LOCUS       NM_009342                791 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus dynein light chain Tctex-type 1B (Dynlt1b), mRNA.
ACCESSION   NM_009342 XM_001006801
VERSION     NM_009342.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 791)
  AUTHORS   Zhang,Y., Chen,Y., Zheng,J., Wang,J., Duan,S., Zhang,W., Yan,X. and
            Zhu,X.
  TITLE     Vertebrate Dynein-f depends on Wdr78 for axonemal localization and
            is essential for ciliary beat
  JOURNAL   J Mol Cell Biol 11 (5), 383-394 (2019)
   PUBMED   30060180
REFERENCE   2  (bases 1 to 791)
  AUTHORS   Brocard,J., Dufour,F., Gory-Faure,S., Arnoult,C., Bosc,C.,
            Denarier,E., Peris,L., Saoudi,Y., De Waard,M. and Andrieux,A.
  TITLE     MAP6 interacts with Tctex1 and Cav 2.2/N-type calcium channels to
            regulate calcium signalling in neurons
  JOURNAL   Eur J Neurosci 46 (11), 2754-2767 (2017)
   PUBMED   29094416
  REMARK    GeneRIF: show that MAP6 proteins interact directly with both Tctex1
            and the C-terminus of Cav2.2/N-type calcium channels.
REFERENCE   3  (bases 1 to 791)
  AUTHORS   Merino-Gracia,J., Zamora-Carreras,H., Bruix,M. and
            Rodriguez-Crespo,I.
  TITLE     Molecular Basis for the Protein Recognition Specificity of the
            Dynein Light Chain DYNLT1/Tctex1: CHARACTERIZATION OF THE
            INTERACTION WITH ACTIVIN RECEPTOR IIB
  JOURNAL   J Biol Chem 291 (40), 20962-20975 (2016)
   PUBMED   27502274
  REMARK    GeneRIF: activin receptor IIB as a novel DYNLT1 ligand and suggest
            that DYNLT1 functions as a molecular dimerization engine bringing
            together two receptor monomers in the cytoplasmic side of the
            membrane.
REFERENCE   4  (bases 1 to 791)
  AUTHORS   Pavlos,N.J., Cheng,T.S., Qin,A., Ng,P.Y., Feng,H.T., Ang,E.S.,
            Carrello,A., Sung,C.H., Jahn,R., Zheng,M.H. and Xu,J.
  TITLE     Tctex-1, a novel interaction partner of Rab3D, is required for
            osteoclastic bone resorption
  JOURNAL   Mol Cell Biol 31 (7), 1551-1564 (2011)
   PUBMED   21262767
  REMARK    GeneRIF: Targeted disruption of Tctex-1 by RNA interference
            significantly impairs bone resorption capacity and mislocalizes
            Rab3D vesicles in osteoclasts.
REFERENCE   5  (bases 1 to 791)
  AUTHORS   Duguay,D., Belanger-Nelson,E., Mongrain,V., Beben,A.,
            Khatchadourian,A. and Cermakian,N.
  TITLE     Dynein light chain Tctex-type 1 modulates orexin signaling through
            its interaction with orexin 1 receptor
  JOURNAL   PLoS One 6 (10), e26430 (2011)
   PUBMED   22028875
  REMARK    GeneRIF: Dynlt1 modulates orexin signaling by regulating OX1R
REFERENCE   6  (bases 1 to 791)
  AUTHORS   O'Neill,M.J. and Artzt,K.
  TITLE     Identification of a germ-cell-specific transcriptional repressor in
            the promoter of Tctex-1
  JOURNAL   Development 121 (2), 561-568 (1995)
   PUBMED   7768192
REFERENCE   7  (bases 1 to 791)
  AUTHORS   Ceci,J.D., Matsuda,Y., Grubber,J.M., Jenkins,N.A., Copeland,N.G.
            and Chapman,V.M.
  TITLE     Interspecific backcrosses provide an important new tool for
            centromere mapping of mouse chromosomes
  JOURNAL   Genomics 19 (3), 515-524 (1994)
   PUBMED   8188294
REFERENCE   8  (bases 1 to 791)
  AUTHORS   Ha,H., Howard,C.A., Yeom,Y.I., Abe,K., Uehara,H., Artzt,K. and
            Bennett,D.
  TITLE     Several testis-expressed genes in the mouse t-complex have
            expression differences between wild-type and t-mutant mice
  JOURNAL   Dev Genet 12 (4), 318-332 (1991)
   PUBMED   1718647
REFERENCE   9  (bases 1 to 791)
  AUTHORS   Howard,C.A., Gummere,G.R., Lyon,M.F., Bennett,D. and Artzt,K.
