LOCUS       NM_001271370            2575 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus dual-specificity tyrosine phosphorylation regulated
            kinase 1b (Dyrk1b), transcript variant 4, mRNA.
ACCESSION   NM_001271370
VERSION     NM_001271370.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2575)
  AUTHORS   Brichkina,A., Ems,M., Suezov,R., Singh,R., Lutz,V., Picard,F.S.R.,
            Nist,A., Stiewe,T., Graumann,J., Daude,M., Diederich,W.E.,
            Finkernagel,F., Chung,H.R., Bartsch,D.K., Roth,K., Keber,C.,
            Denkert,C., Huber,M., Gress,T.M. and Lauth,M.
  TITLE     DYRK1B blockade promotes tumoricidal macrophage activity in
            pancreatic cancer
  JOURNAL   Gut 73 (10), 1684-1701 (2024)
   PUBMED   38834297
  REMARK    GeneRIF: DYRK1B blockade promotes tumoricidal macrophage activity
            in pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2575)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2575)
  AUTHORS   Wongchang,T., Pluangnooch,P., Hongeng,S., Wongkajornsilp,A.,
            Thumkeo,D. and Soontrapa,K.
  TITLE     Inhibition of DYRK1B suppresses inflammation in allergic contact
            dermatitis model and Th1/Th17 immune response
  JOURNAL   Sci Rep 13 (1), 7058 (2023)
   PUBMED   37120440
  REMARK    GeneRIF: Inhibition of DYRK1B suppresses inflammation in allergic
            contact dermatitis model and Th1/Th17 immune response.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2575)
  AUTHORS   Zhuang,L., Jia,K., Chen,C., Li,Z., Zhao,J., Hu,J., Zhang,H.,
            Fan,Q., Huang,C., Xie,H., Lu,L., Shen,W., Ning,G., Wang,J.,
            Zhang,R., Chen,K. and Yan,X.
  TITLE     DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by
            Impairing Mitochondrial Bioenergetics
  JOURNAL   Circulation 145 (11), 829-846 (2022)
   PUBMED   35235343
  REMARK    GeneRIF: DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure
            by Impairing Mitochondrial Bioenergetics.
REFERENCE   5  (bases 1 to 2575)
  AUTHORS   Bhat,N., Narayanan,A., Fathzadeh,M., Kahn,M., Zhang,D., Goedeke,L.,
            Neogi,A., Cardone,R.L., Kibbey,R.G., Fernandez-Hernando,C.,
            Ginsberg,H.N., Jain,D., Shulman,G.I. and Mani,A.
  TITLE     Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin
            signaling and directly activating mTORC2 in mice
  JOURNAL   J Clin Invest 132 (3) (2022)
   PUBMED   34855620
  REMARK    GeneRIF: Dyrk1b promotes hepatic lipogenesis by bypassing canonical
            insulin signaling and directly activating mTORC2 in mice.
REFERENCE   6  (bases 1 to 2575)
  AUTHORS   Deng,X., Ewton,D.Z., Pawlikowski,B., Maimone,M. and Friedman,E.
  TITLE     Mirk/dyrk1B is a Rho-induced kinase active in skeletal muscle
            differentiation
  JOURNAL   J Biol Chem 278 (42), 41347-41354 (2003)
   PUBMED   12902328
  REMARK    GeneRIF: dyrk1B is a Rho-induced kinase active in skeletal muscle
            differentiation
REFERENCE   7  (bases 1 to 2575)
  AUTHORS   Leder,S., Czajkowska,H., Maenz,B., De Graaf,K., Barthel,A.,
            Joost,H.G. and Becker,W.
  TITLE     Alternative splicing variants of dual specificity tyrosine
            phosphorylated and regulated kinase 1B exhibit distinct patterns of
            expression and functional properties
  JOURNAL   Biochem J 372 (Pt 3), 881-888 (2003)
   PUBMED   12633499
REFERENCE   8  (bases 1 to 2575)
  AUTHORS   Lim,S., Zou,Y. and Friedman,E.
  TITLE     The transcriptional activator Mirk/Dyrk1B is sequestered by
            p38alpha/beta MAP kinase
  JOURNAL   J Biol Chem 277 (51), 49438-49445 (2002)
   PUBMED   12384504
  REMARK    GeneRIF: p38 MAP Kinase suppresses the function of Mirk as a
            transcriptional activator only when cells are proliferating
REFERENCE   9  (bases 1 to 2575)
  AUTHORS   Leder,S., Weber,Y., Altafaj,X., Estivill,X., Joost,H.G. and
            Becker,W.
  TITLE     Cloning and characterization of DYRK1B, a novel member of the DYRK
            family of protein kinases
  JOURNAL   Biochem Biophys Res Commun 254 (2), 474-479 (1999)
   PUBMED   9918863
REFERENCE   10 (bases 1 to 2575)
  AUTHORS   Becker,W., Weber,Y., Wetzel,K., Eirmbter,K., Tejedor,F.J. and
            Joost,H.G.
