LOCUS       NM_007892               1805 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus E2F transcription factor 5 (E2f5), mRNA.
ACCESSION   NM_007892
VERSION     NM_007892.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1805)
  AUTHORS   To,B., Broeker,C., Jhan,J.R., Garcia-Lerena,J., Vusich,J.,
            Rempel,R., Rennhack,J.P., Hollern,D., Jackson,L., Judah,D.,
            Swiatnicki,M., Bylett,E., Kubiak,R., Honeysett,J., Nevins,J. and
            Andrechek,E.
  TITLE     Insight into mammary gland development and tumor progression in an
            E2F5 conditional knockout mouse model
  JOURNAL   Oncogene 43 (46), 3402-3415 (2024)
   PUBMED   39341991
REFERENCE   2  (bases 1 to 1805)
  AUTHORS   Akagawa,R., Nabeshima,Y.I. and Kawauchi,T.
  TITLE     Alternative Functions of Cell Cycle-Related and DNA Repair Proteins
            in Post-mitotic Neurons
  JOURNAL   Front Cell Dev Biol 9, 753175 (2021)
   PUBMED   34746147
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1805)
  AUTHORS   Nakano,T., Aochi,H., Hirasaki,M., Takenaka,Y., Fujita,K.,
            Tamura,M., Soma,H., Kamezawa,H., Koizumi,T., Shibuya,H.,
            Inomata,R., Okuda,A., Murakoshi,T., Shimada,A. and Inoue,I.
  TITLE     Effects of Ppargamma1 deletion on late-stage murine embryogenesis
            and cells that undergo endocycle
  JOURNAL   Dev Biol 478, 222-235 (2021)
   PUBMED   34246625
REFERENCE   4  (bases 1 to 1805)
  AUTHORS   Wu,S.C. and Benavente,C.A.
  TITLE     Chromatin remodeling protein HELLS is upregulated by inactivation
            of the RB-E2F pathway and is nonessential for osteosarcoma
            tumorigenesis
  JOURNAL   Oncotarget 9 (66), 32580-32592 (2018)
   PUBMED   30220967
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1805)
  AUTHORS   Otto,T., Candido,S.V., Pilarz,M.S., Sicinska,E., Bronson,R.T.,
            Bowden,M., Lachowicz,I.A., Mulry,K., Fassl,A., Han,R.C.,
            Jecrois,E.S. and Sicinski,P.
  TITLE     Cell cycle-targeting microRNAs promote differentiation by enforcing
            cell-cycle exit
  JOURNAL   Proc Natl Acad Sci U S A 114 (40), 10660-10665 (2017)
   PUBMED   28923932
REFERENCE   6  (bases 1 to 1805)
  AUTHORS   Lindeman,G.J., Dagnino,L., Gaubatz,S., Xu,Y., Bronson,R.T.,
            Warren,H.B. and Livingston,D.M.
  TITLE     A specific, nonproliferative role for E2F-5 in choroid plexus
            function revealed by gene targeting
  JOURNAL   Genes Dev 12 (8), 1092-1098 (1998)
   PUBMED   9553039
REFERENCE   7  (bases 1 to 1805)
  AUTHORS   Bernards,R.
  TITLE     E2F: a nodal point in cell cycle regulation
  JOURNAL   Biochim Biophys Acta 1333 (3), M33-M40 (1997)
   PUBMED   9426200
  REMARK    Review article
REFERENCE   8  (bases 1 to 1805)
  AUTHORS   Dagnino,L., Fry,C.J., Bartley,S.M., Farnham,P., Gallie,B.L. and
            Phillips,R.A.
  TITLE     Expression patterns of the E2F family of transcription factors
            during mouse nervous system development
  JOURNAL   Mech Dev 66 (1-2), 13-25 (1997)
   PUBMED   9376316
REFERENCE   9  (bases 1 to 1805)
  AUTHORS   Dagnino,L., Fry,C.J., Bartley,S.M., Farnham,P., Gallie,B.L. and
            Phillips,R.A.
  TITLE     Expression patterns of the E2F family of transcription factors
            during murine epithelial development
  JOURNAL   Cell Growth Differ 8 (5), 553-563 (1997)
   PUBMED   9149906
REFERENCE   10 (bases 1 to 1805)
  AUTHORS   Buck,V., Allen,K.E., Sorensen,T., Bybee,A., Hijmans,E.M.,
            Voorhoeve,P.M., Bernards,R. and La Thangue,N.B.
  TITLE     Molecular and functional characterisation of E2F-5, a new member of
            the E2F family
  JOURNAL   Oncogene 11 (1), 31-38 (1995)
   PUBMED   7542760
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140350.3.
