LOCUS       NM_148952               2024 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus E2F transcription factor 4 (E2f4), mRNA.
ACCESSION   NM_148952
VERSION     NM_148952.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2024)
  AUTHORS   Tran,N.T., Graf,R., Acevedo-Ochoa,E., Trombke,J., Weber,T.,
            Sommermann,T., Salomon,C., Kuhn,R., Rajewsky,K. and Chu,V.T.
  TITLE     In vivo CRISPR/Cas9-mediated screen reveals a critical function of
            TFDP1 and E2F4 transcription factors in hematopoiesis
  JOURNAL   Leukemia 38 (9), 2003-2015 (2024)
   PUBMED   39043964
  REMARK    GeneRIF: In vivo CRISPR/Cas9-mediated screen reveals a critical
            function of TFDP1 and E2F4 transcription factors in hematopoiesis.
REFERENCE   2  (bases 1 to 2024)
  AUTHORS   Huang,S., Reed,C., Ilsley,M., Magor,G., Tallack,M., Landsberg,M.,
            Mitchell,H., Gillinder,K. and Perkins,A.
  TITLE     Mutations in linker-2 of KLF1 impair expression of membrane
            transporters and cytoskeletal proteins causing hemolysis
  JOURNAL   Nat Commun 15 (1), 7019 (2024)
   PUBMED   39147774
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2024)
  AUTHORS   Rousseau,V., Einig,E., Jin,C., Horn,J., Riebold,M., Poth,T.,
            Jarboui,M.A., Flentje,M. and Popov,N.
  TITLE     Trim33 masks a non-transcriptional function of E2f4 in replication
            fork progression
  JOURNAL   Nat Commun 14 (1), 5143 (2023)
   PUBMED   37612308
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2024)
  AUTHORS   Wang,Y., Liu,L., Song,Y., Yu,X. and Deng,H.
  TITLE     Unveiling E2F4, TEAD1 and AP-1 as regulatory transcription factors
            of the replicative senescence program by multi-omics analysis
  JOURNAL   Protein Cell 13 (10), 742-759 (2022)
   PUBMED   35023014
  REMARK    GeneRIF: Unveiling E2F4, TEAD1 and AP-1 as regulatory transcription
            factors of the replicative senescence program by multi-omics
            analysis.
REFERENCE   5  (bases 1 to 2024)
  AUTHORS   Lopez-Sanchez,N., Ramon-Landreau,M., Trujillo,C., Garrido-Garcia,A.
            and Frade,J.M.
  TITLE     A Mutant Variant of E2F4 Triggers Multifactorial Therapeutic
            Effects in 5xFAD Mice
  JOURNAL   Mol Neurobiol 59 (5), 3016-3039 (2022)
   PUBMED   35254651
  REMARK    GeneRIF: A Mutant Variant of E2F4 Triggers Multifactorial
            Therapeutic Effects in 5xFAD Mice.
REFERENCE   6  (bases 1 to 2024)
  AUTHORS   Dagnino,L., Fry,C.J., Bartley,S.M., Farnham,P., Gallie,B.L. and
            Phillips,R.A.
  TITLE     Expression patterns of the E2F family of transcription factors
            during mouse nervous system development
  JOURNAL   Mech Dev 66 (1-2), 13-25 (1997)
   PUBMED   9376316
REFERENCE   7  (bases 1 to 2024)
  AUTHORS   Lindeman,G.J., Gaubatz,S., Livingston,D.M. and Ginsberg,D.
  TITLE     The subcellular localization of E2F-4 is cell-cycle dependent
  JOURNAL   Proc Natl Acad Sci U S A 94 (10), 5095-5100 (1997)
   PUBMED   9144196
REFERENCE   8  (bases 1 to 2024)
  AUTHORS   Dagnino,L., Fry,C.J., Bartley,S.M., Farnham,P., Gallie,B.L. and
            Phillips,R.A.
  TITLE     Expression patterns of the E2F family of transcription factors
            during murine epithelial development
  JOURNAL   Cell Growth Differ 8 (5), 553-563 (1997)
   PUBMED   9149906
REFERENCE   9  (bases 1 to 2024)
  AUTHORS   Beijersbergen,R.L., Carlee,L., Kerkhoven,R.M. and Bernards,R.
  TITLE     Regulation of the retinoblastoma protein-related p107 by G1 cyclin
            complexes
  JOURNAL   Genes Dev 9 (11), 1340-1353 (1995)
   PUBMED   7797074
REFERENCE   10 (bases 1 to 2024)
  AUTHORS   Beijersbergen,R.L., Kerkhoven,R.M., Zhu,L., Carlee,L.,
            Voorhoeve,P.M. and Bernards,R.
