LOCUS       NP_031916                763 aa            linear   ROD 12-JUN-2025
DEFINITION  dual specificity tyrosine-phosphorylation-regulated kinase 1A
            isoform 1 [Mus musculus].
ACCESSION   NP_031916 XP_128336
VERSION     NP_031916.1
DBSOURCE    REFSEQ: accession NM_007890.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 763)
  AUTHORS   Roh,J.D., Bae,M., Kim,H., Yang,Y., Lee,Y., Cho,Y., Lee,S., Li,Y.,
            Yang,E., Jang,H., Kim,H., Kim,H., Kang,H., Ellegood,J., Lerch,J.P.,
            Bae,Y.C., Kim,J.Y. and Kim,E.
  TITLE     Lithium normalizes ASD-related neuronal, synaptic, and behavioral
            phenotypes in DYRK1A-knockin mice
  JOURNAL   Mol Psychiatry 30 (6), 2584-2596 (2025)
   PUBMED   39633007
REFERENCE   2  (residues 1 to 763)
  AUTHORS   Cortes,D.E., Escudero,M., Korgan,A.C., Mitra,A., Edwards,A.,
            Aydin,S.C., Munger,S.C., Charland,K., Zhang,Z.W., O'Connell,K.M.S.,
            Reinholdt,L.G. and Pera,M.F.
  TITLE     An in vitro neurogenetics platform for precision disease modeling
            in the mouse
  JOURNAL   Sci Adv 10 (14), eadj9305 (2024)
   PUBMED   38569042
REFERENCE   3  (residues 1 to 763)
  AUTHORS   Hu,K., Liu,L., Tang,S., Zhang,X., Chang,H., Chen,W., Fan,T.,
            Zhang,L., Shen,B. and Zhang,Q.
  TITLE     MicroRNA-221-3p inhibits the inflammatory response of keratinocytes
            by regulating the DYRK1A/STAT3 signaling pathway to promote wound
            healing in diabetes
  JOURNAL   Commun Biol 7 (1), 300 (2024)
   PUBMED   38461326
  REMARK    GeneRIF: MicroRNA-221-3p inhibits the inflammatory response of
            keratinocytes by regulating the DYRK1A/STAT3 signaling pathway to
            promote wound healing in diabetes.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 763)
  AUTHORS   Lana-Elola,E., Aoidi,R., Llorian,M., Gibbins,D.,
            Buechsenschuetz,C., Bussi,C., Flynn,H., Gilmore,T.,
            Watson-Scales,S., Haugsten Hansen,M., Hayward,D., Song,O.R.,
            Brault,V., Herault,Y., Deau,E., Meijer,L., Snijders,A.P.,
            Gutierrez,M.G., Fisher,E.M.C. and Tybulewicz,V.L.J.
  TITLE     Increased dosage of DYRK1A leads to congenital heart defects in a
            mouse model of Down syndrome
  JOURNAL   Sci Transl Med 16 (731), eadd6883 (2024)
   PUBMED   38266108
  REMARK    GeneRIF: Increased dosage of DYRK1A leads to congenital heart
            defects in a mouse model of Down syndrome.
REFERENCE   5  (residues 1 to 763)
  AUTHORS   Becker,W., Weber,Y., Wetzel,K., Eirmbter,K., Tejedor,F.J. and
            Joost,H.G.
  TITLE     Sequence characteristics, subcellular localization, and substrate
            specificity of DYRK-related kinases, a novel family of dual
            specificity protein kinases
  JOURNAL   J Biol Chem 273 (40), 25893-25902 (1998)
   PUBMED   9748265
REFERENCE   6  (residues 1 to 763)
  AUTHORS   Cabin,D.E., McKee-Johnson,J.W., Matesic,L.E., Wiltshire,T.,
            Rue,E.E., Mjaatvedt,A.E., Huo,Y.K., Korenberg,J.R. and Reeves,R.H.
  TITLE     Physical and comparative mapping of distal mouse chromosome 16. 5
            p5
  JOURNAL   Genome Res 8 (9), 940-950 (1998)
   PUBMED   9750193
REFERENCE   7  (residues 1 to 763)
  AUTHORS   Song,W.J., Chung,S.H. and Kurnit,D.M.
  TITLE     The murine Dyrk protein maps to chromosome 16, localizes to the
            nucleus, and can form multimers
  JOURNAL   Biochem Biophys Res Commun 231 (3), 640-644 (1997)
   PUBMED   9070862
REFERENCE   8  (residues 1 to 763)
  AUTHORS   Song,W.J., Sternberg,L.R., Kasten-Sportes,C., Keuren,M.L.,
            Chung,S.H., Slack,A.C., Miller,D.E., Glover,T.W., Chiang,P.W.,
            Lou,L. and Kurnit,D.M.
  TITLE     Isolation of human and murine homologues of the Drosophila
            minibrain gene: human homologue maps to 21q22.2 in the Down
            syndrome 'critical region'
  JOURNAL   Genomics 38 (3), 331-339 (1996)
   PUBMED   8975710
REFERENCE   9  (residues 1 to 763)
  AUTHORS   Patil,N., Cox,D.R., Bhat,D., Faham,M., Myers,R.M. and Peterson,A.S.
  TITLE     A potassium channel mutation in weaver mice implicates membrane
            excitability in granule cell differentiation
  JOURNAL   Nat Genet 11 (2), 126-129 (1995)
   PUBMED   7550338
REFERENCE   10 (residues 1 to 763)
  AUTHORS   Tejedor,F., Zhu,X.R., Kaltenbach,E., Ackermann,A., Baumann,A.,
            Canal,I., Heisenberg,M., Fischbach,K.F. and Pongs,O.
