LOCUS       NM_001362571            5182 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus early B cell factor 1 (Ebf1), transcript variant 5,
            mRNA.
ACCESSION   NM_001362571 XM_006532155
VERSION     NM_001362571.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5182)
  AUTHORS   Thiruppathy,M., Teubner,L., Roberts,R.R., Lasser,M.C.,
            Moscatello,A., Chen,Y.W., Hochstim,C., Ruffins,S., Sarkar,A.,
            Tassey,J., Evseenko,D., Lozito,T.P., Willsey,H.R., Gillis,J.A. and
            Crump,J.G.
  TITLE     Repurposing of a gill gene regulatory program for outer-ear
            evolution
  JOURNAL   Nature (2025) In press
   PUBMED   39788155
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 5182)
  AUTHORS   Kc,R., Lopez de Boer,R., Lin,M., Vagnozzi,A.N., Jeannotte,L. and
            Philippidou,P.
  TITLE     Multimodal Hox5 activity generates motor neuron diversity
  JOURNAL   Commun Biol 7 (1), 1166 (2024)
   PUBMED   39289460
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5182)
  AUTHORS   Powers,K.G., Wilkerson,B.A., Beach,K.E., Seo,S.S., Rodriguez,J.S.,
            Baxter,A.N., Hunter,S.E. and Bermingham-McDonogh,O.
  TITLE     Deletion of the Ebf1, a mouse deafness gene, causes a dramatic
            increase in hair cells and support cells of the organ of Corti
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39037017
  REMARK    GeneRIF: Deletion of the Ebf1, a mouse deafness gene, causes a
            dramatic increase in hair cells and support cells of the organ of
            Corti.
REFERENCE   4  (bases 1 to 5182)
  AUTHORS   Wu,Y., Chen,S., Huang,G., Zhang,L., Zhong,L., Feng,Y., Wen,P. and
            Liu,J.
  TITLE     Transcriptome analysis reveals EBF1 ablation-induced injuries in
            cardiac system
  JOURNAL   Theranostics 14 (12), 4894-4915 (2024)
   PUBMED   39239522
  REMARK    GeneRIF: Transcriptome analysis reveals EBF1 ablation-induced
            injuries in cardiac system.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5182)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 5182)
  AUTHORS   Lin,H. and Grosschedl,R.
  TITLE     Failure of B-cell differentiation in mice lacking the transcription
            factor EBF
  JOURNAL   Nature 376 (6537), 263-267 (1995)
   PUBMED   7542362
REFERENCE   7  (bases 1 to 5182)
  AUTHORS   Milatovich,A., Qiu,R.G., Grosschedl,R. and Francke,U.
  TITLE     Gene for a tissue-specific transcriptional activator (EBF or
            Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory
            neurons, is located on human chromosome 5, band q34, and proximal
            mouse chromosome 11
  JOURNAL   Mamm Genome 5 (4), 211-215 (1994)
   PUBMED   8012110
REFERENCE   8  (bases 1 to 5182)
  AUTHORS   Yan,H., Grossman,A., Wang,H., D'Eustachio,P., Mossie,K.,
            Musacchio,J.M., Silvennoinen,O. and Schlessinger,J.
  TITLE     A novel receptor tyrosine phosphatase-sigma that is highly
            expressed in the nervous system
  JOURNAL   J Biol Chem 268 (33), 24880-24886 (1993)
   PUBMED   8227050
REFERENCE   9  (bases 1 to 5182)
  AUTHORS   Travis,A., Hagman,J., Hwang,L. and Grosschedl,R.
  TITLE     Purification of early-B-cell factor and characterization of its
            DNA-binding specificity
  JOURNAL   Mol Cell Biol 13 (6), 3392-3400 (1993)
   PUBMED   8497258
REFERENCE   10 (bases 1 to 5182)
  AUTHORS   Hagman,J., Belanger,C., Travis,A., Turck,C.W. and Grosschedl,R.
  TITLE     Cloning and functional characterization of early B-cell factor, a
            regulator of lymphocyte-specific gene expression
  JOURNAL   Genes Dev 7 (5), 760-773 (1993)
   PUBMED   8491377
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603913.14, AL732622.4 and AL672013.9.
