LOCUS       NM_001013368            3705 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus E2F transcription factor 8 (E2f8), transcript variant
            2, mRNA.
ACCESSION   NM_001013368
VERSION     NM_001013368.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3705)
  AUTHORS   Dou,D., Bi,M., Li,X., Zhang,N., Xu,M., Guo,A., Li,F. and Zhu,W.
  TITLE     ADP Ribosylation Factor 6 Relieves Airway Inflammation and
            Remodeling by Inhibiting Ovalbumin Induced-Epithelial Mesenchymal
            Transition in Experimental Asthma, Possibly by Regulating of E2F
            Transcription Factor 8
  JOURNAL   Immunol Invest 52 (6), 717-734 (2023)
   PUBMED   37326141
  REMARK    GeneRIF: ADP Ribosylation Factor 6 Relieves Airway Inflammation and
            Remodeling by Inhibiting Ovalbumin Induced-Epithelial Mesenchymal
            Transition in Experimental Asthma, Possibly by Regulating of E2F
            Transcription Factor 8.
REFERENCE   2  (bases 1 to 3705)
  AUTHORS   Moreno,E., Matondo,A.B., Bongiovanni,L., van de Lest,C.H.A.,
            Molenaar,M.R., Toussaint,M.J.M., van Essen,S.C., Houweling,M.,
            Helms,J.B., Westendorp,B. and de Bruin,A.
  TITLE     Inhibition of polyploidization in Pten-deficient livers reduces
            steatosis
  JOURNAL   Liver Int 42 (11), 2442-2452 (2022)
   PUBMED   35924448
REFERENCE   3  (bases 1 to 3705)
  AUTHORS   Park,S.A., Lim,Y.J., Ku,W.L., Zhang,D., Cui,K., Tang,L.Y., Chia,C.,
            Zanvit,P., Chen,Z., Jin,W., Wang,D., Xu,J., Liu,O., Wang,F.,
            Cain,A., Guo,N., Nakatsukasa,H., Wu,C., Zhang,Y.E., Zhao,K. and
            Chen,W.
  TITLE     Opposing functions of circadian protein DBP and atypical E2F family
            E2F8 in anti-tumor Th9 cell differentiation
  JOURNAL   Nat Commun 13 (1), 6069 (2022)
   PUBMED   36241625
  REMARK    GeneRIF: Opposing functions of circadian protein DBP and atypical
            E2F family E2F8 in anti-tumor Th9 cell differentiation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3705)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3705)
  AUTHORS   Wenzel,P.L., Wu,L., de Bruin,A., Chong,J.L., Chen,W.Y., Dureska,G.,
            Sites,E., Pan,T., Sharma,A., Huang,K., Ridgway,R., Mosaliganti,K.,
            Sharp,R., Machiraju,R., Saltz,J., Yamamoto,H., Cross,J.C.,
            Robinson,M.L. and Leone,G.
  TITLE     Rb is critical in a mammalian tissue stem cell population
  JOURNAL   Genes Dev 21 (1), 85-97 (2007)
   PUBMED   17210791
REFERENCE   6  (bases 1 to 3705)
  AUTHORS   Stefan,M., Claiborn,K.C., Stasiek,E., Chai,J.H., Ohta,T.,
            Longnecker,R., Greally,J.M. and Nicholls,R.D.
  TITLE     Genetic mapping of putative Chrna7 and Luzp2 neuronal
            transcriptional enhancers due to impact of a transgene-insertion
            and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman
            syndromes
  JOURNAL   BMC Genomics 6, 157 (2005)
   PUBMED   16280085
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3705)
  AUTHORS   Christensen,J., Cloos,P., Toftegaard,U., Klinkenberg,D.,
            Bracken,A.P., Trinh,E., Heeran,M., Di Stefano,L. and Helin,K.
  TITLE     Characterization of E2F8, a novel E2F-like cell-cycle regulated
            repressor of E2F-activated transcription
  JOURNAL   Nucleic Acids Res 33 (17), 5458-5470 (2005)
   PUBMED   16179649
  REMARK    GeneRIF: E2F8 may have an important role in repressing the
            expression of E2F-target genes in the S-phase of the cell cycle.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3705)
  AUTHORS   Logan,N., Graham,A., Zhao,X., Fisher,R., Maiti,B., Leone,G. and La
            Thangue,N.B.
  TITLE     E2F-8: an E2F family member with a similar organization of
            DNA-binding domains to E2F-7
  JOURNAL   Oncogene 24 (31), 5000-5004 (2005)
   PUBMED   15897886
REFERENCE   9  (bases 1 to 3705)
  AUTHORS   Maiti,B., Li,J., de Bruin,A., Gordon,F., Timmers,C., Opavsky,R.,
            Patil,K., Tuttle,J., Cleghorn,W. and Leone,G.
