LOCUS       NM_001014390            2137 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus dual-specificity tyrosine phosphorylation regulated
            kinase 2 (Dyrk2), mRNA.
ACCESSION   NM_001014390 XM_483957
VERSION     NM_001014390.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2137)
  AUTHORS   Yoshida,S., Kawamura,A., Aoki,K., Wiriyasermkul,P., Sugimoto,S.,
            Tomiyoshi,J., Tajima,A., Ishida,Y., Katoh,Y., Tsukada,T.,
            Tsuneoka,Y., Yamada,K., Nagamori,S., Nakayama,K. and Yoshida,K.
  TITLE     Positive regulation of Hedgehog signaling via phosphorylation of
            GLI2/GLI3 by DYRK2 kinase
  JOURNAL   Proc Natl Acad Sci U S A 121 (28), e2320070121 (2024)
   PUBMED   38968120
REFERENCE   2  (bases 1 to 2137)
  AUTHORS   Yoshida,S., Tsuneoka,Y., Tsukada,T., Nakakura,T., Kawamura,A.,
            Kai,W. and Yoshida,K.
  TITLE     Primary Cilia are Required for Cell-Type Determination and
            Angiogenesis in Pituitary Development
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   39001875
REFERENCE   3  (bases 1 to 2137)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2137)
  AUTHORS   Yogosawa,S., Ohkido,M., Horii,T., Okazaki,Y., Nakayama,J.,
            Yoshida,S., Toyokuni,S., Hatada,I., Morimoto,M. and Yoshida,K.
  TITLE     Mice lacking DYRK2 exhibit congenital malformations with lung
            hypoplasia and altered Foxf1 expression gradient
  JOURNAL   Commun Biol 4 (1), 1204 (2021)
   PUBMED   34671097
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2137)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2137)
  AUTHORS   Kudo,L.C., Karsten,S.L., Chen,J., Levitt,P. and Geschwind,D.H.
  TITLE     Genetic analysis of anterior posterior expression gradients in the
            developing mammalian forebrain
  JOURNAL   Cereb Cortex 17 (9), 2108-2122 (2007)
   PUBMED   17150988
REFERENCE   7  (bases 1 to 2137)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 2137)
  AUTHORS   Clark,A.G., Glanowski,S., Nielsen,R., Thomas,P.D., Kejariwal,A.,
            Todd,M.A., Tanenbaum,D.M., Civello,D., Lu,F., Murphy,B.,
            Ferriera,S., Wang,G., Zheng,X., White,T.J., Sninsky,J.J.,
            Adams,M.D. and Cargill,M.
  TITLE     Inferring nonneutral evolution from human-chimp-mouse orthologous
            gene trios
  JOURNAL   Science 302 (5652), 1960-1963 (2003)
   PUBMED   14671302
REFERENCE   9  (bases 1 to 2137)
  AUTHORS   Geiger,J.N., Knudsen,G.T., Panek,L., Pandit,A.K., Yoder,M.D.,
            Lord,K.A., Creasy,C.L., Burns,B.M., Gaines,P., Dillon,S.B. and
            Wojchowski,D.M.
  TITLE     mDYRK3 kinase is expressed selectively in late erythroid progenitor
            cells and attenuates colony-forming unit-erythroid development
  JOURNAL   Blood 97 (4), 901-910 (2001)
   PUBMED   11159515
REFERENCE   10 (bases 1 to 2137)
  AUTHORS   Becker,W., Weber,Y., Wetzel,K., Eirmbter,K., Tejedor,F.J. and
            Joost,H.G.
  TITLE     Sequence characteristics, subcellular localization, and substrate
            specificity of DYRK-related kinases, a novel family of dual
            specificity protein kinases
  JOURNAL   J Biol Chem 273 (40), 25893-25902 (1998)
   PUBMED   9748265
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC154039.17.
