LOCUS       NM_145508               2092 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus dual-specificity tyrosine phosphorylation regulated
            kinase 3 (Dyrk3), transcript variant 1, mRNA.
ACCESSION   NM_145508
VERSION     NM_145508.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2092)
  AUTHORS   Yoshida,S., Tsuneoka,Y., Tsukada,T., Nakakura,T., Kawamura,A.,
            Kai,W. and Yoshida,K.
  TITLE     Primary Cilia are Required for Cell-Type Determination and
            Angiogenesis in Pituitary Development
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   39001875
REFERENCE   2  (bases 1 to 2092)
  AUTHORS   Yogosawa,S., Ohkido,M., Horii,T., Okazaki,Y., Nakayama,J.,
            Yoshida,S., Toyokuni,S., Hatada,I., Morimoto,M. and Yoshida,K.
  TITLE     Mice lacking DYRK2 exhibit congenital malformations with lung
            hypoplasia and altered Foxf1 expression gradient
  JOURNAL   Commun Biol 4 (1), 1204 (2021)
   PUBMED   34671097
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2092)
  AUTHORS   Ivanova,E., Sharma,S.D., Brichkina,A., Pfefferle,P., Keber,U.,
            Pagenstecher,A. and Lauth,M.
  TITLE     DYRK3 contributes to differentiation and hypoxic control in
            neuroblastoma
  JOURNAL   Biochem Biophys Res Commun 567, 215-221 (2021)
   PUBMED   34171798
  REMARK    GeneRIF: DYRK3 contributes to differentiation and hypoxic control
            in neuroblastoma.
REFERENCE   4  (bases 1 to 2092)
  AUTHORS   Wippich,F., Bodenmiller,B., Trajkovska,M.G., Wanka,S., Aebersold,R.
            and Pelkmans,L.
  TITLE     Dual specificity kinase DYRK3 couples stress granule
            condensation/dissolution to mTORC1 signaling
  JOURNAL   Cell 152 (4), 791-805 (2013)
   PUBMED   23415227
  REMARK    GeneRIF: Study identified the dual specificity
            tyrosine-phosphorylation-regulated kinase 3 (DYRK3) as a protein
            with the ability to condense P-granule-like speckles in the cytosol
            and to prevent stress granule dissolution via its N-terminal domain
            when it is in a kinase-inactive form.
REFERENCE   5  (bases 1 to 2092)
  AUTHORS   Guo,X., Williams,J.G., Schug,T.T. and Li,X.
  TITLE     DYRK1A and DYRK3 promote cell survival through phosphorylation and
            activation of SIRT1
  JOURNAL   J Biol Chem 285 (17), 13223-13232 (2010)
   PUBMED   20167603
  REMARK    GeneRIF: DYRK1A and DYRK3 promote cell survival through
            phosphorylation and activation of SIRT1.
REFERENCE   6  (bases 1 to 2092)
  AUTHORS   Wojchowski,D.M., Menon,M.P., Sathyanarayana,P., Fang,J., Karur,V.,
            Houde,E., Kapelle,W. and Bogachev,O.
  TITLE     Erythropoietin-dependent erythropoiesis: New insights and questions
  JOURNAL   Blood Cells Mol Dis 36 (2), 232-238 (2006)
   PUBMED   16524748
  REMARK    Review article
REFERENCE   7  (bases 1 to 2092)
  AUTHORS   Zhang,D., Li,K., Erickson-Miller,C.L., Weiss,M. and Wojchowski,D.M.
  TITLE     DYRK gene structure and erythroid-restricted features of DYRK3 gene
            expression
  JOURNAL   Genomics 85 (1), 117-130 (2005)
   PUBMED   15607427
  REMARK    GeneRIF: DYRK3, expression is strong in erythroid cells and testis,
            but is also detected in adult kidney and liver
REFERENCE   8  (bases 1 to 2092)
  AUTHORS   Li,K., Zhao,S., Karur,V. and Wojchowski,D.M.
