LOCUS       NM_025456               4199 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus E2F-associated phosphoprotein (Eapp), transcript
            variant 1, mRNA.
ACCESSION   NM_025456
VERSION     NM_025456.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4199)
  AUTHORS   Duan,C., Chen,Y., Shen,A., Xu,J., Zhao,Y., Cai,R., Liu,Y., Zhou,L.,
            Lei,Y., Hamre,K. and Lu,L.
  TITLE     Genetic expression analysis of E2F-associated phosphoprotein in
            stress responses in the mouse
  JOURNAL   Gene 581 (2), 130-138 (2016)
   PUBMED   26802973
  REMARK    GeneRIF: Data provide strong evidence that the cis-modulated gene,
            Eapp, is associated with stress responses, and that validated
            downstream targets and members of Eapp gene network may also be
            involved in the development of stress.
REFERENCE   2  (bases 1 to 4199)
  AUTHORS   Chen,M., Ni,Y., Liu,Y., Xia,X., Cao,J., Wang,C., Mao,X., Zhang,W.,
            Chen,C., Chen,X. and Wang,Y.
  TITLE     Spatiotemporal Expression of EAPP Modulates Neuronal Apoptosis and
            Reactive Astrogliosis After Spinal Cord Injury
  JOURNAL   J Cell Biochem 116 (7), 1381-1390 (2015)
   PUBMED   25704466
  REMARK    GeneRIF: Studies have shown that EAPP expression changes after
            spinal cord injury, suggesting that EAPP might participate in
            regulating biochemical and physiological responses following this
            type of injury.
REFERENCE   3  (bases 1 to 4199)
  AUTHORS   Novy,M., Pohn,R., Andorfer,P., Novy-Weiland,T., Galos,B.,
            Schwarzmayr,L. and Rotheneder,H.
  TITLE     EAPP, a novel E2F binding protein that modulates E2F-dependent
            transcription
  JOURNAL   Mol Biol Cell 16 (5), 2181-2190 (2005)
   PUBMED   15716352
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT030142.10, AK007442.1 and AC165349.2.
            
            On Sep 13, 2016 this sequence version replaced NM_025456.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007442.1, AY882557.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                CT030142.10        4229-4307           c
            80-1071             AK007442.1         6-997
            1072-4199           AC165349.2         114216-117343       c
FEATURES             Location/Qualifiers
     source          1..4199
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 23.46 cM"
     gene            1..4199
                     /gene="Eapp"
                     /gene_synonym="1810011O16Rik"
                     /note="E2F-associated phosphoprotein"
                     /db_xref="GeneID:66266"
                     /db_xref="MGI:MGI:1913516"
     exon            1..184
                     /gene="Eapp"
                     /gene_synonym="1810011O16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..956
                     /gene="Eapp"
                     /gene_synonym="1810011O16Rik"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="E2F-associated phosphoprotein isoform 1"
                     /protein_id="NP_079732.1"
                     /db_xref="CCDS:CCDS25910.1"
                     /db_xref="GeneID:66266"
                     /db_xref="MGI:MGI:1913516"
                     /translation="MNRLQDDYDPYAVEEPSDEEPALSSSEDELDVLLHGTPDQKRKL
                     IRECLTGESESSSEDEFEKEMEAELNSTMKTMEDQLSSLGTGSSSGVAKVGGVTEKFY
                     DEIYFDSDSEDEDKTVTKKKKKKQHRIPTNDELLYDPEKDNRDQAWVDAKRRGYHAFG
                     LQRPRQKQQPVPNSDAVLNCPACMTTLCLDCQRHESYKTQYRAMFVMNCSINREEVLR
                     YKNPENRRKRRSAKKMRSNPEDPAEREAEEIYHPVMCTECSTEVAVYDKDEVFHFFNV
                     LASHS"
     exon            185..366
