LOCUS       NM_001362569            5083 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus early B cell factor 1 (Ebf1), transcript variant 8,
            mRNA.
ACCESSION   NM_001362569 XM_006532157
VERSION     NM_001362569.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5083)
  AUTHORS   Thiruppathy,M., Teubner,L., Roberts,R.R., Lasser,M.C.,
            Moscatello,A., Chen,Y.W., Hochstim,C., Ruffins,S., Sarkar,A.,
            Tassey,J., Evseenko,D., Lozito,T.P., Willsey,H.R., Gillis,J.A. and
            Crump,J.G.
  TITLE     Repurposing of a gill gene regulatory program for outer-ear
            evolution
  JOURNAL   Nature (2025) In press
   PUBMED   39788155
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 5083)
  AUTHORS   Kc,R., Lopez de Boer,R., Lin,M., Vagnozzi,A.N., Jeannotte,L. and
            Philippidou,P.
  TITLE     Multimodal Hox5 activity generates motor neuron diversity
  JOURNAL   Commun Biol 7 (1), 1166 (2024)
   PUBMED   39289460
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5083)
  AUTHORS   Powers,K.G., Wilkerson,B.A., Beach,K.E., Seo,S.S., Rodriguez,J.S.,
            Baxter,A.N., Hunter,S.E. and Bermingham-McDonogh,O.
  TITLE     Deletion of the Ebf1, a mouse deafness gene, causes a dramatic
            increase in hair cells and support cells of the organ of Corti
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39037017
  REMARK    GeneRIF: Deletion of the Ebf1, a mouse deafness gene, causes a
            dramatic increase in hair cells and support cells of the organ of
            Corti.
REFERENCE   4  (bases 1 to 5083)
  AUTHORS   Wu,Y., Chen,S., Huang,G., Zhang,L., Zhong,L., Feng,Y., Wen,P. and
            Liu,J.
  TITLE     Transcriptome analysis reveals EBF1 ablation-induced injuries in
            cardiac system
  JOURNAL   Theranostics 14 (12), 4894-4915 (2024)
   PUBMED   39239522
  REMARK    GeneRIF: Transcriptome analysis reveals EBF1 ablation-induced
            injuries in cardiac system.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5083)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 5083)
  AUTHORS   Lin,H. and Grosschedl,R.
  TITLE     Failure of B-cell differentiation in mice lacking the transcription
            factor EBF
  JOURNAL   Nature 376 (6537), 263-267 (1995)
   PUBMED   7542362
REFERENCE   7  (bases 1 to 5083)
  AUTHORS   Milatovich,A., Qiu,R.G., Grosschedl,R. and Francke,U.
  TITLE     Gene for a tissue-specific transcriptional activator (EBF or
            Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory
            neurons, is located on human chromosome 5, band q34, and proximal
            mouse chromosome 11
  JOURNAL   Mamm Genome 5 (4), 211-215 (1994)
   PUBMED   8012110
REFERENCE   8  (bases 1 to 5083)
  AUTHORS   Yan,H., Grossman,A., Wang,H., D'Eustachio,P., Mossie,K.,
            Musacchio,J.M., Silvennoinen,O. and Schlessinger,J.
  TITLE     A novel receptor tyrosine phosphatase-sigma that is highly
            expressed in the nervous system
  JOURNAL   J Biol Chem 268 (33), 24880-24886 (1993)
   PUBMED   8227050
REFERENCE   9  (bases 1 to 5083)
  AUTHORS   Travis,A., Hagman,J., Hwang,L. and Grosschedl,R.
  TITLE     Purification of early-B-cell factor and characterization of its
            DNA-binding specificity
  JOURNAL   Mol Cell Biol 13 (6), 3392-3400 (1993)
   PUBMED   8497258
REFERENCE   10 (bases 1 to 5083)
  AUTHORS   Hagman,J., Belanger,C., Travis,A., Turck,C.W. and Grosschedl,R.
  TITLE     Cloning and functional characterization of early B-cell factor, a
            regulator of lymphocyte-specific gene expression
  JOURNAL   Genes Dev 7 (5), 760-773 (1993)
   PUBMED   8491377
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603913.14, AL732622.4 and AL672013.9.
