LOCUS       NM_177733               4866 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus E2F transcription factor 2 (E2f2), transcript variant
            1, mRNA.
ACCESSION   NM_177733
VERSION     NM_177733.7
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4866)
  AUTHORS   Pang,Y., Ruan,X., Liu,W., Hou,L., Yin,B., Shu,P. and Peng,X.
  TITLE     MicroRNA-495 Modulates Neuronal Layer Fate Determination by
            Targeting Tcf4
  JOURNAL   Int J Biol Sci 20 (15), 6207-6221 (2024)
   PUBMED   39664574
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4866)
  AUTHORS   Huang,S., Reed,C., Ilsley,M., Magor,G., Tallack,M., Landsberg,M.,
            Mitchell,H., Gillinder,K. and Perkins,A.
  TITLE     Mutations in linker-2 of KLF1 impair expression of membrane
            transporters and cytoskeletal proteins causing hemolysis
  JOURNAL   Nat Commun 15 (1), 7019 (2024)
   PUBMED   39147774
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4866)
  AUTHORS   El-Mayet,F.S. and Jones,C.
  TITLE     A cell cycle regulator, E2F2, and glucocorticoid receptor
            cooperatively transactivate the bovine alphaherpesvirus 1 immediate
            early transcription unit 1 promoter
  JOURNAL   J Virol 98 (6), e0042324 (2024)
   PUBMED   38771044
  REMARK    GeneRIF: A cell cycle regulator, E2F2, and glucocorticoid receptor
            cooperatively transactivate the bovine alphaherpesvirus 1 immediate
            early transcription unit 1 promoter.
REFERENCE   4  (bases 1 to 4866)
  AUTHORS   Hua,R., Chu,Q., Guo,F., Chen,Q., Li,M., Zhou,X. and Zhu,Y.
  TITLE     DNM3OS Enhances the Apoptosis and Senescence of Spermatogonia
            Associated with Nonobstructive Azoospermia by Providing miR-214-5p
            and Decreasing E2F2 Expression
  JOURNAL   Anal Cell Pathol (Amst) 2023, 1477658 (2023)
   PUBMED   38152068
  REMARK    GeneRIF: DNM3OS Enhances the Apoptosis and Senescence of
            Spermatogonia Associated with Nonobstructive Azoospermia by
            Providing miR-214-5p and Decreasing E2F2 Expression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4866)
  AUTHORS   Zheng,W., Zhao,S., He,H., Gu,X., Long,G., Chen,X., Liang,G. and
            Li,S.
  TITLE     E2F2 is upregulated by the ERK pathway and regulates
            decidualization via MCM4
  JOURNAL   Gene 871, 147400 (2023)
   PUBMED   37028609
  REMARK    GeneRIF: E2F2 is upregulated by the ERK pathway and regulates
            decidualization via MCM4.
REFERENCE   6  (bases 1 to 4866)
  AUTHORS   Dyson,N.
  TITLE     The regulation of E2F by pRB-family proteins
  JOURNAL   Genes Dev 12 (15), 2245-2262 (1998)
   PUBMED   9694791
  REMARK    Review article
REFERENCE   7  (bases 1 to 4866)
  AUTHORS   Bernards,R.
  TITLE     E2F: a nodal point in cell cycle regulation
  JOURNAL   Biochim Biophys Acta 1333 (3), M33-M40 (1997)
   PUBMED   9426200
  REMARK    Review article
REFERENCE   8  (bases 1 to 4866)
  AUTHORS   Dagnino,L., Fry,C.J., Bartley,S.M., Farnham,P., Gallie,B.L. and
            Phillips,R.A.
  TITLE     Expression patterns of the E2F family of transcription factors
            during mouse nervous system development
  JOURNAL   Mech Dev 66 (1-2), 13-25 (1997)
   PUBMED   9376316
REFERENCE   9  (bases 1 to 4866)
  AUTHORS   Dagnino,L., Fry,C.J., Bartley,S.M., Farnham,P., Gallie,B.L. and
            Phillips,R.A.
  TITLE     Expression patterns of the E2F family of transcription factors
            during murine epithelial development
  JOURNAL   Cell Growth Differ 8 (5), 553-563 (1997)
   PUBMED   9149906
REFERENCE   10 (bases 1 to 4866)
  AUTHORS   Karlseder,J., Rotheneder,H. and Wintersberger,E.