            
            On Dec 21, 2021 this sequence version replaced NM_007892.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003220.1, AK156760.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-409               AC140350.3         52473-52881         c
            410-519             AC140350.3         44077-44186         c
            520-681             AC140350.3         43195-43356         c
            682-725             AC140350.3         30450-30493         c
            726-790             AC140350.3         28784-28848         c
            791-1058            AC140350.3         27591-27858         c
            1059-1103           AC140350.3         26327-26371         c
            1104-1805           AC140350.3         25187-25888         c
FEATURES             Location/Qualifiers
     source          1..1805
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 3.1 cM"
     gene            1..1805
                     /gene="E2f5"
                     /gene_synonym="E2F-5"
                     /note="E2F transcription factor 5"
                     /db_xref="GeneID:13559"
                     /db_xref="MGI:MGI:105091"
     exon            1..409
                     /gene="E2f5"
                     /gene_synonym="E2F-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1213
                     /gene="E2f5"
                     /gene_synonym="E2F-5"
                     /codon_start=1
                     /product="transcription factor E2F5"
                     /protein_id="NP_031918.2"
                     /db_xref="CCDS:CCDS38391.1"
                     /db_xref="GeneID:13559"
                     /db_xref="MGI:MGI:105091"
                     /translation="MAAAEPTSSAQPTPQAQAQPPPHGAPSSQPSAALAGGSSRHEKS
                     LGLLTTKFVSLLQEAQDGVLDLKAAADTLAVRQKRRIYDITNVLEGIDLIEKKSKNSI
                     QWKGVGAGCNTKEVIDRLRCLKAEIEDLELKERELDQQKLWLQQSIKNVMEDSINNRF
                     SYVTHEDICNCFHGDTLLAIQAPSGTQLEVPIPEMGQNGQKKYQINLKSHSGPIHVLL
                     INKESSSSKPVVFPVPPPDDLTQPSSQSSTSVTPQKSTMAAQNLPEQHVSERSQTFQQ
                     TPAAEVSSGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDVQILN
                     Y"
     exon            410..519
                     /gene="E2f5"
                     /gene_synonym="E2F-5"
                     /inference="alignment:Splign:2.1.0"
     exon            520..681
                     /gene="E2f5"
                     /gene_synonym="E2F-5"
                     /inference="alignment:Splign:2.1.0"
     exon            682..725
                     /gene="E2f5"
                     /gene_synonym="E2F-5"
                     /inference="alignment:Splign:2.1.0"
     exon            726..790
                     /gene="E2f5"
                     /gene_synonym="E2F-5"
                     /inference="alignment:Splign:2.1.0"
     exon            791..1058
                     /gene="E2f5"
                     /gene_synonym="E2F-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1103
                     /gene="E2f5"
                     /gene_synonym="E2F-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1805
                     /gene="E2f5"
                     /gene_synonym="E2F-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1778..1783
                     /regulatory_class="polyA_signal_sequence"
                     /gene="E2f5"
                     /gene_synonym="E2F-5"
                     /note="hexamer: AATAAA"
     polyA_site      1800
                     /gene="E2f5"
                     /gene_synonym="E2F-5"
                     /note="major polyA site"
ORIGIN      
        1 acttcctgcc atttaaactc gggcccaccc tcgcggcgct ggccgctcgt gtgaatccgc
       61 gcgctctgtg gtgccgtgcg cgagccgcgc ggctccgggg actggtggac gcggggcgcg
      121 ccgtgggcgg ggagcggagt ccgcgcacct cctctgccgg tggcggagcg gctcctcgcc
      181 agaggacagc agggccgcgg cggtgatggc ggcggcggag cccacgagct ctgctcagcc
      241 cacgccgcag gcccaggctc agccgccgcc gcatggggcg ccatcctcgc agccgtccgc
      301 ggcgctcgcg gggggcagca gccggcacga gaagagcctg ggcttgctta ccaccaaatt
      361 cgtgtcgttg ctgcaggagg cgcaggacgg cgtcctggat ctcaaagcgg ctgcagatac
      421 cttggctgtg aggcaaaagc gaagaattta tgatatcacc aatgtcttag agggaattga
      481 tctaattgaa aaaaaatcaa agaacagtat ccagtggaag ggtgtaggtg ctggctgtaa
      541 tactaaagaa gttatcgata gattaaggtg tcttaaagct gaaattgaag atctcgaatt
      601 gaaggaaaga gaacttgacc agcagaagtt gtggctacag caaagcatca aaaatgtgat
      661 ggaagactcc attaataaca gattttctta tgtaactcac gaagacatct gcaattgctt
      721 tcatggtgat acactgttgg ccattcaggc accttctggt acacagctgg aagtacctat
      781 tccagaaatg ggacagaatg gacaaaagaa ataccagata aatctgaaga gtcactcagg
      841 gcctatccat gtgctactta taaataaaga gtccagttca tctaagccag tggtttttcc
      901 tgttccccca cctgatgacc tcacacagcc ttcctcccag tcctcaactt cagtgactcc
      961 acagaaatcc accatggctg ctcaaaacct gcctgagcag catgtttccg aaagaagcca
     1021 gactttccag cagacaccag ctgcagaagt atcttcagga tctattagtg gagacatcat
     1081 tgatgaactg atgtcttctg atgtgtttcc tcttttacgg ctttctccta ccccagcaga
     1141 tgactacaac tttaatttag atgataatga aggagtttgt gatctgtttg atgttcagat
     1201 actaaattat tagattccat ggaaacttgg gactattatc tacctctata acattttaga
     1261 attctttaat aacctaagta tttaaaatta tgaatgtaac acctttttag ttcactgatt
     1321 ctgaagtgtt cttccctaac attttatttt ttacttcaca aaacttgaaa gggctctgcc
     1381 tgcttctggg gggtagaggt aatgattacc tgtccagcag ctgcccctcc agtgaccaca
     1441 ttcagtttct ttcagtagct tcctctcctg agagggcagt tacagcaggc tccagttcat
     1501 ccaaacaaaa cattgtccag aagatcactt atttgtctta tgttttgccg caaaattgtt
     1561 tctatgtatc cttcaaacag acattcactg ccatatataa agtgaaggat atcactgtta
     1621 agtgaacaga ttttgtgaag tgccttctgt tttagcactt taagcctatc agtttgttga
     1681 cttctgacat tccactttcc tagagtacag gaaagatctg tttatgtagt ttgattataa
     1741 aatgtgccaa tgcctgtaca ttaacaagat ttaaagaaat aaagttgtat gaaacattga
     1801 cttta
//
