LOCUS       NM_001290710            4999 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus early B cell factor 1 (Ebf1), transcript variant 3,
            mRNA.
ACCESSION   NM_001290710
VERSION     NM_001290710.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4999)
  AUTHORS   Thiruppathy,M., Teubner,L., Roberts,R.R., Lasser,M.C.,
            Moscatello,A., Chen,Y.W., Hochstim,C., Ruffins,S., Sarkar,A.,
            Tassey,J., Evseenko,D., Lozito,T.P., Willsey,H.R., Gillis,J.A. and
            Crump,J.G.
  TITLE     Repurposing of a gill gene regulatory program for outer-ear
            evolution
  JOURNAL   Nature (2025) In press
   PUBMED   39788155
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 4999)
  AUTHORS   Kc,R., Lopez de Boer,R., Lin,M., Vagnozzi,A.N., Jeannotte,L. and
            Philippidou,P.
  TITLE     Multimodal Hox5 activity generates motor neuron diversity
  JOURNAL   Commun Biol 7 (1), 1166 (2024)
   PUBMED   39289460
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4999)
  AUTHORS   Powers,K.G., Wilkerson,B.A., Beach,K.E., Seo,S.S., Rodriguez,J.S.,
            Baxter,A.N., Hunter,S.E. and Bermingham-McDonogh,O.
  TITLE     Deletion of the Ebf1, a mouse deafness gene, causes a dramatic
            increase in hair cells and support cells of the organ of Corti
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39037017
  REMARK    GeneRIF: Deletion of the Ebf1, a mouse deafness gene, causes a
            dramatic increase in hair cells and support cells of the organ of
            Corti.
REFERENCE   4  (bases 1 to 4999)
  AUTHORS   Wu,Y., Chen,S., Huang,G., Zhang,L., Zhong,L., Feng,Y., Wen,P. and
            Liu,J.
  TITLE     Transcriptome analysis reveals EBF1 ablation-induced injuries in
            cardiac system
  JOURNAL   Theranostics 14 (12), 4894-4915 (2024)
   PUBMED   39239522
  REMARK    GeneRIF: Transcriptome analysis reveals EBF1 ablation-induced
            injuries in cardiac system.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4999)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 4999)
  AUTHORS   Lin,H. and Grosschedl,R.
  TITLE     Failure of B-cell differentiation in mice lacking the transcription
            factor EBF
  JOURNAL   Nature 376 (6537), 263-267 (1995)
   PUBMED   7542362
REFERENCE   7  (bases 1 to 4999)
  AUTHORS   Milatovich,A., Qiu,R.G., Grosschedl,R. and Francke,U.
  TITLE     Gene for a tissue-specific transcriptional activator (EBF or
            Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory
            neurons, is located on human chromosome 5, band q34, and proximal
            mouse chromosome 11
  JOURNAL   Mamm Genome 5 (4), 211-215 (1994)
   PUBMED   8012110
REFERENCE   8  (bases 1 to 4999)
  AUTHORS   Yan,H., Grossman,A., Wang,H., D'Eustachio,P., Mossie,K.,
            Musacchio,J.M., Silvennoinen,O. and Schlessinger,J.
  TITLE     A novel receptor tyrosine phosphatase-sigma that is highly
            expressed in the nervous system
  JOURNAL   J Biol Chem 268 (33), 24880-24886 (1993)
   PUBMED   8227050
REFERENCE   9  (bases 1 to 4999)
  AUTHORS   Travis,A., Hagman,J., Hwang,L. and Grosschedl,R.
  TITLE     Purification of early-B-cell factor and characterization of its
            DNA-binding specificity
  JOURNAL   Mol Cell Biol 13 (6), 3392-3400 (1993)
   PUBMED   8497258
REFERENCE   10 (bases 1 to 4999)
  AUTHORS   Hagman,J., Belanger,C., Travis,A., Turck,C.W. and Grosschedl,R.