  TITLE     Interaction of Sp1 with the growth- and cell cycle-regulated
            transcription factor E2F
  JOURNAL   Mol Cell Biol 16 (4), 1659-1667 (1996)
   PUBMED   8657141
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ142800.1, CJ141952.1, AK087452.1, BC062101.1, AK033797.1,
            AL935264.12, AV381209.2 and AI553619.1.
            
            On Mar 10, 2015 this sequence version replaced NM_177733.6.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK087452.1, BC062101.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                CJ142800.1         2-48
            48-120              CJ141952.1         37-109
            121-3407            AK087452.1         2-3288
            3408-3530           BC062101.1         2996-3118
            3531-4479           AK033797.1         123-1071
            4480-4480           AL935264.12        89719-89719
            4481-4603           AV381209.2         300-422
            4604-4856           AK033797.1         1196-1448
            4857-4866           AI553619.1         1-10                c
FEATURES             Location/Qualifiers
     source          1..4866
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 68.34 cM"
     gene            1..4866
                     /gene="E2f2"
                     /gene_synonym="E2F-2"
                     /note="E2F transcription factor 2"
                     /db_xref="GeneID:242705"
                     /db_xref="MGI:MGI:1096341"
     exon            1..765
                     /gene="E2f2"
                     /gene_synonym="E2F-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             508..1839
                     /gene="E2f2"
                     /gene_synonym="E2F-2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor E2F2"
                     /codon_start=1
                     /product="transcription factor E2F2 isoform 1"
                     /protein_id="NP_808401.1"
                     /db_xref="CCDS:CCDS18801.1"
                     /db_xref="GeneID:242705"
                     /db_xref="MGI:MGI:1096341"
                     /translation="MLRAPRTLAPATAQPTKSLPALNPTELWPSGLSSPQLCPATTAT
                     TYYTSLYTQTVPSSVALGTCLDATPHGPEGQIVRCAPAGRLPAKRKLDLEGIGRPTVP
                     EFRTPKGKCIRVDGLPSPKTPKSPGEKTRYDTSLGLLTKKFIYLLSESEDGVLDLNWA
                     AEVLDVQKRRIYDITNVLEGIQLIRKKSKNNIQWVGRELFEDPTRPSRQQQLGQELKE
                     LMNAEQTLDQLIQSCSLSFKHLTEDNANKKLAYVTYQDIRAVGNFKEQTVIAVKAPPQ
                     TRLEVPDRAEENLQIYLKSTQGPIEVYLCPEEGQEPDSPAKEALPSTSALSPIPDCAQ
                     PGCSTDSGIAETIEPSVLIPQPIPPPPPPPLPPAPSLVPLEATDNMLELSHPLLQQTE
                     DQFLSPILAANSPLISFSPPLDQDEYLWGMDEGEGISDLFDSYDLGDLLIN"
     exon            766..871
                     /gene="E2f2"
                     /gene_synonym="E2F-2"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1091
                     /gene="E2f2"
                     /gene_synonym="E2F-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1250
                     /gene="E2f2"
                     /gene_synonym="E2F-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1365
                     /gene="E2f2"
                     /gene_synonym="E2F-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1558
                     /gene="E2f2"
                     /gene_synonym="E2F-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..4859
                     /gene="E2f2"
