LOCUS       NM_172859               6871 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus double zinc ribbon and ankyrin repeat domains 1
            (Dzank1), transcript variant 1, mRNA.
ACCESSION   NM_172859
VERSION     NM_172859.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6871)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6871)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 6871)
  AUTHORS   Shen,A.L., Moran,S.A., Glover,E.A., Drinkwater,N.R.,
            Swearingen,R.E., Teixeira,L.B. and Bradfield,C.A.
  TITLE     Association of a Chromosomal Rearrangement Event with Mouse
            Posterior Polymorphous Corneal Dystrophy and Alterations in
            Csrp2bp, Dzank1, and Ovol2 Gene Expression
  JOURNAL   PLoS One 11 (6), e0157577 (2016)
   PUBMED   27310661
  REMARK    GeneRIF: Association of a chromosomal rearrangement event with
            mouse posterior polymorphous corneal dystrophy and alterations in
            Csrp2bp, Dzank1, and Ovol2 gene expression have been reported.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6871)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 6871)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY254795.1, AK032182.1, AK163994.1, AK032632.1, AL808119.6 and
            CJ256961.1.
            
            On Feb 3, 2018 this sequence version replaced NM_172859.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032182.1, SRR9219381.70491.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BY254795.1         3-18
            17-163              AK032182.1         3-149
            164-1154            AK163994.1         139-1129
            1155-2220           AK032182.1         1139-2204
            2221-2295           AK032632.1         2196-2270
            2296-3068           AK032182.1         2280-3052
            3069-3555           AK032182.1         3054-3540
            3556-6618           AL808119.6         53582-56644         c
            6619-6871           CJ256961.1         234-486
FEATURES             Location/Qualifiers
     source          1..6871
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 71.02 cM"
     gene            1..6871
                     /gene="Dzank1"
                     /gene_synonym="2810039F03Rik; 6330439K17Rik; Ankrd64"
                     /note="double zinc ribbon and ankyrin repeat domains 1"
                     /db_xref="GeneID:241688"
                     /db_xref="MGI:MGI:2139080"
     exon            1..135
                     /gene="Dzank1"
                     /gene_synonym="2810039F03Rik; 6330439K17Rik; Ankrd64"
                     /inference="alignment:Splign:2.1.0"
     exon            136..252
                     /gene="Dzank1"
                     /gene_synonym="2810039F03Rik; 6330439K17Rik; Ankrd64"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..2480
                     /gene="Dzank1"
                     /gene_synonym="2810039F03Rik; 6330439K17Rik; Ankrd64"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ankyrin repeat-containing protein C20orf12 homolog; likely
                     ortholog of H. sapiens chromosome 20 open reading frame 12
                     (C20orf12); double zinc ribbon and ankyrin
                     repeat-containing protein 1"
                     /codon_start=1
                     /product="double zinc ribbon and ankyrin repeat-containing
                     protein 1 isoform 1"
                     /protein_id="NP_766447.2"
                     /db_xref="CCDS:CCDS38254.1"
