LOCUS       NM_026556               2476 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus dynein light chain LC8-type 2 (Dynll2), transcript
            variant 1, mRNA.
ACCESSION   NM_026556
VERSION     NM_026556.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2476)
  AUTHORS   He,S., Gillies,J.P., Zang,J.L., Cordoba-Beldad,C.M., Yamamoto,I.,
            Fujiwara,Y., Grantham,J., DeSantis,M.E. and Shibuya,H.
  TITLE     Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate
            mitotic and male meiotic spindle bipolarity
  JOURNAL   Nat Commun 14 (1), 1715 (2023)
   PUBMED   36973253
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2476)
  AUTHORS   Singh,P.K., Roukounakis,A., Weber,A., Das,K.K., Sohm,B.,
            Villunger,A., Garcia-Saez,A.J. and Hacker,G.
  TITLE     Dynein light chain binding determines complex formation and
            posttranslational stability of the Bcl-2 family members Bmf and Bim
  JOURNAL   Cell Death Differ 27 (2), 434-450 (2020)
   PUBMED   31189926
  REMARK    GeneRIF: Dynein light chain binding determines complex formation
            and posttranslational stability of the Bcl-2 family members Bmf and
            Bim.
REFERENCE   3  (bases 1 to 2476)
  AUTHORS   Goggolidou,P., Hadjirin,N.F., Bak,A., Papakrivopoulou,E.,
            Hilton,H., Norris,D.P. and Dean,C.H.
  TITLE     Atmin mediates kidney morphogenesis by modulating Wnt signaling
  JOURNAL   Hum Mol Genet 23 (20), 5303-5316 (2014)
   PUBMED   24852369
REFERENCE   4  (bases 1 to 2476)
  AUTHORS   Goggolidou,P., Stevens,J.L., Agueci,F., Keynton,J., Wheway,G.,
            Grimes,D.T., Patel,S.H., Hilton,H., Morthorst,S.K., DiPaolo,A.,
            Williams,D.J., Sanderson,J., Khoronenkova,S.V., Powles-Glover,N.,
            Ermakov,A., Esapa,C.T., Romero,R., Dianov,G.L., Briscoe,J.,
            Johnson,C.A., Pedersen,L.B. and Norris,D.P.
  TITLE     ATMIN is a transcriptional regulator of both lung morphogenesis and
            ciliogenesis
  JOURNAL   Development 141 (20), 3966-3977 (2014)
   PUBMED   25294941
REFERENCE   5  (bases 1 to 2476)
  AUTHORS   Moutin,E., Raynaud,F., Fagni,L. and Perroy,J.
  TITLE     GKAP-DLC2 interaction organizes the postsynaptic scaffold complex
            to enhance synaptic NMDA receptor activity
  JOURNAL   J Cell Sci 125 (Pt 8), 2030-2040 (2012)
   PUBMED   22328512
  REMARK    GeneRIF: GKAP-DLC2 interaction organizes the postsynaptic scaffold
            complex to enhance synaptic NMDA receptor activity.
REFERENCE   6  (bases 1 to 2476)
  AUTHORS   Chen,Y.M., Gerwin,C. and Sheng,Z.H.
  TITLE     Dynein light chain LC8 regulates syntaphilin-mediated mitochondrial
            docking in axons
  JOURNAL   J Neurosci 29 (30), 9429-9438 (2009)
   PUBMED   19641106
REFERENCE   7  (bases 1 to 2476)
  AUTHORS   Wagner,W., Fodor,E., Ginsburg,A. and Hammer,J.A. 3rd.
  TITLE     The binding of DYNLL2 to myosin Va requires alternatively spliced
            exon B and stabilizes a portion of the myosin's coiled-coil domain
  JOURNAL   Biochemistry 45 (38), 11564-11577 (2006)
   PUBMED   16981716
  REMARK    GeneRIF: These data show that alternative splicing of the myosin Va
            heavy chain controls DYNLL2-myosin Va interaction and that DYNLL2
            binding alters the structure of a portion of the myosin's
            coiled-coil domain.
REFERENCE   8  (bases 1 to 2476)
  AUTHORS   Pfister,K.K., Fisher,E.M., Gibbons,I.R., Hays,T.S., Holzbaur,E.L.,
            McIntosh,J.R., Porter,M.E., Schroer,T.A., Vaughan,K.T.,
            Witman,G.B., King,S.M. and Vallee,R.B.
