LOCUS       NM_007890               6035 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus dual-specificity tyrosine phosphorylation regulated
            kinase 1a (Dyrk1a), transcript variant 1, mRNA.
ACCESSION   NM_007890 XM_128336
VERSION     NM_007890.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6035)
  AUTHORS   Cortes,D.E., Escudero,M., Korgan,A.C., Mitra,A., Edwards,A.,
            Aydin,S.C., Munger,S.C., Charland,K., Zhang,Z.W., O'Connell,K.M.S.,
            Reinholdt,L.G. and Pera,M.F.
  TITLE     An in vitro neurogenetics platform for precision disease modeling
            in the mouse
  JOURNAL   Sci Adv 10 (14), eadj9305 (2024)
   PUBMED   38569042
REFERENCE   2  (bases 1 to 6035)
  AUTHORS   Hu,K., Liu,L., Tang,S., Zhang,X., Chang,H., Chen,W., Fan,T.,
            Zhang,L., Shen,B. and Zhang,Q.
  TITLE     MicroRNA-221-3p inhibits the inflammatory response of keratinocytes
            by regulating the DYRK1A/STAT3 signaling pathway to promote wound
            healing in diabetes
  JOURNAL   Commun Biol 7 (1), 300 (2024)
   PUBMED   38461326
  REMARK    GeneRIF: MicroRNA-221-3p inhibits the inflammatory response of
            keratinocytes by regulating the DYRK1A/STAT3 signaling pathway to
            promote wound healing in diabetes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6035)
  AUTHORS   Lana-Elola,E., Aoidi,R., Llorian,M., Gibbins,D.,
            Buechsenschuetz,C., Bussi,C., Flynn,H., Gilmore,T.,
            Watson-Scales,S., Haugsten Hansen,M., Hayward,D., Song,O.R.,
            Brault,V., Herault,Y., Deau,E., Meijer,L., Snijders,A.P.,
            Gutierrez,M.G., Fisher,E.M.C. and Tybulewicz,V.L.J.
  TITLE     Increased dosage of DYRK1A leads to congenital heart defects in a
            mouse model of Down syndrome
  JOURNAL   Sci Transl Med 16 (731), eadd6883 (2024)
   PUBMED   38266108
  REMARK    GeneRIF: Increased dosage of DYRK1A leads to congenital heart
            defects in a mouse model of Down syndrome.
REFERENCE   4  (bases 1 to 6035)
  AUTHORS   He,W., Meng,D.L., Yang,D., Chen,Q.Y., Li,L. and Wang,L.H.
  TITLE     miRNA-192-5p targets Dyrk1a to attenuate cerebral injury in MCAO
            mice by suppressing neuronal apoptosis and neuroinflammation
  JOURNAL   Folia Histochem Cytobiol 61 (4), 217-230 (2023)
   PUBMED   38258843
  REMARK    GeneRIF: miRNA-192-5p targets Dyrk1a to attenuate cerebral injury
            in MCAO mice by suppressing neuronal apoptosis and
            neuroinflammation.
REFERENCE   5  (bases 1 to 6035)
  AUTHORS   Becker,W., Weber,Y., Wetzel,K., Eirmbter,K., Tejedor,F.J. and
            Joost,H.G.
  TITLE     Sequence characteristics, subcellular localization, and substrate
            specificity of DYRK-related kinases, a novel family of dual
            specificity protein kinases
  JOURNAL   J Biol Chem 273 (40), 25893-25902 (1998)
   PUBMED   9748265
REFERENCE   6  (bases 1 to 6035)
  AUTHORS   Cabin,D.E., McKee-Johnson,J.W., Matesic,L.E., Wiltshire,T.,
            Rue,E.E., Mjaatvedt,A.E., Huo,Y.K., Korenberg,J.R. and Reeves,R.H.
  TITLE     Physical and comparative mapping of distal mouse chromosome 16. 5
            p5
  JOURNAL   Genome Res 8 (9), 940-950 (1998)
   PUBMED   9750193
REFERENCE   7  (bases 1 to 6035)
  AUTHORS   Song,W.J., Chung,S.H. and Kurnit,D.M.