                     /db_xref="GeneID:241688"
                     /db_xref="MGI:MGI:2139080"
                     /translation="MTAGSVCAPQIIPLRVPQPGKANHEIDTNTLLEMKSDTPDVNIY
                     YTLDGSKPDFLKKVGSGENNTFKYVKPITLPDGKIQVKAVAVSKDCRQSGIVTKVFQV
                     DYEPPKMVSSEDNVEDALKGFSKQELKNGFVGPKLRKKYKNAENKSTWNVNLRRLADL
                     KVGERADPKTLKDLRFAESPLEIPAYHEGASARLPTHQAQSPGFAHITGQKSLTSTEI
                     MRIQRETDFLKCAHCLASRPSDPFARFCHECGAPVPPIFGYRLPPPEGAQMGLCAECG
                     SMVPMNTPICVVCEAPLAPQLRPQASLYLKERVICRTCGTGNPAHLRYCVTCEGPLPP
                     TQEQWLCNGDEVPHPPARNGETISCSRCGCQNLWEASFCDWCGAMLGISASHSVCPKC
                     GASNHLTARFCGSCGIYVKSITRFRMHNSLAIVAGAPRPFPEPRSAWQSLNVPLPTSA
                     SGSKKDTGTQTSGLFYPSGKLLAKKELEAASHRQRQEKMSDHRPVLTAVSPGRGYWRK
                     QLDHISAHLRSYAQNNPEFRALIAEPRMGKLISATVHEDGYEVSIRLNYIQVSNKSLY
                     FNKSVNLSDHFLSSVTEGGNGLYDSRSSLVSAYSQSVSDTPESIKKMKNLKAKSFLVN
                     PEPLTPENKLLLEEVGSSGKGRLSVLEQLLDEGADPNCCDSQGRPAVIVAVVNKHYEA
                     IPVLAQRGADIDQQWGPFRNTALHEATLLGLEGRESIATLLGCNANAQKKNTRGQTAY
                     DIALEMGDDLTSSLFAAKFTQGLEDQLSPPGNRILGDS"
     exon            253..406
                     /gene="Dzank1"
                     /gene_synonym="2810039F03Rik; 6330439K17Rik; Ankrd64"
                     /inference="alignment:Splign:2.1.0"
     exon            407..521
                     /gene="Dzank1"
                     /gene_synonym="2810039F03Rik; 6330439K17Rik; Ankrd64"
                     /inference="alignment:Splign:2.1.0"
     exon            522..618
                     /gene="Dzank1"
                     /gene_synonym="2810039F03Rik; 6330439K17Rik; Ankrd64"
                     /inference="alignment:Splign:2.1.0"
     exon            619..743
                     /gene="Dzank1"
                     /gene_synonym="2810039F03Rik; 6330439K17Rik; Ankrd64"
                     /inference="alignment:Splign:2.1.0"
     exon            744..829
                     /gene="Dzank1"
                     /gene_synonym="2810039F03Rik; 6330439K17Rik; Ankrd64"
                     /inference="alignment:Splign:2.1.0"
     exon            830..947
                     /gene="Dzank1"
                     /gene_synonym="2810039F03Rik; 6330439K17Rik; Ankrd64"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1061
                     /gene="Dzank1"
                     /gene_synonym="2810039F03Rik; 6330439K17Rik; Ankrd64"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1154
                     /gene="Dzank1"
                     /gene_synonym="2810039F03Rik; 6330439K17Rik; Ankrd64"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1280
                     /gene="Dzank1"
                     /gene_synonym="2810039F03Rik; 6330439K17Rik; Ankrd64"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1445
                     /gene="Dzank1"
                     /gene_synonym="2810039F03Rik; 6330439K17Rik; Ankrd64"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1653
                     /gene="Dzank1"
                     /gene_synonym="2810039F03Rik; 6330439K17Rik; Ankrd64"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1757
                     /gene="Dzank1"
                     /gene_synonym="2810039F03Rik; 6330439K17Rik; Ankrd64"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1832
                     /gene="Dzank1"
                     /gene_synonym="2810039F03Rik; 6330439K17Rik; Ankrd64"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1929