  TITLE     Cytoplasmic dynein nomenclature
  JOURNAL   J Cell Biol 171 (3), 411-413 (2005)
   PUBMED   16260502
REFERENCE   9  (bases 1 to 2476)
  AUTHORS   Day,C.L., Puthalakath,H., Skea,G., Strasser,A., Barsukov,I.,
            Lian,L.Y., Huang,D.C. and Hinds,M.G.
  TITLE     Localization of dynein light chains 1 and 2 and their pro-apoptotic
            ligands
  JOURNAL   Biochem J 377 (Pt 3), 597-605 (2004)
   PUBMED   14561217
REFERENCE   10 (bases 1 to 2476)
  AUTHORS   Puthalakath,H., Villunger,A., O'Reilly,L.A., Beaumont,J.G.,
            Coultas,L., Cheney,R.E., Huang,D.C. and Strasser,A.
  TITLE     Bmf: a proapoptotic BH3-only protein regulated by interaction with
            the myosin V actin motor complex, activated by anoikis
  JOURNAL   Science 293 (5536), 1829-1832 (2001)
   PUBMED   11546872
  REMARK    Erratum:[Science 2002 Aug 16;297(5584):1122]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY310878.1, AK078434.1 and AL606805.21.
            
            On Dec 15, 2009 this sequence version replaced NM_026556.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040822.1, AK160114.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BY310878.1         2-29
            29-1441             AK078434.1         2-1414
            1442-2476           AL606805.21        169018-170052       c
FEATURES             Location/Qualifiers
     source          1..2476
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 52.35 cM"
     gene            1..2476
                     /gene="Dynll2"
                     /gene_synonym="1700064A15Rik; 6720463E02Rik; Dlc2; DLC8;
                     DLC8b"
                     /note="dynein light chain LC8-type 2"
                     /db_xref="GeneID:68097"
                     /db_xref="MGI:MGI:1915347"
     exon            1..291
                     /gene="Dynll2"
                     /gene_synonym="1700064A15Rik; 6720463E02Rik; Dlc2; DLC8;
                     DLC8b"
                     /inference="alignment:Splign:2.1.0"
     exon            292..430
                     /gene="Dynll2"
                     /gene_synonym="1700064A15Rik; 6720463E02Rik; Dlc2; DLC8;
                     DLC8b"
                     /inference="alignment:Splign:2.1.0"
     CDS             299..568
                     /gene="Dynll2"
                     /gene_synonym="1700064A15Rik; 6720463E02Rik; Dlc2; DLC8;
                     DLC8b"
                     /note="8 kDa dynein light chain b"
                     /codon_start=1
                     /product="dynein light chain 2, cytoplasmic"
                     /protein_id="NP_080832.1"
                     /db_xref="CCDS:CCDS36272.1"
                     /db_xref="GeneID:68097"
                     /db_xref="MGI:MGI:1915347"
                     /translation="MSDRKAVIKNADMSEDMQQDAVDCATQAMEKYNIEKDIAAYIKK
                     EFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG"
     exon            431..2476
                     /gene="Dynll2"
                     /gene_synonym="1700064A15Rik; 6720463E02Rik; Dlc2; DLC8;
                     DLC8b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2450..2455
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dynll2"
                     /gene_synonym="1700064A15Rik; 6720463E02Rik; Dlc2; DLC8;
                     DLC8b"
                     /note="hexamer: ATTAAA"