  TITLE     E2F-4, a new member of the E2F gene family, has oncogenic activity
            and associates with p107 in vivo
  JOURNAL   Genes Dev 8 (22), 2680-2690 (1994)
   PUBMED   7958925
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC026649.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026649.1, AK145950.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2024
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..2024
                     /gene="E2f4"
                     /gene_synonym="2010111M04Rik"
                     /note="E2F transcription factor 4"
                     /db_xref="GeneID:104394"
                     /db_xref="MGI:MGI:103012"
     exon            1..213
                     /gene="E2f4"
                     /gene_synonym="2010111M04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1311
                     /gene="E2f4"
                     /gene_synonym="2010111M04Rik"
                     /note="E2F-4"
                     /codon_start=1
                     /product="transcription factor E2F4"
                     /protein_id="NP_683754.1"
                     /db_xref="CCDS:CCDS40456.1"
                     /db_xref="GeneID:104394"
                     /db_xref="MGI:MGI:103012"
                     /translation="MAEAGPQAPPPPGTPSRHEKSLGLLTTKFVSLLQEAKDGVLDLK
                     LAADTLAVRQKRRIYDITNVLEGIGLIEKKSKNSIQWKGVGPGCNTREIADKLIELKA
                     EIEELQQREQELDQHKVWVQQSIRNVTEDVQNSCLAYVTHEDICRCFAGDTLLAIRAP
                     SGTSLEVPIPEGLNGQKKYQIHLKSMSGPIEVLLVNKEAWSSPPVAVPVPPPDDLLQS
                     PPAVSTPPPLPKPALAQPQESSPPSSPQLTTPTPVLGSTQVSEVACQTSEIAVSGSPG
                     TENKDSGEVSSLPLGLTALDTRPLQSSALLDSSSSSSSSSSSSSSSSSGPNPSTSFEP
                     IKADPTGVLDLPKELSEIFDPTRECMSSELLEELMSSEVFAPLLRLSPPPGDHDYIYN
                     LDESEGVCDLFDVPVLKL"
     exon            214..323
                     /gene="E2f4"
                     /gene_synonym="2010111M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            324..485
                     /gene="E2f4"
                     /gene_synonym="2010111M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            486..529
                     /gene="E2f4"
                     /gene_synonym="2010111M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            530..591
                     /gene="E2f4"
                     /gene_synonym="2010111M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            592..889
                     /gene="E2f4"
                     /gene_synonym="2010111M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1102
                     /gene="E2f4"
                     /gene_synonym="2010111M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1150
                     /gene="E2f4"
                     /gene_synonym="2010111M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1195
                     /gene="E2f4"
                     /gene_synonym="2010111M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1993
                     /gene="E2f4"
                     /gene_synonym="2010111M04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1972..1977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="E2f4"
                     /gene_synonym="2010111M04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1993
                     /gene="E2f4"
                     /gene_synonym="2010111M04Rik"
                     /note="major polyA site"
ORIGIN      
        1 cgactaggaa cggaagcgga agtggcgccg ccgccggcct cgcctggcct ggctgagggg
       61 aggcggcggg cgggcgcgat ggcggaggcc gggccacagg cgccgccgcc cccggggact
      121 ccaagccggc acgagaagag tctgggactt ctcaccacca agttcgtgtc gctcttgcag
      181 gaagccaagg acggcgtgct tgacctcaag ctggcagccg acactcttgc tgtgcgccag
      241 aaacggcgga tctacgacat caccaacgtg ctggaaggca tcggtctgat cgagaagaaa
      301 tccaagaaca gcatccagtg gaagggcgtc gggccaggtt gcaatacccg ggagatcgct
      361 gacaagctga ttgagctcaa ggcagagatc gaggagctgc agcaacgaga gcaagaactg
      421 gaccagcaca aggtgtgggt gcagcagagc atccggaatg tcactgagga cgtccagaac
      481 agctgcttgg cctacgtgac tcatgaagac atctgcagat gctttgctgg agataccctc
      541 cttgccatcc gggcgccatc gggcaccagt ctagaggtgc ccatcccaga gggtctcaat
      601 ggccagaaga agtaccagat tcacttaaag agcatgagtg ggcctatcga ggtgctgcta
      661 gtgaacaagg aggcctggag ttcaccacct gtggctgtgc ctgtccctcc ccctgacgat
      721 ctactccaga gtccacctgc tgtttctaca cctccacctc tgcccaagcc tgccttagct
      781 caaccccaag aatcctctcc tccaagcagc ccccagctaa ctacccccac tcctgtcctt
      841 ggcagcactc aagtctcaga ggtggcatgc cagacatctg agattgcagt gagtggtagc
      901 cctggaactg agaacaagga cagtggtgaa gtcagctcac tcccactggg cctgacagca
      961 ctggacactc ggcctctgca gtcctctgca ctgctggata gtagtagcag cagcagcagc
     1021 agcagcagta gcagcagcag cagttcatct ggacccaacc cttctacctc ctttgagccc
     1081 atcaaagcag accccacagg cgttctggat ctccccaaag agctgtcaga aatcttcgac
     1141 cccacgagag agtgcatgag ctccgagctg ctggaagaac tgatgtcttc agaagtgttt
     1201 gcccccctcc tccgactttc tccacctccc ggagaccacg attacatcta caacctggac
     1261 gagagtgaag gtgtctgtga tctctttgat gttcctgttc tcaaactctg actgacaggg
     1321 acatgtcctg tgcagctgca acccagactg tctgggcctg gagccaacta gggactgccc
     1381 cccaccccca ccctaacccc aagagcccaa ctcttggctt actcagcctt ttctggtcgc
     1441 tcagttcggg ctgtgctctc ctgtcttgca ctggcacttg tgactgtgct agcatagctg
     1501 ggcagagagc ttagccctct ctacatggag ccttccccag ccaggctcag ctgcccctca
     1561 gtggcacctc tgccttgttc ctaccagtca ctatgaagga ggttcagaga gagggtggtg
     1621 ctgggtggtt gcctaccatc acctttcctt tcccacctgc tcaccctgca gcctctggac
     1681 atctcggatg ctccctgaga gtcctgggat ctctgggcag tcatggtgga gggggttaat
     1741 aaggaattgc tgtgtctagc taggagtctg ggagggttgg tacctaagaa tggctccagc
     1801 tcctgcccac ccacccccat ctcccttcac ttccacttat tcacttaccc tcatttagag
     1861 ccattgcaga gatttagaaa gatttacagt aacgaatgaa ttcctatata aagattattt
     1921 ttatactttt ttcaacaaaa ggaaatgtaa tatttgtaca gcattcaagt gaataaagac
     1981 atgcctaagg ctaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
