LOCUS       NM_011560                808 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus dynein light chain Tctex-type 2A1 (Dynlt2a1),
            transcript variant 1, mRNA.
ACCESSION   NM_011560
VERSION     NM_011560.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 808)
  AUTHORS   Ge,T., Yuan,L., Xu,L., Yang,F., Xu,W., Niu,C., Li,G., Zhou,H. and
            Zheng,Y.
  TITLE     Coiled-coil domain containing 159 is required for spermatid head
            and tail assembly in micedagger
  JOURNAL   Biol Reprod 110 (5), 877-894 (2024)
   PUBMED   38236177
REFERENCE   2  (bases 1 to 808)
  AUTHORS   Liu,Y., Zhang,L., Li,W., Huang,Q., Yuan,S., Li,Y., Liu,J.,
            Zhang,S., Pin,G., Song,S., Ray,P.F., Arnoult,C., Cho,C.,
            Garcia-Reyes,B., Knippschild,U., Strauss,J.F. and Zhang,Z.
  TITLE     The sperm-associated antigen 6 interactome and its role in
            spermatogenesis
  JOURNAL   Reproduction 158 (2), 181-197 (2019)
   PUBMED   31146259
REFERENCE   3  (bases 1 to 808)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   4  (bases 1 to 808)
  AUTHORS   Rashid,S., Grzmil,P., Drenckhahn,J.D., Meinhardt,A., Adham,I.,
            Engel,W. and Neesen,J.
  TITLE     Disruption of the murine dynein light chain gene Tcte3-3 results in
            asthenozoospermia
  JOURNAL   Reproduction 139 (1), 99-111 (2010)
   PUBMED   19778998
  REMARK    GeneRIF: results support a role of Tcte3-3 in generation of sperm
            motility as well as in male germ cell differentiation
REFERENCE   5  (bases 1 to 808)
  AUTHORS   Chan,W.Y., Wu,S.M., Ruszczyk,L., Law,E., Lee,T.L., Baxendale,V.,
            Lap-Yin Pang,A. and Rennert,O.M.
  TITLE     The complexity of antisense transcription revealed by the study of
            developing male germ cells
  JOURNAL   Genomics 87 (6), 681-692 (2006)
   PUBMED   16458478
REFERENCE   6  (bases 1 to 808)
  AUTHORS   Huw,L.Y., Goldsborough,A.S., Willison,K. and Artzt,K.
  TITLE     Tctex2: a sperm tail surface protein mapping to the t-complex
  JOURNAL   Dev Biol 170 (1), 183-194 (1995)
   PUBMED   7601308
REFERENCE   7  (bases 1 to 808)
  AUTHORS   Rappold,G.A., Trowsdale,J. and Lichter,P.
  TITLE     Assignment of the human homologue of the mouse t-complex gene TCTE3
            to human chromosome 6q27
  JOURNAL   Genomics 13 (4), 1337-1339 (1992)
   PUBMED   1505969
REFERENCE   8  (bases 1 to 808)
  AUTHORS   Ha,H., Howard,C.A., Yeom,Y.I., Abe,K., Uehara,H., Artzt,K. and
            Bennett,D.
  TITLE     Several testis-expressed genes in the mouse t-complex have
            expression differences between wild-type and t-mutant mice
  JOURNAL   Dev Genet 12 (4), 318-332 (1991)
   PUBMED   1718647
REFERENCE   9  (bases 1 to 808)
  AUTHORS   Lader,E., Ha,H.S., O'Neill,M., Artzt,K. and Bennett,D.
  TITLE     tctex-1: a candidate gene family for a mouse t complex sterility
            locus
  JOURNAL   Cell 58 (5), 969-979 (1989)
   PUBMED   2570638
REFERENCE   10 (bases 1 to 808)
  AUTHORS   Rappold,G.A., Stubbs,L., Labeit,S., Crkvenjakov,R.B. and Lehrach,H.
  TITLE     Identification of a testis-specific gene from the mouse t-complex
            next to a CpG-rich island
  JOURNAL   EMBO J 6 (7), 1975-1980 (1987)
   PUBMED   3653077
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN835332.1, CN842925.1, AK006370.1 and BU919334.1.
            
            On Feb 23, 2006 this sequence version replaced NM_011560.2.