  TITLE     Sequence characteristics, subcellular localization, and substrate
            specificity of DYRK-related kinases, a novel family of dual
            specificity protein kinases
  JOURNAL   J Biol Chem 273 (40), 25893-25902 (1998)
   PUBMED   9748265
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC141883.4.
            
            On Jan 4, 2023 this sequence version replaced NM_001271370.1.
            
            Transcript Variant: This variant (4), uses an alternate 5'
            structure, compared to variant 1. This difference causes
            translation initiation at an upstream AUG and results in an isoform
            (p75), also known as isoform c, that has a longer N-terminus,
            compared to isoform p69.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ537610.1, SRR13422597.27836.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-213               AC141883.4         126045-126257
            214-377             AC141883.4         127340-127503
            378-497             AC141883.4         128192-128311
            498-686             AC141883.4         128410-128598
            687-834             AC141883.4         128895-129042
            835-1121            AC141883.4         130072-130358
            1122-1268           AC141883.4         130899-131045
            1269-1409           AC141883.4         131127-131267
            1410-1725           AC141883.4         131545-131860
            1726-1832           AC141883.4         132193-132299
            1833-2575           AC141883.4         132383-133125
FEATURES             Location/Qualifiers
     source          1..2575
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 16.67 cM"
     gene            1..2575
                     /gene="Dyrk1b"
                     /gene_synonym="Mirk"
                     /note="dual-specificity tyrosine phosphorylation regulated
                     kinase 1b"
                     /db_xref="GeneID:13549"
                     /db_xref="MGI:MGI:1330302"
     exon            1..213
                     /gene="Dyrk1b"
                     /gene_synonym="Mirk"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..2204
                     /gene="Dyrk1b"
                     /gene_synonym="Mirk"
                     /EC_number="2.7.12.1"
                     /note="isoform p75 is encoded by transcript variant 4;
                     dual-specificity tyrosine-(Y)-phosphorylation regulated
                     kinase 1b"
                     /codon_start=1
                     /product="dual specificity
                     tyrosine-phosphorylation-regulated kinase 1B isoform p75"
                     /protein_id="NP_001258299.1"
                     /db_xref="CCDS:CCDS85251.1"
                     /db_xref="GeneID:13549"
                     /db_xref="MGI:MGI:1330302"
                     /translation="MLAARPPHWGPHRAPAPRGPSAIPDPGLSGGGSRGAGCEKAPPG
                     RAPAPGLTPLRPSEPTMAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDAAS
                     APLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSTKKEKKVLNHGYDDDNHDYI
                     VRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRL
                     LELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRK
                     LAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYI
                     QSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMSRIVEVLGIP
                     PAPMLEQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRR
                     AGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSA
                     STSPAPLDTCPSSSTASSISSSGGSSGSSNDNRAYRYSNRYCGGPGPPITDCEMNSPQ
                     VLPSQPLRPWAGGDVPHKTHQAPISASTLPGTGAQLPPLPRCLGRPPSPTSPPPPELM
                     DVSLVGSPPDCSPPPPAPAPQHPAASALRTRMTGGRPPLPPPDDPATLGPRLGLHGVP
                     QSTAASS"
     exon            214..377
                     /gene="Dyrk1b"
                     /gene_synonym="Mirk"
                     /inference="alignment:Splign:2.1.0"
     exon            378..497
                     /gene="Dyrk1b"
                     /gene_synonym="Mirk"
                     /inference="alignment:Splign:2.1.0"
     exon            498..686
                     /gene="Dyrk1b"
                     /gene_synonym="Mirk"
                     /inference="alignment:Splign:2.1.0"
     exon            687..834
                     /gene="Dyrk1b"
                     /gene_synonym="Mirk"
