LOCUS       NM_207210               2116 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus dual-specificity tyrosine phosphorylation regulated
            kinase 4 (Dyrk4), mRNA.
ACCESSION   NM_207210 XM_132896
VERSION     NM_207210.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2116)
  AUTHORS   Papadopoulos C, Arato K, Lilienthal E, Zerweck J, Schutkowski M,
            Chatain N, Muller-Newen G, Becker W and de la Luna S.
  TITLE     Splice variants of the dual specificity tyrosine
            phosphorylation-regulated kinase 4 (DYRK4) differ in their
            subcellular localization and catalytic activity
  JOURNAL   J Biol Chem 286 (7), 5494-5505 (2011)
   PUBMED   21127067
  REMARK    GeneRIF: DYRK1A, DYRK2, and DYRK4 differ in their target
            recognition sequence and that preference for an arginine residue at
            position P -3 is a feature of DYRK1A but not of DYRK2 and DYRK4.
REFERENCE   2  (bases 1 to 2116)
  AUTHORS   Sacher F, Moller C, Bone W, Gottwald U and Fritsch M.
  TITLE     The expression of the testis-specific Dyrk4 kinase is highly
            restricted to step 8 spermatids but is not required for male
            fertility in mice
  JOURNAL   Mol Cell Endocrinol 267 (1-2), 80-88 (2007)
   PUBMED   17292540
  REMARK    GeneRIF: Dyrk4 is a testis-specific kinase with a very restricted
            expression to stage VIII postmeiotic spermatids.
REFERENCE   3  (bases 1 to 2116)
  AUTHORS   Becker W, Weber Y, Wetzel K, Eirmbter K, Tejedor FJ and Joost HG.
  TITLE     Sequence characteristics, subcellular localization, and substrate
            specificity of DYRK-related kinases, a novel family of dual
            specificity protein kinases
  JOURNAL   J Biol Chem 273 (40), 25893-25902 (1998)
   PUBMED   9748265
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK077117.1 and BC052324.1.
            
            [WARNING] On Jan 16, 2024 this sequence was replaced by
            NM_207210.3.
            
            On May 1, 2010 this sequence version replaced NM_207210.1.
            