                     /gene="Dzank1"
                     /gene_synonym="2810039F03Rik; 6330439K17Rik; Ankrd64"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2030
                     /gene="Dzank1"
                     /gene_synonym="2810039F03Rik; 6330439K17Rik; Ankrd64"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2111
                     /gene="Dzank1"
                     /gene_synonym="2810039F03Rik; 6330439K17Rik; Ankrd64"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2239
                     /gene="Dzank1"
                     /gene_synonym="2810039F03Rik; 6330439K17Rik; Ankrd64"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2314
                     /gene="Dzank1"
                     /gene_synonym="2810039F03Rik; 6330439K17Rik; Ankrd64"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..6849
                     /gene="Dzank1"
                     /gene_synonym="2810039F03Rik; 6330439K17Rik; Ankrd64"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3534..3539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dzank1"
                     /gene_synonym="2810039F03Rik; 6330439K17Rik; Ankrd64"
                     /note="hexamer: AATAAA"
     polyA_site      3560
                     /gene="Dzank1"
                     /gene_synonym="2810039F03Rik; 6330439K17Rik; Ankrd64"
                     /note="major polyA site"
     regulatory      6827..6832
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dzank1"
                     /gene_synonym="2810039F03Rik; 6330439K17Rik; Ankrd64"
                     /note="hexamer: AGTAAA"
     polyA_site      6849
                     /gene="Dzank1"
                     /gene_synonym="2810039F03Rik; 6330439K17Rik; Ankrd64"
                     /note="major polyA site"
ORIGIN      
        1 gcggttcgca gcgtctgtgg aaacgcaagc tgcagcggag gagctgtggt gagaccgtga
       61 gaaacctgac aacgggttgg cggcggcggt gctgcgtcgg gggtccttaa tctctgtcct
      121 tgaggctgga gaagggagaa aacatgactg ctggctcagt gtgtgcccct cagatcatac
      181 cactgcgagt gcctcaacct ggaaaagcta accatgaaat tgataccaat actcttttgg
      241 aaatgaaatc cgacacccca gatgtcaaca tatattacac cctggatggc agcaaacctg
      301 acttcctaaa gaaagttggt tctggtgaaa ataatacatt taaatatgta aaacctatta
      361 ctctgcctga tggaaaaatt caagttaaag ctgttgctgt ctctaaagac tgcagacaga
      421 gtggaattgt gacaaaggtg tttcaggtgg actatgaacc accgaagatg gtctcttctg
      481 aagacaatgt tgaagatgct ctcaaggggt tctcaaagca ggaattaaaa aatgggtttg
      541 tcggaccaaa actaaggaag aagtataaga atgctgaaaa taaatcaact tggaacgtta
      601 accttagacg gcttgcagac ctcaaggtag gcgaaagagc agaccctaaa actctgaaag
      661 atcttcgctt cgcagagagt ccactggaaa tcccagccta ccatgaggga gcgagtgctc
      721 gactgcctac tcaccaggcc cagtcccctg gctttgcaca cataactggc cagaagagtc
      781 tgacgagcac cgagatcatg aggatccaga gggagacaga cttcctcaag tgtgcccact
      841 gtctggcttc ccgtccatct gatccatttg ctcgcttctg tcacgaatgt ggagctcctg
      901 tcccacccat atttggctat cgtcttccac ccccagaagg ggctcagatg ggcctgtgtg
      961 cagaatgtgg cagtatggtt cccatgaaca cccccatctg tgtggtgtgc gaagctcctc
     1021 ttgctccaca gcttcggcca caggccagcc tctacttaaa ggagagggta atctgtcgca
     1081 cctgtggcac tgggaatcct gctcatctga gatactgtgt cacctgtgag ggacccctgc
     1141 ctccaacaca agagcagtgg ctgtgcaatg gagatgaagt ccctcatccg cccgctcgaa
     1201 atggggagac catttcctgc tccaggtgtg gctgccagaa cctctgggag gcatccttct
     1261 gtgactggtg tggagccatg cttggcattt ctgctagcca ctctgtctgc ccaaaatgtg
