LOCUS       NM_025947                702 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus dynein light chain roadblock-type 1 (Dynlrb1),
            transcript variant 2, mRNA.
ACCESSION   NM_025947 XM_976951
VERSION     NM_025947.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 702)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 702)
  AUTHORS   He,S., Gillies,J.P., Zang,J.L., Cordoba-Beldad,C.M., Yamamoto,I.,
            Fujiwara,Y., Grantham,J., DeSantis,M.E. and Shibuya,H.
  TITLE     Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate
            mitotic and male meiotic spindle bipolarity
  JOURNAL   Nat Commun 14 (1), 1715 (2023)
   PUBMED   36973253
  REMARK    GeneRIF: Distinct dynein complexes defined by DYNLRB1 and DYNLRB2
            regulate mitotic and male meiotic spindle bipolarity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 702)
  AUTHORS   Ripon,M.K.H., Lee,H., Dash,R., Choi,H.J., Oktaviani,D.F., Moon,I.S.
            and Haque,M.N.
  TITLE     N-acetyl-D-glucosamine kinase binds dynein light chain roadblock 1
            and promotes protein aggregate clearance
  JOURNAL   Cell Death Dis 11 (8), 619 (2020)
   PUBMED   32796833
  REMARK    GeneRIF: N-acetyl-D-glucosamine kinase binds dynein light chain
            roadblock 1 and promotes protein aggregate clearance.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 702)
  AUTHORS   Terenzio,M., Di Pizio,A., Rishal,I., Marvaldi,L., Di Matteo,P.,
            Kawaguchi,R., Coppola,G., Schiavo,G., Fisher,E.M.C. and
            Fainzilber,M.
  TITLE     DYNLRB1 is essential for dynein mediated transport and neuronal
            survival
  JOURNAL   Neurobiol Dis 140, 104816 (2020)
   PUBMED   32088381
REFERENCE   5  (bases 1 to 702)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 702)
  AUTHORS   Jin,Q., Pulipati,N.R., Zhou,W., Staub,C.M., Liotta,L.A. and
            Mulder,K.M.
  TITLE     Role of km23-1 in RhoA/actin-based cell migration
  JOURNAL   Biochem Biophys Res Commun 428 (3), 333-338 (2012)
   PUBMED   23079622
REFERENCE   7  (bases 1 to 702)
  AUTHORS   Song,J. and Markley,J.L.
  TITLE     Cautionary tail: the presence of an N-terminal tag on dynein
            light-chain Roadblock/LC7 affects its interaction with a functional
            partner
  JOURNAL   Protein Pept Lett 14 (3), 265-268 (2007)
   PUBMED   17346231
  REMARK    GeneRIF: The presence of an N-terminal tag on dynein light-chain
            Roadblock/LC7 affects its interaction with a functional partner.
REFERENCE   8  (bases 1 to 702)
  AUTHORS   Pfister,K.K., Fisher,E.M., Gibbons,I.R., Hays,T.S., Holzbaur,E.L.,
            McIntosh,J.R., Porter,M.E., Schroer,T.A., Vaughan,K.T.,
            Witman,G.B., King,S.M. and Vallee,R.B.
  TITLE     Cytoplasmic dynein nomenclature
  JOURNAL   J Cell Biol 171 (3), 411-413 (2005)
   PUBMED   16260502
REFERENCE   9  (bases 1 to 702)
  AUTHORS   Nikulina,K., Patel-King,R.S., Takebe,S., Pfister,K.K. and King,S.M.
  TITLE     The Roadblock light chains are ubiquitous components of cytoplasmic
            dynein that form homo- and heterodimers
  JOURNAL   Cell Motil Cytoskeleton 57 (4), 233-245 (2004)
   PUBMED   14752807
REFERENCE   10 (bases 1 to 702)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929588.11, AK166685.1 and CO041603.1.
            
            On Jul 21, 2009 this sequence version replaced NM_025947.2.
