LOCUS       NM_001362578            5298 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus early B cell factor 1 (Ebf1), transcript variant 11,
            mRNA.
ACCESSION   NM_001362578 XM_017314252
VERSION     NM_001362578.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5298)
  AUTHORS   Thiruppathy,M., Teubner,L., Roberts,R.R., Lasser,M.C.,
            Moscatello,A., Chen,Y.W., Hochstim,C., Ruffins,S., Sarkar,A.,
            Tassey,J., Evseenko,D., Lozito,T.P., Willsey,H.R., Gillis,J.A. and
            Crump,J.G.
  TITLE     Repurposing of a gill gene regulatory program for outer-ear
            evolution
  JOURNAL   Nature (2025) In press
   PUBMED   39788155
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 5298)
  AUTHORS   Kc,R., Lopez de Boer,R., Lin,M., Vagnozzi,A.N., Jeannotte,L. and
            Philippidou,P.
  TITLE     Multimodal Hox5 activity generates motor neuron diversity
  JOURNAL   Commun Biol 7 (1), 1166 (2024)
   PUBMED   39289460
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5298)
  AUTHORS   Powers,K.G., Wilkerson,B.A., Beach,K.E., Seo,S.S., Rodriguez,J.S.,
            Baxter,A.N., Hunter,S.E. and Bermingham-McDonogh,O.
  TITLE     Deletion of the Ebf1, a mouse deafness gene, causes a dramatic
            increase in hair cells and support cells of the organ of Corti
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39037017
  REMARK    GeneRIF: Deletion of the Ebf1, a mouse deafness gene, causes a
            dramatic increase in hair cells and support cells of the organ of
            Corti.
REFERENCE   4  (bases 1 to 5298)
  AUTHORS   Wu,Y., Chen,S., Huang,G., Zhang,L., Zhong,L., Feng,Y., Wen,P. and
            Liu,J.
  TITLE     Transcriptome analysis reveals EBF1 ablation-induced injuries in
            cardiac system
  JOURNAL   Theranostics 14 (12), 4894-4915 (2024)
   PUBMED   39239522
  REMARK    GeneRIF: Transcriptome analysis reveals EBF1 ablation-induced
            injuries in cardiac system.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5298)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 5298)
  AUTHORS   Lin,H. and Grosschedl,R.
  TITLE     Failure of B-cell differentiation in mice lacking the transcription
            factor EBF
  JOURNAL   Nature 376 (6537), 263-267 (1995)
   PUBMED   7542362
REFERENCE   7  (bases 1 to 5298)
  AUTHORS   Milatovich,A., Qiu,R.G., Grosschedl,R. and Francke,U.
  TITLE     Gene for a tissue-specific transcriptional activator (EBF or
            Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory
            neurons, is located on human chromosome 5, band q34, and proximal
            mouse chromosome 11
  JOURNAL   Mamm Genome 5 (4), 211-215 (1994)
   PUBMED   8012110
REFERENCE   8  (bases 1 to 5298)
  AUTHORS   Yan,H., Grossman,A., Wang,H., D'Eustachio,P., Mossie,K.,
            Musacchio,J.M., Silvennoinen,O. and Schlessinger,J.
  TITLE     A novel receptor tyrosine phosphatase-sigma that is highly
            expressed in the nervous system
  JOURNAL   J Biol Chem 268 (33), 24880-24886 (1993)
   PUBMED   8227050
REFERENCE   9  (bases 1 to 5298)
  AUTHORS   Travis,A., Hagman,J., Hwang,L. and Grosschedl,R.
  TITLE     Purification of early-B-cell factor and characterization of its
            DNA-binding specificity
  JOURNAL   Mol Cell Biol 13 (6), 3392-3400 (1993)
   PUBMED   8497258
REFERENCE   10 (bases 1 to 5298)
  AUTHORS   Hagman,J., Belanger,C., Travis,A., Turck,C.W. and Grosschedl,R.
  TITLE     Cloning and functional characterization of early B-cell factor, a
            regulator of lymphocyte-specific gene expression
  JOURNAL   Genes Dev 7 (5), 760-773 (1993)
   PUBMED   8491377
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603913.14, AL732622.4 and AL672013.9.