  TITLE     Cloning and characterization of mouse E2F8, a novel mammalian E2F
            family member capable of blocking cellular proliferation
  JOURNAL   J Biol Chem 280 (18), 18211-18220 (2005)
   PUBMED   15722552
  REMARK    GeneRIF: Overexpression of E2F8 significantly slows down the
            proliferation of primary mouse embryonic fibroblasts.
REFERENCE   10 (bases 1 to 3705)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK084513.1, AK160240.1 and BX528987.1.
            
            On Jul 30, 2009 this sequence version replaced NM_001013368.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157235.1, AK160240.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-245               AK084513.1         2-246
            246-3656            AK160240.1         207-3617
            3657-3705           BX528987.1         323-371
FEATURES             Location/Qualifiers
     source          1..3705
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 31.11 cM"
     gene            1..3705
                     /gene="E2f8"
                     /gene_synonym="4432406C08Rik"
                     /note="E2F transcription factor 8"
                     /db_xref="GeneID:108961"
                     /db_xref="MGI:MGI:1922038"
     exon            1..381
                     /gene="E2f8"
                     /gene_synonym="4432406C08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            382..505
                     /gene="E2f8"
                     /gene_synonym="4432406C08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            506..784
                     /gene="E2f8"
                     /gene_synonym="4432406C08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            785..941
                     /gene="E2f8"
                     /gene_synonym="4432406C08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1256
                     /gene="E2f8"
                     /gene_synonym="4432406C08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1418
                     /gene="E2f8"
                     /gene_synonym="4432406C08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1556
                     /gene="E2f8"
                     /gene_synonym="4432406C08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1757
                     /gene="E2f8"
                     /gene_synonym="4432406C08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1845
                     /gene="E2f8"
                     /gene_synonym="4432406C08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..2371
                     /gene="E2f8"
                     /gene_synonym="4432406C08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2504
                     /gene="E2f8"
                     /gene_synonym="4432406C08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2890
                     /gene="E2f8"
                     /gene_synonym="4432406C08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2891..3691
                     /gene="E2f8"
                     /gene_synonym="4432406C08Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3670..3675
                     /regulatory_class="polyA_signal_sequence"
                     /gene="E2f8"
                     /gene_synonym="4432406C08Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3691
                     /gene="E2f8"
                     /gene_synonym="4432406C08Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtgcttgcg ccgggcggga cgcgggctac tgctggggac tgtacctggg accgggagcg
       61 cagcgtacgg tgcgctttgg catcgcggtg atttcggcac ctagggaatc cttccctcgc
      121 cccagtactt cgtgtattga aagaagcctg aaaaaggggg tcaagatccc aaagcccttt
      181 gtaaatgccc ggtcgtgcgc ttagagcgca gaggctgaat tggagggttg ttctcaggcc
      241 acttcacaag tccttccttc tgagcctgtg cacgtgtgtg tcaggcgaga aacttcagca
      301 tctcccccga tgcaggctcg gtgcgtgctc catcggaacc cgggctcgtg cgctccgtcc
      361 gcagcccgga tcagtgcaca ggatagtaaa aaactttaat cgattggact acttaaacca
      421 ctggaacttg gggaggaact tcagattttt cgtttttaaa gacacactaa atgtatgagg