            
            On Apr 20, 2018 this sequence version replaced XM_006532155.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.254562.1,
                                           SRR1660811.79432.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-213               AL603913.14        137264-137476
            214-370             AL603913.14        139578-139734
            371-434             AL603913.14        140331-140394
            435-490             AL603913.14        141085-141140
            491-564             AL603913.14        151915-151988
            565-633             AL603913.14        162565-162633
            634-715             AL732622.4         52620-52701
            716-833             AL732622.4         67342-67459
            834-967             AL732622.4         91432-91565
            968-1094            AL732622.4         107977-108103
            1095-1183           AL672013.9         31611-31699
            1184-1249           AL672013.9         49263-49328
            1250-1427           AL672013.9         50160-50337
            1428-1607           AL672013.9         51056-51235
            1608-1802           AL672013.9         54753-54947
            1803-5182           AL672013.9         63464-66843
FEATURES             Location/Qualifiers
     source          1..5182
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 26.45 cM"
     gene            1..5182
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /note="early B cell factor 1"
                     /db_xref="GeneID:13591"
                     /db_xref="MGI:MGI:95275"
     exon            1..213
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1834
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /note="isoform 5 is encoded by transcript variant 5;
                     transcription factor COE1; early B-cell factor"
                     /codon_start=1
                     /product="transcription factor COE1 isoform 5"
                     /protein_id="NP_001349500.1"
                     /db_xref="CCDS:CCDS88148.1"
                     /db_xref="GeneID:13591"
                     /db_xref="MGI:MGI:95275"
                     /translation="MFGIQESIQRSGSSMKEEPLGSGMNAVRTWMQGAGVLDANTAAQ
                     SGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVGFVEKEKEANSE
                     KTNNGIHYRLQLLYSNGIRTEQDFYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIM
                     CSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTT
                     VNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEAATPCIKAISPSEGWTTGGATVIII
                     GDNFFDGLQVIFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGR
                     FIYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVILKRAADLVEALYGMPHNNQEI
                     ILKRAADIAEALYSVPRNHNQLPALANTSVHAGMMGVNSFSGQLAVNVSEASQATNQG
                     FTRNSSSVSPHGYVPSTTPQQTNYNSVTTSMNGYGSAAMSNLGGSPTFLNGSAANSPY
                     AIVPSSPTMASSTSLPSNCSSSSGIFSFSPANMVSAVKQKSAFAPVVRPQTSPPPTCT
                     STNGNSLQAISGMIVPPM"
     exon            214..370
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            371..434
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            435..490
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            491..564
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            565..633
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            634..715
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            716..833
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            834..967
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1094