  TITLE     Genetic and molecular analysis of the proximal region of the mouse
            t-complex using new molecular probes and partial t-haplotypes
  JOURNAL   Genetics 126 (4), 1103-1114 (1990)
   PUBMED   2076813
REFERENCE   10 (bases 1 to 791)
  AUTHORS   Lader,E., Ha,H.S., O'Neill,M., Artzt,K. and Bennett,D.
  TITLE     tctex-1: a candidate gene family for a mouse t complex sterility
            locus
  JOURNAL   Cell 58 (5), 969-979 (1989)
   PUBMED   2570638
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC043018.1.
            
            On or before May 4, 2006 this sequence version replaced
            XM_001006801.1, NM_009342.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043018.1, CB572221.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..791
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 3.97 cM"
     gene            1..791
                     /gene="Dynlt1b"
                     /gene_synonym="AGS2; Dynlt1; Tctex-1; Tctex1"
                     /note="dynein light chain Tctex-type 1B"
                     /db_xref="GeneID:21648"
                     /db_xref="MGI:MGI:98643"
     exon            1..127
                     /gene="Dynlt1b"
                     /gene_synonym="AGS2; Dynlt1; Tctex-1; Tctex1"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..442
                     /gene="Dynlt1b"
                     /gene_synonym="AGS2; Dynlt1; Tctex-1; Tctex1"
                     /note="T-complex testis-specific protein 1; activator of
                     G-protein signaling 2; t-complex testis expressed 1;
                     dynein light chain Tctex-type 1D"
                     /codon_start=1
                     /product="dynein light chain Tctex-type 1"
                     /protein_id="NP_033368.1"
                     /db_xref="CCDS:CCDS49936.1"
                     /db_xref="GeneID:21648"
                     /db_xref="MGI:MGI:98643"
                     /translation="MEDFQASEETAFVVDEVSSIVKEAIESAIGGNAYQHSKVNQWTT
                     NVLEQTLSQLTKLGRPFKYIVTCVIMQKNGAGLHSASSCFWDSSTDGSCTVRWENKTM
                     YCIVSTFGLSI"
     exon            128..169
                     /gene="Dynlt1b"
                     /gene_synonym="AGS2; Dynlt1; Tctex-1; Tctex1"
                     /inference="alignment:Splign:2.1.0"
     exon            170..293
                     /gene="Dynlt1b"
                     /gene_synonym="AGS2; Dynlt1; Tctex-1; Tctex1"
                     /inference="alignment:Splign:2.1.0"
     exon            294..371
                     /gene="Dynlt1b"
                     /gene_synonym="AGS2; Dynlt1; Tctex-1; Tctex1"
                     /inference="alignment:Splign:2.1.0"
     exon            372..771
                     /gene="Dynlt1b"
                     /gene_synonym="AGS2; Dynlt1; Tctex-1; Tctex1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggtagtggt cagggtcccc cgcgcggggg cggagtgggc gtggcctgac cgcgcctgcg
       61 cagtccactc tactcggcgg gcgaaggaga tgcgttaaag atggaagact tccaggcctc
      121 agaggagact gcatttgttg ttgatgaagt gagcagcatt gtaaaggagg ctatagaaag
      181 cgccatcggt ggtaatgcct accagcacag caaagtcaac cagtggacca ctaatgtcct
      241 agaacagact ttgagccaac tcaccaaact ggggagacca tttaaataca ttgtgacctg
      301 tgtgatcatg cagaagaacg gtgctgggtt acactccgca agttcctgct tctgggacag
      361 ctccacagac ggaagctgca cagtccgatg ggagaacaag accatgtact gcatcgtcag
      421 taccttcgga ctgtccatct gaccaccttg ccagcctcag cctcgtggtc ccagcatttc
      481 cagtccatct taaccaccag ctatgttggg caaacccctt cctcctaagt tgttctgtgg
      541 cactctcaaa aaaccaaatg actccccagt cacaggaacc acatgacttc agccagatta
      601 gcagccacct gtcatctgag ccaggcagta ccacttgtct taactgtctt ctccaaggtg
      661 ctaaaaactc aagtctgctg gtggaaacag ctctactttc tgaaatgatt cagatacact
      721 aactttccat actttattct ttcttagaat aataaattat tcaaaattaa aaaaaaaaaa
      781 aaaaaaaaaa a
//
