LOCUS       NM_028932               4238 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus ELL associated factor 1 (Eaf1), mRNA.
ACCESSION   NM_028932
VERSION     NM_028932.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4238)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4238)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4238)
  AUTHORS   Pascal,L.E., Su,F., Wang,D., Ai,J., Song,Q., Wang,Y.,
            O'Malley,K.J., Cross,B., Rigatti,L.H., Green,A., Dhir,R. and
            Wang,Z.
  TITLE     Conditional Deletion of Eaf1 Induces Murine Prostatic
            Intraepithelial Neoplasia in Mice
  JOURNAL   Neoplasia 21 (8), 752-764 (2019)
   PUBMED   31229879
  REMARK    GeneRIF: loss of Eaf1 murine prostate can induce pre-neoplastic PIN
            lesions.
REFERENCE   4  (bases 1 to 4238)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 4238)
  AUTHORS   Probert,F., Rice,P., Scudamore,C.L., Wells,S., Williams,R.,
            Hough,T.A. and Cox,I.J.
  TITLE     (1)H NMR metabolic profiling of plasma reveals additional
            phenotypes in knockout mouse models
  JOURNAL   J Proteome Res 14 (5), 2036-2045 (2015)
   PUBMED   25849460
REFERENCE   6  (bases 1 to 4238)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 4238)
  AUTHORS   Shu,H., Chen,S., Bi,Q., Mumby,M. and Brekken,D.L.
  TITLE     Identification of phosphoproteins and their phosphorylation sites
            in the WEHI-231 B lymphoma cell line
  JOURNAL   Mol Cell Proteomics 3 (3), 279-286 (2004)
   PUBMED   14729942
REFERENCE   8  (bases 1 to 4238)
  AUTHORS   Saso,K., Ito,T., Natori,S. and Sekimizu,K.
  TITLE     Identification of a novel tissue-specific transcriptional activator
            FESTA as a protein that interacts with the transcription elongation
            factor S-II
  JOURNAL   J Biochem 133 (4), 493-500 (2003)
   PUBMED   12761297
REFERENCE   9  (bases 1 to 4238)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044181.1, AK036661.1 and AK044737.1.
            
            On May 16, 2009 this sequence version replaced NM_028932.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK044737.1, AK044181.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2524              AK044181.1         2-2525
            2525-3509           AK036661.1         2497-3481
            3510-4061           AK044181.1         3514-4065
            4062-4238           AK044737.1         4000-4176
FEATURES             Location/Qualifiers
     source          1..4238
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 19.14 cM"
     gene            1..4238
                     /gene="Eaf1"
                     /gene_synonym="4933403C17Rik"
                     /note="ELL associated factor 1"
                     /db_xref="GeneID:74427"
                     /db_xref="MGI:MGI:1921677"
     exon            1..293
                     /gene="Eaf1"
                     /gene_synonym="4933403C17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..997
                     /gene="Eaf1"
                     /gene_synonym="4933403C17Rik"
                     /codon_start=1
                     /product="ELL-associated factor 1"
                     /protein_id="NP_083208.1"
                     /db_xref="CCDS:CCDS26914.1"
                     /db_xref="GeneID:74427"
                     /db_xref="MGI:MGI:1921677"
                     /translation="MNGTANPLLDREEHCLRLGESFEKRPRASFHTIRYDFKPASIDT
                     SCEGELQVGKGDEVTITLPHIPGSTPPMTVFKGNKRPYQKDCVLIINHDTGEYVLEKL