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1183
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1249
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1427
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1607
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1802
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..5182
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4413..4418
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /note="hexamer: AAGAAA"
     polyA_site      4429
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /note="major polyA site"
     regulatory      5154..5159
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /note="hexamer: ATTAAA"
     polyA_site      5182
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /note="major polyA site"
ORIGIN      
        1 tttttttttt ttttcctttt tttttttttc aaatattttc aaaggggagg agatttttcc
       61 acaagaaaag gttgttttca tgtttgggat ccaggaaagc atccaacgga gtggaagcag
      121 tatgaaggaa gagccgctgg gcagcggcat gaacgcggtg cggacgtgga tgcagggcgc
      181 cggggtgctg gacgccaaca cagcggcgca gagcggggtg ggtctggccc gggctcactt
      241 tgagaagcag ccgccttcta acctgcggaa atccaacttc ttccacttcg tcctggccct
      301 ctacgacaga cagggccagc ccgtggagat tgagaggacg gcctttgtgg ggttcgtgga
      361 gaaggaaaaa gaagccaaca gcgaaaagac caataatggg atccactacc ggctccagct
      421 cctctacagc aatgggatac ggacagaaca ggatttctat gtgcgcctca tcgactccat
      481 gacaaaacaa gccatagtgt atgaaggcca agacaagaac cctgaaatgt gccgagtatt
      541 gctcacacac gagatcatgt gcagccgctg ttgtgacaag aaaagctgtg gcaaccgaaa
      601 tgagactccc tcagatccag tgataattga caggttcttc ctgaagtttt tccttaaatg
      661 caaccaaaat tgcctaaaga atgcaggaaa cccacgtgac atgcggagat tccaggtcgt
      721 ggtgtctacc acagtcaacg tggatggcca tgtcctggca gtctctgata acatgtttgt
      781 ccacaataac tccaagcacg ggcggagggc tcggaggctt gacccctcgg aagcagctac
      841 tccctgtatc aaagccatca gcccgagtga aggatggacg acgggaggcg cgactgtgat
      901 catcataggg gacaatttct ttgatgggtt acaggtcata ttcggtacca tgctggtctg
      961 gagtgagttg ataactcctc atgccatccg agttcagaca cctcctcggc acatccctgg
     1021 tgtggtggaa gtcacactgt cgtacaagtc caagcagttc tgcaaaggga caccaggcag
     1081 attcatctac acagcactca atgaacccac catcgactac ggcttccaga ggttacagaa
     1141 ggtcattcct cggcatcctg gtgacccaga gcgcttgcca aaggaagtga tccttaaaag
     1201 agctgcagat ctggttgaag ccctgtatgg gatgccccac aacaaccagg agattatcct
     1261 gaagagagct gccgacattg cagaggctct gtacagtgtc cctcggaacc acaaccagct
     1321 cccagccctt gctaacactt cggtccatgc agggatgatg ggtgtgaact ccttcagtgg
     1381 acaactggct gtgaatgtct cggaggcatc acaagccacc aatcaaggtt tcacccgcaa
     1441 ctcaagcagc gtgtcaccac atggctatgt gccgagcacc accccacagc aaaccaacta
     1501 taactcagtc accacaagca tgaatggcta cggctcagcc gccatgtcca atttgggcgg
     1561 ctccccaacc ttcctcaatg gctcagctgc caactcaccc tatgccattg tgccatccag
     1621 ccccaccatg gcctcatcta caagcctccc ctccaactgc agtagctcct ctggcatctt
     1681 ctccttctca ccagccaaca tggtctcagc agtgaaacag aagagtgctt tcgcaccagt
     1741 tgtcagaccc cagacgtccc ctcctcccac ctgcaccagc accaacggga acagcctgca
     1801 agcgatatct ggcatgattg tccctcccat gtgaaagaat tgccttgaag aattttatta
     1861 atgaagaggt tggattctgc tacgaaagtt atctgacatg agtcccagag tggaactttt
     1921 aactcaggcc tttttaagag gaatcacaca ataactgcag atttttaaac aaaatcaccg
     1981 accttgcaaa tactgaaatt ggaaaggggg tctgccagag cagggtgttg gttaaagttg
     2041 taacccccga gtatctgggg gatatattta ttctgtattg ataaaaagca agcccacatt
     2101 ttctttttct ttctttcttt tcttaagctt aactctgcaa ccatttgtct tttataaacc
     2161 attaagctac acacaagggc cactataaac aagactccat gttttaattt atgtttttaa
     2221 agctatggaa ggggagaatg aagtggtgat atttacaaaa aaaaaaaatc taaaaggaga
