LOCUS       NM_007895                716 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus eosinophil-associated, ribonuclease A family, member 2
            (Ear2), mRNA.
ACCESSION   NM_007895
VERSION     NM_007895.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 716)
  AUTHORS   Attery,A. and Batra,J.K.
  TITLE     Mouse eosinophil associated ribonucleases: Mechanism of cytotoxic,
            antibacterial and antiparasitic activities
  JOURNAL   Int J Biol Macromol 94 (Pt A), 445-450 (2017)
   PUBMED   27765572
  REMARK    GeneRIF: Functional activity of four mouse eosinophil associated
            ribonucleases, mEAR2, mEAR5, mEAR7 and mEAR11.
REFERENCE   2  (bases 1 to 716)
  AUTHORS   Bettigole,S.E., Lis,R., Adoro,S., Lee,A.H., Spencer,L.A.,
            Weller,P.F. and Glimcher,L.H.
  TITLE     The transcription factor XBP1 is selectively required for
            eosinophil differentiation
  JOURNAL   Nat Immunol 16 (8), 829-837 (2015)
   PUBMED   26147683
REFERENCE   3  (bases 1 to 716)
  AUTHORS   Kummer,M.P., Hammerschmidt,T., Martinez,A., Terwel,D., Eichele,G.,
            Witten,A., Figura,S., Stoll,M., Schwartz,S., Pape,H.C.,
            Schultze,J.L., Weinshenker,D., Heneka,M.T. and Urban,I.
  TITLE     Ear2 deletion causes early memory and learning deficits in APP/PS1
            mice
  JOURNAL   J Neurosci 34 (26), 8845-8854 (2014)
   PUBMED   24966384
  REMARK    GeneRIF: Testing spatial memory and hippocampal long-term
            potentiation revealed an impairment in APP/PS1 Ear2(-/-) mice,
            whereas APP/PS1 or Ear2(-/-) mice showed only minor changes.
            Erratum:[J Neurosci. 2015 Feb 4;35(5):2321. Urban, Inga [Added]]
REFERENCE   4  (bases 1 to 716)
  AUTHORS   Premzl,M.
  TITLE     Comparative genomic analysis of eutherian ribonuclease A genes
  JOURNAL   Mol Genet Genomics 289 (2), 161-167 (2014)
   PUBMED   24337645
REFERENCE   5  (bases 1 to 716)
  AUTHORS   Jin,G., Mizutani,A., Fukuda,T., Otani,T., Yan,T., Prieto Vila,M.,
            Murakami,H., Kudoh,T., Hirohata,S., Kasai,T., Salomon,D.S. and
            Seno,M.
  TITLE     Eosinophil cationic protein enhances stabilization of beta-catenin
            during cardiomyocyte differentiation in P19CL6 embryonal carcinoma
            cells
  JOURNAL   Mol Biol Rep 40 (4), 3165-3171 (2013)
   PUBMED   23271121
  REMARK    GeneRIF: this suggests that ECP can activate a canonical
            Wnt/b-catenin signaling pathway by enhancing the stabilization of
            b-catenin during cardiomyocyte differentiation.
REFERENCE   6  (bases 1 to 716)
  AUTHORS   Dyer,K.D., Nitto,T., Moreau,J.M., McDevitt,A.L. and Rosenberg,H.F.
  TITLE     Identification of a purine-rich intronic enhancer element in the
            mouse eosinophil-associated ribonuclease 2 (mEar 2) gene
  JOURNAL   Mamm Genome 15 (2), 126-134 (2004)
   PUBMED   15058383
REFERENCE   7  (bases 1 to 716)
  AUTHORS   Yang,D., Rosenberg,H.F., Chen,Q., Dyer,K.D., Kurosaka,K. and
            Oppenheim,J.J.
  TITLE     Eosinophil-derived neurotoxin (EDN), an antimicrobial protein with
            chemotactic activities for dendritic cells
  JOURNAL   Blood 102 (9), 3396-3403 (2003)
   PUBMED   12855582
  REMARK    GeneRIF: was selectively chemotactic for dendritic cells; induced
            the activation of p42/44 MAPK in DCs
REFERENCE   8  (bases 1 to 716)
  AUTHORS   Moreau,J.M., Dyer,K.D., Bonville,C.A., Nitto,T., Vasquez,N.L.,
            Easton,A.J., Domachowske,J.B. and Rosenberg,H.F.