     1321 gggccagcaa tcatctgact gcccgcttct gtggctcctg tggtatttat gtgaagtcca
     1381 taacaaggtt tagaatgcat aacagcttgg ccatagttgc tggagcgcct cgcccatttc
     1441 ctgagccccg atctgcctgg cagtccctaa acgtcccttt gcccacatct gccagtgggt
     1501 ctaagaagga cacgggcact cagacctctg gcctgttcta cccatctggc aagctcctgg
     1561 caaagaagga actggaggcg gcttctcaca ggcagaggca ggagaagatg agtgaccaca
     1621 ggccagtcct cacagccgtc agcccgggaa gaggctactg gagaaagcag ttggatcaca
     1681 tctctgctca cctcaggtcc tatgctcaga acaaccctga attccgggcc ttgattgcag
     1741 agcccaggat ggggaagctt atctctgcca ctgtccatga agatggctat gaagttagca
     1801 tcagactgaa ctatattcaa gtctcaaaca agagcctgta cttcaacaag tcggtgaatc
     1861 tcagtgacca ctttctgagc agtgtcaccg aaggtgggaa cgggctatat gacagcaggt
     1921 ccagcttggt gagtgcctat agccagagcg tctcagacac ccccgaaagt atcaagaaga
     1981 tgaagaatct caaggccaaa agcttccttg tgaacccaga gccgctcaca cctgaaaaca
     2041 aactcctgct ggaggaagtt ggctcctcag ggaaaggaag actgtctgtg ctggaacagc
     2101 tgctggatga aggagcagac cctaactgct gtgatagtca aggtcgacct gctgttattg
     2161 tggctgttgt gaataaacac tatgaagcca ttccagtcct cgctcagaga ggagcagaca
     2221 tcgaccagca gtggggaccg ttcagaaaca cagctcttca cgaagcaact ctacttggcc
     2281 tggaaggaag ggagagcatc gccactttac tgggatgcaa tgcaaacgcc caaaagaaga
     2341 acacaagagg ccagacagca tatgacatcg ctctggagat gggagatgac ctcacctctt
     2401 ctctctttgc cgctaagttc acccaaggtc tggaggacca actttctcca cctgggaacc
     2461 gcatcctagg tgacagttag atctgagggg tcaggaggct gcagagactg cccagctaca
     2521 gctgggctta gtttggaatg cgtatttaag tgtaagaatt acggttgaaa agaactcata
     2581 agactgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tatgagagag
     2641 agagagagag agagaaggga gagtatgtaa gggagggaga agagagagag gagtgtgtgt
     2701 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt ttgtgtgtga gagagagaga ttgagccttg
     2761 cagatgctaa ggcaagcatt gtaccactgg gctatatccc cagctttctt cattttgaaa
     2821 taagatctca taaagttgct caagctggcc ttgaactccc cctatagcat agacaggcct
     2881 tgaacaacgt gggatcttcc tgccgcagcc tccgaagtag ctgagattac aggttgtgac
     2941 aaacaaacac agcttttttt tttttaaggt ggtataacta cccaatacca cctatacctt
     3001 agagtatgat aaaatgaaag ttttgtgttt tattttctgt tttgttgttt tgttttccct
     3061 ttttttttct gagactatat agacatggct ggcctagaaa tttgctatgt agaccaggct
     3121 ggccttaaac acacaggctg tctctgcctc ccaaatgctg gcattaaagg catgtgccac
     3181 catgtccaga tttttaaaaa tattttattg ataattttga aatttggttt ttgatttttt
     3241 gttcttcttt attgttgttt tgagacaggg tctcatgtgt cttgtccttg aacttgttat
     3301 gtggctgagg atgaccttga acttgtgatc ctgccgcctc caccttctaa gtgctgggat
     3361 tacagacttg taccacattg gattttatgt ggtacagggg attgaaccca aggcttcatg
     3421 catgctaacc aaatactcta ccaactgaac tacattccca gcctggttat taatttatct
     3481 ttccatagat aataacactt gtggtttaaa gccaaaagta taaagtacta tataataaag
     3541 ttctcatcca ggttcttaaa ccactgtttc atccttagaa ccagccatgt ctgtgtagag
     3601 gtggtacaac attatataat cacatatgta tatgtacaca aggaggataa cataaaagta
     3661 catagcacgt atatatcctt ccctataata tagcttaatt aaataatttg taagaattca
     3721 tagcagaacg gctatgtcct ttccttagca gagagcagac agtgtatctg aaaagtctct
     3781 tcccaggatc cagaatggga tgaacctgtc ttgtgctccc tcaaactgga ctcagcccat
     3841 ctctgggctc ttccccctct gcccagcagt attccctgcc tggtggtgac ccctcaccca
     3901 cagcagacag atgactggaa acagttctac ttgcatgaca gcgttacaga ctggctcttt
     3961 ctttcctaca aaggatcaaa gaaatatgtt cctaggaatg ggtttaatat ggatgtaact
     4021 tagattctgc taagtctgct gaaagcaaga ccacacttgc tcagcatgac attctgtttc
