LOCUS       NM_019682               2007 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus dynein light chain LC8-type 1 (Dynll1), mRNA.
ACCESSION   NM_019682
VERSION     NM_019682.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2007)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2007)
  AUTHORS   He,S., Gillies,J.P., Zang,J.L., Cordoba-Beldad,C.M., Yamamoto,I.,
            Fujiwara,Y., Grantham,J., DeSantis,M.E. and Shibuya,H.
  TITLE     Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate
            mitotic and male meiotic spindle bipolarity
  JOURNAL   Nat Commun 14 (1), 1715 (2023)
   PUBMED   36973253
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2007)
  AUTHORS   Liu,R., King,A., Tarlinton,D. and Heierhorst,J.
  TITLE     The ASCIZ-DYNLL1 Axis Is Essential for TLR4-Mediated Antibody
            Responses and NF-kappaB Pathway Activation
  JOURNAL   Mol Cell Biol 41 (12), e0025121 (2021)
   PUBMED   34543116
  REMARK    GeneRIF: The ASCIZ-DYNLL1 Axis Is Essential for TLR4-Mediated
            Antibody Responses and NF-kappaB Pathway Activation.
REFERENCE   4  (bases 1 to 2007)
  AUTHORS   Jiao,H., Jiang,D., Hu,X., Du,W., Ji,L., Yang,Y., Li,X., Sho,T.,
            Wang,X., Li,Y., Wu,Y.T., Wei,Y.H., Hu,X. and Yu,L.
  TITLE     Mitocytosis, a migrasome-mediated mitochondrial quality-control
            process
  JOURNAL   Cell 184 (11), 2896-2910 (2021)
   PUBMED   34048705
REFERENCE   5  (bases 1 to 2007)
  AUTHORS   Yuan,J., Zheng,Z., Wang,L., Ran,H., Tang,X., Xie,X., Li,F., Liu,F.,
            Wang,X., Zhang,J., Zhang,J., Huang,Y., Xia,X. and Wan,Y.
  TITLE     The Dynll1-Cox4i1 Complex Regulates Intracellular Pathogen
            Clearance via Release of Mitochondrial Reactive Oxygen Species
  JOURNAL   Infect Immun 88 (4), e00738-19 (2020)
   PUBMED   32041786
  REMARK    GeneRIF: The authors discovered that the dissociation of the
            Dynll1-Cox4i1 complex is required for the release of mitochondrial
            reactive oxygen species and serves as a regulator of intracellular
            proliferation of Listeria monocytogenes. The study shows that
            Dynll1 is an inhibitor of mitochondrial reactive oxygen species.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2007)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 2007)
  AUTHORS   Lim,R., Winteringham,L.N., Williams,J.H., McCulloch,R.K.,
            Ingley,E., Tiao,J.Y., Lalonde,J.P., Tsai,S., Tilbrook,P.A., Sun,Y.,
            Wu,X., Morris,S.W. and Klinken,S.P.
  TITLE     MADM, a novel adaptor protein that mediates phosphorylation of the
            14-3-3 binding site of myeloid leukemia factor 1
  JOURNAL   J Biol Chem 277 (43), 40997-41008 (2002)
   PUBMED   12176995
REFERENCE   8  (bases 1 to 2007)
  AUTHORS   Mok,Y.K., Lo,K.W. and Zhang,M.
  TITLE     Structure of Tctex-1 and its interaction with cytoplasmic dynein
            intermediate chain
  JOURNAL   J Biol Chem 276 (17), 14067-14074 (2001)
   PUBMED   11148215
REFERENCE   9  (bases 1 to 2007)
  AUTHORS   Feng,Y., Olson,E.C., Stukenberg,P.T., Flanagan,L.A., Kirschner,M.W.
            and Walsh,C.A.
  TITLE     LIS1 regulates CNS lamination by interacting with mNudE, a central
            component of the centrosome
  JOURNAL   Neuron 28 (3), 665-679 (2000)
   PUBMED   11163258
REFERENCE   10 (bases 1 to 2007)
  AUTHORS   King,S.M., Barbarese,E., Dillman,J.F. 3rd, Patel-King,R.S.,
            Carson,J.H. and Pfister,K.K.
  TITLE     Brain cytoplasmic and flagellar outer arm dyneins share a highly
            conserved Mr 8,000 light chain
  JOURNAL   J Biol Chem 271 (32), 19358-19366 (1996)
   PUBMED   8702622
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC145070.10.