                     /inference="alignment:Splign:2.1.0"
     exon            835..1121
                     /gene="Dyrk1b"
                     /gene_synonym="Mirk"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1268
                     /gene="Dyrk1b"
                     /gene_synonym="Mirk"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1409
                     /gene="Dyrk1b"
                     /gene_synonym="Mirk"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1725
                     /gene="Dyrk1b"
                     /gene_synonym="Mirk"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1832
                     /gene="Dyrk1b"
                     /gene_synonym="Mirk"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..2575
                     /gene="Dyrk1b"
                     /gene_synonym="Mirk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2557..2562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dyrk1b"
                     /gene_synonym="Mirk"
                     /note="hexamer: AGTAAA"
     polyA_site      2575
                     /gene="Dyrk1b"
                     /gene_synonym="Mirk"
                     /note="major polyA site"
ORIGIN      
        1 agtggcggcg gctgctgttg tcacccaccg ggccgcctgt cccgcttgcc ctcaccgccg
       61 cggggctggc taggctagcc gggccgggga caggcggcca cctcctcatc gccgccgcca
      121 ccaccaccgc cgccatgctg gccgctcgcc caccgcactg gggtccccat cgcgctccag
      181 ccccccgtgg gcccagcgcc atccctgacc cgggtctcag cggcggtggc agccgaggtg
      241 caggatgcga gaaggcgccc cccggccggg ctcccgctcc aggcctcacg cccctgcggc
      301 cctctgagcc caccatggcc gtcccaccag gccatggtcc tttctctggc tttccggggc
      361 cccaggaaca cacacaggta ctacctgatg tgcggctcct gccccggaga ctgcccctgg
      421 ccttccggga tgcggcctca gccccgctgc gcaagctctc ggtggacctc atcaagacct
      481 acaagcacat caatgaggta tactatgcga agaagaagcg gcgggcccaa caggcgccac
      541 cccaggactc gagcaccaaa aaggagaaga aggtcctgaa ccacggttat gatgacgaca
      601 accacgacta cattgtgcgc agtggcgagc gctggctaga gcgctatgag attgactctc
      661 ttattggcaa aggctccttt ggccaggtgg tgaaagccta tgatcaccag actcaggagc
      721 tggtggccat caagatcatc aagaacaaaa aggccttcct gaaccaggca cagattgagc
      781 tacggctgtt ggagctgatg aaccagcatg atacagagat gaagtactac atagtacacc
      841 ttaagcggca cttcatgttc cggaatcacc tgtgcctggt gtttgagctg ctgtcctaca
      901 acctgtacga cctcctccgc aacacacact ttcggggtgt ctcactgaac ctgacgagga
      961 agctggcaca gcagctctgc acagctctgc tctttctggc cacccccgag ctcagcatca
     1021 tccactgcga cctcaagcct gagaacatcc tgctctgcaa ccccaagcgc agtgccatca
     1081 agatcgtgga cttcggcagt tcctgccagc ttggccagcg gatctaccag tatatccaga
     1141 gccgcttcta ccgctcaccc gaggtgctcc tgggtacacc ctatgacctg gccattgaca
     1201 tgtggtccct gggctgcatc ctcgtggaga tgcacaccgg agagcccctc ttcagtggct
     1261 ctaatgaggt ggaccagatg agccgtattg tggaggtgtt gggcatccct cccgcaccca
     1321 tgctggaaca ggcacccaag gctcgaaagt actttgagcg gctgcctggg ggtggctgga
     1381 ccctacgaag gacaaaggaa ctcaggaagg attaccaggg ccctgggaca cggcggctgc
     1441 aggaggtgct gggcgtgcag acgggcgggc ccgggggccg gcgggcgggg gagcccggcc
     1501 acagccccgc cgactacctc cgcttccagg acctggtgct gcgcatgctg gaatatgagc
     1561 ccgccgcccg catcagccct ctgggcgctc tgcagcatgg cttcttccgc cgcacggccg
     1621 acgaggccac caacacgggc ccggcaggca gcagtgcctc cacctcgccg gcgccccttg
     1681 acacctgccc ctcctctagc accgccagct ccatctccag ctctggaggt tccagtggct
     1741 cctccaacga caacagagcc taccgataca gcaaccgata ttgtgggggc ccagggcccc
     1801 ccatcactga ctgtgagatg aacagccccc aggtcctacc ctcccagcct ctgcgcccct
     1861 gggcaggggg tgatgtgccc cacaagacac atcaagcccc tatctctgcc tcaacattgc
     1921 cggggactgg ggctcagtta cccccattgc cccgttgcct tggacgaccc ccatcaccaa
     1981 catcaccacc acccccagag ttgatggatg tgagcctggt gggcagccct ccagactgct
     2041 ctccacctcc tccagcacct gccccccagc acccggctgc ctcagccctc cggactcgga
     2101 tgacaggagg tcgaccacct ctcccacccc ctgatgaccc tgccactctg gggcctcgcc
     2161 tgggtctcca tggtgtaccc cagagcacag cagccagctc atgaccctgc cccctccctg
     2221 gggcccctcc tgaagccata cccccccata tgggggccct gggctcccat cctcatctct
     2281 ccccttgact ggacttgctg ctacccagct ggggtgggtg aggcctgcac tgactggggc
     2341 ccagggcagg gggtcaaggg agaggagttt ggccgcaccc tccccactaa gactggaccc
     2401 ttggcccctc tcttccccct ccccccttgt tttctattta ttgtaccaaa gacagtggtg
     2461 gtccggtaga ggggagattc ccccttaccc agggccctag gagggggtgg gggcaggtag
     2521 ggggagatgg ccttgctcct cctcgctgta ccccccagta aaaagctttc tcaca
//