  TITLE     DYRK3 activation, engagement of protein kinase A/cAMP response
            element-binding protein, and modulation of progenitor cell survival
  JOURNAL   J Biol Chem 277 (49), 47052-47060 (2002)
   PUBMED   12356771
REFERENCE   9  (bases 1 to 2092)
  AUTHORS   Geiger,J.N., Knudsen,G.T., Panek,L., Pandit,A.K., Yoder,M.D.,
            Lord,K.A., Creasy,C.L., Burns,B.M., Gaines,P., Dillon,S.B. and
            Wojchowski,D.M.
  TITLE     mDYRK3 kinase is expressed selectively in late erythroid progenitor
            cells and attenuates colony-forming unit-erythroid development
  JOURNAL   Blood 97 (4), 901-910 (2001)
   PUBMED   11159515
REFERENCE   10 (bases 1 to 2092)
  AUTHORS   Becker,W., Weber,Y., Wetzel,K., Eirmbter,K., Tejedor,F.J. and
            Joost,H.G.
  TITLE     Sequence characteristics, subcellular localization, and substrate
            specificity of DYRK-related kinases, a novel family of dual
            specificity protein kinases
  JOURNAL   J Biol Chem 273 (40), 25893-25902 (1998)
   PUBMED   9748265
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL513351.26.
            
            On Mar 15, 2023 this sequence version replaced NM_145508.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006704.1, AK161495.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               AL513351.26        4243-4417
            176-287             AL513351.26        6126-6237
            288-2092            AL513351.26        12252-14056
FEATURES             Location/Qualifiers
     source          1..2092
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 56.9 cM"
     gene            1..2092
                     /gene="Dyrk3"
                     /note="dual-specificity tyrosine phosphorylation regulated
                     kinase 3"
                     /db_xref="GeneID:226419"
                     /db_xref="MGI:MGI:1330300"
     exon            1..175
                     /gene="Dyrk3"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1859
                     /gene="Dyrk3"
                     /EC_number="2.7.12.1"
                     /note="isoform a is encoded by transcript variant 1;
                     dual-specificity tyrosine-(Y)-phosphorylation regulated
                     kinase 3"
                     /codon_start=1
                     /product="dual specificity
                     tyrosine-phosphorylation-regulated kinase 3 isoform a"
                     /protein_id="NP_663483.1"
                     /db_xref="CCDS:CCDS15267.1"
                     /db_xref="GeneID:226419"
                     /db_xref="MGI:MGI:1330300"
                     /translation="MGGAARDRGRKDAALPGAGLPPQQRRLGDGVYDTFMMIDETKGP
                     PYSDTFSNPSEAPVSRRLNITTEPLTRGHTQHFVNGSEMKVEQLFQEFGNRRSNTLQS
                     DGISNSEKSSPASQGKSSESLSAVKCNLSSRPSKVLPLTPEQALKQYKHHLTAYEKLE
                     IVSYPEIYFVGPNAKKRQGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGS
                     FGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLES
                     FTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCD
                     LKPENILLKHHGRSATKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGCRYSTPIDIW
                     SFGCILAELLTGQPLFPGEDEGDQLACMIELLGMPPQKLLEQSKRAKYFINSKGLPRY