     4081 ttagtggcgg ttcctcttcc cccaacttgc tgtaatgttc aggacatcca tcaggaaaga
     4141 gatccactgt ctataagaga cctaggaggt ctcttcctac agatatgtgg acatctggtt
     4201 agtgctatta gatgcttctg tgtctggtgt tttgttttct gccatctagc aaaatgtcta
     4261 acactcaggc ccctcctttg gagaacattc cacattgtat gagaaactct gggcctccag
     4321 catctctctc tcttcctttt acttacagaa tagtacatgt gagtccactt gaagagaggg
     4381 gtaactgcca ccttgcctgc ctctctgtgt aatgggtgac acagttggtc acaatcagtg
     4441 gcccaatagt agttatgatc ccacagtcct cagagctact ttttccagaa gtcgctctac
     4501 aaacccttga ccaatgtgaa ccccaaatac tctgcctggt tatatgttct gtgtatttcc
     4561 cttgaaaacc atggaactat tcccacacag atacacatac tggcacactt atagagttgg
     4621 catagaacaa tcttagatac agcatttgga agcacagaca gaaagtgtcg agagaagaca
     4681 gagaaatcag accagctaaa gatattggaa tattatggta atggcatcac tatggttctt
     4741 agtacataca aaagagggta tgtaggccaa aaatgttaag tgcagttgag tagagagagg
     4801 ctctgtgacc gtgctggagg aattgatggg atggagtggt catctgatgg atggacttgc
     4861 atggctcaag ggaggagcag ctggttagca gaatacttct ccagactgtt gtctgtctag
     4921 gacattagtg gaatcagagg actattgagt tcttaactga ttggtggtga cagcccaact
     4981 aaagggacat tctctagagc ctacctatgc tctacctatg ctgttgatgt taggtaaatt
     5041 cataataaag tccactagct tatgctgatg acagtttgac ctcattcccc tcataacata
     5101 cctgaaggcc tcggtaaact tcacaggctg atccctttgt aatctcccag agtcctccat
     5161 ctttagcaaa gttgaatttg taaggttgag acaaaaatcg tattctccag caggtacatt
     5221 gtctcctgtg actgctaaag caaagctctc cattgttttt aatctgttac cattttggcc
     5281 cggtctggat ctttctatct tcaagtctca atatctattg taggaaccca ggaggagctg
     5341 tagggttttt ttggttgggg tttttggcca gatgcagtct ataggtttga attaagttca
     5401 ggttacccaa agtgttgagc caaaatatta tctacaaaac tgggccatca agtctgagag
     5461 tctgaaagct gccaagacaa ttcagcttcg aacacaggcc ttccacgtat tctagattca
     5521 ttgaatgtac atctttttaa agtgtaggca gcacgtaggc cagctcacgt accatgtacc
     5581 attagggccc tgtgagaaat gaagctgcac cttcctgcct accagagaca tccacgtggc
     5641 agacagcaag gagctggtga ccccttacct agtctcaagg ttaagatgtt gaaacgggat
     5701 ttttggttgt gtctaatact gtgaaataac aatgtaagtg gtctgtttcc cttcggtaag
     5761 cttcttcagt gatgtgacca tgtgggttgt ttctgtgtta cgttcctgac agccaaagtc
     5821 ctgaaggtgc cttttcacgt taaagtggtt tgatctctga gttgagttat gagaaatagg
     5881 cgagaataga ggagtcccaa gagtaaagct ttaagaaatg tgggctgctg agatgtcttt
     5941 tagtggttga aggtgtgtct ttgaagaggc ttgtgggatc tcctcattct cttttgcttc
     6001 ctggtgatga agtgaatggt tttgttctgg tatgatgtag ttagtgcctt gccacaggct
     6061 caaaggcatg gaaccaaatg atcacggact ggaaacttct aagctgtgag ccaacacaaa
     6121 cctttctgtt tgtaagttga ttatgtccag tattgtgtta tagtgatgaa gcgctgacta
     6181 gtactgtgtt gtgcctgcat gcttacacat ccaacctcca tgcctgaggc tgtaagtctt
     6241 atgtttaagt atagctcttg gcccaaagtg ggctcttagg aaatacttgt gaaaaattac
     6301 ttcatggctt tctgattggt caatatgcct aaaggatagc tttgcaaaat agatacctaa
     6361 gatattaagt ttggaaaaca tttattttct gatataaggc tgtactcaaa aggatcaggc
     6421 atatgctagc aaatttctaa aatgaatcag tatcttggtt gtatcaggtt atgcactgtg
     6481 aggagagtaa tgctggggca ggttttgcct cctagacatg tgtatagttg agatgggcat
     6541 tcagatctca gcagagtgct taatcctgtg tttatcctgt gcagacaagt gattgtctca
     6601 taaaacattt cattcgtata gcactgtaag aatctaaaac agcaaaaaaa tttaaagtaa
     6661 aaactgctga actacacatt cttagagtat ccgttctctc aaggtttctg tgcatgtcag
     6721 atctcagcag agtgattaac tgtttatctt gtgcagacaa gtgattgttt cgtaaaacat
     6781 ttcatgtgtg ttataaagaa tctaaaacag cagaaaattt aaataaagta aaaaaactac
     6841 tgaactataa aaaaaaaaaa aaaaaaaaaa a
//