  TITLE     Diminished expression of an antiviral ribonuclease in response to
            pneumovirus infection in vivo
  JOURNAL   Antiviral Res 59 (3), 181-191 (2003)
   PUBMED   12927308
  REMARK    GeneRIF: decreased expression of total mEar2 mRNA and protein in
            lung tissue and a corresponding fivefold drop in ribonuclease
            activity in BALF in pneumovirus infection of mice
REFERENCE   9  (bases 1 to 716)
  AUTHORS   McDevitt,A.L., Deming,M.S., Rosenberg,H.F. and Dyer,K.D.
  TITLE     Gene structure and enzymatic activity of mouse
            eosinophil-associated ribonuclease 2
  JOURNAL   Gene 267 (1), 23-30 (2001)
   PUBMED   11311552
REFERENCE   10 (bases 1 to 716)
  AUTHORS   Larson,K.A., Olson,E.V., Madden,B.J., Gleich,G.J., Lee,N.A. and
            Lee,J.J.
  TITLE     Two highly homologous ribonuclease genes expressed in mouse
            eosinophils identify a larger subgroup of the mammalian
            ribonuclease superfamily
  JOURNAL   Proc Natl Acad Sci U S A 93 (22), 12370-12375 (1996)
   PUBMED   8901588
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF306665.1.
            
            On Aug 28, 2003 this sequence version replaced NM_007895.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF306665.1, CA455928.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..716
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14"
     gene            1..716
                     /gene="Ear2"
                     /gene_synonym="EAR-13; EAR-2; ECP; ECP 2; Raf3; Rnase2"
                     /note="eosinophil-associated, ribonuclease A family,
                     member 2"
                     /db_xref="GeneID:13587"
                     /db_xref="MGI:MGI:108020"
     exon            1..66
                     /gene="Ear2"
                     /gene_synonym="EAR-13; EAR-2; ECP; ECP 2; Raf3; Rnase2"
                     /inference="alignment:Splign:2.1.0"
     exon            67..716
                     /gene="Ear2"
                     /gene_synonym="EAR-13; EAR-2; ECP; ECP 2; Raf3; Rnase2"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..542
                     /gene="Ear2"
                     /gene_synonym="EAR-13; EAR-2; ECP; ECP 2; Raf3; Rnase2"
                     /note="eosinophil cationic protein 2;
                     eosinophil-associated ribonuclease 13; RNase 3-2;
                     ribonuclease 3-2; eosinophil secondary granule
                     ribonuclease 2; eosinophil-associated ribonuclease 2;
                     eosinophil-derived neurotoxin, liver; ribonuclease A f3"
                     /codon_start=1
                     /product="eosinophil cationic protein 2 precursor"
                     /protein_id="NP_031921.1"
                     /db_xref="CCDS:CCDS26968.1"
                     /db_xref="GeneID:13587"
                     /db_xref="MGI:MGI:108020"
                     /translation="MGPKLLESRLCLLLLLGLVLMLASCLGQTPSQWFAIQHINNNAN
                     LQCNVEMQRINRFRRTCKGLNTFLHTSFANAVGVCGNPSGLCSDNISRNCHNSSSRVR
                     ITVCNITSRRRTPYTQCRYQPRRSLEYYTVACNPRTPQDSPMYPVVPVHLDGTF"
ORIGIN      
        1 acacatttat ccctgatttc caggacaacc agccctaagt tccacgggag ccacaaagca
       61 gacagggaaa catgggtccg aagctgcttg agtctcgact ttgtctcctg ctgctgctag
      121 gacttgtcct aatgcttgcc tcatgcctgg gacaaacccc ttcccagtgg tttgccatcc
      181 agcatatcaa taataatgcc aacctccaat gtaatgttga aatgcagcgt attaacaggt
      241 ttagaagaac atgtaagggc ttaaatactt ttcttcatac aagttttgct aatgctgttg
      301 gtgtgtgtgg aaatccaagt ggcttgtgca gtgacaatat aagtagaaac tgtcataata
      361 gttcatctcg ggtacgtata actgtctgta acatcaccag tcggaggaga acaccttata
      421 cccaatgcag ataccaacca agaagatcat tggagtacta cacagttgcc tgtaacccca
      481 gaactccaca ggacagtccc atgtatccag tggttccagt tcacttggat gggacatttt
      541 agctccagtg ccagcacttt gcacctttgc tcatctgcta ctgccgagat catagtagtg
      601 aagagacaat tcctctgtct gcgctccata tagcacatgt cctcgtgaaa cctgtcactt
      661 actcccttta attttgctga atagatcttt tctaattaat aaataccttt gcatac
//
