LOCUS       NM_053111                738 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus eosinophil-associated, ribonuclease A family, member 6
            (Ear6), mRNA.
ACCESSION   NM_053111
VERSION     NM_053111.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 738)
  AUTHORS   Liu X, Jiao Y, Cao Y, Deng N, Ma Y, Hasty KA, Kang A, Chen H,
            Stuart JM and Gu W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 738)
  AUTHORS   Bettigole SE, Lis R, Adoro S, Lee AH, Spencer LA, Weller PF and
            Glimcher LH.
  TITLE     The transcription factor XBP1 is selectively required for
            eosinophil differentiation
  JOURNAL   Nat Immunol 16 (8), 829-837 (2015)
   PUBMED   26147683
REFERENCE   3  (bases 1 to 738)
  AUTHORS   Cho S, Beintema JJ and Zhang J.
  TITLE     The ribonuclease A superfamily of mammals and birds: identifying
            new members and tracing evolutionary histories
  JOURNAL   Genomics 85 (2), 208-220 (2005)
   PUBMED   15676279
REFERENCE   4  (bases 1 to 738)
  AUTHORS   Nitto T, Dyer KD, Mejia RA, Bystrom J, Wynn TA and Rosenberg HF.
  TITLE     Characterization of the divergent eosinophil ribonuclease, mEar 6,
            and its expression in response to Schistosoma mansoni infection in
            vivo
  JOURNAL   Genes Immun 5 (8), 668-674 (2004)
   PUBMED   15526002
REFERENCE   5  (bases 1 to 738)
  AUTHORS   Dyer KD, Nitto T, Moreau JM, McDevitt AL and Rosenberg HF.
  TITLE     Identification of a purine-rich intronic enhancer element in the
            mouse eosinophil-associated ribonuclease 2 (mEar 2) gene
  JOURNAL   Mamm Genome 15 (2), 126-134 (2004)
   PUBMED   15058383
REFERENCE   6  (bases 1 to 738)
  AUTHORS   Cormier SA, Larson KA, Yuan S, Mitchell TL, Lindenberger K,
            Carrigan P, Lee NA and Lee JJ.
  TITLE     Mouse eosinophil-associated ribonucleases: a unique subfamily
            expressed during hematopoiesis
  JOURNAL   Mamm Genome 12 (5), 352-361 (2001)
   PUBMED   11331942
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY316150.1.
            
            On Jul 17, 2003 this sequence version replaced NM_053111.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY316150.1, AK157836.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..738
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 26.7 cM"
     gene            1..738
                     /gene="Ear6"
                     /note="eosinophil-associated, ribonuclease A family,
                     member 6"
                     /db_xref="GeneID:93719"
                     /db_xref="MGI:MGI:1890463"
     exon            1..62
                     /gene="Ear6"
                     /inference="alignment:Splign:2.1.0"
     exon            63..713
                     /gene="Ear6"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..535
                     /gene="Ear6"
                     /EC_number="4.6.1.18"
                     /note="eosinophil-associated ribonuclease 6"
                     /codon_start=1
                     /product="non-secretory ribonuclease precursor"
                     /protein_id="NP_444341.1"
                     /db_xref="CCDS:CCDS27045.1"
                     /db_xref="GeneID:93719"
                     /db_xref="MGI:MGI:1890463"
                     /translation="MGPKLLESQLCLLLMLGLVLMLASCQKPTASQWFATQHITYKAN
                     LQCNVEMQAINMHRPRCKGLNTFLHTSFINVVGVCSNPSGLCSDKISQNCHNSSSRVP
                     ITVCNLTTPRRNYTQCRYQTKGSVEYYTVACEPRVAWDCPIYPVVPVHLDGTF"
     regulatory      692..697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ear6"
ORIGIN      
        1 cattatccct gatttccagg acaaccagtg ctcagttcca cgggagccac aacacagact
       61 gggaaacatg ggtccgaagc tgcttgagtc ccaactttgt ctcctgctga tgctgggact
      121 tgtcctaatg cttgcctcat gccagaaacc aaccgcatcc cagtggtttg ctacccagca
      181 tatcacttat aaagccaacc tccaatgtaa tgttgaaatg caggctatta acatgcatag
      241 accaagatgt aagggcttaa atacttttct tcatacaagt tttattaatg ttgttggtgt
      301 gtgtagcaat ccaagtggct tgtgcagcga caaaataagt caaaactgtc ataatagttc
      361 gtctcgggta cctataactg tctgtaacct cacaactccg agaagaaatt atacccaatg
      421 cagataccaa acaaagggat cagtggagta ctacacagtt gcctgtgagc ccagagttgc
      481 atgggattgt cccatctatc cagtggttcc agttcacttg gatgggacat tttagctcca
      541 gtgccagcac tttgtacctt cgatcatctg ctactgccaa gatcatagta gtgaagaacc
      601 aattcctctg tctgcgctgc atatcagcac ctgtcctcat gaaacctgtc cctgactccc
      661 tttaactcag ctgaatagat cttttctaat taataaacac atttgcatac aaaaaaaaaa
      721 aaaaaaaaaa aaaaaaaa
//
