LOCUS       NM_025943               4914 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus DAZ interacting protein 1 (Dzip1), transcript variant
            1, mRNA.
ACCESSION   NM_025943 XM_006519385 XM_356765
VERSION     NM_025943.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4914)
  AUTHORS   Guo,L., Beck,T., Fulmer,D., Ramos-Ortiz,S., Glover,J., Wang,C.,
            Moore,K., Gensemer,C., Morningstar,J., Moore,R., Schott,J.J., Le
            Tourneau,T., Koren,N. and Norris,R.A.
  TITLE     DZIP1 regulates mammalian cardiac valve development through a
            Cby1-beta-catenin mechanism
  JOURNAL   Dev Dyn 250 (10), 1432-1449 (2021)
   PUBMED   33811421
  REMARK    GeneRIF: DZIP1 regulates mammalian cardiac valve development
            through a Cby1-beta-catenin mechanism.
REFERENCE   2  (bases 1 to 4914)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4914)
  AUTHORS   Fulmer,D., Toomer,K.A., Glover,J., Guo,L., Moore,K., Moore,R.,
            Stairley,R., Gensemer,C., Abrol,S., Rumph,M.K., Emetu,F.,
            Lipschutz,J.H., McDowell,C., Bian,J., Wang,C., Beck,T., Wessels,A.,
            Renault,M.A. and Norris,R.A.
  TITLE     Desert hedgehog-primary cilia cross talk shapes mitral valve tissue
            by organizing smooth muscle actin
  JOURNAL   Dev Biol 463 (1), 26-38 (2020)
   PUBMED   32151560
REFERENCE   4  (bases 1 to 4914)
  AUTHORS   Lv,M., Liu,W., Chi,W., Ni,X., Wang,J., Cheng,H., Li,W.Y., Yang,S.,
            Wu,H., Zhang,J., Gao,Y., Liu,C., Li,C., Yang,C., Tan,Q., Tang,D.,
            Zhang,J., Song,B., Chen,Y.J., Li,Q., Zhong,Y., Zhang,Z., Saiyin,H.,
            Jin,L., Xu,Y., Zhou,P., Wei,Z., Zhang,C., He,X., Zhang,F. and
            Cao,Y.
  TITLE     Homozygous mutations in DZIP1 can induce asthenoteratospermia with
            severe MMAF
  JOURNAL   J Med Genet 57 (7), 445-453 (2020)
   PUBMED   32051257
  REMARK    GeneRIF: Homozygous mutations in DZIP1 can induce
            asthenoteratospermia with severe MMAF.
REFERENCE   5  (bases 1 to 4914)
  AUTHORS   Toomer,K.A., Yu,M., Fulmer,D., Guo,L., Moore,K.S., Moore,R.,
            Drayton,K.D., Glover,J., Peterson,N., Ramos-Ortiz,S., Drohan,A.,
            Catching,B.J., Stairley,R., Wessels,A., Lipschutz,J.H.,
            Delling,F.N., Jeunemaitre,X., Dina,C., Collins,R.L., Brand,H.,
            Talkowski,M.E., Del Monte,F., Mukherjee,R., Awgulewitsch,A.,
            Body,S., Hardiman,G., Hazard,E.S., da Silveira,W.A., Wang,B.,
            Leyne,M., Durst,R., Markwald,R.R., Le Scouarnec,S., Hagege,A., Le
            Tourneau,T., Kohl,P., Rog-Zielinska,E.A., Ellinor,P.T.,
            Levine,R.A., Milan,D.J., Schott,J.J., Bouatia-Naji,N.,
            Slaugenhaupt,S.A. and Norris,R.A.
  TITLE     Primary cilia defects causing mitral valve prolapse
  JOURNAL   Sci Transl Med 11 (493) (2019)
   PUBMED   31118289
REFERENCE   6  (bases 1 to 4914)
  AUTHORS   Wang,C., Low,W.C., Liu,A. and Wang,B.
  TITLE     Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting
            cytoplasmic retention of transcription factor GLI3 and affecting
            ciliogenesis
  JOURNAL   J Biol Chem 288 (41), 29518-29529 (2013)
   PUBMED   23955340
  REMARK    GeneRIF: Data indicate that the centrosomal protein DZIP1 interacts
            with GLI3 transcription factor in the cytoplasm and regulates
            Hedgehog signaling and ciliogenesis.
REFERENCE   7  (bases 1 to 4914)
  AUTHORS   Licatalosi,D.D., Yano,M., Fak,J.J., Mele,A., Grabinski,S.E.,
            Zhang,C. and Darnell,R.B.
