LOCUS       NM_010093               5106 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus E2F transcription factor 3 (E2f3), transcript variant
            1, mRNA.
ACCESSION   NM_010093 XM_127250 XM_891633 XM_909434 XM_921317
VERSION     NM_010093.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5106)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5106)
  AUTHORS   Fong,B.C., Chakroun,I., Iqbal,M.A., Paul,S., Bastasic,J.,
            O'Neil,D., Yakubovich,E., Bejjani,A.T., Ahmadi,N., Carter,A.,
            Clark,A., Leone,G., Park,D.S., Ghanem,N., Vandenbosch,R. and
            Slack,R.S.
  TITLE     The Rb/E2F axis is a key regulator of the molecular signatures
            instructing the quiescent and activated adult neural stem cell
            state
  JOURNAL   Cell Rep 41 (5), 111578 (2022)
   PUBMED   36323247
REFERENCE   3  (bases 1 to 5106)
  AUTHORS   Yang,X., Li,G., Tian,Y., Wang,X., Xu,J., Liu,R., Deng,M., Shao,C.,
            Pan,Y., Wu,X., Li,M., Zhang,C., Liu,R., Qin,J., Zhang,C., Liu,Z.,
            Wu,X., Plikus,M.V., Lengner,C.J., Zheng,Z., Lv,C. and Yu,Z.
  TITLE     Identifying the E2F3-MEX3A-KLF4 signaling axis that sustains cancer
            cells in undifferentiated and proliferative state
  JOURNAL   Theranostics 12 (16), 6865-6882 (2022)
   PUBMED   36276637
  REMARK    GeneRIF: Identifying the E2F3-MEX3A-KLF4 signaling axis that
            sustains cancer cells in undifferentiated and proliferative state.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5106)
  AUTHORS   Liu,Z., Mo,H., Liu,R., Niu,Y., Chen,T., Xu,Q., Tu,K. and Yang,N.
  TITLE     Matrix stiffness modulates hepatic stellate cell activation into
            tumor-promoting myofibroblasts via E2F3-dependent signaling and
            regulates malignant progression
  JOURNAL   Cell Death Dis 12 (12), 1134 (2021)
   PUBMED   34873170
  REMARK    GeneRIF: Matrix stiffness modulates hepatic stellate cell
            activation into tumor-promoting myofibroblasts via E2F3-dependent
            signaling and regulates malignant progression.
            Erratum:[Cell Death Dis. 2022 Jan 28;13(1):91. doi:
            10.1038/s41419-022-04528-y.. PMID: 35091557]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5106)
  AUTHORS   Akagawa,R., Nabeshima,Y.I. and Kawauchi,T.
  TITLE     Alternative Functions of Cell Cycle-Related and DNA Repair Proteins
            in Post-mitotic Neurons
  JOURNAL   Front Cell Dev Biol 9, 753175 (2021)
   PUBMED   34746147
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5106)
  AUTHORS   Dyson,N.
  TITLE     The regulation of E2F by pRB-family proteins
  JOURNAL   Genes Dev 12 (15), 2245-2262 (1998)
   PUBMED   9694791
  REMARK    Review article
REFERENCE   7  (bases 1 to 5106)
  AUTHORS   Bernards,R.
  TITLE     E2F: a nodal point in cell cycle regulation
  JOURNAL   Biochim Biophys Acta 1333 (3), M33-M40 (1997)
   PUBMED   9426200
  REMARK    Review article
REFERENCE   8  (bases 1 to 5106)
  AUTHORS   Dagnino,L., Fry,C.J., Bartley,S.M., Farnham,P., Gallie,B.L. and
            Phillips,R.A.
  TITLE     Expression patterns of the E2F family of transcription factors
            during mouse nervous system development
  JOURNAL   Mech Dev 66 (1-2), 13-25 (1997)
   PUBMED   9376316
REFERENCE   9  (bases 1 to 5106)
  AUTHORS   Dagnino,L., Fry,C.J., Bartley,S.M., Farnham,P., Gallie,B.L. and
            Phillips,R.A.
  TITLE     Expression patterns of the E2F family of transcription factors
            during murine epithelial development
  JOURNAL   Cell Growth Differ 8 (5), 553-563 (1997)
   PUBMED   9149906
REFERENCE   10 (bases 1 to 5106)
  AUTHORS   Karlseder,J., Rotheneder,H. and Wintersberger,E.