                     /gene="Eapp"
                     /gene_synonym="1810011O16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            367..462
                     /gene="Eapp"
                     /gene_synonym="1810011O16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            463..574
                     /gene="Eapp"
                     /gene_synonym="1810011O16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            575..688
                     /gene="Eapp"
                     /gene_synonym="1810011O16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            689..4199
                     /gene="Eapp"
                     /gene_synonym="1810011O16Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1050..1055
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eapp"
                     /gene_synonym="1810011O16Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1072
                     /gene="Eapp"
                     /gene_synonym="1810011O16Rik"
                     /note="major polyA site"
     regulatory      3223..3228
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eapp"
                     /gene_synonym="1810011O16Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3244
                     /gene="Eapp"
                     /gene_synonym="1810011O16Rik"
     polyA_site      3691
                     /gene="Eapp"
                     /gene_synonym="1810011O16Rik"
     regulatory      3715..3720
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eapp"
                     /gene_synonym="1810011O16Rik"
                     /note="hexamer: AATGAA"
     polyA_site      3736
                     /gene="Eapp"
                     /gene_synonym="1810011O16Rik"
     regulatory      4178..4183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eapp"
                     /gene_synonym="1810011O16Rik"
                     /note="hexamer: AATATA"
     polyA_site      4199
                     /gene="Eapp"
                     /gene_synonym="1810011O16Rik"
ORIGIN      
        1 gcacaggaag gactcgcagt acgggcggaa gtggagtctc cgggaagctt tggggaaggc
       61 gctggcggag tacacagacg ccggggcggt gtaggcgtcc tcaggtcgcc atgaaccgac
      121 tccaggatga ctatgacccg tacgcggtgg aagagccgag cgacgaggag ccggctctga
      181 gcagttctga agatgaactg gatgtgcttt tacatggaac cccagaccaa aagcgaaaac
      241 tcatccggga atgtcttact ggagaaagtg agtcatcaag tgaagatgaa tttgaaaaag
      301 aaatggaggc tgaactaaac tccaccatga agacaatgga ggaccagtta tcctcactgg
      361 gaacagggtc ttcttcagga gttgccaaag tgggaggagt cacagaaaag ttctatgatg
      421 agatatattt tgattctgat tctgaggatg aggacaaaac agtgaccaag aagaagaaga
      481 agaaacaaca caggattcca acaaacgatg agctgctgta tgatcctgag aaagataaca
      541 gagaccaggc ctgggttgac gccaagagga ggggttatca tgcttttgga ttgcaaaggc
      601 cacgtcagaa acaacagcct gttccaaaca gtgatgctgt tctgaattgc ccagcctgta
      661 tgacgacatt gtgccttgat tgccagaggc atgaatccta caagacgcag tacagggcaa
      721 tgtttgtgat gaattgttct atcaacagag aagaggttct gagatacaag aatccagaaa
      781 acaggaggaa acggcggagt gctaagaaga tgaggtctaa tcctgaagat cccgcagaga
      841 gagaagcgga ggaaatctat caccctgtca tgtgcacaga gtgttcaact gaagtggcag
      901 tctatgacaa ggatgaagtc tttcactttt tcaatgtttt agcgagccat tcttgatcaa
      961 tgtgacaggt aactgcccag ctctgtgtat aaggcaaaca tagactcttg ttttcctctt
     1021 tcctattcat atcattcagt gatgttgtta ttaaaacagt atttcatctt tatgaaaagg
     1081 agtggttatc aacctctatc tcttctccct ttttgccttt taattttccc atgaggacag
     1141 attattcatt ccacttctag tgcatatttg tagacattgg agcttcttat ttattaagtt
     1201 agctttctag actaaaacag ttttggaata agtatttgtt tcctagtgtt tggtccattt
     1261 tctgttgctg taacaaatta ctacagcctg cagtgtttta taaagaaatg aggcttagct