            
            On Apr 20, 2018 this sequence version replaced XM_017314252.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR1660813.151492.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849375, SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-213               AL603913.14        137264-137476
            214-370             AL603913.14        139578-139734
            371-553             AL603913.14        140331-140513
            554-609             AL603913.14        141085-141140
            610-683             AL603913.14        151915-151988
            684-752             AL603913.14        162565-162633
            753-834             AL732622.4         52620-52701
            835-952             AL732622.4         67342-67459
            953-1083            AL732622.4         91435-91565
            1084-1210           AL732622.4         107977-108103
            1211-1299           AL672013.9         31611-31699
            1300-1365           AL672013.9         49263-49328
            1366-1543           AL672013.9         50160-50337
            1544-1723           AL672013.9         51056-51235
            1724-1918           AL672013.9         54753-54947
            1919-5298           AL672013.9         63464-66843
FEATURES             Location/Qualifiers
     source          1..5298
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 26.45 cM"
     gene            1..5298
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /note="early B cell factor 1"
                     /db_xref="GeneID:13591"
                     /db_xref="MGI:MGI:95275"
     exon            1..213
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            214..370
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            371..553
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            554..609
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             598..1950
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /note="isoform 10 is encoded by transcript variant 11;
                     transcription factor COE1; early B-cell factor"
                     /codon_start=1
                     /product="transcription factor COE1 isoform 10"
                     /protein_id="NP_001349507.1"
                     /db_xref="GeneID:13591"
                     /db_xref="MGI:MGI:95275"
                     /translation="MTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETP
                     SDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVNVDGHVLAVSDNMFVH
                     NNSKHGRRARRLDPSEATPCIKAISPSEGWTTGGATVIIIGDNFFDGLQVIFGTMLVW
                     SELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGRFIYTALNEPTIDYGFQRL
                     QKVIPRHPGDPERLPKEVILKRAADLVEALYGMPHNNQEIILKRAADIAEALYSVPRN
                     HNQLPALANTSVHAGMMGVNSFSGQLAVNVSEASQATNQGFTRNSSSVSPHGYVPSTT
                     PQQTNYNSVTTSMNGYGSAAMSNLGGSPTFLNGSAANSPYAIVPSSPTMASSTSLPSN
                     CSSSSGIFSFSPANMVSAVKQKSAFAPVVRPQTSPPPTCTSTNGNSLQAISGMIVPPM
                     "
     exon            610..683
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            684..752
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            753..834
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            835..952
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1083
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1210
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1299
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1365
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1543
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1723