  TITLE     Interaction of Sp1 with the growth- and cell cycle-regulated
            transcription factor E2F
  JOURNAL   Mol Cell Biol 16 (4), 1659-1667 (1996)
   PUBMED   8657141
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133828.1, BC059262.1 and AV509156.1.
            
            On Jan 11, 2008 this sequence version replaced NM_010093.2.
            
            Transcript Variant: This variant (1, also known as E2f3a)
            represents the longer transcript and encodes the longer isoform
            (E2f3a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133828.1, AF015948.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1840              AK133828.1         3-1842
            1841-5092           BC059262.1         1240-4491
            5093-5106           AV509156.1         279-292
FEATURES             Location/Qualifiers
     source          1..5106
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 13.09 cM"
     gene            1..5106
                     /gene="E2f3"
                     /gene_synonym="E2f3a; E2F3b"
                     /note="E2F transcription factor 3"
                     /db_xref="GeneID:13557"
                     /db_xref="MGI:MGI:1096340"
     exon            1..764
                     /gene="E2f3"
                     /gene_synonym="E2f3a; E2F3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             396..1769
                     /gene="E2f3"
                     /gene_synonym="E2f3a; E2F3b"
                     /note="isoform E2f3a is encoded by transcript variant 1;
                     transcription factor E2F3"
                     /codon_start=1
                     /product="transcription factor E2F3 isoform E2f3a"
                     /protein_id="NP_034223.1"
                     /db_xref="CCDS:CCDS26413.1"
                     /db_xref="GeneID:13557"
                     /db_xref="MGI:MGI:1096340"
                     /translation="MRKGIQPALEQYLVTAGGGEGAAVVAAAAAASMDKRALLASPGF
                     AAAAAPGTYIQILTTNPSTTSCATSLQSGALTAGPLLPSVPGTEPAASSLYTTPQGPS
                     SRVGLLQQPPAPGRGGGGGPPAKRRLELGESGHQYLSDGLKTPKGKGRAALRSPDSPK
                     TPKSPSEKTRYDTSLGLLTKKFIQLLSQSPDGVLDLNKAAEVLKVQKRRIYDITNVLE
                     GIHLIKKKSKNNVQWMGCSLSEDGGMLAQCQGLSKEVTELSQEEKKLDELIQSCTLDL
                     KLLTEDSENQRLAYVTYQDIRKISGLKDQTVIVVKAPPETRLEVPDSIESLQIHLAST
                     QGPIEVYLCPEETETHRPMKTNNQDHNGNIPKPTSKDLASNNSGHSDCSVSTANLSPL
                     ASPANLLQQTEDQIPSNLEGPFVNLLPPLLQEDYLLSLGEEEGISDLFDAYDLEKLPL
                     VEDFMCS"
     exon            765..876
                     /gene="E2f3"
                     /gene_synonym="E2f3a; E2F3b"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1096
                     /gene="E2f3"
                     /gene_synonym="E2f3a; E2F3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1255
                     /gene="E2f3"
                     /gene_synonym="E2f3a; E2F3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1370
                     /gene="E2f3"
                     /gene_synonym="E2f3a; E2F3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1506
                     /gene="E2f3"
                     /gene_synonym="E2f3a; E2F3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..5097
                     /gene="E2f3"
                     /gene_synonym="E2f3a; E2F3b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5071..5076