  TITLE     The murine Dyrk protein maps to chromosome 16, localizes to the
            nucleus, and can form multimers
  JOURNAL   Biochem Biophys Res Commun 231 (3), 640-644 (1997)
   PUBMED   9070862
REFERENCE   8  (bases 1 to 6035)
  AUTHORS   Song,W.J., Sternberg,L.R., Kasten-Sportes,C., Keuren,M.L.,
            Chung,S.H., Slack,A.C., Miller,D.E., Glover,T.W., Chiang,P.W.,
            Lou,L. and Kurnit,D.M.
  TITLE     Isolation of human and murine homologues of the Drosophila
            minibrain gene: human homologue maps to 21q22.2 in the Down
            syndrome 'critical region'
  JOURNAL   Genomics 38 (3), 331-339 (1996)
   PUBMED   8975710
REFERENCE   9  (bases 1 to 6035)
  AUTHORS   Patil,N., Cox,D.R., Bhat,D., Faham,M., Myers,R.M. and Peterson,A.S.
  TITLE     A potassium channel mutation in weaver mice implicates membrane
            excitability in granule cell differentiation
  JOURNAL   Nat Genet 11 (2), 126-129 (1995)
   PUBMED   7550338
REFERENCE   10 (bases 1 to 6035)
  AUTHORS   Tejedor,F., Zhu,X.R., Kaltenbach,E., Ackermann,A., Baumann,A.,
            Canal,I., Heisenberg,M., Fischbach,K.F. and Pongs,O.
  TITLE     minibrain: a new protein kinase family involved in postembryonic
            neurogenesis in Drosophila
  JOURNAL   Neuron 14 (2), 287-301 (1995)
   PUBMED   7857639
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF462682.1, CD540384.1, BC129888.1, AK052390.1, AK163136.1 and
            CX566606.1.
            
            On Jan 11, 2008 this sequence version replaced NM_007890.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Transcript variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: U58497.2, BC138716.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849375, SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-369               BF462682.1         1-369
            370-849             CD540384.1         86-565
            850-2697            BC129888.1         453-2300
            2698-4233           AK052390.1         1574-3109
            4234-5591           AK163136.1         1070-2427
            5592-6035           CX566606.1         193-636
FEATURES             Location/Qualifiers
     source          1..6035
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 55.3 cM"
     gene            1..6035
                     /gene="Dyrk1a"
                     /gene_synonym="2310043O08Rik; D16Ertd272e; D16Ertd493e;
                     Dyrk; Gm10783; mmb; Mnbh; Mp86"
                     /note="dual-specificity tyrosine phosphorylation regulated
                     kinase 1a"
                     /db_xref="GeneID:13548"
                     /db_xref="MGI:MGI:1330299"
     exon            1..329
                     /gene="Dyrk1a"
                     /gene_synonym="2310043O08Rik; D16Ertd272e; D16Ertd493e;
                     Dyrk; Gm10783; mmb; Mnbh; Mp86"
                     /inference="alignment:Splign:2.1.0"
     exon            330..415
                     /gene="Dyrk1a"
                     /gene_synonym="2310043O08Rik; D16Ertd272e; D16Ertd493e;
                     Dyrk; Gm10783; mmb; Mnbh; Mp86"
                     /inference="alignment:Splign:2.1.0"
     CDS             406..2697
                     /gene="Dyrk1a"
                     /gene_synonym="2310043O08Rik; D16Ertd272e; D16Ertd493e;
                     Dyrk; Gm10783; mmb; Mnbh; Mp86"
                     /EC_number="2.7.11.23"
