LOCUS       NM_001166629            4978 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus dynein light chain Tctex-type 1A (Dynlt1a), mRNA.
ACCESSION   NM_001166629
VERSION     NM_001166629.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4978)
  AUTHORS   Blake,G.E.T., Zhao,X., Yung,H.W., Burton,G.J., Ferguson-Smith,A.C.,
            Hamilton,R.S. and Watson,E.D.
  TITLE     Defective folate metabolism causes germline epigenetic instability
            and distinguishes Hira as a phenotype inheritance biomarker
  JOURNAL   Nat Commun 12 (1), 3714 (2021)
   PUBMED   34140513
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC087868.1, AK030569.1, AC183097.2 and BC055792.1.
            
            On Mar 19, 2013 this sequence version replaced NM_001166629.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030569.1, BC087868.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-745               BC087868.1         1-745
            746-3295            AK030569.1         708-3257
            3296-4490           AC183097.2         111777-112971       c
            4491-4978           BC055792.1         13-500
FEATURES             Location/Qualifiers
     source          1..4978
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 3.88 cM"
     gene            1..4978
                     /gene="Dynlt1a"
                     /gene_synonym="AGS2; Dynlt1; Tctel1; Tctex-1; Tctex1"
                     /note="dynein light chain Tctex-type 1A"
                     /db_xref="GeneID:100310872"
                     /db_xref="MGI:MGI:3807506"
     exon            1..101
                     /gene="Dynlt1a"
                     /gene_synonym="AGS2; Dynlt1; Tctel1; Tctex-1; Tctex1"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..416
                     /gene="Dynlt1a"
                     /gene_synonym="AGS2; Dynlt1; Tctel1; Tctex-1; Tctex1"
                     /note="Dynein light chain Tctex-type 1; Activator of
                     G-protein signaling 2; T-complex testis-specific protein
                     1"
                     /codon_start=1
                     /product="dynein light chain Tctex-type 1A"
                     /protein_id="NP_001160101.1"
                     /db_xref="CCDS:CCDS49935.1"
                     /db_xref="GeneID:100310872"
                     /db_xref="MGI:MGI:3807506"
                     /translation="MEDFQASEETAFVVDEVSSIVKEAIESAIGGNAYQHSKVNQWTT
                     NVLEQTLSQLTKLGRPFKYIVTCVIMQKNGAGLHSASSCFWDSSTDGSCTVRWENKTM
                     YCIVSTFGLSI"
     exon            102..143
                     /gene="Dynlt1a"
                     /gene_synonym="AGS2; Dynlt1; Tctel1; Tctex-1; Tctex1"
                     /inference="alignment:Splign:2.1.0"
     exon            144..267
                     /gene="Dynlt1a"
                     /gene_synonym="AGS2; Dynlt1; Tctel1; Tctex-1; Tctex1"
                     /inference="alignment:Splign:2.1.0"
     exon            268..345
                     /gene="Dynlt1a"
                     /gene_synonym="AGS2; Dynlt1; Tctel1; Tctex-1; Tctex1"
                     /inference="alignment:Splign:2.1.0"
     exon            346..4945
                     /gene="Dynlt1a"
                     /gene_synonym="AGS2; Dynlt1; Tctel1; Tctex-1; Tctex1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      725..730
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dynlt1a"
                     /gene_synonym="AGS2; Dynlt1; Tctel1; Tctex-1; Tctex1"