      481 aattgacaaa atggagaacc aaaaggaaaa cctcttttct gagccacata aaaggggact
      541 gatgaaaagc cccctgcatc cgtcctcgaa ggccaacatg gtgttggctg agatccagcc
      601 tgacttgggc cctctaacca caccaaccaa gcccaaggaa gtctcccaag gagagccatg
      661 gacacccaca gccaacctga aaatgctcat cagcgccgtg agccccgaga tccgaagtcg
      721 agatcagaaa aggggcctgt ctgacaaccg aagtgcatta cctgaagcta gagactgttt
      781 gcacgaacac ttatcaggag acgaatttga gaaatcccag ccgagtcgga aggagaagag
      841 cttggggttg ctatgccaca aattcctagc gcggtacccc aagtacccca accctgctgt
      901 gaataacgac atctgcctgg acgaggtggc cgaggagctc aatgttgaac gtcggcggat
      961 ttatgacatt gtgaatgtcc tagagagcct gcacatggtg agccgccttg ccaaaaacag
     1021 gtacacttgg catggccggc acaacctcac caaaaccctc gggacgctga agagtgtcgg
     1081 ggaagagaac aagtacgctg agcagatcat gatgatcaaa aggaaagaat atgagcaaga
     1141 gtttgatttt atcaagagct gtggcataga ggaccacgtg atcaagtcac acactggcca
     1201 gaatgggcat tcagacatgt gcttcgtaga actccctgga gtagaattcc gggcagcttc
     1261 tgtaaacagc cgcaaagaca agtccttacg cgtgatgagc cagaagtttg tgatgctgtt
     1321 cttggtgtcg acgcctcaga tagtgagcct ggaaattgct gccaagattt taattgggga
     1381 agaccacgtg gaagatctgg ataaaagcaa gtataaaaca aaaattagga ggctgtatga
     1441 cattgctaat gtcctgagta gcttggatct tatcaagaaa gtccatgtta cagaagaaag
     1501 aggtcgaaaa ccagctttta aatggacggg cccagaaatc agcccaaaca acagtggttc
     1561 cagccccatc atgcctcttc ctgcctcctt agaggctgag cagtctgcaa aagagaactg
     1621 tgccaaaaac ctcttctcta cgcgggggaa acccagcttc actcgacacc cgtccctcat
     1681 caagttggta aagagcatag aaaatgatcg gaggaagatc agttccgctc ccagcagccc
     1741 tgtcaagagc aacaaagctg agagttctca aaattctcca cccgtcccaa acaaaatggc
     1801 tcagctcgcc gctatttgca agatgcagtt ggaagagcag tcaagtgaac ccaggaagaa
     1861 agtgaaagta aacctagcaa gatctgggca ctacaaacca ctggctcccc tggaccctac
     1921 agtgaacact gagctagaac tgcttacacc gtcccttatc cagcccctgg gcgtggtccc
     1981 cctgatccct agcccattgt catctgcagt gcctgtgatc ctacctcagg ccccttcggg
     2041 cccatcctat gccatctact tacaacctgc ccaagcccaa atgttgacac caccccctgg
     2101 cctgagccca accgtctgcc ccacccagcc ctctaatgct actggatcca aagaccctac
     2161 agacgcccct gctgagaaga cggccacaga cgccgccaca accggaagct tgcagccagc
     2221 accagaaagg catggtgcta agcatcgaag caaggagacg accggagatc ggggtacaaa
     2281 gaggatgatc accgcggagg acagtggtcc cagttctgta aagaaaccta aagaggacct
     2341 gaaagcgctt gagaacgtcc ccacccccac gcccctgttc ccatcaggat acctaatccc
     2401 tcttacccag tgctcatccc tagggccaga ctctgtgttg tctaacactg aaaactcagg
     2461 tacaccctct ccaaaccacc ggatctatgg ctcccccatt gcaggtgtga tcccagtggc
     2521 atcatcggaa ctcactgctg tgaattttcc cccattccat gtgacacctc tgaaacttat
     2581 ggtctcccca acatctatgg cggccgtacc tgttgggaac agcccagccc tcaactccgg
     2641 ccaccctgct cccgcccaga acccaagctc ggctatcgta aactttaccc tgcagcactt
     2701 gggactcatc tccccgggcg tgcagatgtc tgccagcccg gggcctggag ctggcacagt
     2761 cccggtatcc ccacgtgtag aagcagataa cttgagctct cggcaaagga gggccaccaa
     2821 ccatgactcg ccagtcctgg gccagagcca actaaacgga caaccagtcg cggggacagg
     2881 ggcacagcag cctgttcctg tgacacccaa aggctcccag ttggtggctg aaaatttctt
     2941 ccgtactccg ggtggaccaa ctaagcctac cagctcaccc tacacagatt tcgatggtgc
     3001 taacaaaacc tccttcggaa ccctctttgt cccacagcgc aaactggaag tctcaactga
     3061 ggatatccac tgattgacaa gatggtggtt taatttaatt ttctaaagag ctatttaatg
     3121 agacaatata cacatataga tggagagaac accaccttta acaatactgt aaatatttgg
     3181 ggtttttact caatatcaca gcagatatac acacatgcgc atgcgagtgc acccacccat
     3241 acacacacac acacacacac acacacacac acactcatac atgcgcacac atttgtacaa
     3301 gaccaaattc agccttcagt actataaaat aaaatgttga actaaggtac attaacttct
     3361 gggggagggg aattaatttt ttcacctgtg cctctattat tatgcaaagt aactttatta
     3421 aagtttactt ccctttcagc aaatgtttga cttacctaac acagcacctg ctcaaacttt
     3481 ttgcacaaag gaaatgctgt gtaatgtata atgtattttt acctagggag gcgatagcta
     3541 tatttttttg taatttcttt aatcctttgc tgttgcagtc tgtctttttg tagagtttac
     3601 aaccctcctc aatcaagtct atggaaaaaa attatttata aaatgtattt ttaatcataa
     3661 gttgttgaaa ttaaaactct tctaaaatgc aaaaaaaaaa aaaaa
//