                     SSSIQVKKTRAEGSSKIQARMEQQPARPPQPSQPPPPPPPMPFRAPTKPPAGPKTSPL
                     KDNPSPEPQLDDIKRELRAEVDIIEQMSSSSGSSSSDSESSSGSDDDSSSSAGEDNGP
                     ASPPQPSHQQPYNSRPAVANGTSRPQGSSQLMNTLRNDLQLSESGSDSDD"
     exon            294..388
                     /gene="Eaf1"
                     /gene_synonym="4933403C17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            389..525
                     /gene="Eaf1"
                     /gene_synonym="4933403C17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            526..716
                     /gene="Eaf1"
                     /gene_synonym="4933403C17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            717..950
                     /gene="Eaf1"
                     /gene_synonym="4933403C17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            951..4238
                     /gene="Eaf1"
                     /gene_synonym="4933403C17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4040..4045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eaf1"
                     /gene_synonym="4933403C17Rik"
                     /note="hexamer: AATAAA"
     regulatory      4046..4051
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eaf1"
                     /gene_synonym="4933403C17Rik"
                     /note="hexamer: AATGAA"
     polyA_site      4062
                     /gene="Eaf1"
                     /gene_synonym="4933403C17Rik"
                     /note="major polyA site"
     polyA_site      4069
                     /gene="Eaf1"
                     /gene_synonym="4933403C17Rik"
ORIGIN      
        1 acttccgcag agtctctcga gacgcggagt agattggttt ccggccccgg gtgggcgcgg
       61 acttggttca gtgcgcgctc cggagcggtg tcccgggagc gcggtcctgc gggccgcttg
      121 cgcggggatc cggggggact gcggccgcgc gaggagagct ccaatccggg tgccgggcaa
      181 gtgcaaggcc atgaacggca cggcgaaccc gctgctggac cgggaggaac actgtctgcg
      241 gctaggggaa agcttcgaga agcggccgcg ggcctccttc cacacgattc gctacgattt
      301 taagccagca tcaatagaca cttcctgtga aggagaactc caggttggca aaggagatga
      361 agtcaccatt acgctgccac acatccctgg gtccacgccg ccaatgacgg tgttcaaagg
      421 gaacaagcgg ccctatcaga aagactgtgt gctcattatt aaccacgaca ctggagagta
      481 tgtgctggag aagctgagca gcagcattca ggtcaagaag acaagagctg agggaagcag
      541 taaaatccaa gctcgaatgg agcagcagcc cgctcgtccc ccacagccgt cacagccacc
      601 ccctccacct ccacccatgc cgttccgagc cccaacgaag cctccagctg gacccaaaac
      661 ttctcccctg aaggataacc cctcacctga gccccagttg gatgacatca aaagagagct
      721 gagggccgag gtggacatta ttgagcagat gagcagcagc agtgggagca gctcctccga
      781 ctctgagagc tcctcgggaa gtgacgacga cagctccagc agcgcaggcg aagacaatgg
      841 cccagcctcg cctccccagc cctcacacca gcagccctac aacagcaggc ctgcggtggc
      901 caatggaacc agccggcccc aaggaagctc tcagctcatg aacacgctca gaaatgacct
      961 gcagctaagt gagtctggca gtgacagtga tgactagcac caggcttttc aaatctgctt
     1021 tctggaactc aaacatgcta caagacccag ctccatctgc caggaccaca tgtcacagga
     1081 ggatgttgca gatcagagcc aataggagtt aaggcctaga agcactcaga tactcagtct
     1141 ttaacttggt ggtggtgggt gattttctca tgtaattttt gaacaatctc ttgattcaca
     1201 gtttaagtat atctatagga gaactaacag aaatctcttt tatttggtta acattgttaa
     1261 tgaaaagcag accagtgtac cctggtctag gatactcaaa atccatatct tcataggtca
     1321 gtgattgagc agctcagctt gcctgggtgg tctctatcag taaaatacaa gtcttttaag
     1381 ggcatggaaa gaaaagagat cttcaaattg tgtcatagaa atacattaag accactttac