            
            Transcript Variant: This variant (2) contains an alternate 5'
            terminal exon, and it thus differs in the 5' UTR and 5' coding
            region, compared to variant 1. The encoded isoform (b) has a
            distinct N-terminus and is shorter than isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CA319060.1, CO041603.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AL929588.11        60896-60919
            25-681              AK166685.1         1-657
            682-702             CO041603.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..702
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 77.07 cM"
     gene            1..702
                     /gene="Dynlrb1"
                     /gene_synonym="2010012N15Rik; 2010320M17Rik;
                     9430076K19Rik; Dncl2a; DNLC2A; km23-1"
                     /note="dynein light chain roadblock-type 1"
                     /db_xref="GeneID:67068"
                     /db_xref="MGI:MGI:1914318"
     exon            1..85
                     /gene="Dynlrb1"
                     /gene_synonym="2010012N15Rik; 2010320M17Rik;
                     9430076K19Rik; Dncl2a; DNLC2A; km23-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..373
                     /gene="Dynlrb1"
                     /gene_synonym="2010012N15Rik; 2010320M17Rik;
                     9430076K19Rik; Dncl2a; DNLC2A; km23-1"
                     /note="isoform b is encoded by transcript variant 2;
                     dynein, cytoplasmic, light chain 2A; dynein, cytoplasmic,
                     light polypeptide 2A; dynein light chain 2A, cytoplasmic"
                     /codon_start=1
                     /product="dynein light chain roadblock-type 1 isoform b"
                     /protein_id="NP_080223.2"
                     /db_xref="CCDS:CCDS38294.1"
                     /db_xref="GeneID:67068"
                     /db_xref="MGI:MGI:1914318"
                     /translation="MAEVEETLKRLQSQKGVQGIIVVNTEGIPIKSTMDNPTTTQYAN
                     LMHNFILKARSTVREIDPQNDLTFLRIRSKKNEIMVAPDKDYFLIVIQNPTE"
     exon            86..161
                     /gene="Dynlrb1"
                     /gene_synonym="2010012N15Rik; 2010320M17Rik;
                     9430076K19Rik; Dncl2a; DNLC2A; km23-1"
                     /inference="alignment:Splign:2.1.0"
     exon            162..329
                     /gene="Dynlrb1"
                     /gene_synonym="2010012N15Rik; 2010320M17Rik;
                     9430076K19Rik; Dncl2a; DNLC2A; km23-1"
                     /inference="alignment:Splign:2.1.0"
     exon            330..686
                     /gene="Dynlrb1"
                     /gene_synonym="2010012N15Rik; 2010320M17Rik;
                     9430076K19Rik; Dncl2a; DNLC2A; km23-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      661..666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dynlrb1"
                     /gene_synonym="2010012N15Rik; 2010320M17Rik;
                     9430076K19Rik; Dncl2a; DNLC2A; km23-1"
                     /note="hexamer: AGTAAA"
     polyA_site      682
                     /gene="Dynlrb1"
                     /gene_synonym="2010012N15Rik; 2010320M17Rik;
                     9430076K19Rik; Dncl2a; DNLC2A; km23-1"
                     /note="major polyA site"
ORIGIN      
        1 ccacaaagga ctgtgcgcag gctcagaagg gcggggaacg cggctaagtg ttggcgattc
       61 ggagctgcag gatccgtccg agatggcaga ggtggaggaa acactcaaga ggcttcagag
      121 ccagaaagga gtgcagggca tcatcgtggt gaacacagaa ggcattccca tcaagagcac
      181 aatggacaat cccaccacta cacagtatgc caacctcatg cacaacttca tcttgaaggc
      241 gcggagcact gtgcgtgaga ttgaccccca aaacgaccta accttccttc gaattcgctc
      301 caagaaaaat gaaattatgg tggcaccaga taaagactat ttcctgattg tgatccagaa
      361 tccaactgaa taagccactg tctgggcttc ctgtgtcatt ccttaattta atgtccccca
      421 agaataatag tgctaatcat gtcagtgggc acgtggtggc cacctgagcc tgtgtagacc
      481 atgccattga tcaagggtcg ctctgcccac cccacaagga gtgcctctga tccagtcagc
      541 ccctggggaa tcagttcgcc cttgcaggct ttggaatgag agcttatgat aagcccacac
      601 ccagctcttc aaactttcag ttcaccttgt cccccttgga aagctgtttt tgttttttaa
      661 agtaaaaatt acttcaaccc ccctacaaaa aaaaaaaaaa aa
//