            
            On Apr 20, 2018 this sequence version replaced XM_006532157.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849375,
                              SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                AL603913.14        139392-139481
            91-247              AL603913.14        139578-139734
            248-311             AL603913.14        140331-140394
            312-367             AL603913.14        141085-141140
            368-441             AL603913.14        151915-151988
            442-510             AL603913.14        162565-162633
            511-592             AL732622.4         52620-52701
            593-734             AL732622.4         67342-67483
            735-868             AL732622.4         91432-91565
            869-995             AL732622.4         107977-108103
            996-1084            AL672013.9         31611-31699
            1085-1150           AL672013.9         49263-49328
            1151-1328           AL672013.9         50160-50337
            1329-1508           AL672013.9         51056-51235
            1509-1703           AL672013.9         54753-54947
            1704-5083           AL672013.9         63464-66843
FEATURES             Location/Qualifiers
     source          1..5083
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 26.45 cM"
     gene            1..5083
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /note="early B cell factor 1"
                     /db_xref="GeneID:13591"
                     /db_xref="MGI:MGI:95275"
     exon            1..90
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1735
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /note="isoform 8 is encoded by transcript variant 8;
                     transcription factor COE1; early B-cell factor"
                     /codon_start=1
                     /product="transcription factor COE1 isoform 8"
                     /protein_id="NP_001349498.1"
                     /db_xref="GeneID:13591"
                     /db_xref="MGI:MGI:95275"
                     /translation="MEGAQGMFWEQRSGVGLARAHFEKQPPSNLRKSNFFHFVLALYD
                     RQGQPVEIERTAFVGFVEKEKEANSEKTNNGIHYRLQLLYSNGIRTEQDFYVRLIDSM
                     TKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFL
                     KCNQNCLKNAGNPRDMRRFQVVVSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRLDPS
                     EGTPSYLEHAATPCIKAISPSEGWTTGGATVIIIGDNFFDGLQVIFGTMLVWSELITP
                     HAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGRFIYTALNEPTIDYGFQRLQKVIPR
                     HPGDPERLPKEVILKRAADLVEALYGMPHNNQEIILKRAADIAEALYSVPRNHNQLPA
                     LANTSVHAGMMGVNSFSGQLAVNVSEASQATNQGFTRNSSSVSPHGYVPSTTPQQTNY
                     NSVTTSMNGYGSAAMSNLGGSPTFLNGSAANSPYAIVPSSPTMASSTSLPSNCSSSSG
                     IFSFSPANMVSAVKQKSAFAPVVRPQTSPPPTCTSTNGNSLQAISGMIVPPM"
     exon            91..247
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            248..311
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            312..367
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            368..441
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            442..510
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            511..592
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..734
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            735..868
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            869..995
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1084