                     /note="hexamer: AATAAA"
     polyA_site      745
                     /gene="Dynlt1a"
                     /gene_synonym="AGS2; Dynlt1; Tctel1; Tctex-1; Tctex1"
                     /note="major polyA site"
     regulatory      2499..2504
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dynlt1a"
                     /gene_synonym="AGS2; Dynlt1; Tctel1; Tctex-1; Tctex1"
                     /note="hexamer: ATTAAA"
     polyA_site      2520
                     /gene="Dynlt1a"
                     /gene_synonym="AGS2; Dynlt1; Tctel1; Tctex-1; Tctex1"
                     /note="major polyA site"
ORIGIN      
        1 ggggcggagt gggcgtggcc tggccgcgcc tgcgcagtcc actctactcg gcgggcgaag
       61 gacaggcatt aaagatggaa gacttccagg cctccgagga gactgcattt gttgttgatg
      121 aagtgagcag cattgtaaag gaggctatag aaagcgccat cggtggtaat gcctaccagc
      181 acagcaaagt caaccagtgg accactaatg tcctagaaca gactttgagc caactcacca
      241 aactggggag accatttaaa tacattgtga cctgtgtgat catgcagaag aacggtgctg
      301 ggttacactc cgcaagttcc tgcttctggg acagctccac agacggaagc tgcacagtcc
      361 gatgggagaa caagaccatg tactgcatcg tcagtacctt cggactgtcc atctgaccac
      421 cttgccagcc tcagcctcgt gatcccagca tttccagtcc atcttaacca ccagctatgt
      481 tgggcaaacc ccttcctcct aagttgttct gtggcactct caaaaaacca aatgactccc
      541 cagtcacagg aaccacatga cttcagccag attagcagcc acctgtcatc tgagccaggc
      601 agtaccactt gtcttaactg tcttctccaa ggtgctaaaa actcaagtct gctggtggaa
      661 acagctctac tttctgaaat gattcagata cactaacttt ccatacttta ttctttctta
      721 gaataataaa ttattcaaaa ttaaagtttt tgtgttcctt gtagcccgga gcatcacccg
      781 agaatgagtt tgagaaggga gaaggttgct tttagccttc tgcatgctga catcgagtat
      841 acctgagctg ctggtctcag gacagtgcac agccagcttt gcaggtcatg cttgaagccg
      901 cgggcctgtt tcttactgtg atggcgaaac ctgctgacat tggcagagct ggagagaggc
      961 cacagacctc aggggcgggc taggcacttg tgacatgtgg ccgcacgcag agatctagaa
     1021 aagtggccca tgtctgggga aatgggctac atcagtttag ctctgtttaa ttttttaatt
     1081 acattcgtgt gtgagagcga gtaagcatgc gtcccatggc acacctgtgg agttcagagg
     1141 tcaaaggcag tttgtgggac ttggctcttt ctccaccact gggtcccagg aatgaactta
     1201 ggtagtcagg gttggtggca aacccctcta cctgctgtac cagctcactg gcccaccagt
     1261 ttactttcgt tgcactcact gccagcctca ggtggcacaa accaggaagc aaaaagaaca
     1321 ggaggaaagc ttaccctagc aatctggcaa acatgtctgc cctctcagta gagggcgaga
     1381 tgaacgaacg ccttggtcct ccaggacggg aataggccac ttcacctgta ggacaggaac
     1441 ctagccatgc tgcaatccta cattcctagt ccctgcttcc tggacgtgac ggttgtgcaa
     1501 gccatgagct ccgacctatg tctgcttggc ccagcgcagt tcgcctgctg ctttcggacc
     1561 taggctttgg cattttagta gcagcagcag ctacatattt agaattttac agcttacaga
     1621 atggtttcag gattgctgtg tccttaacaa tgcttagctt gggtatcaca aagggcccac
     1681 agtttatcca gttaatttca agtcataaat cctagtgaga agggacccca acagactagg
     1741 ttgtctgttg accgctctag ggtgctcctt gtgggccacc taagacacta tgattggcat
     1801 tgccacttgc tgtgtgtatg tctgaaggag tgcacactca tgcatggtct tgtgtgtgcc
     1861 cagttccagc atatttcctg agatggggtc tctcactgaa cctggagcac aatgtttgag
     1921 ctaaatttgc tggccaccaa aacagtggga cacacctgtc tctgctccgt tttcccagcc
     1981 ctggggttac agacacacac cactgtgccc gcttttacat ggatgctgca gctctaaact
     2041 tgggccctca ttctcacaaa gcaagcattt aacccactga cctgtctccc cgatatccct
     2101 ggctgaagag ccttgctgtg gtcttctttc taaagcattc atataaaaag ctagtaatac
     2161 ataaagaatt aaaaattaga aatatattaa catcggtgaa caagagacag tgtcagaatg