  TITLE     Ptbp2 represses adult-specific splicing to regulate the generation
            of neuronal precursors in the embryonic brain
  JOURNAL   Genes Dev 26 (14), 1626-1642 (2012)
   PUBMED   22802532
REFERENCE   8  (bases 1 to 4914)
  AUTHORS   Jin,Z., Mei,W., Strack,S., Jia,J. and Yang,J.
  TITLE     The antagonistic action of B56-containing protein phosphatase 2As
            and casein kinase 2 controls the phosphorylation and Gli turnover
            function of Daz interacting protein 1
  JOURNAL   J Biol Chem 286 (42), 36171-36179 (2011)
   PUBMED   21878643
  REMARK    GeneRIF: reversible phosphorylation of Dzip1, which is controlled
            by the antagonistic action of CK2 and B56-containing PP2As, has an
            important impact on the stability of Gli transcription factors and
            Hh signaling.
REFERENCE   9  (bases 1 to 4914)
  AUTHORS   Curry,B.J., Holt,J.E., McLaughlin,E.A. and Aitken,R.J.
  TITLE     Characterization of structure and expression of the Dzip1 gene in
            the rat and mouse
  JOURNAL   Genomics 87 (2), 275-285 (2006)
   PUBMED   16368222
  REMARK    GeneRIF: Dzip1S mRNA was confined to the spermatogenic lineage,
            specifically premeiotic spermatogonia
REFERENCE   10 (bases 1 to 4914)
  AUTHORS   Moore,F.L., Jaruzelska,J., Dorfman,D.M. and Reijo-Pera,R.A.
  TITLE     Identification of a novel gene, DZIP (DAZ-interacting protein),
            that encodes a protein that interacts with DAZ (deleted in
            azoospermia) and is expressed in embryonic stem cells and germ
            cells
  JOURNAL   Genomics 83 (5), 834-843 (2004)
   PUBMED   15081113
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY296162.1, BC098211.1,
            BY732624.1, BX525663.1 and AC154377.4.
            
            On or before Feb 15, 2015 this sequence version replaced
            XM_006519385.2, NM_025943.2.
            
            Summary: This gene encodes a zinc finger protein that has been
            demonstrated to interact with the deleted in azoospermia (DAZ)
            protein. DAZ plays an important role early in germ cell development
            to maintain the initial germ cell population. Deletion of this gene
            in mice compromises Hedgehog signaling during embryogenesis. Mouse
            embryos lacking the encoded protein show severe developmental
            defects with dorsalized neural tubes and underdeveloped somites.
            Alternative splicing of this gene results in multiple transcript
            variants. A pseudogene for this gene has been identified on
            chromosome 5. [provided by RefSeq, Jan 2015].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098211.1, AK141247.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                BY296162.1         2-84
            84-3524             BC098211.1         1-3441
            3525-4162           BC098211.1         3443-4080
            4163-4534           BY732624.1         1-372               c
            4535-4565           BX525663.1         350-380             c
            4566-4566           AC154377.4         107443-107443
            4567-4883           BX525663.1         32-348              c
            4884-4884           AC154377.4         107761-107761
            4885-4914           BX525663.1         1-30                c
FEATURES             Location/Qualifiers
     source          1..4914
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 62.56 cM"
     gene            1..4914
                     /gene="Dzip1"
                     /gene_synonym="2510025K24Rik; 2810422M04Rik"
                     /note="DAZ interacting protein 1"
                     /db_xref="GeneID:66573"
                     /db_xref="MGI:MGI:1914311"
     exon            1..330
                     /gene="Dzip1"
                     /gene_synonym="2510025K24Rik; 2810422M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            331..424
                     /gene="Dzip1"
