LOCUS       NM_001113401            1888 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus ELL associated factor 2 (Eaf2), transcript variant 2,
            mRNA.
ACCESSION   NM_001113401
VERSION     NM_001113401.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1888)
  AUTHORS   Pascal,L.E., Su,F., Wang,D., Ai,J., Song,Q., Wang,Y.,
            O'Malley,K.J., Cross,B., Rigatti,L.H., Green,A., Dhir,R. and
            Wang,Z.
  TITLE     Conditional Deletion of Eaf1 Induces Murine Prostatic
            Intraepithelial Neoplasia in Mice
  JOURNAL   Neoplasia 21 (8), 752-764 (2019)
   PUBMED   31229879
REFERENCE   2  (bases 1 to 1888)
  AUTHORS   Wang,Y., Pascal,L.E., Zhong,M., Ai,J., Wang,D., Jing,Y., Pilch,J.,
            Song,Q., Rigatti,L.H., Graham,L.E., Nelson,J.B., Parwani,A.V. and
            Wang,Z.
  TITLE     Combined Loss of EAF2 and p53 Induces Prostate Carcinogenesis in
            Male Mice
  JOURNAL   Endocrinology 158 (12), 4189-4205 (2017)
   PUBMED   29029019
  REMARK    GeneRIF: Data show that p53 and EAF2 knockout mice developed
            prostate cancer.
REFERENCE   3  (bases 1 to 1888)
  AUTHORS   Ai,J., Pascal,L.E., Wei,L., Zang,Y., Zhou,Y., Yu,X., Gong,Y.,
            Nakajima,S., Nelson,J.B., Levine,A.S., Lan,L. and Wang,Z.
  TITLE     EAF2 regulates DNA repair through Ku70/Ku80 in the prostate
  JOURNAL   Oncogene 36 (15), 2054-2065 (2017)
   PUBMED   27721405
REFERENCE   4  (bases 1 to 1888)
  AUTHORS   Li,Y., Takahashi,Y., Fujii,S., Zhou,Y., Hong,R., Suzuki,A.,
            Tsubata,T., Hase,K. and Wang,J.Y.
  TITLE     EAF2 mediates germinal centre B-cell apoptosis to suppress
            excessive immune responses and prevent autoimmunity
  JOURNAL   Nat Commun 7, 10836 (2016)
   PUBMED   26935903
  REMARK    GeneRIF: These results demonstrate that EAF2-mediated apoptosis in
            GC B cells limits excessive humoral immune responses and is
            important for maintaining self-tolerance.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1888)
  AUTHORS   Jiang,Y., Fu,R., Zhao,J., Wu,D., Qiao,G., Li,R. and Zhang,J.
  TITLE     Effects of ELL-associated factor 2 on ultraviolet radiation-induced
            cataract formation in mice
  JOURNAL   Mol Med Rep 12 (5), 6605-6611 (2015)
   PUBMED   26328919
  REMARK    GeneRIF: The results showed that Eaf2 knockout can reduce
            UV-induced apoptosis in crystalline lenses and mitigate the
            formation of cataracts.
REFERENCE   6  (bases 1 to 1888)
  AUTHORS   Xiao,W., Zhang,Q., Habermacher,G., Yang,X., Zhang,A.Y., Cai,X.,
            Hahn,J., Liu,J., Pins,M., Doglio,L., Dhir,R., Gingrich,J. and
            Wang,Z.
  TITLE     U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma,
            hepatocellular carcinoma and prostatic intraepithelial neoplasia
  JOURNAL   Oncogene 27 (11), 1536-1544 (2008)
   PUBMED   17873910
  REMARK    GeneRIF: Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma,
            hepatocellular carcinoma and prostatic intraepithelial neoplasia
REFERENCE   7  (bases 1 to 1888)
  AUTHORS   Ito,T., Saso,K., Arimitsu,N. and Sekimizu,K.
  TITLE     Defective FESTA/EAF2-mediated transcriptional activation in
            S-II-deficient embryonic stem cells
  JOURNAL   Biochem Biophys Res Commun 363 (3), 603-609 (2007)
   PUBMED   17892859
  REMARK    GeneRIF: Transcriptional activation mediated by FESTA/EAF2, a
            transcription factor that interacts with S-II, was decreased in RNA
            polymerase II deficient embryonic stem cells.