  TITLE     Cloning and functional characterization of early B-cell factor, a
            regulator of lymphocyte-specific gene expression
  JOURNAL   Genes Dev 7 (5), 760-773 (1993)
   PUBMED   8491377
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK141175.1, AK139021.1 and AL672013.9.
            
            Transcript Variant: This variant (3) has multiple differences in
            the coding region but maintains reading frame, compared to variant
            1. The encoded isoform (3) is shorter, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK139021.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AK141175.1         1-29
            30-2071             AK139021.1         28-2069
            2072-4999           AL672013.9         63916-66843
FEATURES             Location/Qualifiers
     source          1..4999
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 26.45 cM"
     gene            1..4999
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /note="early B cell factor 1"
                     /db_xref="GeneID:13591"
                     /db_xref="MGI:MGI:95275"
     exon            1..213
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1651
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     transcription factor COE1; early B-cell factor"
                     /codon_start=1
                     /product="transcription factor COE1 isoform 3"
                     /protein_id="NP_001277639.1"
                     /db_xref="GeneID:13591"
                     /db_xref="MGI:MGI:95275"
                     /translation="MFGIQESIQRSGSSMKEEPLGSGMNAVRTWMQGAGVLDANTAAQ
                     SGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVGFVEKEKEANSE
                     KTNNGIHYRLQLLYSNGIRTEQDFYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIM
                     CSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTT
                     VNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEATPCIKAISPSEGWTTGGATVIIIG
                     DNFFDGLQVIFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGRF
                     IYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVILKRAADLVEALYGMPHNNQEII
                     LKRAADIAEALYSVPRNHNQLPALANTSVHAGMMGVNSFSGQLAVNVSEASQATNQVV
                     PSSPTMASSTSLPSNCSSSSGIFSFSPANMVSAVKQKSAFAPVVRPQTSPPPTCTSTN
                     GNSLQAISGMIVPPM"
     exon            214..370
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            371..434
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            435..490
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            491..564
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            565..633
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            634..715
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            716..833
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            834..964
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1091
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1180
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1246
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1424
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1619
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..4999
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4230..4235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /note="hexamer: AAGAAA"