            
            On Jul 5, 2022 this sequence version replaced NM_019682.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082923.1, AK147977.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               AC145070.10        20652-20756
            106-243             AC145070.10        20938-21075
            244-2007            AC145070.10        22755-24518
FEATURES             Location/Qualifiers
     source          1..2007
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 56.04 cM"
     gene            1..2007
                     /gene="Dynll1"
                     /gene_synonym="Dlc8; Dnclc1; Pin"
                     /note="dynein light chain LC8-type 1"
                     /db_xref="GeneID:56455"
                     /db_xref="MGI:MGI:1861457"
     exon            1..105
                     /gene="Dynll1"
                     /gene_synonym="Dlc8; Dnclc1; Pin"
                     /inference="alignment:Splign:2.1.0"
     exon            106..243
                     /gene="Dynll1"
                     /gene_synonym="Dlc8; Dnclc1; Pin"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..381
                     /gene="Dynll1"
                     /gene_synonym="Dlc8; Dnclc1; Pin"
                     /note="protein inhibitor of nitric oxide synthase; mPIN; 8
                     kDa dynein light chain; protein inhibitor of neuronal
                     nitric oxide synthase; 8kDa LC; 8kD LC; dynein,
                     cytoplasmic, light peptide; dynein, cytoplasmic, light
                     chain 1"
                     /codon_start=1
                     /product="dynein light chain 1, cytoplasmic"
                     /protein_id="NP_062656.3"
                     /db_xref="CCDS:CCDS39227.1"
                     /db_xref="GeneID:56455"
                     /db_xref="MGI:MGI:1861457"
                     /translation="MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKK
                     EFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG"
     exon            244..2007
                     /gene="Dynll1"
                     /gene_synonym="Dlc8; Dnclc1; Pin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      635..640
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dynll1"
                     /gene_synonym="Dlc8; Dnclc1; Pin"
                     /note="hexamer: AATAAA"
     polyA_site      655
                     /gene="Dynll1"
                     /gene_synonym="Dlc8; Dnclc1; Pin"
                     /note="major polyA site"
     regulatory      1930..1935
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dynll1"
                     /gene_synonym="Dlc8; Dnclc1; Pin"
                     /note="hexamer: AATAAA"
     polyA_site      1950
                     /gene="Dynll1"
                     /gene_synonym="Dlc8; Dnclc1; Pin"
     regulatory      1985..1990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dynll1"
                     /gene_synonym="Dlc8; Dnclc1; Pin"
                     /note="hexamer: AATACA"
     polyA_site      2007
                     /gene="Dynll1"
                     /gene_synonym="Dlc8; Dnclc1; Pin"
ORIGIN      
        1 ttagatgcgc cacggcttcg gtagcgaccg gctgtcttct gctgcttgag cggcgcccgc
       61 accttcccta ggagctcgca gcagccggct ggcctctgct ccacggtaac catgtgcgac
      121 cggaaggcgg tgatcaaaaa tgcagacatg tcggaagaga tgcaacagga ctcggtggag
      181 tgcgctaccc aggcgttgga gaagtacaac atcgagaagg atattgcggc ccatatcaag
      241 aaggagtttg acaagaagta caaccctacc tggcactgca ttgtgggccg aaacttcggt
      301 agttatgtga cacatgaaac caaacacttc atctacttct acctgggtca ggtggccatt
      361 cttctgttca aatctggtta aaagcatgga ctgtgccaaa cacccagtga tccatccaaa
      421 aacaaggact gcatccaaat tccaaatacc agagactgaa tcttcagcct tgctaaggga
      481 acacctcgtt tgaatctgtt gtgttgtgta cagggcttca ttctctgtac aagtctgtgg
      541 ttataaaatt agtaaaacag cttacatttg tatttatttt ctagtccata cttctgtacc
      601 cccatttttt tctcccttag gtcattcctt taaaaataaa tctgttggag atgtatgtct
      661 ctgctagttt gttcaagata gggttgatga ggcttagcag ttggtaagtg acttggtctg
      721 ttgtctgagg tgttcctgtt ctgtaggatt agtttagttc tcttgatgga atgtctggca
      781 ggccacacct gtctttccag atgatttgga ttattagcca caggtctgag gccctgttcc
      841 tgtcagccta gcacttggga agctaaggaa ggagtagagc aggttctagg cggccctgga
      901 ttagcggacc gaccacaaga gttcatttgc taggctgctg ctttcactgg ctgtgctcag
      961 aaatcatcag tacatgtgag tcacagcttc acttggggac ctaatgaaag ctatgggccc
     1021 ggagtcacca agttgccccg ttgtcagttg gagctactgt aacccaagga gaggcctgca
     1081 taggagactc ctgcaggtag aggcccaggc agccagccca cacttcacta tgcttcttac
     1141 ggagagcctc aggacagctt tgtaagctga acttggtcag acattgtgtt ctgtcaggac
     1201 caggagtgtg agactttgct gttggtgtgt gcgcagtcag tgattctcta ctgtgtagat
     1261 tctaagactc agcagcaagt ctattccata agccatcttg caagcctgtt tctttgtgaa
     1321 agtgtcttag gaaatccagt cctggcctca aactatgtca tggttaggga taaccttagt
     1381 gttccttttt gtttttgttt tgaggcaggg tttctctgtg tagccctggc tgtcctggaa
     1441 ctcactctgt agaccaggct agcctcgaac tcagaaatcc acctgcctct gcctcccgag
     1501 tgctgggatt aaaggtatgc gccaccactg cctggcaacc ttaaatgttc ctttgtccct
     1561 gccaagtact gggattgcag atgggcaccc ctcctgattg ttttaccgtt ttgtgacagt
     1621 agacatgcct ctcctactat ctgcagaaac aatggggtac ttggagtcat gtgaccacag
     1681 atagggcagt taagtttgtc tattttgaac aggtaaaact gtttgcatga atggagtccc
     1741 tcttcctcct tgtgacctga ctagttttgg ccatcagact gtaattgcta agtctccagt
     1801 agcagtcccc agtgccacgc gagaccgcgt ggctggacac tgagagtcta acttgatcag
     1861 gctttgtttg ctgtcaggag ctggtgactt gtattttcgg gttcagatgt gagaacatgt
     1921 tgctatagaa ataaaattgg tttgatggtg tatggagttt ctcccaatgc tggctcaaaa
     1981 acaaaataca acactgtcta aggttta
//
