LOCUS       NM_007894                739 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus eosinophil-associated, ribonuclease A family, member 1
            (Ear1), mRNA.
ACCESSION   NM_007894
VERSION     NM_007894.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 739)
  AUTHORS   Bettigole,S.E., Lis,R., Adoro,S., Lee,A.H., Spencer,L.A.,
            Weller,P.F. and Glimcher,L.H.
  TITLE     The transcription factor XBP1 is selectively required for
            eosinophil differentiation
  JOURNAL   Nat Immunol 16 (8), 829-837 (2015)
   PUBMED   26147683
REFERENCE   2  (bases 1 to 739)
  AUTHORS   Chen,J.Q., Mori,H., Cardiff,R.D., Trott,J.F., Hovey,R.C.,
            Hubbard,N.E., Engelberg,J.A., Tepper,C.G., Willis,B.J., Khan,I.H.,
            Ravindran,R.K., Chan,S.R., Schreiber,R.D. and Borowsky,A.D.
  TITLE     Abnormal Mammary Development in 129:STAT1-Null Mice is
            Stroma-Dependent
  JOURNAL   PLoS One 10 (6), e0129895 (2015)
   PUBMED   26075897
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 739)
  AUTHORS   Premzl,M.
  TITLE     Comparative genomic analysis of eutherian ribonuclease A genes
  JOURNAL   Mol Genet Genomics 289 (2), 161-167 (2014)
   PUBMED   24337645
REFERENCE   4  (bases 1 to 739)
  AUTHORS   O'Reilly,M.A., Yee,M., Buczynski,B.W., Vitiello,P.F., Keng,P.C.,
            Welle,S.L., Finkelstein,J.N., Dean,D.A. and Lawrence,B.P.
  TITLE     Neonatal oxygen increases sensitivity to influenza A virus
            infection in adult mice by suppressing epithelial expression of
            Ear1
  JOURNAL   Am J Pathol 181 (2), 441-451 (2012)
   PUBMED   22677423
  REMARK    GeneRIF: These findings demonstrate that novel epithelial
            expression of Ear1 functions to limit influenza A virus infection.
REFERENCE   5  (bases 1 to 739)
  AUTHORS   Cho,S., Beintema,J.J. and Zhang,J.
  TITLE     The ribonuclease A superfamily of mammals and birds: identifying
            new members and tracing evolutionary histories
  JOURNAL   Genomics 85 (2), 208-220 (2005)
   PUBMED   15676279
REFERENCE   6  (bases 1 to 739)
  AUTHORS   Nitto,T., Dyer,K.D., Mejia,R.A., Bystrom,J., Wynn,T.A. and
            Rosenberg,H.F.
  TITLE     Characterization of the divergent eosinophil ribonuclease, mEar 6,
            and its expression in response to Schistosoma mansoni infection in
            vivo
  JOURNAL   Genes Immun 5 (8), 668-674 (2004)
   PUBMED   15526002
REFERENCE   7  (bases 1 to 739)
  AUTHORS   Dyer,K.D., Nitto,T., Moreau,J.M., McDevitt,A.L. and Rosenberg,H.F.
  TITLE     Identification of a purine-rich intronic enhancer element in the
            mouse eosinophil-associated ribonuclease 2 (mEar 2) gene
  JOURNAL   Mamm Genome 15 (2), 126-134 (2004)
   PUBMED   15058383
REFERENCE   8  (bases 1 to 739)
  AUTHORS   Singhania,N.A., Dyer,K.D., Zhang,J., Deming,M.S., Bonville,C.A.,
            Domachowske,J.B. and Rosenberg,H.F.
  TITLE     Rapid evolution of the ribonuclease A superfamily: adaptive
            expansion of independent gene clusters in rats and mice
  JOURNAL   J Mol Evol 49 (6), 721-728 (1999)
   PUBMED   10594173
REFERENCE   9  (bases 1 to 739)
  AUTHORS   Larson,K.A., Olson,E.V., Madden,B.J., Gleich,G.J., Lee,N.A. and
            Lee,J.J.
  TITLE     Two highly homologous ribonuclease genes expressed in mouse
            eosinophils identify a larger subgroup of the mammalian
            ribonuclease superfamily
  JOURNAL   Proc Natl Acad Sci U S A 93 (22), 12370-12375 (1996)
   PUBMED   8901588
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY316149.1.
            
            On Aug 14, 2003 this sequence version replaced NM_007894.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY316149.1, BC117060.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..739
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 22.51 cM"
     gene            1..739
                     /gene="Ear1"
                     /gene_synonym="EAR-1; ECP 1; Raf1"
                     /note="eosinophil-associated, ribonuclease A family,
                     member 1"
                     /db_xref="GeneID:13586"
                     /db_xref="MGI:MGI:108021"
     exon            1..63
                     /gene="Ear1"
                     /gene_synonym="EAR-1; ECP 1; Raf1"
                     /inference="alignment:Splign:2.1.0"
     exon            64..713
                     /gene="Ear1"
                     /gene_synonym="EAR-1; ECP 1; Raf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..536
                     /gene="Ear1"
                     /gene_synonym="EAR-1; ECP 1; Raf1"
                     /note="eosinophil-associated ribonuclease 1; eosinophil
                     cationic protein 1; RNase 3-1; ribonuclease 3-1;
                     eosinophil secondary granule ribonuclease 1; ribonuclease
                     A f1"
                     /codon_start=1
                     /product="eosinophil cationic protein 1 precursor"
                     /protein_id="NP_031920.1"
                     /db_xref="CCDS:CCDS26964.1"
                     /db_xref="GeneID:13586"
                     /db_xref="MGI:MGI:108021"
                     /translation="MGPKLLESRLCLLLLLGLVLMLASCLGQTPSQKFAIQHINNNTN
                     LQCNVEMMRINRARRTCKGLNTFLHTSFANAVGVCGNPSGLCSDKRSQNCHNSSSRVH
                     ITVCNITSRATNYTQCRYQSRRSLEYYTVACDPRTPQDSPMYPVVPVHLDGTF"
ORIGIN      
        1 acattatccc tgatttccag gacaaccagc cctcagttcc acgggagcca caaagcagac
       61 agggaaacat gggtccgaag ctgcttgagt cccgactttg tctcctgctg ctgctaggac
      121 ttgtcctaat gcttgcctca tgcctgggtc aaaccccttc ccagaagttt gccatccagc
      181 atatcaataa taataccaac ctccaatgta atgttgaaat gatgcgtatt aacagggcta
      241 gaagaacatg taagggctta aatacttttc ttcatacaag ttttgctaat gctgttggtg
      301 tgtgtggaaa tccaagtggc ttgtgcagtg acaagagaag tcaaaactgt cataatagtt
      361 catctcgggt acatataact gtctgtaaca tcaccagtcg ggcaacaaat tatacccaat
      421 gcagatacca atcaagaaga tcattggagt actacacagt tgcctgtgac cccagaactc
      481 cacaggacag tcccatgtat ccagtggttc cagttcactt ggatgggaca ttttagctcc
      541 agtgccagca ctttgcacct tcgctcatct gctactgccg agatcatagt agtgaagaga
      601 caattcctct gtctgcgctc catataacac atgtcctcgt gaaacctgtc acttactccc
      661 tttaattttg ctgaatagat cttttctaat taataaatac ctttgcatac aaaaaaaaaa
      721 aaaaaaaaaa aaaaaaaaa
//