                     /gene_synonym="2510025K24Rik; 2810422M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            425..681
                     /gene="Dzip1"
                     /gene_synonym="2510025K24Rik; 2810422M04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             679..3237
                     /gene="Dzip1"
                     /gene_synonym="2510025K24Rik; 2810422M04Rik"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein DZIP1; DAZ-interacting protein 1 homolog;
                     DAZ-interacting zinc finger protein 1; cilium assembly
                     protein DZIP1"
                     /codon_start=1
                     /product="cilium assembly protein DZIP1 isoform 1"
                     /protein_id="NP_080219.2"
                     /db_xref="CCDS:CCDS37011.1"
                     /db_xref="GeneID:66573"
                     /db_xref="MGI:MGI:1914311"
                     /translation="MPFQKHVYYPLANSPEGPDASAIGAAPMAFVPPSAASGPLPFFQ
                     FRPRLESVDWRRLSAIDVDKVAGAVDVLTLQENIMNITFCKLEDEKCPHCQSGVDPVL
                     LKLIRLAQLTIEYLMHSQEFLTSQLNLVEERLRLSLLDYEQSKQLLTKQAGEIKLLKE
                     ECKRRKKMLSTQQLMIEAKASYYQCHFCDKAFMNQAFLQSHIQRRHTEDSHLEYNTKA
                     QTDRLQKEIDMLKEQLQLTRSQLESAQHSHAVRFSKDYEMQKSKEEDFLKLFDRWKEE
                     EKEKLLEEMEKVKGMFMREFKELTSKNSALEYQLLEIQKSNIQIKSNIGTLRDVTELR
                     EDHLPCPQDFQNMLQLLDSQASKWTDRFQVLNEEHSKEKGQLLSHIEKLRSSMMKDLS
                     ADNVFYKRRVEELGQKLQEQNELIISQKQQIREFASKPYSSISELKGTPLTRQTLEPK
                     SAAPTTPMTASATQNLDGASSLTMVHEQVFSSHILEPIEELSSEEEKGRENEQKLNKK
                     TSLRKPSSTSPSPQELRTNLERELGNKLRSFGIGANIQGIPCEILNRSLKAMQVARHD
                     LAKQMPDIQQIRESLEHQLICKMEEKVSLSSDRHHVPSMTTFPPEEVPKATQLPHKSR
                     PLVRQRTVFTDKVSVPKLKKNTKESHFLRRFPSTKTPPFSSEEEPDEEDLLHAYLSPD
                     SLATAATQPPKSSMSHFGKSAVKSDTDWTEGSEMDDSDFSPKLTGTSITIQTDTVETM
                     ALPQGSGNKAVPGMNPADTVIKKESLQELKCTDADDEDWDISSLEEEKSLGSKIEQRE
                     PPPAKRDPSCTQVQRAWGPVNPREFKEEGLHENEPSTLKSNLVTVTDWSDVLDV"
     exon            682..1230
                     /gene="Dzip1"
                     /gene_synonym="2510025K24Rik; 2810422M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1315
                     /gene="Dzip1"
                     /gene_synonym="2510025K24Rik; 2810422M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1440
                     /gene="Dzip1"
                     /gene_synonym="2510025K24Rik; 2810422M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1602
                     /gene="Dzip1"
                     /gene_synonym="2510025K24Rik; 2810422M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1740
                     /gene="Dzip1"
                     /gene_synonym="2510025K24Rik; 2810422M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1803
                     /gene="Dzip1"
                     /gene_synonym="2510025K24Rik; 2810422M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1944
                     /gene="Dzip1"
                     /gene_synonym="2510025K24Rik; 2810422M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..1993
                     /gene="Dzip1"
                     /gene_synonym="2510025K24Rik; 2810422M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2050
                     /gene="Dzip1"
                     /gene_synonym="2510025K24Rik; 2810422M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2107
                     /gene="Dzip1"
                     /gene_synonym="2510025K24Rik; 2810422M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2170
                     /gene="Dzip1"
                     /gene_synonym="2510025K24Rik; 2810422M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2307
                     /gene="Dzip1"
                     /gene_synonym="2510025K24Rik; 2810422M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2470