     1441 agtgttgata ctaagtggta aggaagtttg tgacctagtt tgaccagacc atagaagttg
     1501 accttggcag agtctttggg tcagttgtgt gtgtgtgtgc tcgagatcca atagctcagt
     1561 ccagcacagc taggaaaatg gacgcacaca gcagggaact gccagtcact gtccctgggc
     1621 aagcttgctc acgaattcct ctttttgaat tacacttgct ggcttcagat tctctggcct
     1681 ggaactttct attggattct gaaaaaacaa aagcattgct ggcattcagc ttgggttcag
     1741 actcgggcag ttccagctgt gtgtgcgcgt tcagctcatc tgaggtgttt gcttttgtgc
     1801 agatccatcc ctaggttctt cattcccagg atgttagcag agggtagaaa tcagagggat
     1861 gtggtgaaga acttctgagc acattagcca gcagcaaggc tccacaggtg agaatccaga
     1921 caggagttgg gcagtatgga acagtcttta gaagctgttt gctttgtgct gctgttggtg
     1981 cctgactccc agtctcgtgg gttattttta tagaagagaa tcacaagatt gccttttgct
     2041 gtgtgccatt tccaaataaa tgttcttgct ggaaactggt cactagtcag ggttgcacat
     2101 tgaggaagta tgtggtgact tatgtgtctg cccatctctg tggtctgaat gaatatatcc
     2161 taggaaatcc ctgtctttct gctttaagac attaacaatg ctgttctttc ctcctgcata
     2221 gtggaggaag gtggtctgga cctggtgggg ccgtaggtca tatagattag ctttatggtc
     2281 gacacaccat acagatcagc tgatccactc agagactgaa gtgaactgag atgggtgggg
     2341 ccattgccca gcagcacacc tacacgtctc agcacaagct cagatgcaga gtgtgcaccc
     2401 ataccctctg ctcagtctca gcccactggg agatgctcta tggatccatg gcaggtggaa
     2461 cctatttaaa gcaaactgat aattgcttta taattctttg gtaatgctgg gtgtggtgcc
     2521 gcacgccttt aatcccagca ctcgggaggc agaggcaggt ggatttctga gttccaggac
     2581 agccagggcc atacagagaa accctgcctc gaaaaaccaa aaaacaaaca aaccaaccaa
     2641 ccctctttgg taatgacagc tcagggaagg tgagggttgt gactgggtga cttgagttgt
     2701 caccagatgt gggcattgaa ctgtttttac tgctcttcgc tgttcagact gtggcaggct
     2761 ccaggaactt gaactaaaaa tgcctattta agtctcccct tgccccgctt ttctccaaaa
     2821 gccttggttt gtgtagacag agctgtggtg ttggcattcc agttggggac tgttgccata
     2881 ggaagtactt gcatgtggca ctgggcttga taaattgagc tttctgtgcc tcagacgatc
     2941 tagtcacccg gcttacccag caccacaggt ccttctgtag atggctccag gttttgctct
     3001 ctgcacaaat cctccggtga ttctttctgc ttcccccact agagtaagaa agctattttt
     3061 ggaaatccag aatgtagcct cccagatggc ttctcagggg tatccttgtg ccaaccaaag
     3121 gactccttcc tgtcgctgtg cctttgctgt cccctcctct tcacccactc taaacctctc
     3181 tccagagcgc ctatttcaca agctcttcat ttctttcaac ctatgggtaa gccctggtat
     3241 atatacaaac taccattcta cctggtcttg gttagtatta gtgcctcaaa agcaggggct
     3301 gtcatcacgg aactagacat gcaggtgctc ctactctggt tgggaaagag atggagacaa
     3361 ctactagtga agggtggagg gtaaactgaa acattccagg cattgagaca aagctggaaa
     3421 tctgtacgca gtgcccatgc aggtctctac cgaatctgtc aatgaccttt ttttaatttg
     3481 ctctatgcaa tgttcacttg ggcaaggtgg aaggactaat tctacagaga tgccatggca
     3541 atctttgaaa accattggga aaatgcaata cagataaact agagattcgt ataatgccac
     3601 gtgttagctt gtttctgtag cagaataact ctctgcggtg acgtgctgga gtgagaggga
     3661 aacttgaaaa ttccaaagtc cttccctctt ttgagagact ggttgtgtgt gtgatattta
     3721 ttaattattt taagagagaa ttgttttgta gatagatatg tattaagaac agccaaactg
     3781 gatctttcca cttggcaagg aacagaaact ttttgaaact caggccttaa ccagtagctt
     3841 ggaagaccaa ctcaagtgtt aggaactgtg tgtttttgtt tcctgttatt tctgtcttag
     3901 attctttgtg tcctttaatg atatttaaaa tcttgtgcct aaaaatttat tttgcttaat
     3961 tctgatgtag acatgcatgt ttacatttat ataaaatatt ttctgtatag tttactctct
     4021 ttcaagatga atatatttaa ataaaaatga aggtcagcaa tatatttaat gtcttgtttt
     4081 attttaaact gacatctatg tgaaatagag ttaagaatcc tttatgtggc tctttaagct
     4141 ttcgcctttc ttactcccat ctctagccct ccttctctct ctccctcttt ctacctctct
     4201 ttttctccct gccattctac aataaagctc taaaacca
//
