LOCUS       NM_007891               2739 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus E2F transcription factor 1 (E2f1), transcript variant
            1, mRNA.
ACCESSION   NM_007891
VERSION     NM_007891.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2739)
  AUTHORS   Lehr,S., Bruckner,D.B., Minchington,T.G., Greunz-Schindler,M.,
            Merrin,J., Hannezo,E. and Kicheva,A.
  TITLE     Self-organized pattern formation in the developing mouse neural
            tube by a temporal relay of BMP signaling
  JOURNAL   Dev Cell 60 (4), 567-580 (2025)
   PUBMED   39603235
REFERENCE   2  (bases 1 to 2739)
  AUTHORS   Allen,R.S., Biswas,S.K. and Seifert,A.W.
  TITLE     Ear pinna growth and differentiation is conserved in murids and
            requires BMP signaling for chondrocyte proliferation
  JOURNAL   Development 152 (3) (2025)
   PUBMED   39846506
REFERENCE   3  (bases 1 to 2739)
  AUTHORS   Feng,W., Hong,N., Wu,Y., Huang,J., Zhang,Q., Liu,G., Qian,Z.,
            Chen,Y., Jin,L., Ding,X., Zhao,P., Chen,A.F. and Yu,Y.
  TITLE     Deficiency of Sox7 leads to congenital aortic stenosis via abnormal
            valve remodeling
  JOURNAL   J Mol Cell Cardiol 199, 81-94 (2025)
   PUBMED   39746830
REFERENCE   4  (bases 1 to 2739)
  AUTHORS   Hudacova,E., Abaffy,P., Kaplan,M.M., Krausova,M., Kubista,M. and
            Machon,O.
  TITLE     Single-cell transcriptomic resolution of osteogenesis during
            craniofacial morphogenesis
  JOURNAL   Bone 190, 117297 (2025)
   PUBMED   39461490
REFERENCE   5  (bases 1 to 2739)
  AUTHORS   Follmer,M.L., Isner,T.J., Ozekin,Y.H., Levitt,C.H., Burek,C.L.,
            Benninger,R.K.P. and Bates,E.A.
  TITLE     Depolarization induces calcium-dependent BMP4 release from mouse
            embryonic palate mesenchymal cells
  JOURNAL   Nat Commun 15 (1), 9806 (2024)
   PUBMED   39532850
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2739)
  AUTHORS   Corbeil,H.B., Whyte,P. and Branton,P.E.
  TITLE     Characterization of transcription factor E2F complexes during
            muscle and neuronal differentiation
  JOURNAL   Oncogene 11 (5), 909-920 (1995)
   PUBMED   7675450
REFERENCE   7  (bases 1 to 2739)
  AUTHORS   Yagi,H., Kato,T., Nagata,T., Habu,T., Nozaki,M., Matsushiro,A.,
            Nishimune,Y. and Morita,T.
  TITLE     Regulation of the mouse histone H2A.X gene promoter by the
            transcription factor E2F and CCAAT binding protein
  JOURNAL   J Biol Chem 270 (32), 18759-18765 (1995)
   PUBMED   7642525
REFERENCE   8  (bases 1 to 2739)
  AUTHORS   Wu,C.L., Zukerberg,L.R., Ngwu,C., Harlow,E. and Lees,J.A.
  TITLE     In vivo association of E2F and DP family proteins
  JOURNAL   Mol Cell Biol 15 (5), 2536-2546 (1995)
   PUBMED   7739537
REFERENCE   9  (bases 1 to 2739)
  AUTHORS   Zhao,J., Nornes,H.O. and Neuman,T.
  TITLE     Expression of Rb, E2F1, cdc2, and D, and B cyclins in developing
            spinal cord
  JOURNAL   Neurosci Lett 190 (1), 49-52 (1995)
   PUBMED   7624053
REFERENCE   10 (bases 1 to 2739)
  AUTHORS   Williamson,C.M., Dutton,E.R., Abbott,C.M., Beechey,C.V., Ball,S.T.
            and Peters,J.
  TITLE     Thirteen genes (Cebpb, E2f1, Tcf4, Cyp24, Pck1, Acra4, Edn3, Kcnb1,
            Mc3r, Ntsr, Cd40, Plcg1 and Rcad) that probably lie in the distal
            imprinting region of mouse chromosome 2 are not monoallelically
            expressed
  JOURNAL   Genet Res 65 (2), 83-93 (1995)
   PUBMED   7781998
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772292.10, BY254403.1 and AK017841.1.