                     /regulatory_class="polyA_signal_sequence"
                     /gene="E2f3"
                     /gene_synonym="E2f3a; E2F3b"
                     /note="hexamer: AATAAA"
     polyA_site      5097
                     /gene="E2f3"
                     /gene_synonym="E2f3a; E2F3b"
                     /note="major polyA site"
ORIGIN      
        1 gagtttcgcg ggaggacctt ggcgcgtaaa ccgtatccct tcattcattg tcagcagcag
       61 cttcctggag ccatttttca gctgccggcc gcagcacccg ggctgccgcc accgcctcgc
      121 aatccgttgc atcggctgcc cccgacgcct ccatccctcc tcggggcctg atatccgtgc
      181 ggccgggacc ctcctctctc cagacccccg attatttttg gcccccgggg cctgtgcggt
      241 gcggaaaaat aaaaagaaaa gagagagaga gggttcggaa gcgccgggag gggaggcgag
      301 aaggagagac ttggaaactc cggctgcaaa taataaaaga aattgaaagc aatacgttaa
      361 tatatcgtaa cactaaaaaa gagcaggagc gagagatgag aaaggggatc cagcccgccc
      421 tggagcagta cctggtgacc gccgggggtg gggagggggc ggctgtcgtc gccgccgccg
      481 ctgcagcctc catggacaaa agggcactgc tagccagccc cggcttcgcc gccgccgccg
      541 ccccgggcac gtacatccag atcctcacta cgaacccttc caccacgtcc tgtgccacct
      601 ccctccaaag tggcgccctg accgccggcc cccttctccc cagtgtcccc ggcacggagc
      661 cggccgccag cagcctctac accacgccac aaggaccctc cagcagagtc gggctgctgc
      721 agcagccacc agcaccagga cgcggcggcg gcggtggccc accggcaaag cgaaggctgg
      781 aactgggcga gagtggccat cagtacctct cagatggtct aaagaccccc aagggcaaag
      841 gaagagctgc actacggagt cccgatagtc caaaaactcc aaaatctccc tcagaaaaaa
      901 cgcggtatga tacgtccctc ggtctgctca ccaagaagtt cattcagctc ctgagccagt
      961 ctcctgatgg ggtcctggat ctgaacaagg cagcagaggt gctcaaggtg cagaagagga
     1021 ggatttacga catcaccaac gtgctggaag gcatccacct cattaagaag aagtctaaga
     1081 acaacgtcca gtggatgggc tgcagtctgt ctgaggatgg gggcatgctg gcccagtgtc
     1141 aaggcctgtc caaagaagtg actgagctca gtcaggaaga gaagaaatta gatgagctga
     1201 tccaaagctg taccctggac ctcaaactgt taaccgagga ttcagagaat caaaggttag
     1261 cttatgttac atatcaagat attcgaaaaa ttagtggcct taaagaccaa actgttatag
     1321 ttgtgaaagc ccctccagaa acgagacttg aagtgcctga ctcaatagag agcctacaaa
     1381 tccatttggc aagtacccaa gggcccattg aggtttactt gtgtccagaa gagacggaaa
     1441 cacacagacc catgaaaaca aataaccaag accacaatgg gaatatcccc aagcccactt
     1501 ccaaagactt ggcttctaac aactcaggac atagtgactg ctcggtttct acagcaaacc
     1561 tctctcctct ggcctcccca gccaaccttt tacagcagac tgaggaccaa atcccgtcca
     1621 accttgaagg accttttgtg aacttactgc ctcccctgct ccaagaggac tacctgctga
     1681 gcctggggga ggaagagggc atcagtgacc tcttcgatgc ctatgatttg gaaaagctgc
     1741 ctctggtgga ggacttcatg tgtagttgat tgggctttgt acaaactgtc cttataaacc
     1801 aatatttttt tatcacggaa tcagaaacgt gtatcgcagt gttgtccctt cctaccttct
     1861 tcctccaaga gtatcatgaa gtaaacttca gaacaaagct gacattttga tgaattaatt
     1921 ttttttttct aagcgcacag ttgcaggctc ccttgggaaa gccctgcctg gtcccaggct
     1981 cccaaatctt cctgatgagt cagcaagtga gaagatgtgc aatcaggtgt ctctcacctg
     2041 tccttccctc ccctccttcc tctcctttcc ttgcggactg gcttgctgtg cctaacggat
     2101 gggctgttga ctgggtccgg ccgcctggcc cgttggaaac agcgccctcc cttaacagca
     2161 gttcaagccg tgccttctct tgcagaatgc atgtctttgt gagtctgcta ccacggaatg
     2221 gaattctgcc acaaatgcaa gcttgaagtc atgcaaagga atgacacgga tttctccagc
     2281 tcttaggaat atttaaatta ctctcataat tcagtgtaag ctatgggccg ctagtgtccc
     2341 actaggaggc ggcaagagcc tccacagcct ttttggatga agaacttgtt tgcaagtact
