LOCUS       NM_001301784            2669 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus E4F transcription factor 1 (E4f1), transcript variant
            1, mRNA.
ACCESSION   NM_001301784 XM_006523594
VERSION     NM_001301784.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2669)
  AUTHORS   Di Michele,M., Attina,A., Roux,P.F., Tabet,I., Laguesse,S.,
            Florido,J., Houdeville,M., Choquet,A., Encislai,B., Arena,G., De
            Blasio,C., Wendling,O., Frenois,F.X., Papon,L., Stuani,L.,
            Fuentes,M., Jahannault Talignani,C., Rousseau,M., Guegan,J.,
            Buscail,Y., Dupre,P., Michaud,H.A., Rodier,G., Bellvert,F.,
            Kulyk,H., Ferraro Peyret,C., Mathieu,H., Close,P., Rapino,F.,
            Chaveroux,C., Pirot,N., Rubio,L., Torro,A., Sorg,T., Ango,F.,
            Hirtz,C., Compan,V., Lebigot,E., Legati,A., Ghezzi,D., Nguyen,L.,
            David,A., Sardet,C., Lacroix,M. and Le Cam,L.
  TITLE     E4F1 coordinates pyruvate metabolism and the activity of the
            elongator complex to ensure translation fidelity during brain
            development
  JOURNAL   Nat Commun 16 (1), 67 (2025)
   PUBMED   39747033
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2669)
  AUTHORS   Lacroix,M., Linares,L.K., Rueda-Rincon,N., Bloch,K., Di Michele,M.,
            De Blasio,C., Fau,C., Gayte,L., Blanchet,E., Mairal,A., Derua,R.,
            Cardona,F., Beuzelin,D., Annicotte,J.S., Pirot,N., Torro,A.,
            Tinahones,F.J., Bernex,F., Bertrand-Michel,J., Langin,D., Fajas,L.,
            Swinnen,J.V. and Le Cam,L.
  TITLE     The multifunctional protein E4F1 links P53 to lipid metabolism in
            adipocytes
  JOURNAL   Nat Commun 12 (1), 7037 (2021)
   PUBMED   34857760
  REMARK    GeneRIF: The multifunctional protein E4F1 links P53 to lipid
            metabolism in adipocytes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2669)
  AUTHORS   Yan,R.G., Yang,Q.L. and Yang,Q.E.
  TITLE     E4 Transcription Factor 1 (E4F1) Regulates Sertoli Cell
            Proliferation and Fertility in Mice
  JOURNAL   Animals (Basel) 10 (9), 1691 (2020)
   PUBMED   32962114
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2669)
  AUTHORS   Lacroix,M., Rodier,G., Kirsh,O., Houles,T., Delpech,H., Seyran,B.,
            Gayte,L., Casas,F., Pessemesse,L., Heuillet,M., Bellvert,F.,
            Portais,J.C., Berthet,C., Bernex,F., Brivet,M., Boutron,A., Le
            Cam,L. and Sardet,C.
  TITLE     E4F1 controls a transcriptional program essential for pyruvate
            dehydrogenase activity
  JOURNAL   Proc Natl Acad Sci U S A 113 (39), 10998-11003 (2016)
   PUBMED   27621446
  REMARK    GeneRIF: these data identify E4F1 as a master regulator of the PDC.
REFERENCE   5  (bases 1 to 2669)
  AUTHORS   Goguet-Rubio,P., Seyran,B., Gayte,L., Bernex,F., Sutter,A.,
            Delpech,H., Linares,L.K., Riscal,R., Repond,C., Rodier,G.,
            Kirsh,O., Touhami,J., Noel,J., Vincent,C., Pirot,N., Pavlovic,G.,
            Herault,Y., Sitbon,M., Pellerin,L., Sardet,C., Lacroix,M. and Le
            Cam,L.
  TITLE     E4F1-mediated control of pyruvate dehydrogenase activity is
            essential for skin homeostasis
  JOURNAL   Proc Natl Acad Sci U S A 113 (39), 11004-11009 (2016)
   PUBMED   27621431
  REMARK    GeneRIF: These data reveal a central role for Dlat in the metabolic
            program regulated by E4F1 in basal keratinocytes.