                     /gene="Dzip1"
                     /gene_synonym="2510025K24Rik; 2810422M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2600
                     /gene="Dzip1"
                     /gene_synonym="2510025K24Rik; 2810422M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2654
                     /gene="Dzip1"
                     /gene_synonym="2510025K24Rik; 2810422M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2857
                     /gene="Dzip1"
                     /gene_synonym="2510025K24Rik; 2810422M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2858..2988
                     /gene="Dzip1"
                     /gene_synonym="2510025K24Rik; 2810422M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2989..3157
                     /gene="Dzip1"
                     /gene_synonym="2510025K24Rik; 2810422M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3158..4900
                     /gene="Dzip1"
                     /gene_synonym="2510025K24Rik; 2810422M04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3440..3445
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dzip1"
                     /gene_synonym="2510025K24Rik; 2810422M04Rik"
                     /note="hexamer: CATAAA"
     polyA_site      3467
                     /gene="Dzip1"
                     /gene_synonym="2510025K24Rik; 2810422M04Rik"
                     /note="major polyA site"
     regulatory      4144..4149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dzip1"
                     /gene_synonym="2510025K24Rik; 2810422M04Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      4167
                     /gene="Dzip1"
                     /gene_synonym="2510025K24Rik; 2810422M04Rik"
ORIGIN      
        1 agaggagccg ggtaagcgga gagaagaggc caccagaaga ccgtagaggg gagggggcgg
       61 gaggggggtg gggcagcctt aaccacccac ggcctggagc ctgggaggac aaggagcgac
      121 gctgggctac ccgcctcgtc acaacttgcc cggaccagac acgctttatc ttgcgccctg
      181 gaagaaggag ccgcctgcct cttgctgctc agttgctcct cggcctcggc gagccccgcc
      241 tctgcgccag cagcaatccc gggatctgga tcccccgtga ctccccgtgc cttgcagcgc
      301 ccggctttcg cccaggagcg cgcagctggg gtgcttgaaa cacagcggtg agcgacacac
      361 ctcccctgtt cccgctgatc ctgccagccc agtggatgga gcccagaatc cacaaacctg
      421 ccaggtccct gggcgcatgc tgaacgcgcg tgggcggaca cgccctgtac tccaggtcgg
      481 ggcagggcgc tgccatagca acgtcctgga cgcccagatc ctaggccgcc gccgccgccg
      541 ccgcagccgc agccggggtc tgggccatca gaggctcacg aggagagtgg cggcggcggc
      601 ccaaggcggc cagggctggg gagacgactc tgctccgccc ctccagcgca agcctaggcg
      661 gcggactggc ttgcaagcat gcccttccag aagcacgtct actaccctct ggccaacagc
      721 cccgaggggc ctgacgcctc tgccataggc gcggctccca tggcctttgt cccccccagc
      781 gcggcctcgg gccccctgcc cttcttccag ttccggccgc gactggagag cgtggactgg
      841 aggcggctga gcgccatcga cgtggacaag gttgccggcg ccgtggacgt cctgacactg
      901 caggagaaca ttatgaacat caccttctgc aagctggagg acgagaagtg cccgcactgc
      961 cagtcagggg tagacccagt gctgctgaag ctgatccgcc tggcgcagct cacgatcgaa
     1021 tacctgatgc actcgcagga gttcctcacc tcgcagctaa acctggtgga ggagaggctg
     1081 cgcctgagcc tgctcgacta tgagcagagc aagcagctgc tcaccaagca ggctggcgag
     1141 atcaagctgc tgaaggagga gtgtaaacgc aggaagaaga tgctgtccac gcagcagctg
     1201 atgatagagg ccaaggccag ctattaccag tgccatttct gtgacaaggc ctttatgaac
     1261 caagcgttcc tacaaagcca catccagcgc cgccatactg aagactctca cctcgagtat
     1321 aatacaaagg cccagaccga caggctccag aaggagattg acatgttgaa ggaacagctg
     1381 cagctcacta ggtctcagct ggagtctgca cagcactctc atgcagttcg cttctctaag
     1441 gactatgaaa tgcagaaatc aaaagaggaa gactttctga agctgtttga cagatggaaa
     1501 gaggaggaga aggagaagtt actcgaggag atggagaagg tcaaggggat gtttatgagg
     1561 gaatttaaag agttaacttc taagaactca gcattagaat atcagttgtt agaaatacag
     1621 aagtctaaca tccagatcaa gtccaacata ggcaccttaa gagacgttac tgagctgaga
     1681 gaagaccatc ttccgtgtcc ccaggacttc cagaacatgc tacagctgct tgacagccag