                     /gene_synonym="E2F-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4835..4840
                     /regulatory_class="polyA_signal_sequence"
                     /gene="E2f2"
                     /gene_synonym="E2F-2"
                     /note="hexamer: ATTAAA"
     regulatory      4839..4844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="E2f2"
                     /gene_synonym="E2F-2"
                     /note="hexamer: AATAAT"
     polyA_site      4855
                     /gene="E2f2"
                     /gene_synonym="E2F-2"
                     /note="major polyA site"
     polyA_site      4859
                     /gene="E2f2"
                     /gene_synonym="E2F-2"
                     /note="major polyA site"
ORIGIN      
        1 ggcattttcc gcgggagatc cgaatttggc ggcatatagt ttggcgctaa aaaaaaaaaa
       61 aaagaaaaaa aaaagaaaaa gaaagaaaaa agaagaaaga aaagaaaaag gagtccaagc
      121 aagggacggg aactagaggg gtgaacgcag agctcagcag ggcgcacagg acacccttcg
      181 cgggtcagag cacacgagtg tccgcggggt ccgtgggcat tccgggacgc tttcacgcac
      241 gggcgcgact ccggacgccc agatattcgg ggcacgagcc ggaccgggcc aactcctggc
      301 agtgccacct gtgccacgcg atctccgagt ggcgatctcc gagctcggca gcgctgggcg
      361 gcgggccagg aggggagggt ccggccttgc ccggcgggcg tccattggcg gctgctcccg
      421 gcgtccgcgg tgcagccggc tgcaaagccc gcaggtgccc cgcgcgcgcg cgccagaccc
      481 gagtgggtag ggggcgccgc actcgccatg ctgcgcgcgc cgcggaccct ggctccggcc
      541 acggcgcaac ctacaaagag cttgccggcg ctgaacccca ccgagctgtg gccttcgggt
      601 ctgagcagcc cccagctctg cccggccacc accgccacca cctactacac ttcgctttac
      661 acgcagacgg tgccttcctc tgtggcgctg ggcacctgcc tcgacgccac tccccacgga
      721 cccgagggcc aaattgtgcg atgtgcaccc gcaggccggc tgccggccaa aaggaagttg
      781 gacctggagg gcattgggag gcctacggtc cctgaattcc ggacccccaa ggggaagtgc
      841 atccgcgtgg atggtttgcc aagccccaaa acccccaagt ctcctgggga gaagacacgc
      901 tatgacacgt cgctggggct cctgaccaag aagttcattt acctcctgag cgagtcggag
      961 gatggagtcc tggacctgaa ctgggcagcc gaggtgctgg atgtgcaaaa gcggcgcatc
     1021 tatgacatca ccaacgtgct ggagggtatc cagctcatcc gcaagaagtc caaaaacaac
     1081 atccagtggg taggcaggga actatttgaa gaccccaccc gaccctccag gcagcagcag
     1141 ttggggcagg agctgaagga gctgatgaat gccgagcaga ccttggacca gctcattcag
     1201 agttgctccc tgagcttcaa gcacctgacc gaagataatg ccaacaagaa actggcctat
     1261 gtgacctacc aggatatccg tgccgtaggc aacttcaagg agcagacagt gattgcggtc
     1321 aaggccccac cacagacaag attggaagtg ccggacaggg ccgaggagaa cctgcagatt
     1381 tatctaaaga gtacccaagg ccccattgaa gtctacctgt gcccagagga ggggcaggag
     1441 ccagacagtc ctgccaagga ggcgctcccc tccacctctg ccctcagccc cattcctgac
     1501 tgcgctcagc cgggctgcag cactgactct gggatcgcag agaccataga gccttcagta
     1561 ctgatacccc agccgatacc accgcctcct ccaccaccac tgccgccagc cccatccctc
     1621 gtccccttgg aagccactga caacatgctg gagctgtcac accctcttct acaacagact
     1681 gaggaccagt tcctgtcccc aatcctggcg gccaactccc ccctgatcag cttctccccg
     1741 cccttggacc aggacgaata cctgtggggc atggacgagg gggaaggcat cagtgacctc
     1801 ttcgactcct atgaccttgg ggacctgttg attaattgaa gcgtcctgca tctgtctacc
     1861 tcctcacaga cagattgaca ggctctctgc ccagatgggg gacaccagac accaggtgtc
     1921 accctccgtc tgcgcggctc tcttccagcc ttccttaggg cggaggccag ctagggagat
     1981 gtggaggatt cggctgggga gtgatatcag ggctaagccc tgaccctcct cttctgacct
     2041 ccgacccctt catgaaggac tacgggtgca ggtggccatg ttcagggaaa gggctcactg
     2101 cctccttctg aggggcaggg ggaccctgac tttttcaaga agcacttaac gcctttgtat