            
            Summary: This gene is one of three genes with a very high degree of
            similarity to each other within a 77 kb genomic span on Chromosome
            17 A2. This gene is the most distal copy of the three genes.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) is the longer transcript and
            it encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU961474.1, U21674.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               CN835332.1         3-120
            119-136             CN842925.1         80-97
            137-788             AK006370.1         2-653
            789-808             BU919334.1         555-574
FEATURES             Location/Qualifiers
     source          1..808
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 8.95 cM"
     gene            1..808
                     /gene="Dynlt2a1"
                     /gene_synonym="D17Leh117c; Dynlt2; LC2; Tcte-3; Tcte3;
                     Tctex-2; Tctex-4; Tctex2; Tctex4"
                     /note="dynein light chain Tctex-type 2A1"
                     /db_xref="GeneID:21647"
                     /db_xref="MGI:MGI:98642"
     exon            1..264
                     /gene="Dynlt2a1"
                     /gene_synonym="D17Leh117c; Dynlt2; LC2; Tcte-3; Tcte3;
                     Tctex-2; Tctex-4; Tctex2; Tctex4"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..738
                     /gene="Dynlt2a1"
                     /gene_synonym="D17Leh117c; Dynlt2; LC2; Tcte-3; Tcte3;
                     Tctex-2; Tctex-4; Tctex2; Tctex4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     t-complex testis-expressed 4; tctex1 domain-containing
                     protein 3; T-complex testis-specific protein 2; T-complex
                     testis-specific protein 3; T-complex-associated
                     testis-expressed protein 3; T-complex-associated
                     testis-expressed protein 4; t-complex-associated testis
                     expressed 3; dynein light chain Tctex-type protein 2"
                     /codon_start=1
                     /product="dynein light chain Tctex-type protein 2 isoform
                     1"
                     /protein_id="NP_035690.2"
                     /db_xref="CCDS:CCDS28408.1"
                     /db_xref="GeneID:21647"
                     /db_xref="MGI:MGI:98642"
                     /translation="MERRGRMAKTPTGQTHQSPVSKRERKPSMFEKESYAQILRERLR
                     ESFHDVQYVEPPFDDSIADVGKEWKSALAKLKFANSYRMEPLKKFQAHLVETKIQQIL
                     KDSLKDVKYDDKAPHLSLELADRILAAVKEFAYHRYKFIIQVLFIQKTGQAINIASRW
                     IWDVAWDNWVEAKHETESYVVLALVFALYCE"
     exon            265..471
                     /gene="Dynlt2a1"
                     /gene_synonym="D17Leh117c; Dynlt2; LC2; Tcte-3; Tcte3;
                     Tctex-2; Tctex-4; Tctex2; Tctex4"
                     /inference="alignment:Splign:2.1.0"
     exon            472..627
                     /gene="Dynlt2a1"
                     /gene_synonym="D17Leh117c; Dynlt2; LC2; Tcte-3; Tcte3;
                     Tctex-2; Tctex-4; Tctex2; Tctex4"
                     /inference="alignment:Splign:2.1.0"
     exon            628..791
                     /gene="Dynlt2a1"
                     /gene_synonym="D17Leh117c; Dynlt2; LC2; Tcte-3; Tcte3;
                     Tctex-2; Tctex-4; Tctex2; Tctex4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      773..778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dynlt2a1"
                     /gene_synonym="D17Leh117c; Dynlt2; LC2; Tcte-3; Tcte3;
                     Tctex-2; Tctex-4; Tctex2; Tctex4"
                     /note="hexamer: AATAAA"
     polyA_site      791
                     /gene="Dynlt2a1"
                     /gene_synonym="D17Leh117c; Dynlt2; LC2; Tcte-3; Tcte3;
                     Tctex-2; Tctex-4; Tctex2; Tctex4"
                     /note="major polyA site"
ORIGIN      
        1 gactcacgtg cctctcttcc ccggcttccg ggacgcggct gcacgcggcg taggcgcgag
       61 ccctgtgctc cgcggcatct gagcagggcc gttgggcagt tacacggcgg agggcggagg
      121 gcggagggcg gagggcggag gcgtcccggt gagccgatca agatggagcg gcgaggccga
      181 atggcgaaga cgcccaccgg ccaaacgcat caatccccgg tgtctaagag agaaaggaag
      241 cctagcatgt tcgagaagga gtcatatgca cagatcttaa gagaaagact gagagagtct
      301 tttcatgatg ttcagtacgt ggaacctccg tttgatgact caattgctga tgtaggcaaa
      361 gaatggaaaa gtgccctggc aaaattaaag tttgctaatt catacagaat ggagccactg
      421 aagaaatttc aagcacattt ggtagaaact aaaatccagc agatattaaa ggacagtctt
      481 aaagatgtca aatatgatga caaagcccct catttgtcac ttgaattggc agatcgaata
      541 ttggcagcag tcaaagaatt tgcataccat cgttataaat tcattataca agtattattt
      601 attcaaaaga ctggtcaagc aataaatatt gccagcagat ggatctggga tgtggcatgg
      661 gacaactggg tagaagctaa acatgaaaca gagtcttacg tggtattggc cttggtgttt
      721 gctctctatt gtgaatagct caggaccagc attttcaccc cccatccttc aaaataaatg
      781 atatatacag aaaaaaaaaa aaaaaaaa
//