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1918
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..5298
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4529..4534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /note="hexamer: AAGAAA"
     polyA_site      4545
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /note="major polyA site"
     regulatory      5270..5275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /note="hexamer: ATTAAA"
     polyA_site      5298
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /note="major polyA site"
ORIGIN      
        1 tttttttttt ttttcctttt tttttttttc aaatattttc aaaggggagg agatttttcc
       61 acaagaaaag gttgttttca tgtttgggat ccaggaaagc atccaacgga gtggaagcag
      121 tatgaaggaa gagccgctgg gcagcggcat gaacgcggtg cggacgtgga tgcagggcgc
      181 cggggtgctg gacgccaaca cagcggcgca gagcggggtg ggtctggccc gggctcactt
      241 tgagaagcag ccgccttcta acctgcggaa atccaacttc ttccacttcg tcctggccct
      301 ctacgacaga cagggccagc ccgtggagat tgagaggacg gcctttgtgg ggttcgtgga
      361 gaaggaaaaa gaagccaaca gcgaaaagac caataatggg atccactacc ggctccagct
      421 cctctacagc aatggtgagg ctcctgtcgg gtcggtgcca gcaccctggg gctccgggtc
      481 agggcaaggg gctcacggag ctccaggtgg acgaaaaccc cccagcgaag ctcagccgtc
      541 agccaccctc cagggatacg gacagaacag gatttctatg tgcgcctcat cgactccatg
      601 acaaaacaag ccatagtgta tgaaggccaa gacaagaacc ctgaaatgtg ccgagtattg
      661 ctcacacacg agatcatgtg cagccgctgt tgtgacaaga aaagctgtgg caaccgaaat
      721 gagactccct cagatccagt gataattgac aggttcttcc tgaagttttt ccttaaatgc
      781 aaccaaaatt gcctaaagaa tgcaggaaac ccacgtgaca tgcggagatt ccaggtcgtg
      841 gtgtctacca cagtcaacgt ggatggccat gtcctggcag tctctgataa catgtttgtc
      901 cacaataact ccaagcacgg gcggagggct cggaggcttg acccctcgga agctactccc
      961 tgtatcaaag ccatcagccc gagtgaagga tggacgacgg gaggcgcgac tgtgatcatc
     1021 ataggggaca atttctttga tgggttacag gtcatattcg gtaccatgct ggtctggagt
     1081 gagttgataa ctcctcatgc catccgagtt cagacacctc ctcggcacat ccctggtgtg
     1141 gtggaagtca cactgtcgta caagtccaag cagttctgca aagggacacc aggcagattc
     1201 atctacacag cactcaatga acccaccatc gactacggct tccagaggtt acagaaggtc
     1261 attcctcggc atcctggtga cccagagcgc ttgccaaagg aagtgatcct taaaagagct
     1321 gcagatctgg ttgaagccct gtatgggatg ccccacaaca accaggagat tatcctgaag
     1381 agagctgccg acattgcaga ggctctgtac agtgtccctc ggaaccacaa ccagctccca
     1441 gcccttgcta acacttcggt ccatgcaggg atgatgggtg tgaactcctt cagtggacaa
     1501 ctggctgtga atgtctcgga ggcatcacaa gccaccaatc aaggtttcac ccgcaactca
     1561 agcagcgtgt caccacatgg ctatgtgccg agcaccaccc cacagcaaac caactataac
     1621 tcagtcacca caagcatgaa tggctacggc tcagccgcca tgtccaattt gggcggctcc
     1681 ccaaccttcc tcaatggctc agctgccaac tcaccctatg ccattgtgcc atccagcccc
     1741 accatggcct catctacaag cctcccctcc aactgcagta gctcctctgg catcttctcc
     1801 ttctcaccag ccaacatggt ctcagcagtg aaacagaaga gtgctttcgc accagttgtc
     1861 agaccccaga cgtcccctcc tcccacctgc accagcacca acgggaacag cctgcaagcg
     1921 atatctggca tgattgtccc tcccatgtga aagaattgcc ttgaagaatt ttattaatga
     1981 agaggttgga ttctgctacg aaagttatct gacatgagtc ccagagtgga acttttaact
     2041 caggcctttt taagaggaat cacacaataa ctgcagattt ttaaacaaaa tcaccgacct
     2101 tgcaaatact gaaattggaa agggggtctg ccagagcagg gtgttggtta aagttgtaac
     2161 ccccgagtat ctgggggata tatttattct gtattgataa aaagcaagcc cacattttct
     2221 ttttctttct ttcttttctt aagcttaact ctgcaaccat ttgtctttta taaaccatta
     2281 agctacacac aagggccact ataaacaaga ctccatgttt taatttatgt ttttaaagct
     2341 atggaagggg agaatgaagt ggtgatattt acaaaaaaaa aaaatctaaa aggagaaaaa