            
            On Mar 26, 2014 this sequence version replaced NM_007891.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153968.1, L21973.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-381               AL772292.10        172682-173062       c
            382-425             BY254403.1         78-121
            426-2077            AK017841.1         374-2025
            2078-2739           AL772292.10        162570-163231       c
FEATURES             Location/Qualifiers
     source          1..2739
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 76.79 cM"
     gene            1..2739
                     /gene="E2f1"
                     /gene_synonym="E2F-1; mKIAA4009; Tg(Wnt1-cre)2Sor"
                     /note="E2F transcription factor 1"
                     /db_xref="GeneID:13555"
                     /db_xref="MGI:MGI:101941"
     exon            1..404
                     /gene="E2f1"
                     /gene_synonym="E2F-1; mKIAA4009; Tg(Wnt1-cre)2Sor"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1451
                     /gene="E2f1"
                     /gene_synonym="E2F-1; mKIAA4009; Tg(Wnt1-cre)2Sor"
                     /note="isoform a is encoded by transcript variant 1;
                     transcription factor E2F1"
                     /codon_start=1
                     /product="transcription factor E2F1 isoform a"
                     /protein_id="NP_031917.1"
                     /db_xref="CCDS:CCDS16935.1"
                     /db_xref="GeneID:13555"
                     /db_xref="MGI:MGI:101941"
                     /translation="MAVAPAGGQHAPALEALLGAGALRLLDSSQIVIISTAPDVGAPQ
                     LPAAPPTGPRDSDVLLFATPQAPRPAPSAPRPALGRPPVKRRLDLETDHQYLAGSSGP
                     FRGRGRHPGKGVKSPGEKSRYETSLNLTTKRFLELLSRSADGVVDLNWAAEVLKVQKR
                     RIYDITNVLEGIQLIAKKSKNHIQWLGSHTMVGIGKRLEGLTQDLQQLQESEQQLDHL
                     MHICTTQLQLLSEDSDTQRLAYVTCQDLRSIADPAEQMVIVIKAPPETQLQAVDSSET
                     FQISLKSKQGPIDVFLCPEESADGISPGKTSCQETSSGEDRTADSGPAGPPPSPPSTS
                     PALDPSQSLLGLEQEAVLPRMGHLRVPMEEDQLSPLVAADSLLEHVKEDFSGLLPGEF
                     ISLSPPHEALDYHFGLEEGEGIRDLFDCDFGDLTPLDF"
     exon            405..495
                     /gene="E2f1"
                     /gene_synonym="E2F-1; mKIAA4009; Tg(Wnt1-cre)2Sor"
                     /inference="alignment:Splign:2.1.0"
     exon            496..715
                     /gene="E2f1"
                     /gene_synonym="E2F-1; mKIAA4009; Tg(Wnt1-cre)2Sor"
                     /inference="alignment:Splign:2.1.0"
     exon            716..868
                     /gene="E2f1"
                     /gene_synonym="E2F-1; mKIAA4009; Tg(Wnt1-cre)2Sor"
                     /inference="alignment:Splign:2.1.0"
     exon            869..983
                     /gene="E2f1"
                     /gene_synonym="E2F-1; mKIAA4009; Tg(Wnt1-cre)2Sor"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1203
                     /gene="E2f1"
                     /gene_synonym="E2F-1; mKIAA4009; Tg(Wnt1-cre)2Sor"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..2739
                     /gene="E2f1"
                     /gene_synonym="E2F-1; mKIAA4009; Tg(Wnt1-cre)2Sor"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2079
                     /gene="E2f1"
                     /gene_synonym="E2F-1; mKIAA4009; Tg(Wnt1-cre)2Sor"
                     /note="major polyA site"
     regulatory      2485..2490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="E2f1"
                     /gene_synonym="E2F-1; mKIAA4009; Tg(Wnt1-cre)2Sor"
                     /note="hexamer: AATAAA"
     polyA_site      2506
                     /gene="E2f1"
                     /gene_synonym="E2F-1; mKIAA4009; Tg(Wnt1-cre)2Sor"
                     /note="major polyA site"