            CCDS Note: The coding region has been updated to represent an
            alternate splice pattern that is more supported by the available
            transcript and protein data. This new splice pattern represents an
            extended exon structure, including a longer 5' CDS with its splice
            sites affected and changing the splice donor in the third last
            exon. The update changes the protein length from 594 aa to 632 aa.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077117.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849376,
                                           SAMN00849377 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               AK077117.1         2-220
            220-220             BC052324.1         274-274
            221-2062            AK077117.1         222-2063
            2063-2116           BC052324.1         2108-2161
FEATURES             Location/Qualifiers
     source          1..2116
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 61.92 cM"
     gene            1..2116
                     /gene="Dyrk4"
                     /gene_synonym="Dyrk4a; Dyrk4b"
                     /note="dual-specificity tyrosine phosphorylation regulated
                     kinase 4"
                     /db_xref="GeneID:101320"
                     /db_xref="MGI:MGI:1330292"
     exon            1..90
                     /gene="Dyrk4"
                     /gene_synonym="Dyrk4a; Dyrk4b"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1951
                     /gene="Dyrk4"
                     /gene_synonym="Dyrk4a; Dyrk4b"
                     /EC_number="2.7.12.1"
                     /note="dual-specificity tyrosine-(Y)-phosphorylation
                     regulated kinase 4"
                     /codon_start=1
                     /product="dual specificity
                     tyrosine-phosphorylation-regulated kinase 4"
                     /protein_id="NP_997093.2"
                     /db_xref="CCDS:CCDS20559.2"
                     /db_xref="GeneID:101320"
                     /db_xref="MGI:MGI:1330292"
                     /translation="MQLLRLPALTRTETSMDTNKARKRSLTTFPILKARKKQSFTSVK
                     VESKPLGHLQKPSSKNKKLRVNRCPQKIPSNTAFPFVDTKGKRNTVNFPQIGNKVPSK
                     GPMQYQENQIHNQVLSSELKTSEIPFNINTKAQDTKPHPELQKKHKVPLTVAEALKFF
                     KNQLSPYEQSEILGYSELWFLGLEAKKLNVVPEKFSKTSFDDEHGSYMKVLHDHIAYR
                     YEVLEMIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHHQALVELKILEALRRKDKD
                     NNHNVVHMKDFFYFRNHLCITFELLGINLYELMKNNSFHGFNLSIVRRFTFSILKCLH
                     MLYVEKIIHCDLKPENIVLYQRGQVTVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVIL
                     GHPYNMAIDMWSLGCIMAELYTGYPLFPGENEVEQLACIMEVLGLPPAHFTQTASRRQ
                     VFFDSKGLPKNINNNRGGKRYPDSKDLTMVVKTYDSSFLDFLRRCLVWEPSLRMTPEQ
                     ALKHAWIHEPRKFKPRPKPQILRKPGASISSEISTEKAEEQQASKGKKDEATKETTDK
                     LKDEAEKHLENSGKQQSSVEHTADTIQLPHLTEASGKSETVAGSEMSAEQQSTSSPKS
                     TNILPPIV"
     exon            91..184
                     /gene="Dyrk4"
                     /gene_synonym="Dyrk4a; Dyrk4b"
                     /inference="alignment:Splign:2.1.0"
     exon            185..265
                     /gene="Dyrk4"
                     /gene_synonym="Dyrk4a; Dyrk4b"
                     /inference="alignment:Splign:2.1.0"
     exon            266..376
                     /gene="Dyrk4"
                     /gene_synonym="Dyrk4a; Dyrk4b"
                     /inference="alignment:Splign:2.1.0"
     exon            377..515
                     /gene="Dyrk4"
                     /gene_synonym="Dyrk4a; Dyrk4b"
                     /inference="alignment:Splign:2.1.0"
     exon            516..679
                     /gene="Dyrk4"
                     /gene_synonym="Dyrk4a; Dyrk4b"
                     /inference="alignment:Splign:2.1.0"
     exon            680..816
                     /gene="Dyrk4"
                     /gene_synonym="Dyrk4a; Dyrk4b"
                     /inference="alignment:Splign:2.1.0"
     exon            817..957
                     /gene="Dyrk4"
                     /gene_synonym="Dyrk4a; Dyrk4b"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1096
                     /gene="Dyrk4"
                     /gene_synonym="Dyrk4a; Dyrk4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1178
                     /gene="Dyrk4"
                     /gene_synonym="Dyrk4a; Dyrk4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1351
                     /gene="Dyrk4"
                     /gene_synonym="Dyrk4a; Dyrk4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1412
                     /gene="Dyrk4"
                     /gene_synonym="Dyrk4a; Dyrk4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1542
                     /gene="Dyrk4"
                     /gene_synonym="Dyrk4a; Dyrk4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1721
                     /gene="Dyrk4"
                     /gene_synonym="Dyrk4a; Dyrk4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..2073
                     /gene="Dyrk4"
                     /gene_synonym="Dyrk4a; Dyrk4b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggttgagggt tcctcctaaa cctctgcagg gatccctgtc tgtgacagcc ggatgcagct
       61 cctccgactt cctgccctca cccggacaga gacttcaatg gatacaaaca aggcaaggaa
      121 acgcagtttg acaaccttcc caattttgaa agcaaggaag aagcagagtt tcacctctgt
      181 gaaggttgag agtaagcctt tgggtcacct ccagaagcca tcctccaaga acaagaagct
      241 gagagtgaac cgatgtccac aaaagattcc aagtaacacg gcgttccctt ttgtggacac
      301 aaaggggaag aggaacacag ttaacttccc ccagattggc aacaaagtcc catcaaaggg
      361 gcccatgcag tatcaggaaa atcaaattca taatcaagtg ctatcctctg aactcaagac
      421 ttcagaaata cctttcaaca ttaacaccaa agcccaagac accaagccac acccagaact
      481 acaaaagaag cacaaagtcc ctcttacagt agcagaggcc ctaaagttct ttaagaatca
      541 gctgtcccct tatgagcaaa gcgaaatcct gggctactca gagctgtggt tcctgggcct
      601 tgaagccaag aagctcaacg tggttccaga gaagttcagc aagacaagct ttgatgatga
      661 gcacggttcc tatatgaagg tcctgcatga ccacattgcc taccgatatg aggttctgga
      721 gatgatcggg aaagggtcct ttggacaggt ggccaagtgc ttggatcaca aaaacaatga
      781 gttggtggcc ctgaaaatca tcaggaacaa aaagagattt caccatcagg ctctggtgga
      841 gctgaagatc ctggaagccc tcagaaggaa ggacaaagac aacaaccaca atgtggtcca
      901 catgaaggat ttcttctact tccggaatca cctctgtatc acctttgagc tcctgggaat
      961 caacctgtat gagttgatga agaacaacag ctttcatggc ttcaatctgt ccatagttcg
     1021 gcgcttcacc ttttccattt tgaaatgctt acacatgctt tatgtagaga aaatcatcca
     1081 ctgtgacctc aagccggaaa atattgtgct ataccagagg ggccaagtca ctgttaaagt
     1141 tattgacttt gggtcaagct gttatgaaca ccagaaagtg tatacgtaca tccaaagtcg
     1201 tttctaccga tccccagagg tgattctggg acacccctat aacatggcca ttgacatgtg
     1261 gagcctgggc tgcatcatgg cggagctgta caccggatac ccactgttcc ctggggagaa
     1321 cgaggtggag cagctggctt gcatcatgga ggtgctgggc ctgccacctg cccacttcac
     1381 ccagacagcc tccaggagac aggtattctt tgattccaaa ggtcttccca aaaatataaa
     1441 caacaacaga gggggaaaaa gatacccaga ttccaaggat ctcacgatgg tggtgaaaac
     1501 ctacgattcc agcttcctgg actttctcag aaggtgtttg gtgtgggagc cttctctgcg
     1561 catgaccccc gagcaggccc tcaagcatgc ctggattcac gagccgagga aattcaaacc
     1621 acggcccaag ccacagatat taaggaagcc tggtgccagt atttcctctg agataagcac
     1681 ggaaaaggct gaagagcaac aggccagcaa aggcaaaaaa gatgaggcta ccaaagaaac
     1741 tacagacaaa ttgaaggacg aagctgagaa gcaccttgag aattcgggca aacagcagag
     1801 ctctgtggag cacacagcag acaccatcca gctgcctcac ctaacagaag cttctggaaa
     1861 gtcagagact gttgctgggt cagagatgtc cgcagaacag cagagcacct cctcccccaa
     1921 gagcacaaac atcttaccac ccatcgtgtg accctcgtgg caggcgggca tgtcccgctc
     1981 ccttccgcca ccaatttgta ttagagaagg cactttgatt gtacaatact tcacattgct
     2041 tttttaatgc ataaaggttt gtaagaaaaa tcaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2101 aaaaaaaaaa aaaaaa
//