REFERENCE   8  (bases 1 to 1888)
  AUTHORS   Li,M., Wu,X., Zhuang,F., Jiang,S., Jiang,M. and Liu,Y.H.
  TITLE     Expression of murine ELL-associated factor 2 (Eaf2) is
            developmentally regulated
  JOURNAL   Dev Dyn 228 (2), 273-280 (2003)
   PUBMED   14517999
  REMARK    GeneRIF: Expression of Eaf2 is developmentally regulated.
REFERENCE   9  (bases 1 to 1888)
  AUTHORS   Xiao,W., Zhang,Q., Jiang,F., Pins,M., Kozlowski,J.M. and Wang,Z.
  TITLE     Suppression of prostate tumor growth by U19, a novel
            testosterone-regulated apoptosis inducer
  JOURNAL   Cancer Res 63 (15), 4698-4704 (2003)
   PUBMED   12907652
REFERENCE   10 (bases 1 to 1888)
  AUTHORS   Saso,K., Ito,T., Natori,S. and Sekimizu,K.
  TITLE     Identification of a novel tissue-specific transcriptional activator
            FESTA as a protein that interacts with the transcription elongation
            factor S-II
  JOURNAL   J Biochem 133 (4), 493-500 (2003)
   PUBMED   12761297
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY034479.1, BG144504.1 and AC117662.13.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004721.1, AY034479.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-934               AY034479.1         8-941
            935-997             BG144504.1         38-100              c
            998-1888            AC117662.13        272693-273583       c
FEATURES             Location/Qualifiers
     source          1..1888
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 26.05 cM"
     gene            1..1888
                     /gene="Eaf2"
                     /gene_synonym="Festa; FESTA-L; FESTA-S; Traits; U19"
                     /note="ELL associated factor 2"
                     /db_xref="GeneID:106389"
                     /db_xref="MGI:MGI:2146616"
     exon            1..209
                     /gene="Eaf2"
                     /gene_synonym="Festa; FESTA-L; FESTA-S; Traits; U19"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..892
                     /gene="Eaf2"
                     /gene_synonym="Festa; FESTA-L; FESTA-S; Traits; U19"
                     /note="isoform b is encoded by transcript variant 2;
                     testosterone regulated apoptosis inducer and tumor
                     suppressor; ehrlich S-II transcriptional activator factor;
                     testosterone-regulated apoptosis inducer and tumor
                     suppressor protein"
                     /codon_start=1
                     /product="ELL-associated factor 2 isoform b"
                     /protein_id="NP_001106872.1"
                     /db_xref="CCDS:CCDS49843.1"
                     /db_xref="GeneID:106389"
                     /db_xref="MGI:MGI:2146616"
                     /translation="MSGPAGLAYLDRRERVLKLGESFEKQPRCAFHTVRYDFKPASID
                     TSCEGNLEVGKGEQVTITLPNIEGSTPPVTVFKGSKRPYLKECILIINHDTGECRLEK
                     LSSNITVKKTRVEGSSRIQYRLEQQQQQMWNLPRTSNLVQHSPSEEKMSPTSLMDDIE
                     RELKAEASLMDQMSSCDSSSDSKSSSSSSSEDSSSDSEDDDQFSPLGPRKYSSEHPSM
                     SAGPQYRTSEADATCHRLQDHSTLLMSTLRSDLQLSESESDSED"
     exon            210..304
                     /gene="Eaf2"
                     /gene_synonym="Festa; FESTA-L; FESTA-S; Traits; U19"
                     /inference="alignment:Splign:2.1.0"
     exon            305..441
                     /gene="Eaf2"
                     /gene_synonym="Festa; FESTA-L; FESTA-S; Traits; U19"
                     /inference="alignment:Splign:2.1.0"
     exon            442..587
                     /gene="Eaf2"