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1150
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1328
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1508
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1703
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..5083
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4314..4319
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /note="hexamer: AAGAAA"
     polyA_site      4330
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /note="major polyA site"
     regulatory      5055..5060
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /note="hexamer: ATTAAA"
     polyA_site      5083
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /note="major polyA site"
ORIGIN      
        1 catgagtggc atttgtccgg ttcgtcagcc gctcttgagc tcctgatggg tcatggaagg
       61 agcccagggg atgttttggg agcagagaag cggggtgggt ctggcccggg ctcactttga
      121 gaagcagccg ccttctaacc tgcggaaatc caacttcttc cacttcgtcc tggccctcta
      181 cgacagacag ggccagcccg tggagattga gaggacggcc tttgtggggt tcgtggagaa
      241 ggaaaaagaa gccaacagcg aaaagaccaa taatgggatc cactaccggc tccagctcct
      301 ctacagcaat gggatacgga cagaacagga tttctatgtg cgcctcatcg actccatgac
      361 aaaacaagcc atagtgtatg aaggccaaga caagaaccct gaaatgtgcc gagtattgct
      421 cacacacgag atcatgtgca gccgctgttg tgacaagaaa agctgtggca accgaaatga
      481 gactccctca gatccagtga taattgacag gttcttcctg aagtttttcc ttaaatgcaa
      541 ccaaaattgc ctaaagaatg caggaaaccc acgtgacatg cggagattcc aggtcgtggt
      601 gtctaccaca gtcaacgtgg atggccatgt cctggcagtc tctgataaca tgtttgtcca
      661 caataactcc aagcacgggc ggagggctcg gaggcttgac ccctcggaag gtacgccctc
      721 ttatctggaa catgcagcta ctccctgtat caaagccatc agcccgagtg aaggatggac
      781 gacgggaggc gcgactgtga tcatcatagg ggacaatttc tttgatgggt tacaggtcat
      841 attcggtacc atgctggtct ggagtgagtt gataactcct catgccatcc gagttcagac
      901 acctcctcgg cacatccctg gtgtggtgga agtcacactg tcgtacaagt ccaagcagtt
      961 ctgcaaaggg acaccaggca gattcatcta cacagcactc aatgaaccca ccatcgacta
     1021 cggcttccag aggttacaga aggtcattcc tcggcatcct ggtgacccag agcgcttgcc
     1081 aaaggaagtg atccttaaaa gagctgcaga tctggttgaa gccctgtatg ggatgcccca
     1141 caacaaccag gagattatcc tgaagagagc tgccgacatt gcagaggctc tgtacagtgt
     1201 ccctcggaac cacaaccagc tcccagccct tgctaacact tcggtccatg cagggatgat
     1261 gggtgtgaac tccttcagtg gacaactggc tgtgaatgtc tcggaggcat cacaagccac
     1321 caatcaaggt ttcacccgca actcaagcag cgtgtcacca catggctatg tgccgagcac
     1381 caccccacag caaaccaact ataactcagt caccacaagc atgaatggct acggctcagc
     1441 cgccatgtcc aatttgggcg gctccccaac cttcctcaat ggctcagctg ccaactcacc
     1501 ctatgccatt gtgccatcca gccccaccat ggcctcatct acaagcctcc cctccaactg
     1561 cagtagctcc tctggcatct tctccttctc accagccaac atggtctcag cagtgaaaca
     1621 gaagagtgct ttcgcaccag ttgtcagacc ccagacgtcc cctcctccca cctgcaccag
     1681 caccaacggg aacagcctgc aagcgatatc tggcatgatt gtccctccca tgtgaaagaa
     1741 ttgccttgaa gaattttatt aatgaagagg ttggattctg ctacgaaagt tatctgacat
     1801 gagtcccaga gtggaacttt taactcaggc ctttttaaga ggaatcacac aataactgca
     1861 gatttttaaa caaaatcacc gaccttgcaa atactgaaat tggaaagggg gtctgccaga
     1921 gcagggtgtt ggttaaagtt gtaacccccg agtatctggg ggatatattt attctgtatt
     1981 gataaaaagc aagcccacat tttctttttc tttctttctt ttcttaagct taactctgca
     2041 accatttgtc ttttataaac cattaagcta cacacaaggg ccactataaa caagactcca
     2101 tgttttaatt tatgttttta aagctatgga aggggagaat gaagtggtga tatttacaaa
     2161 aaaaaaaaat ctaaaaggag aaaaaaaaaa gaaaaacagg gaaaaataaa tttaaaaaaa