     2161 ttatttctag ttcagatgtg tttgtttgtc caccctgagt tttagcaggg agatttgttc
     2221 tagtttctcc tcagacaggc ccacccacgc ccagtgccta agcgcacatc tgggcttcca
     2281 ggggtctagg ccagctcctt gccccccgtc cccccgtccc cccagtggtg cctgggtctt
     2341 gaggggacta tccagtttgc ttgaattaat tgcacttagg ctttgtaatt ttagaaaatg
     2401 ccaggcccag ccaaggcacc ggcttggaat tctccatctc ctccatccta gagaaagttc
     2461 cagtagctac tctgggggag gtagccaagg gggctggctt cctattggat gtcttatctt
     2521 tcctgagcct cccaatgtaa atgtaggcct tcaggaatta gcccagaaga gctcctggga
     2581 aaagcaggag gccacgcccg tgcctcctag atgcccttcc tcaggaggtc agagacctgg
     2641 aaggtggagg cagagaggag tgagaagaaa acaagaaaca ccctggggtc tgcccatgtt
     2701 tccctgggag gattattttt gtttcttggt tgcagttgga gggggaagat tccttaaaca
     2761 cccactgtcc caaagccctc acttcacttc caaggtcaga tgtgacagga gcttggtgac
     2821 aggtttgcac ctttccccac tggagtgctt cgggggtgag ggggcagggg tggggtgctc
     2881 ttccctgcag actaggcctc agcagctcat gacgggatag gctggcgcct gccacctctc
     2941 ctggcatggg gatctgggaa gagctcttgg tctctcttgt tctgcccata gactgaccat
     3001 ccagggttcc tgtggtcagg agacggcaag agtccgcttt tcttcctcgc ctttccaggc
     3061 atggagaatg ggcttaacca aggccacgtg tccagagagg tgtacccagg ggtgacgggg
     3121 tctgagaggc cttccaccta ccctcaggga gcctgggttt ctcaggggct cagtggggca
     3181 gcactttttg cttgttgttg ttttaagttt gtagcattaa attgatttaa aagatgaagt
     3241 tggctatgcc aggtaggtcc gagctagctg actgggaatt tgaagtttgg atgttgagct
     3301 aatatgtact ggtgcccatt tgggttaatt tgtcttatcc tcgagtcagc ttcctggtgc
     3361 cacaaactta gtcctgtccg aggagtggtc agcgactcac ccccccccac acacacttga
     3421 aatttgtcta tttttacacc gagtgtccaa ccttttgaca tatgtgacct cgtcgtctct
     3481 aaagttcacc ctcaggaact gcatagataa gctaccaaaa aaaaaaaaaa tctcatgatg
     3541 tttgaagtac gtttacaact ctgtgttggg ctgtgttcgt aggtgtctgc gacccgtgct
     3601 gcaggttaga tacacctgct gcagagatgt ccttggtctc taccaagcga ggggggtttc
     3661 tcagaccacc cagaaagccc agtgtgctct agacacaggg ggtcccttga gtgatgaggg
     3721 tgctacctga gatctggttt gatgcacatg aggccggaga cagcattgct gtttcctggt
     3781 ctttgccgtt tagctgtgcg ccaacagaga tatctgacct ctgtgccttg ggctctgggt
     3841 ggaggagagc ttggcttagc gagaagaggg ctgccattcc tgtctggtgt gaggttaaga
     3901 atacagtcca gattcaagtt cagtcaaaag acccagcgca gggatggatg gaggcttccc
     3961 cagtcttttt gatctctgag ctctttctta tcaaccctgc ctggtccagg ggctggacct
     4021 cccgggagaa gcccgaggct agcgtgggaa caagctcaca cctctttctt gccaatgata
     4081 cttgagacct ctttaagttc cttagagtgc tttaaaagaa cggggtgtac cccttttgga
     4141 acactgtttt gagtggtatg tcttttaggc cctagggaaa cgttcatgct agggtgggaa
     4201 agctaccagt ttctttctga ggggaatact ttcttcaggg aagtttccca gccctaccag
     4261 tgtcccctgc tgatatccct ggggactcca gagcatttag cagaattaaa cttgtaaata
     4321 ggcttggaga tgcaccattg aagatgtcag gctgagtccc ttctctgtgt ggctgtgagg
     4381 agtgggagtt tgggggagtt tgtaaactat ttcagggggt gcagtgtggt ttcccctccc
     4441 tgtgaggcct cagcctctct tctgcacaga ttccgtgttg taaagagttt gctcatgccg
     4501 ccatcggtgt gctatagctt taacgcttct gaaacctctg gggttgatta gaagccgggg
     4561 cttaagtttc cgtcgtaccc agaggcccca cctcacccag gtcgtctctt ctcccacaag
     4621 gctcttcagg gaccgtggtg gctacaggtc tggccagcct ctggctccta ggaaatatgc
     4681 agtcttgtgg ggtttgatca ttttgaagat acctgggggt gggaaggtct ggagtccctg
     4741 ggttgggact ccatgtgggt cacctacctc ctggtttcac ccaaagtcct gccttgaacc
     4801 accagcaagt ttcattctgt tgtgataatt gggcattaaa taatggcggc tctggtaaaa
     4861 aaaaaa
//