                     /EC_number="2.7.12.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein kinase minibrain homolog; dual specificity
                     YAK1-related kinase; dual-specificity
                     tyrosine-(Y)-phosphorylation regulated kinase 1a"
                     /codon_start=1
                     /product="dual specificity
                     tyrosine-phosphorylation-regulated kinase 1A isoform 1"
                     /protein_id="NP_031916.1"
                     /db_xref="CCDS:CCDS28350.1"
                     /db_xref="GeneID:13548"
                     /db_xref="MGI:MGI:1330299"
                     /translation="MHTGGETSACKPSSVRLAPSFSFHAAGLQMAAQMPHSHQYSDRR
                     QPSISDQQVSALPYSDQIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIK
                     TYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYE
                     IDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK
                     YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFL
                     ATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLL
                     GMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKAR
                     KFFEKLPDGTWSLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYL
                     KFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVSTSPAMEQSQSSGTT
                     SSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFAAAVQAMDCETHSPQVRQQFPAPL
                     GWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHHGQQAL
                     GNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSSTTSSSTSSSSTGNQGNQAYQN
                     RPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGPAHYMTEGHLAMR
                     QGADREESPMTGVCVQQSPVASS"
     exon            416..612
                     /gene="Dyrk1a"
                     /gene_synonym="2310043O08Rik; D16Ertd272e; D16Ertd493e;
                     Dyrk; Gm10783; mmb; Mnbh; Mp86"
                     /inference="alignment:Splign:2.1.0"
     exon            613..732
                     /gene="Dyrk1a"
                     /gene_synonym="2310043O08Rik; D16Ertd272e; D16Ertd493e;
                     Dyrk; Gm10783; mmb; Mnbh; Mp86"
                     /inference="alignment:Splign:2.1.0"
     exon            733..921
                     /gene="Dyrk1a"
                     /gene_synonym="2310043O08Rik; D16Ertd272e; D16Ertd493e;
                     Dyrk; Gm10783; mmb; Mnbh; Mp86"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1069
                     /gene="Dyrk1a"
                     /gene_synonym="2310043O08Rik; D16Ertd272e; D16Ertd493e;
                     Dyrk; Gm10783; mmb; Mnbh; Mp86"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1356
                     /gene="Dyrk1a"
                     /gene_synonym="2310043O08Rik; D16Ertd272e; D16Ertd493e;
                     Dyrk; Gm10783; mmb; Mnbh; Mp86"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1503
                     /gene="Dyrk1a"
                     /gene_synonym="2310043O08Rik; D16Ertd272e; D16Ertd493e;
                     Dyrk; Gm10783; mmb; Mnbh; Mp86"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1644
                     /gene="Dyrk1a"
                     /gene_synonym="2310043O08Rik; D16Ertd272e; D16Ertd493e;
                     Dyrk; Gm10783; mmb; Mnbh; Mp86"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1951
