     /db_xref="GeneID:13591"
                     /db_xref="MGI:MGI:95275"
                     /translation="MFGIQESIQRSGSSMKEEPLGSGMNAVRTWMQGAGVLDANTAAQ
                     SGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVGFVEKEKEANSE
                     KTNNGIHYRLQLLYSNGIRTEQDFYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIM
                     CSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTT
                     VNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEGTPSYLEHATPCIKAISPSEGWTTG
                     GATVIIIGDNFFDGLQVIFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQF
                     CKGTPGRFIYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVILKRAADLVEALYGM
                     PHNNQEIILKRAADIAEALYSVPRNHNQLPALANTSVHAGMMGVNSFSGQLAVNVSEA
                     SQATNQGFTRNSSSVSPHGYVPSTTPQQTNYNSVTTSMNGYGSAAMSNLGGSPTFLNG
                     SAANSPYAIVPSSPTMASSTSLPSNCSSSSGIFSFSPANMVSAVKQKSAFAPVVRPQT
                     SPPPTCTSTNGNSLQAISGMIVPPM"
     exon            214..370
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            371..434
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            435..490
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            491..564
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            565..633
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            634..715
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            716..857
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            858..988
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1115
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1204
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1270
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1448
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1628
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1823
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..5203
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4434..4439
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /note="hexamer: AAGAAA"
     polyA_site      4450
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /note="major polyA site"
     regulatory      5175..5180
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /note="hexamer: ATTAAA"
     polyA_site      5203
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /note="major polyA site"
ORIGIN      
        1 tttttttttt ttttcctttt tttttttttc aaatattttc aaaggggagg agatttttcc
       61 acaagaaaag gttgttttca tgtttgggat ccaggaaagc atccaacgga gtggaagcag
      121 tatgaaggaa gagccgctgg gcagcggcat gaacgcggtg cggacgtgga tgcagggcgc
      181 cggggtgctg gacgccaaca cagcggcgca gagcggggtg ggtctggccc gggctcactt
      241 tgagaagcag ccgccttcta acctgcggaa atccaacttc ttccacttcg tcctggccct
      301 ctacgacaga cagggccagc ccgtggagat tgagaggacg gcctttgtgg ggttcgtgga
      361 gaaggaaaaa gaagccaaca gcgaaaagac caataatggg atccactacc ggctccagct
      421 cctctacagc aatgggatac ggacagaaca ggatttctat gtgcgcctca tcgactccat
      481 gacaaaacaa gccatagtgt atgaaggcca agacaagaac cctgaaatgt gccgagtatt
      541 gctcacacac gagatcatgt gcagccgctg ttgtgacaag aaaagctgtg gcaaccgaaa
      601 tgagactccc tcagatccag tgataattga caggttcttc ctgaagtttt tccttaaatg
      661 caaccaaaat tgcctaaaga atgcaggaaa cccacgtgac atgcggagat tccaggtcgt
      721 ggtgtctacc acagtcaacg tggatggcca tgtcctggca gtctctgata acatgtttgt
      781 ccacaataac tccaagcacg ggcggagggc tcggaggctt gacccctcgg aaggtacgcc
      841 ctcttatctg gaacatgcta ctccctgtat caaagccatc agcccgagtg aaggatggac
      901 gacgggaggc gcgactgtga tcatcatagg ggacaatttc tttgatgggt tacaggtcat
      961 attcggtacc atgctggtct ggagtgagtt gataactcct catgccatcc gagttcagac
     1021 acctcctcgg cacatccctg gtgtggtgga agtcacactg tcgtacaagt ccaagcagtt
     1081 ctgcaaaggg acaccaggca gattcatcta cacagcactc aatgaaccca ccatcgacta
     1141 cggcttccag aggttacaga aggtcattcc tcggcatcct ggtgacccag agcgcttgcc
     1201 aaaggaagtg atccttaaaa gagctgcaga tctggttgaa gccctgtatg ggatgcccca
     1261 caacaaccag gagattatcc tgaagagagc tgccgacatt gcagaggctc tgtacagtgt
     1321 ccctcggaac cacaaccagc tcccagccct tgctaacact tcggtccatg cagggatgat
     1381 gggtgtgaac tccttcagtg gacaactggc tgtgaatgtc tcggaggcat cacaagccac
     1441 caatcaaggt ttcacccgca actcaagcag cgtgtcacca catggctatg tgccgagcac
     1501 caccccacag caaaccaact ataactcagt caccacaagc atgaatggct acggctcagc
     1561 cgccatgtcc aatttgggcg gctccccaac cttcctcaat ggctcagctg ccaactcacc