     polyA_site      2469
                     /gene="Dynll2"
                     /gene_synonym="1700064A15Rik; 6720463E02Rik; Dlc2; DLC8;
                     DLC8b"
                     /note="major polyA site"
ORIGIN      
        1 atttcagggc cgcgcgtcgg ccgcgctcag cggcggagcg gagcggacgg cgaggtatca
       61 gccgagacag gcggtcggcc gggtggcacg aggcggagcg cgggcgtccg gggaagctcg
      121 gagggcgacc agcagtgcga gcgctcggcc ccggggctgc gggagcaggg ggataccgcg
      181 gcggcagcgg ctgctgctgc aggacgagcc caggggacac cgcccctgct cgagctttgc
      241 ttcagcccag cgctgctccc caggggcctg tgcggactcg cctgcgtgac gtgtcacgat
      301 gtctgaccgg aaggcagtga tcaagaacgc agacatgtct gaggacatgc aacaggatgc
      361 cgttgactgt gccacacagg ccatggagaa gtacaacata gagaaggaca ttgctgccta
      421 tatcaagaag gaatttgaca agaaatataa ccctacctgg cattgtatcg tgggccggaa
      481 ttttggcagc tatgtcacac acgagacaaa gcacttcatc tatttttact tgggtcaagt
      541 tgcaatcctc ctcttcaagt cgggctaggt ggccgaggcg aaggtgtccg tggcggcggc
      601 agcgatggca agcaggcggc gttgctggga ctgttgcact ggggccagca tcaggaagtc
      661 ctctccaatg gctgtgctac tgcatggact gtgtactcga tttcatgtgt gtgtcgcagt
      721 aaacaaaaac caaactcctt tctgtttagt tgcctgggga agaaggctgc tttgcgtttg
      781 tttttaagac gttaacatta tttttttggt tgtactgcac taggaaatct ctcctacccc
      841 tccttttctc ttctctccct agataaaaat aaaaggccct cctcgaagcc ctaaggacta
      901 ggagggccga ggaatagaaa taggtctgag gtggaagtta agctgcaggt gcctcttggg
      961 tggtgggtgc tgctgtagga ggccggggag gctgtgagga cagggttagg attggcaagg
     1021 agaggggcag gaaggtgggg gggggggtgg tggctctagt accggggaga atattccaca
     1081 gaactgtgac tatggcttgg ggcaggggtg ggtgtgcagt ctctaagggg ccctaaggtg
     1141 tgtttgtggt gtgggaatgg ggagcagact cgtcttgccg tctgtcagga ttttaagtaa
     1201 gggctgtgtc tttgtgggtc atcttcccat attcttccag ccagaagtcg tgttgggagg
     1261 atgctgggag tagggttagc ctgacttccc ctttacattc tgtctgctcc ctgcttagcc
     1321 ctcgtttttt ctcattcctt cgttctctta gagcagcccc tattgttggc tggcaaggga
     1381 atttctggtg actgtagttc cttagttagg tcttagcaat caaaccaaat caatgcccgt
     1441 cagttcttct ttgtgtacgt ttgtgtttgt ctgtgtgcgt gtgtgggggt gggtttgggg
     1501 tagaagggtg ggaaggggca ggataagtgg aatctctagg gtgtatggga agtagagggc
     1561 agttagttct aagtgggctt ttatgttccc tgttgtgagg gtgagaacag gttggtatca
     1621 aaccatcccc ctccccttag ttcatcttgc ttggacactg ctttgccttg tggctgtctg
     1681 ttccctggga aaggttttgg aaggtcaccc agaacaggat ggccatacta acatctttcc
     1741 tggagttgga tctgggacca ggtgactggt ctctagtggg aagtgagaat ggaagtgatg
     1801 gggtggaggg ctccttggaa caggtctgaa gtatagcaat gacctctggg aggcaggagg
     1861 tggagaatgg aagtggggtg gagggctcct ggaacaggtc tgaagtatag caatgacctc
     1921 tgggaggcag gaggtggaga aggctgactg ggaggagatt ccagagaaga gtgcaaggga
     1981 aaccttgtct gtcggtgaca tgattggggt gggtgggggt tgtcattgcc aattgagctg
     2041 ctgattctta tgaatcacat tcagaactcg catagggttg acactgtaag gggtggggaa
     2101 atctagctat ttttttttcc ccagcccatt cttgggggtc ggggggaggc aggagaatgc
     2161 cccttcctcc taagcccttc ctgtgtgttg agcttttgtt tttcttcagt gctggcaggg
     2221 gagggtggga actggtgggg actgagttcc ctgttcaaac cgttattggg tacaggattg
     2281 aatgtttgat tttaggtttt atttttctta tgaatgtcca gatctgtgtt tccctgccct
     2341 cccagactct ggccagttgg aagtgtctcg tttttgttca tctctcattt ctggtgcagt
     2401 gactgagacc ctgccacatc tatgctctgc atccacgcct cttttggaca ttaaaggtcg
     2461 attgatgcac ttctga
//