                     /gene="Dyrk1a"
                     /gene_synonym="2310043O08Rik; D16Ertd272e; D16Ertd493e;
                     Dyrk; Gm10783; mmb; Mnbh; Mp86"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2076
                     /gene="Dyrk1a"
                     /gene_synonym="2310043O08Rik; D16Ertd272e; D16Ertd493e;
                     Dyrk; Gm10783; mmb; Mnbh; Mp86"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..6015
                     /gene="Dyrk1a"
                     /gene_synonym="2310043O08Rik; D16Ertd272e; D16Ertd493e;
                     Dyrk; Gm10783; mmb; Mnbh; Mp86"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3037..3042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dyrk1a"
                     /gene_synonym="2310043O08Rik; D16Ertd272e; D16Ertd493e;
                     Dyrk; Gm10783; mmb; Mnbh; Mp86"
                     /note="hexamer: AATAAA"
     polyA_site      3064
                     /gene="Dyrk1a"
                     /gene_synonym="2310043O08Rik; D16Ertd272e; D16Ertd493e;
                     Dyrk; Gm10783; mmb; Mnbh; Mp86"
                     /note="major polyA site"
     regulatory      5344..5349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dyrk1a"
                     /gene_synonym="2310043O08Rik; D16Ertd272e; D16Ertd493e;
                     Dyrk; Gm10783; mmb; Mnbh; Mp86"
                     /note="hexamer: AATAAT"
     polyA_site      5352
                     /gene="Dyrk1a"
                     /gene_synonym="2310043O08Rik; D16Ertd272e; D16Ertd493e;
                     Dyrk; Gm10783; mmb; Mnbh; Mp86"
                     /note="major polyA site"
     regulatory      5537..5542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dyrk1a"
                     /gene_synonym="2310043O08Rik; D16Ertd272e; D16Ertd493e;
                     Dyrk; Gm10783; mmb; Mnbh; Mp86"
                     /note="hexamer: AGTAAA"
     polyA_site      5563
                     /gene="Dyrk1a"
                     /gene_synonym="2310043O08Rik; D16Ertd272e; D16Ertd493e;
                     Dyrk; Gm10783; mmb; Mnbh; Mp86"
                     /note="major polyA site"
     regulatory      5998..6003
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dyrk1a"
                     /gene_synonym="2310043O08Rik; D16Ertd272e; D16Ertd493e;
                     Dyrk; Gm10783; mmb; Mnbh; Mp86"
                     /note="hexamer: AATAAA"
     polyA_site      6015
                     /gene="Dyrk1a"
                     /gene_synonym="2310043O08Rik; D16Ertd272e; D16Ertd493e;
                     Dyrk; Gm10783; mmb; Mnbh; Mp86"
ORIGIN      
        1 gcggccgcca ctcggcgccc ggcctcgccg ccgccgccgc cctccgcacc gggccgggcc
       61 gggccccgcc gccgacactc gggggcccgg ggactgcggt atttgccggg gaggggctgt
      121 cgcctgcctc cccggccgcg ggcgccgccg gccccgccag cccgacggac cctgagccag
      181 cgcggctgcg gcgcggagcc gggacgccgg gggcggagag aggcggccgg ggcggcgctg
      241 gctgcggagg ccgcggcggg agcgcggcgc gggagctcga ggctgagact caccggaggg
      301 agcggcgcga gcgccccgcc atcgtcccgt gttatagttt tgccgctgga ctcttccctc
      361 ccttccccca ccccatcagg atgatatgag acttgaaaga agacgatgca tacaggagga
      421 gagacttcag catgcaaacc ttcatctgtc cggcttgcac cgtcgttctc attccatgct
      481 gctggccttc agatggctgc acagatgccc cactcacacc agtacagtga ccgtcgccag
      541 ccgagcataa gtgaccagca ggtgtctgcc ttaccatatt ctgaccagat tcagcaacct