     polyA_site      4246
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /note="major polyA site"
     regulatory      4971..4976
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /note="hexamer: ATTAAA"
     polyA_site      4999
                     /gene="Ebf1"
                     /gene_synonym="Ebf; O/E-1; OE-1; Olf-1; Olf1"
                     /note="major polyA site"
ORIGIN      
        1 tttttttttt ttttcctttt tttttttttc aaatattttc aaaggggagg agatttttcc
       61 acaagaaaag gttgttttca tgtttgggat ccaggaaagc atccaacgga gtggaagcag
      121 tatgaaggaa gagccgctgg gcagcggcat gaacgcggtg cggacgtgga tgcagggcgc
      181 cggggtgctg gacgccaaca cagcggcgca gagcggggtg ggtctggccc gggctcactt
      241 tgagaagcag ccgccttcta acctgcggaa atccaacttc ttccacttcg tcctggccct
      301 ctacgacaga cagggccagc ccgtggagat tgagaggacg gcctttgtgg ggttcgtgga
      361 gaaggaaaaa gaagccaaca gcgaaaagac caataatggg atccactacc ggctccagct
      421 cctctacagc aatgggatac ggacagaaca ggatttctat gtgcgcctca tcgactccat
      481 gacaaaacaa gccatagtgt atgaaggcca agacaagaac cctgaaatgt gccgagtatt
      541 gctcacacac gagatcatgt gcagccgctg ttgtgacaag aaaagctgtg gcaaccgaaa
      601 tgagactccc tcagatccag tgataattga caggttcttc ctgaagtttt tccttaaatg
      661 caaccaaaat tgcctaaaga atgcaggaaa cccacgtgac atgcggagat tccaggtcgt
      721 ggtgtctacc acagtcaacg tggatggcca tgtcctggca gtctctgata acatgtttgt
      781 ccacaataac tccaagcacg ggcggagggc tcggaggctt gacccctcgg aagctactcc
      841 ctgtatcaaa gccatcagcc cgagtgaagg atggacgacg ggaggcgcga ctgtgatcat
      901 cataggggac aatttctttg atgggttaca ggtcatattc ggtaccatgc tggtctggag
      961 tgagttgata actcctcatg ccatccgagt tcagacacct cctcggcaca tccctggtgt
     1021 ggtggaagtc acactgtcgt acaagtccaa gcagttctgc aaagggacac caggcagatt
     1081 catctacaca gcactcaatg aacccaccat cgactacggc ttccagaggt tacagaaggt
     1141 cattcctcgg catcctggtg acccagagcg cttgccaaag gaagtgatcc ttaaaagagc
     1201 tgcagatctg gttgaagccc tgtatgggat gccccacaac aaccaggaga ttatcctgaa
     1261 gagagctgcc gacattgcag aggctctgta cagtgtccct cggaaccaca accagctccc
     1321 agcccttgct aacacttcgg tccatgcagg gatgatgggt gtgaactcct tcagtggaca
     1381 actggctgtg aatgtctcgg aggcatcaca agccaccaat caagttgtgc catccagccc
     1441 caccatggcc tcatctacaa gcctcccctc caactgcagt agctcctctg gcatcttctc
     1501 cttctcacca gccaacatgg tctcagcagt gaaacagaag agtgctttcg caccagttgt
     1561 cagaccccag acgtcccctc ctcccacctg caccagcacc aacgggaaca gcctgcaagc
     1621 gatatctggc atgattgtcc ctcccatgtg aaagaattgc cttgaagaat tttattaatg
     1681 aagaggttgg attctgctac gaaagttatc tgacatgagt cccagagtgg aacttttaac
     1741 tcaggccttt ttaagaggaa tcacacaata actgcagatt tttaaacaaa atcaccgacc
     1801 ttgcaaatac tgaaattgga aagggggtct gccagagcag ggtgttggtt aaagttgtaa
     1861 cccccgagta tctgggggat atatttattc tgtattgata aaaagcaagc ccacattttc
     1921 tttttctttc tttcttttct taagcttaac tctgcaacca tttgtctttt ataaaccatt
     1981 aagctacaca caagggccac tataaacaag actccatgtt ttaatttatg tttttaaagc
     2041 tatggaaggg gagaatgaag tggtgatatt tacaaaaaaa aaaaatctaa aaggagaaaa
     2101 aaaaaagaaa aacagggaaa aataaattta aaaaaagagc tcgtatggac agaataggaa
     2161 tgccagttag attttttagt gaactaaggg tcggcttctg cgccttaaag cttatcagtg
     2221 gtagttagct cagacagtgc attttcaata tctaacttaa cacgccaccc cttagcagtg
     2281 caagcttcgt tctctctttt gtatggttgt cttaagtaac tgtgtaaata agtgtagcct