     1741 gcaagcaagt ggacagatcg atttcaagtt ctcaacgaag aacacagcaa ggaaaagggg
     1801 cagctcctgt cccacataga gaagcttcga agctcaatga tgaaggattt aagtgcagat
     1861 aatgtcttct acaagaggcg ggtagaagag ttaggccaga aactgcagga gcagaacgag
     1921 ctgattatca gtcagaagca gcagattaga gaatttgcca gtaaaccata cagcagcatc
     1981 agcgagctga aagggactcc tttaacccga caaacactgg aacctaaatc ggctgcacca
     2041 accacaccca tgactgcctc ggccacacag aatctggatg gtgcatccag cctgaccatg
     2101 gtacatgagc aagtgttctc ttcacacata ctggaaccaa tagaagaact ttcttcagag
     2161 gaggaaaaag gtcgagaaaa tgagcagaaa ttaaataaaa agacgtcctt aaggaaaccg
     2221 tcgagcacca gcccatcccc ccaggagctg aggactaacc tggagcggga gctggggaat
     2281 aaactaagaa gctttgggat tggcgcgaac atccaaggta ttccgtgcga gatcttgaat
     2341 agatcgctta aagccatgca agttgccaga catgacctag caaaacaaat gcctgacatc
     2401 cagcaaatcc gagaatccct cgagcaccag ctgatctgta agatggagga aaaagtgtca
     2461 ctctcttcag acaggcacca tgtcccttcc atgaccacct ttccacccga agaagtaccc
     2521 aaggcaaccc agcttcccca caaaagcaga ccgttggtca gacagagaac tgtgtttact
     2581 gataaagtgt ctgtcccaaa acttaagaaa aataccaaag aaagtcattt tctcagaagg
     2641 tttccatcca ccaagacgcc tcccttcagc tcggaagagg agccagatga agaggacctc
     2701 ctccatgctt acctctcccc agactcactt gccaccgctg ccacacagcc acctaaaagc
     2761 agcatgagtc actttggaaa gagcgctgtc aaaagtgaca cggactggac ggagggaagt
     2821 gaaatggatg actcggactt ctctcctaag ctgacaggaa cctccattac gatacagact
     2881 gacactgttg agaccatggc tttaccccaa ggaagtggga ataaagcagt gccgggaatg
     2941 aaccctgctg acacggttat caaaaaggaa tcgttgcaag agttaaagtg cacagatgct
     3001 gatgacgagg actgggatat atcgtcctta gaggaagaga agtctctggg gagtaaaata
     3061 gagcagaggg agccgcctcc ggccaagcgg gaccccagct gcacccaggt gcagagggcc
     3121 tggggcccag tgaaccctcg ggaattcaag gaagaaggac ttcatgaaaa cgaaccgagc
     3181 acactcaaga gcaacttagt cactgtgact gactggagcg atgtcctgga tgtctaagca
     3241 cggcctcgca catcggaagc ctgtgccgag gccgccagca tcagtgcagt caacagccta
     3301 taggactcta atgctcttag tgtttccaac catagcaagg aagccggttc tgaacaaggg
     3361 tgtctcttat gacacgtaac acagtgccga gaacaaactg tcagctgtcc actgtgtaaa
     3421 aacaacgtat cctttaagtc ataaaaactc ttttcttcag tacagaactc tctagtgtta
     3481 aatgtatttt ttttcgacta acttttaagt cttttttttt ttttgactga tagcaggctt
     3541 cagtttgaat tactatagct ctttaaaata tatatgtact gtcccattgg tagttcttat
     3601 gttaaaacaa tcctgtcgtc tcttcaaact gaattagcga actcaatgat cccatgaatg
     3661 gtaacagtta gctaggccca tggtaaatac atttccttaa aagtcccttt gatcccactg
     3721 agctctgagg ccctgtcagc atgccgttac taacgagttc ttttctgcag tgtaaccttc
     3781 atcttggatg ttttatgaat aatgtgcagc tgttgtaact gccaattgat tcctgtgaga
     3841 tggtcactag aaaaagatga gccgttatta agtcacccac atgtcatttt cctgtgttca
     3901 gtccccagcc catagtataa aatacctcag aactaattta tattcttgaa taatgatctt
     3961 ggcaatgatc agaaagttta tataggaatt gtttgggttt tttttttctt tttaaacttt
     4021 tttccttttt taaaaaaata ttttttatac tttgtagaac tattaggact atctccaaaa
     4081 acaaaaaagg aacctattaa tggcttgttg atttggggtc tcctgtcatt cacctactgt
     4141 accagtaaag tcctccatca cacactgcga ctgtggctgc ttattaagaa aaccgcttgg
     4201 ctagctttat aagagggcaa agccctggca tctaacaaac cctgaccttg aaatgtatct
     4261 ctgtgactat tgtggctacc atctagaaac ctatgtgtgc ccattccaaa ccatgaaaaa
     4321 aaaaattctc ccacctccct gcggggagct gttgtgtgca aataggctca ctttatgtgt
     4381 aagcttatct aaaagcttta ggaatcgaga gtcaggccat gagttgtggg cagagatcaa
     4441 cagccttccc atctctcaca tcaacaggtt tttattgtca ctacgggttt gggtagaaat
     4501 caagagttgt gttccagact ctgtgtctac cacaggtccc cacccccacc cccagccccc
     4561 aggacaggta aggacctggc caaacccaac atttaaattc agttggtgtt tgtaggtcac
     4621 aaagcccagt cctttaactt atccgtgttt agggtttccc cttcttgtcc tcattcagtt
     4681 gttttattcc ttttccttga cagagcttag gcggcccctc cctgaccacc atgccttcac
     4741 accccactct ctctacattc tcagtctagc tgctgtcttc accagctcat ctgaagaaaa
     4801 aaatcatttt aaacgtgtgc ctacacagca ctgttcccac gctggtctgc ggttcctaac
     4861 ctgtctttat ggaagcaaaa tatatgacac tggaaaatgt aaaaaaaaaa aaaa
//