     2401 aaaaagaaaa acagggaaaa ataaatttaa aaaaagagct cgtatggaca gaataggaat
     2461 gccagttaga ttttttagtg aactaagggt cggcttctgc gccttaaagc ttatcagtgg
     2521 tagttagctc agacagtgca ttttcaatat ctaacttaac acgccacccc ttagcagtgc
     2581 aagcttcgtt ctctcttttg tatggttgtc ttaagtaact gtgtaaataa gtgtagcctg
     2641 gaaagttacc aagcgacata catgatcacg tttgcccttg tactcgaaaa gccagtgcct
     2701 ctagacagat tgtttaaaaa caaacaaaaa caaaacaaaa caaaacaaaa caacatgcat
     2761 ctttaaaccc gatcttattc ttttacttaa catcaacttc tcccgaagcc agcggcctct
     2821 gagagtggag caacacatgt tccgagcgag aatctccttc aagacttcac aggacagggt
     2881 ccaggcacag aattccatat atgccctcca gtttaccaag ccaaaatctc gctcgcactc
     2941 caccgtcaag agatccaagc ttactcaagc tggaatccta gatattaact ctagatctgg
     3001 gctcaaaaac ccaaataaag caaacccaca aaggcaagta ggtgtgctgt tccgggctcc
     3061 caaatcacac gggtctatac ccgcaagact ccgcaaggtc ccaaatcaca caggggtctg
     3121 tatccgcaag actccgcaag gttggaaagt tctatattca gtcaacaggt aaagtgcttt
     3181 ggagttcagt gtgaaaggaa actgggagag aggaagggaa ggttgaggct tcaaactcag
     3241 ctttctatgg gaaattttgc tttcaactgg gaagtgttct taaagaatcc atagcaaaga
     3301 ttcagccagc aaggctctga gggggcgtgt tcctgctgac ctctgccctt ctgtttctgt
     3361 atgtagttat aaatactgta gatttctttt gtgatttttt ttttgccaaa gttgttttat
     3421 ttatacattt taatgtctta agattttcga tctcacacac gcaaagaatt atactgcata
     3481 ttttgcaaag aaataaaaag cgcactacct ttagcttgca catacttgca aagttaattc
     3541 aaaggctttc tgtttgtttg ttttaatggg gattttgtaa aatatccata taaataatgt
     3601 atttatcttt ggaatttgta cattgctttt ctctccttcc tcccatcccc cacccctagt
     3661 ttattttgtg tgtgtgtttg ctttgtgaac agtgcgcaag tatagtttgg tcacttatag
     3721 ttgtattagc tgtttcaatg tgatttttaa acaattcatt tataggtatt tttagtattg
     3781 ttttaaacca tgcttcattt ttttatttcc acccaaaagc cattgtctat ttttgtatta
     3841 tttgtaagtt aagaagtttt ttccaatata tggcaaaaaa atagtagcat attattcttg
     3901 tagtatttag ttctgtagat ttaaaaataa tgtacccttt gctttggaag catacaaaaa
     3961 cgctgtttta ctctagtaat atgcatggaa tctctccctt tggagtgacg cattttgtgc
     4021 attaaatttg ggggagaaac ttcatagaga tcaatgaaca tactttcttt cttaagtctg
     4081 cttgtatatt ctctgtcttt cacataaata taaaccagca gattggatgc cttaacaatg
     4141 caaatcatat ccatttcacc tgtacattgt actgtgcacc ccccccaact gtcagccatc
     4201 actaacattc taagaaaaaa aaaaaagaaa aagaagaaaa aaaaagagag aaatcgaaaa
     4261 gcacaaaaga actgttttgt tactttaaga caatgttact ttttctagta gagcaagaga
     4321 acattaacaa agctgcgact gtgcatgccc ggatggattt caacggtttt cactagactg
     4381 tcagagtgcg gatttttatg ggttggggag gggaggggag ggaagttggg ggggttggta
     4441 ggggagggga gggaggaaag ctgatttttc atggtgagaa ataataataa tgacaactga
     4501 tgataataat aataataata aaaataaaaa gaaactggaa aaaaatataa gcaaggttta
     4561 gcattgcttc tccgtactca gaaaggttgt ctgaattcgt gtggtaagcg ctggcctcaa
     4621 gatgtctaac gtctaaagcc atattttgtc tggtgagcca gacaactgtc tgcaaaggaa
     4681 cgagcagcaa gccggtgagg tgtccggctc agaccctgac aaaagacgcc accaatctgt
     4741 tagccacgtg ctgtgacgtg atgagaactt tactggaaag cccaaagagc ctttaaaaag
     4801 aaaatgtgta tcaattgtgt tttgttactt ctgtttgatt agccgatgga gaagtagttt
     4861 ggttttagga accactttct tctacacaaa atcttgtttt taagtccctt taagatatag
     4921 ccccctaaat acagaatatg gcttttaaaa agaagatgga gtagagaatt caattcagat
     4981 ttccgttttg ggggaagagc cctgcctctg gatgactgga tatgtccacg ccatgcccgg
     5041 cctcacaatg taggatgcag ctccatgaac tcattctgca aatctttcac cttcttttca
     5101 aacgttttca atagacacac actgtacaat ccaattgtta gagcactcaa ctactgtaga
     5161 gattgttata tttcattctt ttttatttct ttctttcttt tcttttcttc tccttttttt
     5221 ttttcaaaaa ttcaaactgt aaaaaacttt tcaacgttca cgatatttaa ttaaagttac
     5281 ttcctgtctg tgatagca
//