     2341 ggaaagttac caagcgacat acatgatcac gtttgccctt gtactcgaaa agccagtgcc
     2401 tctagacaga ttgtttaaaa acaaacaaaa acaaaacaaa acaaaacaaa acaacatgca
     2461 tctttaaacc cgatcttatt cttttactta acatcaactt ctcccgaagc cagcggcctc
     2521 tgagagtgga gcaacacatg ttccgagcga gaatctcctt caagacttca caggacaggg
     2581 tccaggcaca gaattccata tatgccctcc agtttaccaa gccaaaatct cgctcgcact
     2641 ccaccgtcaa gagatccaag cttactcaag ctggaatcct agatattaac tctagatctg
     2701 ggctcaaaaa cccaaataaa gcaaacccac aaaggcaagt aggtgtgctg ttccgggctc
     2761 ccaaatcaca cgggtctata cccgcaagac tccgcaaggt cccaaatcac acaggggtct
     2821 gtatccgcaa gactccgcaa ggttggaaag ttctatattc agtcaacagg taaagtgctt
     2881 tggagttcag tgtgaaagga aactgggaga gaggaaggga aggttgaggc ttcaaactca
     2941 gctttctatg ggaaattttg ctttcaactg ggaagtgttc ttaaagaatc catagcaaag
     3001 attcagccag caaggctctg agggggcgtg ttcctgctga cctctgccct tctgtttctg
     3061 tatgtagtta taaatactgt agatttcttt tgtgattttt tttttgccaa agttgtttta
     3121 tttatacatt ttaatgtctt aagattttcg atctcacaca cgcaaagaat tatactgcat
     3181 attttgcaaa gaaataaaaa gcgcactacc tttagcttgc acatacttgc aaagttaatt
     3241 caaaggcttt ctgtttgttt gttttaatgg ggattttgta aaatatccat ataaataatg
     3301 tatttatctt tggaatttgt acattgcttt tctctccttc ctcccatccc ccacccctag
     3361 tttattttgt gtgtgtgttt gctttgtgaa cagtgcgcaa gtatagtttg gtcacttata
     3421 gttgtattag ctgtttcaat gtgattttta aacaattcat ttataggtat ttttagtatt
     3481 gttttaaacc atgcttcatt tttttatttc cacccaaaag ccattgtcta tttttgtatt
     3541 atttgtaagt taagaagttt tttccaatat atggcaaaaa aatagtagca tattattctt
     3601 gtagtattta gttctgtaga tttaaaaata atgtaccctt tgctttggaa gcatacaaaa
     3661 acgctgtttt actctagtaa tatgcatgga atctctccct ttggagtgac gcattttgtg
     3721 cattaaattt gggggagaaa cttcatagag atcaatgaac atactttctt tcttaagtct
     3781 gcttgtatat tctctgtctt tcacataaat ataaaccagc agattggatg ccttaacaat
     3841 gcaaatcata tccatttcac ctgtacattg tactgtgcac cccccccaac tgtcagccat
     3901 cactaacatt ctaagaaaaa aaaaaaagaa aaagaagaaa aaaaaagaga gaaatcgaaa
     3961 agcacaaaag aactgttttg ttactttaag acaatgttac tttttctagt agagcaagag
     4021 aacattaaca aagctgcgac tgtgcatgcc cggatggatt tcaacggttt tcactagact
     4081 gtcagagtgc ggatttttat gggttgggga ggggagggga gggaagttgg gggggttggt
     4141 aggggagggg agggaggaaa gctgattttt catggtgaga aataataata atgacaactg
     4201 atgataataa taataataat aaaaataaaa agaaactgga aaaaaatata agcaaggttt
     4261 agcattgctt ctccgtactc agaaaggttg tctgaattcg tgtggtaagc gctggcctca
     4321 agatgtctaa cgtctaaagc catattttgt ctggtgagcc agacaactgt ctgcaaagga
     4381 acgagcagca agccggtgag gtgtccggct cagaccctga caaaagacgc caccaatctg
     4441 ttagccacgt gctgtgacgt gatgagaact ttactggaaa gcccaaagag cctttaaaaa
     4501 gaaaatgtgt atcaattgtg ttttgttact tctgtttgat tagccgatgg agaagtagtt
     4561 tggttttagg aaccactttc ttctacacaa aatcttgttt ttaagtccct ttaagatata
     4621 gccccctaaa tacagaatat ggcttttaaa aagaagatgg agtagagaat tcaattcaga
     4681 tttccgtttt gggggaagag ccctgcctct ggatgactgg atatgtccac gccatgcccg
     4741 gcctcacaat gtaggatgca gctccatgaa ctcattctgc aaatctttca ccttcttttc
     4801 aaacgttttc aatagacaca cactgtacaa tccaattgtt agagcactca actactgtag
     4861 agattgttat atttcattct tttttatttc tttctttctt ttcttttctt ctcctttttt
     4921 tttttcaaaa attcaaactg taaaaaactt ttcaacgttc acgatattta attaaagtta
     4981 cttcctgtct gtgatagca
//