      601 ctaactaacc aggtgatgcc tgacattgtc atgttacaga ggcggatgcc ccaaaccttc
      661 cgtgatccag caactgctcc tctgagaaaa ctctctgtgg acttgatcaa aacatacaag
      721 catattaatg aggtttacta tgcaaaaaag aagcgaagac accaacaggg ccagggggac
      781 gattccagtc ataagaagga gcggaaggtt tacaatgatg gttacgatga tgataactat
      841 gattatattg taaaaaacgg ggaaaagtgg atggatcggt atgaaatcga ctccttaata
      901 ggcaaaggtt catttggaca ggttgtgaaa gcttatgaca gagtggagca agaatgggtc
      961 gccattaaaa tcatcaagaa caagaaagcg tttctgaatc aagcccagat agaagtgcgg
     1021 ctgcttgagc tcatgaacaa acacgacact gaaatgaagt actacatagt gcatttgaaa
     1081 cgccacttta tgtttcgaaa ccatctctgt ttagtgtttg aaatgctgtc ctataatctc
     1141 tatgatttgt tgagaaacac caacttccga ggggtctctt tgaacctaac acgaaagttt
     1201 gcgcaacaga tgtgcacagc attgcttttt cttgcgactc cagaacttag tatcattcac
     1261 tgtgacttaa agcctgagaa catccttctg tgtaacccca aacggagtgc aatcaagatt
     1321 gttgattttg gcagctcttg tcagttgggg cagaggatat accagtatat tcagagtcgc
     1381 ttttatcggt ctccagaggt gctactggga atgccttatg accttgctat cgacatgtgg
     1441 tcccttggat gtatcttggt tgaaatgcac actggagagc ctctgttcag tggtgccaat
     1501 gaggtcgatc agatgaataa aatagtggaa gtcttgggca tcccacctgc tcatattctt
     1561 gaccaagcac cgaaagcaag aaagttcttt gagaagttgc ccgatggcac ttggagctta
     1621 aagaagacca aagatggaaa acgggagtac aaaccaccag gaacccgtaa acttcataat
     1681 attcttggag tagaaacagg aggacctggc gggcggcgtg ctggggaatc gggtcatact
     1741 gtagctgact acttgaagtt caaagacctc attttaagga tgcttgatta tgaccccaaa
     1801 actcggattc aaccttatta tgccctgcag cacagttttt tcaagaaaac agctgatgaa
     1861 ggtaccaaca caagtaacag tgtgtctacc agccctgcga tggagcagtc tcagtcttca
     1921 ggcaccacct ccagcacctc ctccagctca ggtggatcct cgggaacgag taacagtggg
     1981 agagccaggt cggatccgac gcaccagcat cgacacagcg gtggacactt cgctgctgct
     2041 gtccaggcca tggactgtga gacacacagt ccccaggtgc gccagcagtt tccggctcct
     2101 ctgggatggt caggcactga agctcctaca caagtcactg ttgaaactca tcctgttcaa
     2161 gagacaacct ttcatgtagc cccccagcag aacgcattgc atcatcacca tggaaacagt
     2221 tcccatcacc accaccacca ccatcaccac caccaccacc atggacagca agccttgggt
     2281 aaccggacca ggccaagggt ctacaattct ccaacaaata gctcctctac ccaggattct
     2341 atggaggttg gccacagtca ccactccatg acatccctgt cttcctcaac aacttcttcc
     2401 tcgacatctt cctcctctac tggtaatcaa ggcaatcagg cctatcagaa ccgcccagtg
     2461 gctgctaaca ccttggactt tggacagaat ggagctatgg acgttaattt gaccgtctac
     2521 tccaatcccc gccaagagac tggcatagct ggacatccaa cataccaatt ttctgctaat
     2581 acaggtcctg cacattacat gactgaagga catctggcga tgagacaagg ggctgataga
     2641 gaagagtctc ccatgacagg agtttgtgtg caacagagtc ctgtagctag ctcgtgacta
     2701 cattgaaact tgagtttgtt tcttgtgtgt ttttatagaa gtggtgtttt tttcccaaaa
     2761 aacaaaagtg caaagctgct tgaatcagaa ggagattaac acactgaacc gctacaagag
     2821 ggcaaagctg actttttttt ttaacttgaa aagattgcaa agggacaatg aagtttttaa
     2881 gagccatgtc cacccatctt cacggagagc tcagagtgtc ctctttctgc ctcccccatt
     2941 taacttccat ctcctggtca cagtgggttt tgtctttcta tccaacaaga gttaatgttc
     3001 agctgttggt cttggtcatt tgccaactaa ttttaaaata aaaaggcact gcacataatt
     3061 tgcataaagg gccccataag ggtgttttgt tttgttttca tttttatttt ttcccttttt
     3121 cccttgtttt gttttgtttc attttgggct gggggtgggg tgggaaattt gggtttttta
     3181 tgtcctctac acacttgggc acggaaatgc agtactgtaa ggaagaggga cctctagcac
     3241 acacaaacat catcttcagc tgtgtgaaag ggacgattgt gttgacattt gtaaggcaca
     3301 ttaagcatgc taagtggcgg ggatcaggac tctcctatct gagcctactg aggagcaaag