     1321 gttggcaaga tgactctgca cttggcatgc aagcctgata acctgagttc aatccctgga
     1381 atctgcagtg gaaggagaga atcaactctt gaaagttttc ctatttctta acataggtgc
     1441 acgcagacag acagacagac agacagacag acagacacac acacacacac acacacacac
     1501 acactcactc caaagtttcc ctgaaggggc ctctagtatg ccctgagggg aactatttct
     1561 ctctctgatt accttctggg ccttctccaa gctacaagtc aggagagctg ggccagtgag
     1621 agtttgaatg gagttgagac aacaggaaat gaatggttcc ttttgtcttc tgtggatggg
     1681 gaggagcagt gatggagtgc gtgcttgaca tgtgcaggtt cctggactgg atagccaaca
     1741 ctacaccagc acacaagtga gcttctaaga cattctcagt gcttagggca tggtggccta
     1801 taattcaagc acttgggaaa gacaagaagg gaaggaacgg gggaaagaag ttggtgtcag
     1861 tgtgttggtg gctagcatat ttgataattt ttataatatg gtggtatcta tatggaggca
     1921 atatgtactt gacattttta gtttcaaatt agcacatggg agtatgttat agagcagcac
     1981 tcagtctgat tatcgtagct ttgtaggctc tcctctggta gtgttattgc aagcccgact
     2041 ttcttctcag atttagtgac caccctagtg caccacacct ccagtccagc gggaagttgt
     2101 gaaatcacct ggagagggct ggagagatgg ctcagtggtt aagagcactg actgcttgct
     2161 ctaacagagg tcctgagtcc aattcccagc aaccacatgg tggctcacaa ctatctctaa
     2221 tgggatttga caccctcttc tgggtgtgtc tgaagacagc tacagtgtac tcatataagt
     2281 gaaataaata aatcttaaaa aaaaatgcaa aaaagcttgc ctttgggtct ctctgagaag
     2341 atgatgctgt aacaagcaag gaatcccaat gtgtaaagat gtaatctgat ggtgacaagg
     2401 gaagaaaaca gctatagaga ggagaatccc atgtactatt tatactaagt ttactaattg
     2461 gaactacttc tttttttttt tttttttttt ttttttaaag atttatttat tgattatatg
     2521 taagtacact gtagctgtct tcagacactc cagaagaggg agtcagatct tgttacggat
     2581 ggttgtgagc caccatgtgg ttgctgggat ttgaactcct gaccttcgga agagcagtcg
     2641 ggtgctctta cccactgagc catctcacca gccctggaac tacttctttt aggatgatat
     2701 ttcaaatgcc taggatattc atggcaattt tatcagggaa aaaaaatgaa aatgaaaatg
     2761 aaggattaga gagatggctc agcagttaag agcactgact tcttttccag aggaaatttc
     2821 tagcaaccac aggacagctc acaactgttt gtaactctaa gatctgatat catcacacag
     2881 acatacataa aataaaataa aatacattga aaataatcta agaatagact atatttacgc
     2941 ataaaagtat ttactacatg gggaaaagac ctagaggggg aggcatgtgt ggaggtgggg
     3001 aaaacaaact gtggcatgct ttgtcatgcg cacattgttt tccttgagtc tgttgaaata
     3061 cacattcaca caggccctga aaagtggggg agggaatgtt gactgacagt ttgggggcga
     3121 gcaaacatgt gggacagtga ctaggagcaa agttcagtgc tgtgcgtatg aaaatgccat
     3181 aatgaatgag acctgttttg tatacttaca aaaccaacat taaataaaac actattagca
     3241 gctattgttc atgtcctttc attagaaaaa gatcttgaga tgtcagacac tgcctaaggc
     3301 cgtttgggct agacaccaag agccatgctt tgttcctatc tgatttccct tcgtagcttt
     3361 gagtatcttt ctctcccttc actgggatgg tttctgtaac gacctgtaag tgctgtttct
     3421 gagatggagc cgcctcatct ttaccatcga acctcctttt ctttctaggt taagcagctg
     3481 cccataaacc tttgaaggat cacttatggc cttgctttag cctcaactct tccccatcga
     3541 tgtccgactc cccttgtggc cgaggttgac ctagagctcc tgctcatcct gtgcctacct
     3601 ccccgctccc cactgctgcc tgcaccagca catctagctt taagtccttt gtaaatggag
     3661 cacaaaatgt tttaaagggg tttaaacaga attggatctg gagttctatt tgctaatgaa
     3721 gctgctcatt ccctcacccc ctggctgtcg tgtcgggtcc tgttgctgtg cagcatgaca
     3781 caatcataca gagtagcaca catccactgt cttacttttt tttttttttt cttttttaat
     3841 taggagcctg gccacagtta agcagtgtat ttactcaaga ttagctcaca aaggctataa
     3901 ggaaccttaa agcctttgca gtgtatatta ggtaatatac attatacatt aggtagtgtt
     3961 ctcacgtggc taggcaagta tctgttccaa gtatcagggt attggcagaa tgggcatctt
     4021 tatagccata ggactgaagt atcgccccca cccccacccc caccccgttg ttggcctgta
     4081 gggatttaag tttacttaaa aaaatttttt ttatgtgctg attgattaac caggaagtgg
     4141 tgtcaggtcc cagaggctaa ttacctctgg ttgtagaaat atataaaata ttaaaatca
//