REFERENCE   6  (bases 1 to 2669)
  AUTHORS   Fajas,L., Paul,C., Zugasti,O., Le Cam,L., Polanowska,J.,
            Fabbrizio,E., Medema,R., Vignais,M.L. and Sardet,C.
  TITLE     pRB binds to and modulates the transrepressing activity of the
            E1A-regulated transcription factor p120E4F
  JOURNAL   Proc Natl Acad Sci U S A 97 (14), 7738-7743 (2000)
   PUBMED   10869426
REFERENCE   7  (bases 1 to 2669)
  AUTHORS   Meighan-Mantha,R.L., Hsu,D.K., Guo,Y., Brown,S.A., Feng,S.L.,
            Peifley,K.A., Alberts,G.F., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Richards,C.M. and Winkles,J.A.
  TITLE     The mitogen-inducible Fn14 gene encodes a type I transmembrane
            protein that modulates fibroblast adhesion and migration
  JOURNAL   J Biol Chem 274 (46), 33166-33176 (1999)
   PUBMED   10551889
REFERENCE   8  (bases 1 to 2669)
  AUTHORS   Rooney,R.J., Daniels,R.R., Jenkins,N.A., Gilbert,D.J.,
            Rothammer,K., Morris,S.W., Higgs,D.R. and Copeland,N.G.
  TITLE     Chromosomal location and tissue expression of the gene encoding the
            adenovirus E1A-regulated transcription factor E4F in humans and
            mice
  JOURNAL   Mamm Genome 9 (4), 320-323 (1998)
   PUBMED   9530632
REFERENCE   9  (bases 1 to 2669)
  AUTHORS   Fernandes,E.R., Zhang,J.Y. and Rooney,R.J.
  TITLE     Adenovirus E1A-regulated transcription factor p120E4F inhibits cell
            growth and induces the stabilization of the cdk inhibitor p21WAF1
  JOURNAL   Mol Cell Biol 18 (1), 459-467 (1998)
   PUBMED   9418893
REFERENCE   10 (bases 1 to 2669)
  AUTHORS   Fognani,C., Della Valle,G. and Babiss,L.E.
  TITLE     Repression of adenovirus E1A enhancer activity by a novel zinc
            finger-containing DNA-binding protein related to the GLI-Kruppel
            protein
  JOURNAL   EMBO J 12 (13), 4985-4992 (1993)
   PUBMED   8262041
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY310538.1, AC154237.1,
            AK033285.1, BC057011.1 and BC031757.1.
            
            On Sep 16, 2014 this sequence version replaced XM_006523594.1.
            
            Summary: This gene encodes a member of the GLI-Kruppel zinc finger
            family. The encoded protein is likely to be multi-functional, with
            both adenovirus E1A-regulated transcription factor and ubiquitin E3
            ligase activities, including roles in cell cycle regulation and the
            ubiquitination of p53. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Sep 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784646.709509.1,
                                           SRR17784643.890771.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BY310538.1         2-11
            11-11               AC154237.1         115461-115461       c
            12-81               BY310538.1         13-82
            82-1367             AK033285.1         2-1287
            1368-1370           BC057011.1         939-941
            1371-2658           AK033285.1         1288-2575
            2659-2669           BC031757.1         2708-2718
FEATURES             Location/Qualifiers
     source          1..2669
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.39 cM"
     gene            1..2669
                     /gene="E4f1"
                     /gene_synonym="p120E4F; phi-AP3"
                     /note="E4F transcription factor 1"
                     /db_xref="GeneID:13560"
                     /db_xref="MGI:MGI:109530"
     exon            1..258
                     /gene="E4f1"
                     /gene_synonym="p120E4F; phi-AP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..2456