            
            On Nov 17, 2006 this sequence version replaced NM_001014390.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085145.1, AK149371.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               AC154039.17        63219-63401         c
            184-332             AC154039.17        62648-62796         c
            333-2137            AC154039.17        53847-55651         c
FEATURES             Location/Qualifiers
     source          1..2137
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 66.75 cM"
     gene            1..2137
                     /gene="Dyrk2"
                     /gene_synonym="1810038L18Rik"
                     /note="dual-specificity tyrosine phosphorylation regulated
                     kinase 2"
                     /db_xref="GeneID:69181"
                     /db_xref="MGI:MGI:1330301"
     exon            1..183
                     /gene="Dyrk2"
                     /gene_synonym="1810038L18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1934
                     /gene="Dyrk2"
                     /gene_synonym="1810038L18Rik"
                     /EC_number="2.7.12.1"
                     /note="dual-specificity tyrosine-(Y)-phosphorylation
                     regulated kinase 2"
                     /codon_start=1
                     /product="dual specificity
                     tyrosine-phosphorylation-regulated kinase 2"
                     /protein_id="NP_001014412.1"
                     /db_xref="CCDS:CCDS24201.1"
                     /db_xref="GeneID:69181"
                     /db_xref="MGI:MGI:1330301"
                     /translation="MLTRKPSAAAPAAYPTGRGGDTAVRQLQASPGIGAGAPRSGVGT
                     GPPSPIALPPLRASNATTTAHTIGGSKHTMNDHLHLNSHGQIQVQQLFEDNSNKRTVL
                     TTQPNGLTTVGKTGLPGVPERQLESIHRRQGSSTSLKSMEGMGKVKASPMTPEQAMKQ
                     YMQKLTAFEHHEIFSYPEIYFLGPNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAY
                     RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDK
                     DNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCL
                     DALHKNRIIHCDLKPENILLKQQGRSSIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVI
                     LGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRA
                     KNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLD
                     FLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGEKTAVKRVTESTGAITSISKLPP
                     PSSSASKLRTNLAQMTDANGNIQQRTVLPKLVS"
     exon            184..332
                     /gene="Dyrk2"
                     /gene_synonym="1810038L18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            333..2137
                     /gene="Dyrk2"
                     /gene_synonym="1810038L18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2105..2110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dyrk2"
                     /gene_synonym="1810038L18Rik"
                     /note="hexamer: TATAAA"
     polyA_site      2126
                     /gene="Dyrk2"
                     /gene_synonym="1810038L18Rik"
                     /note="major polyA site"
ORIGIN      
        1 cgggagcgag gcggcgacga ggcgcgggtg acccgcgtga ggggcgacca ggaggcggcg
       61 gcggcggcgg cgaggagtag cggcgggacc ggcggcgagg gcagcactgc catgcacgtt
      121 cctctcccgc ggccatgtta accaggaaac cttcggccgc cgctcccgcc gcctacccga
      181 ccggccgagg aggggacacc gccgttcgcc agcttcaggc ttccccgggg atcggcgcgg
      241 gggctccccg aagcggagtg gggaccggcc cgccctcccc catcgccctg ccgcctctcc
      301 gggccagcaa cgctaccact acagcccaca cgattggcgg cagtaagcac accatgaatg
      361 accacctcca cctcaacagc cacggacaga tccaggttca gcagctgttc gaggataata
      421 gtaacaaaag gacagtgctc acaacacagc ccaatgggct tacgacggtg ggcaagacag
      481 gcttgcctgg ggtgcccgag cggcagctgg agagcattca ccgacggcag ggcagctcca
      541 cctctctgaa gtccatggaa ggcatgggga aggtaaaagc ctcccccatg acgcccgaac
      601 aagcgatgaa gcaatacatg caaaaactca cagccttcga acaccatgag atttttagct
      661 accctgaaat atacttcttg ggtccaaatg caaagaaacg ccaaggcatg accggtggac
      721 ccaacaatgg tggttatgac gacgaccagg gatcgtacgt gcaggtgccc catgatcacg
      781 tggcttacag gtacgaggtc ctcaaggtca tcgggaaggg gagctttggg caggtggtca
      841 aggcctatga ccacaaagtc caccagcacg tggccctgaa gatggtgcgg aacgagaagc
      901 gcttccacag gcaggcggcc gaggagatcc ggatcttgga acacctacgg aagcaggaca
      961 aggacaacac tatgaacgtc atccacatgc tggagaactt caccttccgc aaccacatct
     1021 gcatgacgtt cgagttgctg agcatgaacc tctatgagct catcaagaag aataagttcc
     1081 agggcttcag cctgcctctg gtgcgcaagt ttgcccactc cattctgcag tgcttggatg
     1141 ctttgcacaa gaacagaata atccactgtg accttaagcc cgagaacatt ttgttaaagc
     1201 agcagggtcg aagcagtatt aaagtgattg actttggctc cagttgttac gagcaccaac
     1261 gcgtctacac gtacatccag tcacgctttt accgggctcc ggaagtgatc ctcggagcca
     1321 ggtatggcat gcccatagac atgtggagcc tgggttgcat cctcgcggaa ctcctgacgg
     1381 gttaccccct cttgcctggg gaggatgaag gggaccagct ggcttgtatg atcgagcttt
     1441 tgggcatgcc ctctcagaaa ctcctggatg cttccaaacg agccaaaaat ttcgtgagct
     1501 ccaagggtta cccccgatac tgcacagtta cgactctttc agatggctct gtggtcctca
     1561 acgggggccg atcccggaga gggaaactaa ggggtccgcc agagagcaga gagtggggga
     1621 acgcactgaa gggatgcgat gaccctcttt tccttgactt cttaaaacag tgtttggagt
     1681 gggatcccgc ggtccgcatg accccgggcc aggctttgcg gcacccgtgg cttaggaggc
     1741 gcttgccaaa gcctccgacc ggagagaaga cagcggtgaa gagggtcaca gagagtactg
     1801 gtgctatcac ctccatttcc aagttacctc caccctccag ttcagcttcc aagctgagga
     1861 ctaacttggc acagatgaca gatgccaatg ggaatattca gcagaggaca gtgttgccga
     1921 aactcgttag ctgagctcca gtccccctga tgctggcaat ctgaagagag agagagagag
     1981 agagaaccgc gttatagctg agccttactg ggttgaaaaa gtgtagctca gacctgtttt
     2041 tatttgctca ataactcgac tcatttgtat cttttcagca cttgatgtaa gactgttttg
     2101 tttttataaa atacatgggg acaatgcttt aagtttt
//