     2221 gagctcgtat ggacagaata ggaatgccag ttagattttt tagtgaacta agggtcggct
     2281 tctgcgcctt aaagcttatc agtggtagtt agctcagaca gtgcattttc aatatctaac
     2341 ttaacacgcc accccttagc agtgcaagct tcgttctctc ttttgtatgg ttgtcttaag
     2401 taactgtgta aataagtgta gcctggaaag ttaccaagcg acatacatga tcacgtttgc
     2461 ccttgtactc gaaaagccag tgcctctaga cagattgttt aaaaacaaac aaaaacaaaa
     2521 caaaacaaaa caaaacaaca tgcatcttta aacccgatct tattctttta cttaacatca
     2581 acttctcccg aagccagcgg cctctgagag tggagcaaca catgttccga gcgagaatct
     2641 ccttcaagac ttcacaggac agggtccagg cacagaattc catatatgcc ctccagttta
     2701 ccaagccaaa atctcgctcg cactccaccg tcaagagatc caagcttact caagctggaa
     2761 tcctagatat taactctaga tctgggctca aaaacccaaa taaagcaaac ccacaaaggc
     2821 aagtaggtgt gctgttccgg gctcccaaat cacacgggtc tatacccgca agactccgca
     2881 aggtcccaaa tcacacaggg gtctgtatcc gcaagactcc gcaaggttgg aaagttctat
     2941 attcagtcaa caggtaaagt gctttggagt tcagtgtgaa aggaaactgg gagagaggaa
     3001 gggaaggttg aggcttcaaa ctcagctttc tatgggaaat tttgctttca actgggaagt
     3061 gttcttaaag aatccatagc aaagattcag ccagcaaggc tctgaggggg cgtgttcctg
     3121 ctgacctctg cccttctgtt tctgtatgta gttataaata ctgtagattt cttttgtgat
     3181 tttttttttg ccaaagttgt tttatttata cattttaatg tcttaagatt ttcgatctca
     3241 cacacgcaaa gaattatact gcatattttg caaagaaata aaaagcgcac tacctttagc
     3301 ttgcacatac ttgcaaagtt aattcaaagg ctttctgttt gtttgtttta atggggattt
     3361 tgtaaaatat ccatataaat aatgtattta tctttggaat ttgtacattg cttttctctc
     3421 cttcctccca tcccccaccc ctagtttatt ttgtgtgtgt gtttgctttg tgaacagtgc
     3481 gcaagtatag tttggtcact tatagttgta ttagctgttt caatgtgatt tttaaacaat
     3541 tcatttatag gtatttttag tattgtttta aaccatgctt cattttttta tttccaccca
     3601 aaagccattg tctatttttg tattatttgt aagttaagaa gttttttcca atatatggca
     3661 aaaaaatagt agcatattat tcttgtagta tttagttctg tagatttaaa aataatgtac
     3721 cctttgcttt ggaagcatac aaaaacgctg ttttactcta gtaatatgca tggaatctct
     3781 ccctttggag tgacgcattt tgtgcattaa atttggggga gaaacttcat agagatcaat
     3841 gaacatactt tctttcttaa gtctgcttgt atattctctg tctttcacat aaatataaac
     3901 cagcagattg gatgccttaa caatgcaaat catatccatt tcacctgtac attgtactgt
     3961 gcaccccccc caactgtcag ccatcactaa cattctaaga aaaaaaaaaa agaaaaagaa
     4021 gaaaaaaaaa gagagaaatc gaaaagcaca aaagaactgt tttgttactt taagacaatg
     4081 ttactttttc tagtagagca agagaacatt aacaaagctg cgactgtgca tgcccggatg
     4141 gatttcaacg gttttcacta gactgtcaga gtgcggattt ttatgggttg gggaggggag
     4201 gggagggaag ttgggggggt tggtagggga ggggagggag gaaagctgat ttttcatggt
     4261 gagaaataat aataatgaca actgatgata ataataataa taataaaaat aaaaagaaac
     4321 tggaaaaaaa tataagcaag gtttagcatt gcttctccgt actcagaaag gttgtctgaa
     4381 ttcgtgtggt aagcgctggc ctcaagatgt ctaacgtcta aagccatatt ttgtctggtg
     4441 agccagacaa ctgtctgcaa aggaacgagc agcaagccgg tgaggtgtcc ggctcagacc
     4501 ctgacaaaag acgccaccaa tctgttagcc acgtgctgtg acgtgatgag aactttactg
     4561 gaaagcccaa agagccttta aaaagaaaat gtgtatcaat tgtgttttgt tacttctgtt
     4621 tgattagccg atggagaagt agtttggttt taggaaccac tttcttctac acaaaatctt
     4681 gtttttaagt ccctttaaga tatagccccc taaatacaga atatggcttt taaaaagaag
     4741 atggagtaga gaattcaatt cagatttccg ttttggggga agagccctgc ctctggatga
     4801 ctggatatgt ccacgccatg cccggcctca caatgtagga tgcagctcca tgaactcatt
     4861 ctgcaaatct ttcaccttct tttcaaacgt tttcaataga cacacactgt acaatccaat
     4921 tgttagagca ctcaactact gtagagattg ttatatttca ttctttttta tttctttctt
     4981 tcttttcttt tcttctcctt tttttttttc aaaaattcaa actgtaaaaa acttttcaac
     5041 gttcacgata tttaattaaa gttacttcct gtctgtgata gca
//