     2401 cgttgcagat acagagactg gtagagttct gctgctcgaa gctgttgtgg atttccctgt
     2461 ctccataccc cacttccact gcccccatcc tgcgtatttg tgagttttcc cggttgatta
     2521 cttgtgactt aggagttcct tgtgggttgt tttagaagtt tttatttttc tagctgccat
     2581 tgaagcattc ctgtggcgcc catcactatt tcaattgaat tgtttacctt aaagcgagtt
     2641 ttgcaaattc ttattccttt agcagaggga gagcacctct actgataaaa agcatctaac
     2701 cccgtgtgac ctaaggtcca ccaaccagcc tctgcgagaa gcatcctctg tcttgcctcc
     2761 tttcccagga ggggagcttg gagcgagaac agctccgggg cttgctgact cgagtggtcc
     2821 acagtgagga cctcgggcca gatacagctg tcccgtggag cagcaggcat ggatcccctc
     2881 catccttggg cttcccgggc ccctgcgacc ggggaaaggg ctctaatgcc acactcaggg
     2941 agaccacttc tcaggatgcg gtcaggtgga gaggccctag ggagaaagac atcccatggt
     3001 gtgagtggca ttctatcagg gacacttccc taagtaggag cgaggagctc ccactgtgtc
     3061 tgggggttgg actagttcta gccagaaccc attctccgaa tccactgtga gtgggtgagt
     3121 ttggactaag ggaggtcagg agacgggaaa tgcactgata gaatgccagg gcgactccct
     3181 tgttactcct caggaatggt gtcccaaact ggaggctttg tgtcagcaag gacccttcca
     3241 gttaacttcc aagaatagcg ttcccactgg caggtggcaa gggccatctt gtcctggtgt
     3301 tgaatatggc atagtacctc aaatccattc cttggatgct aagggctgcg gaaatgagtt
     3361 agtcacgaaa actaacctcc agctgagcag tttgaaacac tacgtgcctg gccttcccgg
     3421 gaggcacgta gtaggcactc aactcataca cgtttgatcg agttgaaaat atcccttggg
     3481 aaaacctttt actgaaacca caagaaccct ggccagttta ctctagatag atttccacaa
     3541 tatgcaaagt ggtggtggtg gggggagggt ggagacagaa gacaccggca ctttaaactc
     3601 tgtgtgtggg tatgcgtggt gtatgtttgg gaagaaaaaa caaaggtgca gactatcttc
     3661 ctctctcttc agcctccagc cccggcctcc tcccctcaca cactctggac ttggtaccga
     3721 ataatcccgt gtggtcctag ctgaagcact ggggtggagg agggaggggg agcttcgtgt
     3781 taagtgccta ctggaaatgc actgtggggt tttttcctgt atgggaaacc gtttatgcca
     3841 agctttcccc caatgcccta tatttatctc atctggttag ctgcctctgc ttctggcttt
     3901 gtgtaattct ctttgccagc tgcatcgagc tgggtttctg tccccaaagt ctaatgacta
     3961 aactcacctg gctctaggtt gttgtgtgtt tggttgactt ttcttgttga aactattcgt
     4021 attgtgatgc cgtatttatt gttttaagaa acgaaaagga atactaataa gtcttcaagc
     4081 gttctctcaa tgcataataa gactttctcc agttaagggg cttaactggc gtacacagtg
     4141 tgagacatcc atgctctatt ctgtttgcat tttaggcatt ttctttgctc gtagtatctg
     4201 gcacacaaag tagatgagta ctacagtatt tttgttactt taagtcctga gatgcaggtt
     4261 ccctggtacc attgagttgc tgctactaaa agctcacatg cggaatggct gaaagttaca
     4321 catgtgcgaa tgaagacggc gtgagcctca gaactaaaac tgtataaagg gcaacacatg
     4381 agctgtcaaa cagtgttagg cgtgtgtttg tgtacatagc cgttttattt aagtcgatac
     4441 agtccgctca cattgccatt atttaccagg tttgtacaga gatagcaatt catttgtaaa
     4501 cactgccaga atattttcta gctggtttgt aattttttta agaccgtcgc cttgggtttt
     4561 tgtgttttgt ttctgttgtt ttcgcctgtg actctcgttt gccttttttt ttttctgtcg
     4621 tacatgtagc tctgtctgta aatagaatcg cagtatttaa agctttagct ttcaggaaaa
     4681 acgaagtaag aatccaagcg tgtgcatgac aggttgtgtg tgtgagaagg gatctgagga
     4741 agatgccttg cggaggaggc tgggtgacag ttggcagggt gtgggaatgt ctttcctacg
     4801 gggtgcaggc ttttgtaaaa aaggaagtgt ttctcccaac actgggagta ggcaaactac
     4861 taatcagttt agctttgtgt tgtatgctag tttgaaataa ataaataaat aaataaataa
     4921 tgtaatataa tgtaaaaata gacaaacaaa caaacaaaag cttttatgat ggattttgta
     4981 aatagatttg ttacagggtg acctgttcca gctgtgatct taccacttca aatggatgta
     5041 atttgaataa attttgtatg gtaaagggtc aataaaatga ttttttttaa gagttcaaaa
     5101 aaaaaa
//