                     /gene="E4f1"
                     /gene_synonym="p120E4F; phi-AP3"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor E4F1; transcription factor phi AP3;
                     putative E3 ubiquitin-protein ligase E4F1; RING-type E3
                     ubiquitin transferase E4F1"
                     /codon_start=1
                     /product="transcription factor E4F1 isoform 1"
                     /protein_id="NP_001288713.1"
                     /db_xref="GeneID:13560"
                     /db_xref="MGI:MGI:109530"
                     /translation="MEGAMAVRVTAAHTAEARAEAGREAGEGGVAAAAALSSGGFLGL
                     PAPFSEEDEDDVHRCGRCQVEFTALEDFVQHKIQKTCHRAPQEALPTTPAATALLDQE
                     VVPTAAEGGPDEPITVAHIVVEATSLAEDISHAPDLVGSGHIKEVIVAAEAEPGDVEM
                     AEAPGSPNHQELGLLGEGEQAHVKLLVNKEGRYVCMLCHKTFKTGSILKAHMVTHSSR
                     KDHECKLCGASFRTKGSLIRHHRRHTDERPYKCAKCGKSFRESGALTRHLKSLTPCTE
                     KIRFSISKDTAVGKEEVPAGSSASTVGTVTSSVAGDPMETSPVIHLVTDAKGTVIHEV
                     HVQMQELPLGMKALTPESPDSEELPCSSENSRENLLHQAMQNSGIVLERVAGEESALE
                     PAPPSGSSPQCLGDGSPELPLLKVEQIETQVASEAATVPRTHPCPQCSETFPTAATLE
                     AHKRGHIAPRPFTCTQCGKAFPKAYLLKKHQEVHVHERRFRCGDCGKLYKTIAHVRGH
                     RRVHSDERPFPCPQCGKRYKTKNAQQVHFRTHLEEKPHVCQFCSRGFREKGSLVRHVR
                     HHTGEKPFKCYKCGRGFAEHGTLNRHLRTKGGCLLEVEELLVSEESPSAAATVLAEDP
                     HTVLVEFSSVVADTQEYIIEATADDTETSEATEIIEGTQTEVDSHIMKVVQQIVHQAG
                     AGHQIIVQNVTMDQETALGSEATAADTITIATPESLTEQVAMTLASAISEGTVLTARA
                     GPNSTEQATVTMVSSEDIEILEHGGELVIASPEGQLEVQTVIV"
     exon            259..410
                     /gene="E4f1"
                     /gene_synonym="p120E4F; phi-AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            411..522
                     /gene="E4f1"
                     /gene_synonym="p120E4F; phi-AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            523..716
                     /gene="E4f1"
                     /gene_synonym="p120E4F; phi-AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            717..837
                     /gene="E4f1"
                     /gene_synonym="p120E4F; phi-AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            838..990
                     /gene="E4f1"
                     /gene_synonym="p120E4F; phi-AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1157
                     /gene="E4f1"
                     /gene_synonym="p120E4F; phi-AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1367
                     /gene="E4f1"
                     /gene_synonym="p120E4F; phi-AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1476
                     /gene="E4f1"
                     /gene_synonym="p120E4F; phi-AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1694
                     /gene="E4f1"
                     /gene_synonym="p120E4F; phi-AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1893
                     /gene="E4f1"
                     /gene_synonym="p120E4F; phi-AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2036
                     /gene="E4f1"
                     /gene_synonym="p120E4F; phi-AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2099
                     /gene="E4f1"
                     /gene_synonym="p120E4F; phi-AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2659
                     /gene="E4f1"
                     /gene_synonym="p120E4F; phi-AP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2638..2643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="E4f1"