     regulatory      2714..2719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="E2f1"
                     /gene_synonym="E2F-1; mKIAA4009; Tg(Wnt1-cre)2Sor"
                     /note="hexamer: AGTAAA"
     polyA_site      2735
                     /gene="E2f1"
                     /gene_synonym="E2F-1; mKIAA4009; Tg(Wnt1-cre)2Sor"
ORIGIN      
        1 tttcgcggca aaaaggattt ggcgcgtaaa agtggcccgg actttgcagg cagcggcggc
       61 cggggcggag cgggatcgag ccctcgccgc ggcctgccag tcatgggccc gcgccgccgc
      121 cgccgcctgc ctcccgggcc acgcgggccg tgagcgccat ggccgtagcc cccgcgggcg
      181 gccagcacgc gccagcgctg gaggccctgc tcggggcggg cgcgttgcgg ctgctcgact
      241 cctcgcagat cgtcatcatc tccaccgcgc ccgatgtcgg cgccccgcag ctccccgccg
      301 cgccgcccac tggccctcgc gattctgacg tgctgctctt cgccacgccg caggcgcccc
      361 gacccgcgcc tagtgcaccg cgcccggctc tcggccgccc gccggtgaaa cggaggctgg
      421 atctggagac tgaccatcag tacctcgctg gtagcagtgg gccattccgg ggcagaggcc
      481 gccacccagg gaaaggtgtg aaatctccgg gggagaagtc acgctatgaa acctcactaa
      541 atctgaccac caaacgcttc ttggagctgc tgagccgctc agctgacggt gtcgttgacc
      601 tgaactgggc agctgaggtg ctgaaggtgc agaaacggcg catctatgac atcaccaatg
      661 tcctggaggg catccagctc attgccaaga agtccaagaa tcatatccag tggctaggca
      721 gccacaccat ggtggggatt ggtaagcggc ttgaaggcct gacccaggac ctgcagcaac
      781 tgcaggagag tgagcagcag ctggatcacc tgatgcacat ctgtaccaca cagctgcaac
      841 tgctttcgga ggactccgac acccagcgcc tggcctatgt gacctgccag gaccttcgca
      901 gcattgcaga ccctgcagaa cagatggtca tagtgatcaa ggcccctcct gagacccaac
      961 tacaagctgt ggattcttca gagacatttc agatctccct taagagcaaa caaggcccca
     1021 ttgatgtttt cctgtgcccg gaggagagtg cagacgggat tagccctggg aagacctcat
     1081 gccaggagac atcctctggg gaggaccgga ctgcagactc tggcccagca gggcctccac
     1141 catcacctcc ctccacatcc ccagccttgg atcccagtca atccctgttg ggcctggagc
     1201 aagaagcagt attgccacgg atgggccacc tgagggtccc tatggaagag gaccaactgt
     1261 caccactggt ggctgctgac tcactcctgg agcatgttaa agaagacttc tctgggctcc
     1321 tccctgggga gttcatcagc ctctccccac cccacgaggc ccttgactat cactttggtc
     1381 tcgaggaggg tgagggcatt agagatctct ttgactgtga ctttggggac ctgacccctc
     1441 tggatttctg acagaagcct agggattcag ggtgtctgga gatgcccacc tgtctgcagc
     1501 tttggagcct cctgccctgg gccatccttc ctgcctcatt ggaatagcac gatccatacc
     1561 ctctgtccca atagcttcta gctctggggt ttggttgctg ccacattgag cagaccaaaa
     1621 tgggaaggat gttgtacagt gtgtgtgcat gcaccccaca ctgcgcactg tgtgcctggg
     1681 gtgtgtgtct gagtgtgtgt gtgtgtgtgt gtgtgtgagt gtgtgtgtgt gtgtgtgtga
     1741 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtatgt atgtgtatgt
     1801 gcacgtgtgc ccgggaatga aggtgaacac atctgtatgt gtgctgcaga cacatcctgg
     1861 tgtgtccaca tgtgtgcatg gatccatgtg tgcgcattgg ggtgggggtg ggctctaact
     1921 gcacttttgg tgtccttgct gcaggggccc tgtgaggccc agggtggctg cctgctttca
     1981 gaatcctgtg tgtcagccag gccgggtggt acagcttgcc tggctgggtt tgcagggcag
     2041 caagagcact gcttaaaagt tttccgatcg aagctttaat ggagcgttta tttatttatc
     2101 gaggcctctg gcaagcctgg ggggataagc aaagggtggg gggcatgggt gataccttaa
     2161 gtccctgttc tctgaagcaa gggcaggatc cctacccaag agttgctgag gcccaagcag
     2221 tttatttatt gggaaaggga gagggagaca gactgacagc catggatggg ctggagaaac
     2281 agtccctttg taccagtact ccagccgcat gtatccaggg gatctgagat ggggagggta
     2341 cgtgagggcc ttggctgact gcggccagga ggggtgggta tgcgtccttc ctatggctgg
     2401 agtgctcctc tgctgtcctc cccaccctcc agtctgcact ttgatttgtt tcctaacagt
     2461 tctgttccct cctgctttga ttttaataaa tgttttgatg gtgttagggc tgggtttgaa
     2521 actctccgcc agccagagtg aggctagtgt tggagggaat gttcactccc tcttcctatc
     2581 tgacttaatt tcctttcagt ttgtaacccc ttgagaagaa aactgaccca atggtgggta
     2641 gggagttatg cttgggacct aagtacagaa gagggagcgt cagagtcagc ttgctgtgca
     2701 ccttctgaac attagtaaag atgcaacaca gtgaactgt
//