     1621 ctatgccatt gtgccatcca gccccaccat ggcctcatct acaagcctcc cctccaactg
     1681 cagtagctcc tctggcatct tctccttctc accagccaac atggtctcag cagtgaaaca
     1741 gaagagtgct ttcgcaccag ttgtcagacc ccagacgtcc cctcctccca cctgcaccag
     1801 caccaacggg aacagcctgc aagcgatatc tggcatgatt gtccctccca tgtgaaagaa
     1861 ttgccttgaa gaattttatt aatgaagagg ttggattctg ctacgaaagt tatctgacat
     1921 gagtcccaga gtggaacttt taactcaggc ctttttaaga ggaatcacac aataactgca
     1981 gatttttaaa caaaatcacc gaccttgcaa atactgaaat tggaaagggg gtctgccaga
     2041 gcagggtgtt ggttaaagtt gtaacccccg agtatctggg ggatatattt attctgtatt
     2101 gataaaaagc aagcccacat tttctttttc tttctttctt ttcttaagct taactctgca
     2161 accatttgtc ttttataaac cattaagcta cacacaaggg ccactataaa caagactcca
     2221 tgttttaatt tatgttttta aagctatgga aggggagaat gaagtggtga tatttacaaa
     2281 aaaaaaaaat ctaaaaggag aaaaaaaaaa gaaaaacagg gaaaaataaa tttaaaaaaa
     2341 gagctcgtat ggacagaata ggaatgccag ttagattttt tagtgaacta agggtcggct
     2401 tctgcgcctt aaagcttatc agtggtagtt agctcagaca gtgcattttc aatatctaac
     2461 ttaacacgcc accccttagc agtgcaagct tcgttctctc ttttgtatgg ttgtcttaag
     2521 taactgtgta aataagtgta gcctggaaag ttaccaagcg acatacatga tcacgtttgc
     2581 ccttgtactc gaaaagccag tgcctctaga cagattgttt aaaaacaaac aaaaacaaaa
     2641 caaaacaaaa caaaacaaca tgcatcttta aacccgatct tattctttta cttaacatca
     2701 acttctcccg aagccagcgg cctctgagag tggagcaaca catgttccga gcgagaatct
     2761 ccttcaagac ttcacaggac agggtccagg cacagaattc catatatgcc ctccagttta
     2821 ccaagccaaa atctcgctcg cactccaccg tcaagagatc caagcttact caagctggaa
     2881 tcctagatat taactctaga tctgggctca aaaacccaaa taaagcaaac ccacaaaggc
     2941 aagtaggtgt gctgttccgg gctcccaaat cacacgggtc tatacccgca agactccgca
     3001 aggtcccaaa tcacacaggg gtctgtatcc gcaagactcc gcaaggttgg aaagttctat
     3061 attcagtcaa caggtaaagt gctttggagt tcagtgtgaa aggaaactgg gagagaggaa
     3121 gggaaggttg aggcttcaaa ctcagctttc tatgggaaat tttgctttca actgggaagt
     3181 gttcttaaag aatccatagc aaagattcag ccagcaaggc tctgaggggg cgtgttcctg
     3241 ctgacctctg cccttctgtt tctgtatgta gttataaata ctgtagattt cttttgtgat
     3301 tttttttttg ccaaagttgt tttatttata cattttaatg tcttaagatt ttcgatctca
     3361 cacacgcaaa gaattatact gcatattttg caaagaaata aaaagcgcac tacctttagc
     3421 ttgcacatac ttgcaaagtt aattcaaagg ctttctgttt gtttgtttta atggggattt
     3481 tgtaaaatat ccatataaat aatgtattta tctttggaat ttgtacattg cttttctctc
     3541 cttcctccca tcccccaccc ctagtttatt ttgtgtgtgt gtttgctttg tgaacagtgc
     3601 gcaagtatag tttggtcact tatagttgta ttagctgttt caatgtgatt tttaaacaat
     3661 tcatttatag gtatttttag tattgtttta aaccatgctt cattttttta tttccaccca
     3721 aaagccattg tctatttttg tattatttgt aagttaagaa gttttttcca atatatggca
     3781 aaaaaatagt agcatattat tcttgtagta tttagttctg tagatttaaa aataatgtac
     3841 cctttgcttt ggaagcatac aaaaacgctg ttttactcta gtaatatgca tggaatctct
     3901 ccctttggag tgacgcattt tgtgcattaa atttggggga gaaacttcat agagatcaat
     3961 gaacatactt tctttcttaa gtctgcttgt atattctctg tctttcacat aaatataaac
     4021 cagcagattg gatgccttaa caatgcaaat catatccatt tcacctgtac attgtactgt
     4081 gcaccccccc caactgtcag ccatcactaa cattctaaga aaaaaaaaaa agaaaaagaa
     4141 gaaaaaaaaa gagagaaatc gaaaagcaca aaagaactgt tttgttactt taagacaatg
     4201 ttactttttc tagtagagca agagaacatt aacaaagctg cgactgtgca tgcccggatg
     4261 gatttcaacg gttttcacta gactgtcaga gtgcggattt ttatgggttg gggaggggag
     4321 gggagggaag ttgggggggt tggtagggga ggggagggag gaaagctgat ttttcatggt
     4381 gagaaataat aataatgaca actgatgata ataataataa taataaaaat aaaaagaaac
     4441 tggaaaaaaa tataagcaag gtttagcatt gcttctccgt actcagaaag gttgtctgaa
     4501 ttcgtgtggt aagcgctggc ctcaagatgt ctaacgtcta aagccatatt ttgtctggtg
     4561 agccagacaa ctgtctgcaa aggaacgagc agcaagccgg tgaggtgtcc ggctcagacc
     4621 ctgacaaaag acgccaccaa tctgttagcc acgtgctgtg acgtgatgag aactttactg
     4681 gaaagcccaa agagccttta aaaagaaaat gtgtatcaat tgtgttttgt tacttctgtt
     4741 tgattagccg atggagaagt agtttggttt taggaaccac tttcttctac acaaaatctt
     4801 gtttttaagt ccctttaaga tatagccccc taaatacaga atatggcttt taaaaagaag
     4861 atggagtaga gaattcaatt cagatttccg ttttggggga agagccctgc ctctggatga
     4921 ctggatatgt ccacgccatg cccggcctca caatgtagga tgcagctcca tgaactcatt
     4981 ctgcaaatct ttcaccttct tttcaaacgt tttcaataga cacacactgt acaatccaat
     5041 tgttagagca ctcaactact gtagagattg ttatatttca ttctttttta tttctttctt
     5101 tcttttcttt tcttctcctt tttttttttc aaaaattcaa actgtaaaaa acttttcaac
     5161 gttcacgata tttaattaaa gttacttcct gtctgtgata gca
//