     2281 aaaaaaaaag aaaaacaggg aaaaataaat ttaaaaaaag agctcgtatg gacagaatag
     2341 gaatgccagt tagatttttt agtgaactaa gggtcggctt ctgcgcctta aagcttatca
     2401 gtggtagtta gctcagacag tgcattttca atatctaact taacacgcca ccccttagca
     2461 gtgcaagctt cgttctctct tttgtatggt tgtcttaagt aactgtgtaa ataagtgtag
     2521 cctggaaagt taccaagcga catacatgat cacgtttgcc cttgtactcg aaaagccagt
     2581 gcctctagac agattgttta aaaacaaaca aaaacaaaac aaaacaaaac aaaacaacat
     2641 gcatctttaa acccgatctt attcttttac ttaacatcaa cttctcccga agccagcggc
     2701 ctctgagagt ggagcaacac atgttccgag cgagaatctc cttcaagact tcacaggaca
     2761 gggtccaggc acagaattcc atatatgccc tccagtttac caagccaaaa tctcgctcgc
     2821 actccaccgt caagagatcc aagcttactc aagctggaat cctagatatt aactctagat
     2881 ctgggctcaa aaacccaaat aaagcaaacc cacaaaggca agtaggtgtg ctgttccggg
     2941 ctcccaaatc acacgggtct atacccgcaa gactccgcaa ggtcccaaat cacacagggg
     3001 tctgtatccg caagactccg caaggttgga aagttctata ttcagtcaac aggtaaagtg
     3061 ctttggagtt cagtgtgaaa ggaaactggg agagaggaag ggaaggttga ggcttcaaac
     3121 tcagctttct atgggaaatt ttgctttcaa ctgggaagtg ttcttaaaga atccatagca
     3181 aagattcagc cagcaaggct ctgagggggc gtgttcctgc tgacctctgc ccttctgttt
     3241 ctgtatgtag ttataaatac tgtagatttc ttttgtgatt ttttttttgc caaagttgtt
     3301 ttatttatac attttaatgt cttaagattt tcgatctcac acacgcaaag aattatactg
     3361 catattttgc aaagaaataa aaagcgcact acctttagct tgcacatact tgcaaagtta
     3421 attcaaaggc tttctgtttg tttgttttaa tggggatttt gtaaaatatc catataaata
     3481 atgtatttat ctttggaatt tgtacattgc ttttctctcc ttcctcccat cccccacccc
     3541 tagtttattt tgtgtgtgtg tttgctttgt gaacagtgcg caagtatagt ttggtcactt
     3601 atagttgtat tagctgtttc aatgtgattt ttaaacaatt catttatagg tatttttagt
     3661 attgttttaa accatgcttc atttttttat ttccacccaa aagccattgt ctatttttgt
     3721 attatttgta agttaagaag ttttttccaa tatatggcaa aaaaatagta gcatattatt
     3781 cttgtagtat ttagttctgt agatttaaaa ataatgtacc ctttgctttg gaagcataca
     3841 aaaacgctgt tttactctag taatatgcat ggaatctctc cctttggagt gacgcatttt
     3901 gtgcattaaa tttgggggag aaacttcata gagatcaatg aacatacttt ctttcttaag
     3961 tctgcttgta tattctctgt ctttcacata aatataaacc agcagattgg atgccttaac
     4021 aatgcaaatc atatccattt cacctgtaca ttgtactgtg cacccccccc aactgtcagc
     4081 catcactaac attctaagaa aaaaaaaaaa gaaaaagaag aaaaaaaaag agagaaatcg
     4141 aaaagcacaa aagaactgtt ttgttacttt aagacaatgt tactttttct agtagagcaa
     4201 gagaacatta acaaagctgc gactgtgcat gcccggatgg atttcaacgg ttttcactag
     4261 actgtcagag tgcggatttt tatgggttgg ggaggggagg ggagggaagt tgggggggtt
     4321 ggtaggggag gggagggagg aaagctgatt tttcatggtg agaaataata ataatgacaa
     4381 ctgatgataa taataataat aataaaaata aaaagaaact ggaaaaaaat ataagcaagg
     4441 tttagcattg cttctccgta ctcagaaagg ttgtctgaat tcgtgtggta agcgctggcc
     4501 tcaagatgtc taacgtctaa agccatattt tgtctggtga gccagacaac tgtctgcaaa
     4561 ggaacgagca gcaagccggt gaggtgtccg gctcagaccc tgacaaaaga cgccaccaat
     4621 ctgttagcca cgtgctgtga cgtgatgaga actttactgg aaagcccaaa gagcctttaa
     4681 aaagaaaatg tgtatcaatt gtgttttgtt acttctgttt gattagccga tggagaagta
     4741 gtttggtttt aggaaccact ttcttctaca caaaatcttg tttttaagtc cctttaagat
     4801 atagccccct aaatacagaa tatggctttt aaaaagaaga tggagtagag aattcaattc
     4861 agatttccgt tttgggggaa gagccctgcc tctggatgac tggatatgtc cacgccatgc
     4921 ccggcctcac aatgtaggat gcagctccat gaactcattc tgcaaatctt tcaccttctt
     4981 ttcaaacgtt ttcaatagac acacactgta caatccaatt gttagagcac tcaactactg
     5041 tagagattgt tatatttcat tcttttttat ttctttcttt cttttctttt cttctccttt
     5101 ttttttttca aaaattcaaa ctgtaaaaaa cttttcaacg ttcacgatat ttaattaaag
     5161 ttacttcctg tctgtgatag ca
//