                     CSVSTQTDGRVVLLGGRSRRGKKRGPPGSKDWATALKGCGDYLFIEFLKRCLQWDPSA
                     RLTPAQALRHPWISKSTPKPLTMDKVPGKRVVNPTNAFQGLGSKLPPVVGIASKLKAN
                     LMSETSGSIPLCSVLPKLIS"
     exon            176..287
                     /gene="Dyrk3"
                     /inference="alignment:Splign:2.1.0"
     exon            288..2092
                     /gene="Dyrk3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2069..2074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dyrk3"
                     /note="hexamer: ATTAAA"
     polyA_site      2092
                     /gene="Dyrk3"
                     /note="major polyA site"
ORIGIN      
        1 agtgcccagc ctcgtcttgt agcgaagcca gcaggtgcgg tgctggaggc gacccaccgg
       61 gccaaccgcc gcctctgtgt ccgcggggcg agctcgcgat gggaggcgca gcccgcgatc
      121 gcgggaggaa ggacgcggcg ctgccggggg ccgggctccc gccgcagcag cggaggttgg
      181 gggatggtgt ctatgatact ttcatgatga tagatgaaac caagggccca ccctattcgg
      241 acacattcag caacccctct gaagcacctg tctccagaag gctaaatatt accactgagc
      301 cactcacgag aggccacact cagcactttg tgaatggaag tgagatgaag gtggaacagc
      361 tgtttcaaga atttggcaac agaagatcca atactctcca gtcagatggc atcagcaact
      421 cggaaaagtc ttctccggct tctcagggga aaagttcgga aagcctgagc gcggtgaagt
      481 gcaacctttc ctccaggccg tctaaggtgc tgccgctgac tcctgagcaa gcgctgaagc
      541 agtataaaca ccacctcact gcctacgaga agctggagat cgtcagctac ccagaaatct
      601 actttgtggg tccgaatgcc aaaaagcggc agggagttat tggtggtccc aataacggtg
      661 gctacgacga tgcggatggg gcctatattc atgtgccccg ggaccatctg gcttaccgct
      721 atgaggtgct gaaaatcatc ggcaagggga gttttggaca ggtagcccgg gtctatgatc
      781 acaaacttcg gcagtacgtg gccctgaaaa tggtgcgcaa tgagaaacgc ttccatcgcc
      841 aggcggccga ggagatccgg atcttggagc atcttaaaaa gcaagacaaa actggtagca
      901 tgaacgtcat ccacatgcta gaaagtttca ccttccggaa ccacgtgtgc atggcctttg
      961 aactgctaag catagacctg tatgagctta ttaaaaaaaa caagttccag ggcttcagcg
     1021 tccagttggt tcggaagttc gcccagtcca tcctacagtc cctggacgct ctgcacaaaa
     1081 acaagatcat ccactgcgac ctgaagccgg aaaacattct cctgaaacac cacggccgaa
     1141 gcgccaccaa ggtcatcgac tttggctcca gctgcttcga gtatcagaag ctttacacgt
     1201 atatccagtc ccgcttctac agagccccag agatcatcct ggggtgccgc tacagcaccc
     1261 cgatcgacat atggagcttt ggttgcatcc ttgcagaact tttgacagga cagcccctgt
     1321 tccctggaga ggacgaagga gaccagttgg cctgcatgat agagttgcta ggaatgccac
     1381 cgcagaaact tctggagcaa tccaagcgtg ccaagtactt tattaactcc aaaggcttgc
     1441 ctcgatactg ctccgtatct acccagacgg acgggagggt ggtgcttctc gggggtcgct
     1501 cacgcagggg taaaaagcga ggcccgccag gcagcaaaga ctgggcaacc gcactgaagg
     1561 gctgtggtga ctacttgttc atagagtttc tgaaacgatg cctccagtgg gacccctctg
     1621 cccgcctcac cccggctcaa gcattaagac atccttggat tagcaagtct acacccaaac
     1681 ctctcaccat ggacaaggtg ccagggaagc gggtagttaa ccctacaaat gctttccagg
     1741 gactgggttc caagctgcct ccagtcgttg ggatagccag taagcttaaa gctaacctaa
     1801 tgtccgaaac cagtggtagt atacctctgt gcagtgtatt gccaaagctg attagctagt
     1861 ggaccactca gagactgata catatcatat gtatttttaa ttaccttgca aacatgcaaa
     1921 tggaaaacgg aataattgaa gcccattcac tgatggatat gtttttgtta gacttttttt
     1981 taacaaggca gaacattttt atatgactat aaaagaacgc ttcaagggct aatgtcaaac
     2041 cagcttgtat tggccatctg gagtatacat taaatgactt tttcataggt ca
//