                     /gene_synonym="p120E4F; phi-AP3"
                     /note="hexamer: AATAAA"
     polyA_site      2655
                     /gene="E4f1"
                     /gene_synonym="p120E4F; phi-AP3"
                     /note="major polyA site"
ORIGIN      
        1 gtttttgtcc cgccccctgc ctgtcggaca cgcagccctc ggtgcggccc gttgttatga
       61 cgacatggtc gtaaatccgc catcttcctg tggcgcgttg cgacatggag ggcgcgatgg
      121 cagtgcgggt gacggccgct catacggcag aagcccgggc cgaagccggg cgtgaagcgg
      181 gcgagggcgg ggttgcggcg gcggcggcct tgtcctccgg cggcttcctt gggctcccag
      241 cgcccttcag cgaggaagat gaggacgatg tgcacagatg tggccgctgc caagtggaat
      301 tcactgcctt ggaggacttt gtccagcaca agattcagaa gacctgccat cgggccccgc
      361 aggaggccct gcccaccacc cctgctgcca ctgcactgct ggaccaggag gtggtgccca
      421 cagcagcaga gggaggtcca gatgaaccca tcactgtggc tcacatcgtg gtggaggcca
      481 cctctctagc agaagacatc agccacgctc ctgaccttgt tggaagtggg cacatcaaag
      541 aggtcattgt ggctgctgag gcagagccag gggatgtcga gatggcagag gctccaggca
      601 gtcctaatca tcaggaactt gggcttcttg gggagggcga gcaggcccat gtcaagctgc
      661 tggtgaacaa ggaaggccgc tacgtgtgca tgctatgtca caagaccttc aaaacgggca
      721 gcatcctcaa ggcccacatg gtaacgcaca gcagccgcaa ggaccacgag tgcaagctct
      781 gtggggcctc ttttcggacc aagggctctc tcatccggca ccaccgacgg cacactgatg
      841 agcgccccta caaatgtgcc aagtgtggaa agagtttccg agagtcaggc gcactgactc
      901 ggcacctcaa atctctcact ccatgcacag aaaagatccg cttcagcata agcaaggaca
      961 cagctgtggg caaagaggaa gtgcctgcag ggtccagtgc ctccactgtg gggacggtga
     1021 catcatcagt ggcaggagac cccatggaga catcacctgt gattcacctg gtgacagatg
     1081 ccaagggtac tgtcatccat gaagtccacg tccagatgca ggagcttccc ctgggcatga
     1141 aagccctgac cccagagtcc ccagactcgg aggagctccc ctgttccagt gagaacagcc
     1201 gtgagaacct gctacatcag gccatgcaga attctggcat cgtccttgag agggttgctg
     1261 gagaggagag tgctctggag ccagcccctc cctctgggtc cagtccccag tgcctgggag
     1321 atgggtcccc tgaactgcct ctgctgaagg tggagcagat agagacacag gtggccagtg
     1381 aggccgccac cgtgcccagg acccacccgt gccctcagtg cagtgagact ttcccaacag
     1441 cagccacgct ggaggcccac aagagaggtc acatagcgcc gaggccgttc acctgcacac
     1501 agtgtggcaa ggccttcccc aaagcctacc tgctcaagaa gcaccaggag gtgcacgtgc
     1561 acgagcgccg cttccgttgt ggagactgtg ggaagcttta caagaccatc gctcatgtgc
     1621 ggggccaccg gcgtgttcac tcagacgaga ggcctttccc ttgtccccag tgcggcaagc
     1681 gttacaaaac caagaatgcc cagcaagtac acttccggac acacctggaa gaaaagcccc
     1741 acgtgtgcca gttctgcagc cgaggcttcc gggagaaggg ctctctggtg cggcatgtga
     1801 ggcaccacac aggcgagaaa cctttcaagt gctacaagtg tggccgtggc ttcgcggagc
     1861 atggcacact caaccggcac ctgcgcacta aagggggctg cctgctagaa gtggaggagt
     1921 tgctggtgtc tgaggagagc ccttctgcgg ctgccactgt gcttgcagaa gacccccaca
     1981 ccgtgctggt ggagttctcg tctgtggtag ctgataccca agagtacatt attgaggcca
     2041 ctgcagatga cacagagacc agtgaagcca ccgagatcat tgagggcacg cagacagagg
     2101 tggacagtca catcatgaag gtggtccagc agatcgtgca ccaggctggt gctgggcacc
     2161 agatcatcgt gcagaatgtc accatggacc aggagacagc actgggttcg gaggcaactg
     2221 ctgcagacac gatcaccatt gccactcctg agagtcttac tgagcaggtg gccatgacac
     2281 tggcttcagc gatcagtgag ggtactgtgc tcacagcccg ggcaggtcca aacagtactg
     2341 aacaggccac tgtgacaatg gtgtcatcag aggacataga gatccttgag cacggaggag
     2401 agctggtcat tgcttcacca gagggccagc ttgaggtaca gacggtcatc gtatagtttg
     2461 agggcctctg ctgtggaaga tcgaggaccc tgagtgtctg cccgcacttg cctggtcaga
     2521 agacttcagg cagccaaagg agagagagag agagagagag agagagagag agagagagag
     2581 agagagagag aacaggcagt tttgggattg tttttgtttg tttgttttct gctttacaat
     2641 aaaacataaa aaacctgcaa aaaaaaaaa
//