     2221 aagctgataa ggtttgttat ggatgagaaa tgtcccccat cggtgtgtga tggtttgaat
     2281 atgcctggcc cagggagtgg cactgttaga aggtgtgtca ctgtgggtgt gggctttaag
     2341 accctcattc tagctgccta gaagccagta ttctgctagc agccttcaga tgaagatgta
     2401 gaactttcag ctctgcttgc accatgcctg cttggatgct gccatgctcc tgccttgatg
     2461 ataatggact gaacctctga gcctgtaagc cagccccaat taaatgttgt ccttataaga
     2521 gttgccttgg tcatggtgtc tgttcacagc agtaaaaccc tgttgcggcc ggcctgcagc
     2581 ttgcaacgaa tggttcagca gagatggcaa ctcgggctga gagagaaaag actacaaaac
     2641 cctaagacaa ggtgtgtgtc aaacacttgc tcttcatctg gcagtgacat ttggggagga
     2701 tctgggaact tggaggtgga gcgtgctgaa ggaagcagga tacagcaagt atccctagtg
     2761 gttgagggtc tctgccttgt tctggcccct tcccgtcatt ctgctttgag tcctggctac
     2821 caggaggtga gtgacttggc cacactctgt aggcactgtg ttcctcatcc cgggctcatg
     2881 gtggagggag ccagccatgg accggtgagc taaagtgact ctctcctgtg aggtttttca
     2941 tcagatttcg gtcacagcaa caaaaagtct catacaaaat ctcaaaatgt gacttttatt
     3001 gagtttttca taaataagca tttattcctt gactgactgc tcagacaaca gtggtgcact
     3061 gatggtcaaa cggtgttcct tctggactta gaggttagtg tttttattta acagatattt
     3121 acagacattt gtaaaaaggt agttttcagg agcagaaaat ccctctgtca tacaatggaa
     3181 ttaacctgtt ctgtgtcaca ggacagatca cagaatggta gcacctagca gcacccgagc
     3241 caccaagaga aacattcagc aaggcttctg acgacatcca ttttcctttg gcctgaaaaa
     3301 aaaaaaaaaa aaaaagagcc acatctcccc caacccccaa aaatgtaatc actaaggcaa
     3361 acgctcaaat atacaataca tatcaagcct catatctgtt cctcatggag ggacttagtt
     3421 ctctcttttg tgggtgcttg tgtttttcct ataaagatta gtaaccatat ttgaacctgt
     3481 tcatcctaac tgtgccttca atggttcagc acttgaggct ggcgagattt gctttataaa
     3541 ctgcccatct gcaggatggc tttacatacc taagcttact tcagtctaac tgtacagaga
     3601 gcaagcgcct cacgagcctc ggatgtaagt ttacataccc tcttctctag cctttcgatg
     3661 gggcttgaag gcaccgaatc actgctgcca tgaatgacaa taaatcacgc agatttacta
     3721 cccacaggga aaatgaagct ctcaccggga atctgggagc cgtcaccttc caggttcccc
     3781 tggattggac caatataaaa aataccccaa agacaggagg attcaaaccg ttaccctgaa
     3841 agaactaagt cagccctttg aacttataat ttaagtttac aaaattttaa tcccctcaga
     3901 acagaacagt cttctggtga ctatcaaaag tcctggcgga gtttagtgtt ttaagctcac
     3961 ccctgagctg ctgcctacac actgaagtct tagttctgta agcagagctt tgcacagcat
     4021 ctaatacagg atgcacacga ccctaggagt gctgctttat aattcatatt tcaacagcaa
     4081 aaaaaatatt cccttagttt tacggacact aggatcagtt tataattatt ctatagggca
     4141 gtttttaaaa gttctgaagt ctgtacctaa atgcttaaaa tatcttacac tgactgatac
     4201 atagtgttat aaaccatgga gacttattta taatgatgaa gacatgtaaa ctctcacata
     4261 ttcgaacatc ttgggatcag tacgagtcag cgtccataag atggcagctg cagggctcca
     4321 ctggaaggga agggctggta acataagata ttctggtatc ttccccaaca gactcagtga
     4381 tcacagcaag tgcaaactca tgtaaacccg ttaccctcgc agtgagtttc cattccaatg
     4441 ttcatagtta caagttgttt tgtttttaaa aaaaatgcac atggaatcca tattaaagta
     4501 tgaagtttaa gaagacaggc agactgaaga acgtcttcca ccctggagtc gggcccacac
     4561 ggacagtaac ctgcagctca gagcggaaat ctgagtcggt gcacagacga agggaacaga
     4621 agagggatct accggaactg ggcctctgga tttgccaaga cagaggcagg caggatgcta
     4681 cctttaccag gtgttcgcag agacgctgtg tggggaaact gaggagcggg aaggaaggcg
     4741 gtggccctga ggacttccaa tgctgaactt cagtgtgggt gacatccgtt ttccacagag
     4801 ccacactcca aacccagaac aaccttgggg ggactccctt catctgcagc tgtctctata
     4861 gccattcaaa atgtcttact ttctctttac tttagttcct aattaaaaca gaaagtcttt
     4921 ctggcaataa agtatttcta atacaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