  TITLE     minibrain: a new protein kinase family involved in postembryonic
            neurogenesis in Drosophila
  JOURNAL   Neuron 14 (2), 287-301 (1995)
   PUBMED   7857639
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF462682.1, CD540384.1, BC129888.1, AK052390.1, AK163136.1 and
            CX566606.1.
            
            On Dec 17, 2003 this sequence version replaced XP_128336.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Transcript variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: U58497.2, BC138716.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849375, SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..763
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 55.3 cM"
     Protein         1..763
                     /product="dual specificity
                     tyrosine-phosphorylation-regulated kinase 1A isoform 1"
                     /EC_number="2.7.11.23"
                     /EC_number="2.7.12.1"
                     /note="protein kinase minibrain homolog; dual specificity
                     YAK1-related kinase; dual-specificity
                     tyrosine-(Y)-phosphorylation regulated kinase 1a"
                     /calculated_mol_wt=85363
     Site            14
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13627; propagated from
                     UniProtKB/Swiss-Prot (Q61214.1)"
     Region          33..61
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61214.1)"
     Site            111
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q13627; propagated from
                     UniProtKB/Swiss-Prot (Q61214.1)"
     Region          115..136
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61214.1)"
     Region          117..134
                     /region_name="Bipartite nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61214.1)"
     Site            140
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q13627; propagated from
                     UniProtKB/Swiss-Prot (Q61214.1)"
     Site            145
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:18034455; propagated from
                     UniProtKB/Swiss-Prot (Q61214.1)"
     Region          148..484
                     /region_name="PKc_DYRK1"
                     /note="Catalytic domain of the protein kinase,
                     Dual-specificity tYrosine-phosphorylated and -Regulated
                     Kinase 1; cd14226"
                     /db_xref="CDD:271128"
     Site            159
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q13627; propagated from
                     UniProtKB/Swiss-Prot (Q61214.1)"
     Site            order(165..169,173,186,188,202,222,238..241,244,246..247,
                     287,289,291..292,294,307,310,319,321..324,326,363)
                     /site_type="active"
                     /db_xref="CDD:271128"
     Site            order(165..169,173,186,188,222,238..241,244,287,289,
                     291..292,294,307)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271128"
     Site            177
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q13627; propagated from
                     UniProtKB/Swiss-Prot (Q61214.1)"
     Site            order(202,246,287,289,310,319,321..324,326,363)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271128"
     Site            219
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q63470; propagated from
                     UniProtKB/Swiss-Prot (Q61214.1)"
     Site            306..326
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271128"
     Site            310
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q13627; propagated from
                     UniProtKB/Swiss-Prot (Q61214.1)"
     Site            319
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q13627; propagated from
                     UniProtKB/Swiss-Prot (Q61214.1)"
     Site            321
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q13627; propagated from
                     UniProtKB/Swiss-Prot (Q61214.1)"
     Site            402
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q13627; propagated from
                     UniProtKB/Swiss-Prot (Q61214.1)"
     Region          408..442
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61214.1)"
     Site            449
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q13627; propagated from
                     UniProtKB/Swiss-Prot (Q61214.1)"
     Region          485..540
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61214.1)"
     Site            529
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13627; propagated from
                     UniProtKB/Swiss-Prot (Q61214.1)"
     Site            538
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61214.1)"
     Region          595..625
                     /region_name="Histidine-rich domain (HRD).
                     /evidence=ECO:0000250|UniProtKB:Q13627"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61214.1)"
     Region          596..679
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61214.1)"
     Site            748
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61214.1)"
     Site            758
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61214.1)"
     CDS             1..763
                     /gene="Dyrk1a"
                     /gene_synonym="2310043O08Rik; D16Ertd272e; D16Ertd493e;
                     Dyrk; Gm10783; mmb; Mnbh; Mp86"
                     /coded_by="NM_007890.2:406..2697"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS28350.1"
                     /db_xref="GeneID:13548"
                     /db_xref="MGI:MGI:1330299"
ORIGIN      
        1 mhtggetsac kpssvrlaps fsfhaaglqm aaqmphshqy sdrrqpsisd qqvsalpysd
       61 qiqqpltnqv mpdivmlqrr mpqtfrdpat aplrklsvdl iktykhinev yyakkkrrhq
      121 qgqgddsshk kerkvyndgy dddnydyivk ngekwmdrye idsligkgsf gqvvkaydrv
      181 eqewvaikii knkkaflnqa qievrllelm nkhdtemkyy ivhlkrhfmf rnhlclvfem
      241 lsynlydllr ntnfrgvsln ltrkfaqqmc tallflatpe lsiihcdlkp enillcnpkr
      301 saikivdfgs scqlgqriyq yiqsrfyrsp evllgmpydl aidmwslgci lvemhtgepl
      361 fsganevdqm nkivevlgip pahildqapk arkffeklpd gtwslkktkd gkreykppgt
      421 rklhnilgve tggpggrrag esghtvadyl kfkdlilrml dydpktriqp yyalqhsffk
      481 ktadegtnts nsvstspame qsqssgttss tssssggssg tsnsgrarsd pthqhrhsgg
      541 hfaaavqamd cethspqvrq qfpaplgwsg teaptqvtve thpvqettfh vapqqnalhh
      601 hhgnsshhhh hhhhhhhhhg qqalgnrtrp rvynsptnss stqdsmevgh shhsmtslss
      661 sttssstsss stgnqgnqay qnrpvaantl dfgqngamdv nltvysnprq etgiaghpty
      721 qfsantgpah ymteghlamr qgadreespm tgvcvqqspv ass
//