                     /gene_synonym="Festa; FESTA-L; FESTA-S; Traits; U19"
                     /inference="alignment:Splign:2.1.0"
     exon            588..845
                     /gene="Eaf2"
                     /gene_synonym="Festa; FESTA-L; FESTA-S; Traits; U19"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1888
                     /gene="Eaf2"
                     /gene_synonym="Festa; FESTA-L; FESTA-S; Traits; U19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1001..1006
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eaf2"
                     /gene_synonym="Festa; FESTA-L; FESTA-S; Traits; U19"
                     /note="hexamer: AATAAA"
     polyA_site      1028
                     /gene="Eaf2"
                     /gene_synonym="Festa; FESTA-L; FESTA-S; Traits; U19"
                     /note="major polyA site"
     regulatory      1862..1867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eaf2"
                     /gene_synonym="Festa; FESTA-L; FESTA-S; Traits; U19"
                     /note="hexamer: AATAAA"
     polyA_site      1888
                     /gene="Eaf2"
                     /gene_synonym="Festa; FESTA-L; FESTA-S; Traits; U19"
ORIGIN      
        1 gagctggtcc cgggcaccga actcaagctc gcagccagtg cagctgttcc agaggctgtg
       61 gcaggggacg gcgaaggcca aaagcgggag gcaggggacg aggatgagtg gaccagcggg
      121 acttgcatac ctggaccgtc gcgagcgggt tctcaagcta ggcgaaagtt tcgagaagca
      181 gccgcgctgt gccttccaca ccgtgcgcta tgacttcaaa cctgcttcta ttgatacttc
      241 ttgtgaagga aatcttgagg ttggcaaagg tgaacaggtg acaataactc ttccaaatat
      301 agaaggttca actccaccag tcacagtttt caaaggttcc aagagacctt acttaaaaga
      361 atgcattttg attattaacc atgatactgg ggaatgtcgc ctagaaaagc tcagcagcaa
      421 catcactgtg aaaaaaacaa gagtggaagg gagtagcaga atccagtaca gactagaaca
      481 acagcaacag caaatgtgga atctgcctag gacttccaat cttgtacagc attctccatc
      541 agaagagaag atgtctccaa cgtctctaat ggatgatatt gaaagagaac tgaaagcaga
      601 agctagtctt atggaccaga tgagtagttg tgatagttca tcagattcca aaagttcttc
      661 atcttcaagt agtgaggata gttctagtga ttctgaagat gatgaccaat tctctccttt
      721 gggtccaagg aaatacagct cggagcaccc tagcatgtct gctgggccac agtacaggac
      781 ttcagaggct gatgctactt gtcaccgact tcaggaccac agtacccttc tgatgagtac
      841 tttacgaagt gacttgcagc tgagtgagtc agaaagcgac agtgaggact gaagcagtat
      901 caagctacag agaaaacatt tgtgagatgt gtaagaatct gttttgtatt gagaataaat
      961 attcctatgt ttatggaaat tgtgcaactt ttgctgaaaa aataaagttg gttcagaatt
     1021 ttcaactatt tgttggtatt ctcatgtgat atcttcattt agtcataaca aaatgttatc
     1081 acatttggta gatgaaaaac agattcagat attagggaac ttaacttgcc ccaggaattg
     1141 ctaacaaatg agctgcagat ccactattcc agagtctctg tccactgttg ccccaaattg
     1201 tgaaatgcta aaataattga tttatagtaa gagtttatgg ttttcattgt agttgtgcct
     1261 ttcctatctg atatgcctta aattatgact gaatatactt taattcctgc caaatttaca
     1321 ctttatataa aattgaagtt aaataattat cctaattgat gttttgttat ctcttataat
     1381 gaaagatcct gacagaatgt aaaaggacac agaagccctg aaattggcaa gatagatgtc
     1441 agtgttagca gaactagctt cactgatttt aaaaaataga ggtgcacaat gctctggcca
     1501 ctcctcgaac ctgtgtgtct gccaatgttt tgaccgttcc ttgacccatg tgtgtgccca
     1561 ctgatgaagc ccattgccag gtgtttgtga tatcggttgc tgagaaagag tcagaaaatc
     1621 tccccagcaa ccacagccca gccaatcctg agttgctaca cctgccccag actctttcct
     1681 tgtacccgtc ccatacccat ttcttgagaa tagacattgt ttagatctgg aaatccccta
     1741 ctctccccct tctcctttct cccctgaggg cctataaaaa ctgggaactc tttcctctcg
     1801 aggtcaactc ctctacccct gtgtgggata tgagtcgtcc ccagagctct ggctttccct
     1861 gaataaagcc tcatgtggtt tgcaacaa
//