     3361 cagccattgc atgggatcct gtgggtctcc tgctggagag gccacaggag gataggatgg
     3421 aacgtgactg gtcggtctcc ttaccaaggc gcactgagaa gcaatcagcg ggtcggttgt
     3481 ggccagtcct ggggaggtct gagtggtggt ccttgggata acctttggcc ttacggattt
     3541 ggactcggag ttagaagagc ccaccatttc agatgcaatc acttgtggac atgcgtttgc
     3601 agacagtcct taatgctgaa aacacagaga atgggtaatt caagaggcct ttcttttaaa
     3661 atagactttt gtgacccact aattgtaagg tattgcaagg tcactttgcg tgtgtcataa
     3721 agctgactcc cttcttggtt gaaggccaca gaggtagtgg tttgctttga tggaaatagc
     3781 tacagctgtg tcccttcctg cttttccctt ttctttggct ttttctcggc acgtggtgtc
     3841 tccaccattt cttctgcaca aagacgtctt ctgttcaccc tgaacatttt aaaatgcaga
     3901 attttatgtg actgcttttt tgcctcacaa ttatgctgtg aattttacaa aaatttattt
     3961 tcttttttga taatttattg taccaaagct gtttttatag cacatagatg tctgtaacca
     4021 ataatgtcgc aggcctgcac tttgacacag gtgtaacgag accgttttaa acgtcagttg
     4081 aaatgatggc tgtactattg cttaaacaaa actggaactg ttgttgaatc catagccaat
     4141 acatttacag caatcttgta ctggacagaa tagattgaca tctaattcaa gattacaaca
     4201 cctgtcacat tctaaatgtg ttcaggcttc tgaagggaaa gggacactgg atccagaagc
     4261 tatggagcca gcagttgatc ttgtattcct gattaacttc cttgtaaact tgaacttgag
     4321 accttgattg aaccgacagg tccacagtag gaacaggaag caggcagagc tctgagcatg
     4381 acctgaagga agcaggctgg cactagcagt tgccttgtct ggagatgctg ctgccttcaa
     4441 gtagcacagt ctggcagtgg ctaaatctgt gttcccattg aaattgagca attttagggt
     4501 gttatactct gaagcagttg aattgggaga atgaagatag agtaatttcc ctgtccagga
     4561 tcaaaagaag cctagaaaga agcagtgatc tacctctgcc aataaccctg ttggaagcaa
     4621 cgcagcagaa caccacggta ctttttattg cttaattcca cgtggctgac taggtcaagg
     4681 tttgtttggt gttttttttt tttttttttg tttctgagca aaagcaggtt tttttttgtt
     4741 ttttatatgt aaacaaaaga aaggcctaag ctctgtgagt gcaagtggag actcagagag
     4801 ccccgtttct ataaacacag acacttcagg tgttaatcag gaaacccata ttgattttgt
     4861 aattaaatgt caagcctgtg gattgttttg agcttggtag ttgatgagca tttccgtaca
     4921 gaggcctcac cttgagcaca gcactgtcag gagggcgcag cgcctgtggc tgcggagccc
     4981 caggtgccac acacccaccc cacgtggctc aggtcattct ttttttcttt ctgtgctggt
     5041 tgccacattt tagcaagcac caaaaaagaa agcagttttt aaagctatat ttacgtaaag
     5101 agagccacac aatccagtgc ttctgcatac cgtgtcacgt tacagtccag ttttgtgtgc
     5161 tttactacac agtttggtta caggacttct gtgcattgta aacataaaca gcatggagag
     5221 gttaaatacc tgtgttcaga ttgtaagatc tagtccagac ttgctgtgta tattgtaacg
     5281 ttaaatgaaa aaagaccccc ctttgtatta tagtcatgcg gtcttatgta tgataaacag
     5341 ttgaataatt tgtcctcaga gtctttacta tgctttttta aaaattaact taaggaaaaa
     5401 tgtaaacagt aaaaaaacaa tcttcgtgtg cagtgaagcg ggtccgggtg tggtaggtaa
     5461 agcaggcaca atcctgtcgc ctatgtaaag ggaaaagact tgtgagacag agacattggc
     5521 tgcaagtgtc tttgaaagta aaaattggag gtttaacaga taatttggtt tttaaaatgg
     5581 attctttacc tgagtgatta tcatgttgat ttgtgctccc ctgtggtact gtctctgtgt
     5641 tgagagcacg tgggggcctg tcctgtgggg atgaaggaca gaactgagtg ccatctccct
     5701 gagtctgctc tgtccctttc ctgtgcagag cccggaatcc tgccgtgcgg aggcagtttc
     5761 taacccacag ccctctcttt tcagtgctag cctgcacagg gtctgttgag tggccttcag
     5821 aaggtaagaa acttaggtag aaaagaaaca aatgtgattc tggacactgt gctcatagtc
     5881 agagcttgtg taccagagca gaactgcctt ttgtcatggg ctacaggact ctgctttagt
     5941 taggtaacaa gcatattttg tgatattgga caacataccc aagagttact tatacctaat
     6001 aaatagtaga actacaaaaa aaaaaaaaaa aaaaa
//
