LOCUS       NM_172256               1355 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus dynein cytoplasmic 2 light intermediate chain 1
            (Dync2li1), mRNA.
ACCESSION   NM_172256 XM_916992
VERSION     NM_172256.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1355)
  AUTHORS   Lee,H. and Ko,H.W.
  TITLE     Cell cycle-related kinase is a crucial regulator for ciliogenesis
            and Hedgehog signaling in embryonic mouse lung development
  JOURNAL   BMB Rep 53 (7), 367-372 (2020)
   PUBMED   32317081
REFERENCE   2  (bases 1 to 1355)
  AUTHORS   Hai,Q., Ritchey,B., Robinet,P., Alzayed,A.M., Brubaker,G., Zhang,J.
            and Smith,J.D.
  TITLE     Quantitative Trait Locus Mapping of Macrophage Cholesterol
            Metabolism and CRISPR/Cas9 Editing Implicate an ACAT1 Truncation as
            a Causal Modifier Variant
  JOURNAL   Arterioscler Thromb Vasc Biol 38 (1), 83-91 (2018)
   PUBMED   29097366
REFERENCE   3  (bases 1 to 1355)
  AUTHORS   Goggolidou,P., Stevens,J.L., Agueci,F., Keynton,J., Wheway,G.,
            Grimes,D.T., Patel,S.H., Hilton,H., Morthorst,S.K., DiPaolo,A.,
            Williams,D.J., Sanderson,J., Khoronenkova,S.V., Powles-Glover,N.,
            Ermakov,A., Esapa,C.T., Romero,R., Dianov,G.L., Briscoe,J.,
            Johnson,C.A., Pedersen,L.B. and Norris,D.P.
  TITLE     ATMIN is a transcriptional regulator of both lung morphogenesis and
            ciliogenesis
  JOURNAL   Development 141 (20), 3966-3977 (2014)
   PUBMED   25294941
REFERENCE   4  (bases 1 to 1355)
  AUTHORS   Smith,S.B., Qu,H.Q., Taleb,N., Kishimoto,N.Y., Scheel,D.W., Lu,Y.,
            Patch,A.M., Grabs,R., Wang,J., Lynn,F.C., Miyatsuka,T.,
            Mitchell,J., Seerke,R., Desir,J., Vanden Eijnden,S., Abramowicz,M.,
            Kacet,N., Weill,J., Renard,M.E., Gentile,M., Hansen,I., Dewar,K.,
            Hattersley,A.T., Wang,R., Wilson,M.E., Johnson,J.D.,
            Polychronakos,C. and German,M.S.
  TITLE     Rfx6 directs islet formation and insulin production in mice and
            humans
  JOURNAL   Nature 463 (7282), 775-780 (2010)
   PUBMED   20148032
REFERENCE   5  (bases 1 to 1355)
  AUTHORS   Hossain,Z., Ali,S.M., Ko,H.L., Xu,J., Ng,C.P., Guo,K., Qi,Z.,
            Ponniah,S., Hong,W. and Hunziker,W.
  TITLE     Glomerulocystic kidney disease in mice with a targeted inactivation
            of Wwtr1
  JOURNAL   Proc Natl Acad Sci U S A 104 (5), 1631-1636 (2007)
   PUBMED   17251353
REFERENCE   6  (bases 1 to 1355)
  AUTHORS   Pfister,K.K., Fisher,E.M., Gibbons,I.R., Hays,T.S., Holzbaur,E.L.,
            McIntosh,J.R., Porter,M.E., Schroer,T.A., Vaughan,K.T.,
            Witman,G.B., King,S.M. and Vallee,R.B.
  TITLE     Cytoplasmic dynein nomenclature
  JOURNAL   J Cell Biol 171 (3), 411-413 (2005)
   PUBMED   16260502
REFERENCE   7  (bases 1 to 1355)
  AUTHORS   Rana,A.A., Barbera,J.P., Rodriguez,T.A., Lynch,D., Hirst,E.,
            Smith,J.C. and Beddington,R.S.
  TITLE     Targeted deletion of the novel cytoplasmic dynein mD2LIC disrupts
            the embryonic organiser, formation of the body axes and
            specification of ventral cell fates
  JOURNAL   Development 131 (20), 4999-5007 (2004)
   PUBMED   15371312
  REMARK    GeneRIF: required to maintain or establish ventral cell fates and
            for correct signalling by the organiser and midline
REFERENCE   8  (bases 1 to 1355)
  AUTHORS   Bonnafe,E., Touka,M., AitLounis,A., Baas,D., Barras,E., Ucla,C.,
            Moreau,A., Flamant,F., Dubruille,R., Couble,P., Collignon,J.,
            Durand,B. and Reith,W.
  TITLE     The transcription factor RFX3 directs nodal cilium development and
            left-right asymmetry specification
  JOURNAL   Mol Cell Biol 24 (10), 4417-4427 (2004)
   PUBMED   15121860
REFERENCE   9  (bases 1 to 1355)
  AUTHORS   Sousa-Nunes,R., Rana,A.A., Kettleborough,R., Brickman,J.M.,
            Clements,M., Forrest,A., Grimmond,S., Avner,P., Smith,J.C.,
            Dunwoodie,S.L. and Beddington,R.S.
  TITLE     Characterizing embryonic gene expression patterns in the mouse
            using nonredundant sequence-based selection
  JOURNAL   Genome Res 13 (12), 2609-2620 (2003)
   PUBMED   14613977
REFERENCE   10 (bases 1 to 1355)
  AUTHORS   Perrone,C.A., Tritschler,D., Taulman,P., Bower,R., Yoder,B.K. and
            Porter,M.E.
  TITLE     A novel dynein light intermediate chain colocalizes with the
            retrograde motor for intraflagellar transport at sites of axoneme
            assembly in chlamydomonas and Mammalian cells
  JOURNAL   Mol Biol Cell 14 (5), 2041-2056 (2003)
   PUBMED   12802074
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132353.3.
            
            On Aug 21, 2018 this sequence version replaced NM_172256.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039070.1, AK160259.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               AC132353.3         34569-34670         c
            103-220             AC132353.3         32743-32860         c
            221-255             AC132353.3         29475-29509         c
            256-325             AC132353.3         27557-27626         c
            326-414             AC132353.3         24825-24913         c
            415-601             AC132353.3         18087-18273         c
            602-670             AC132353.3         16972-17040         c
            671-748             AC132353.3         16349-16426         c
            749-825             AC132353.3         13824-13900         c
            826-896             AC132353.3         13429-13499         c
            897-994             AC132353.3         11832-11929         c
            995-1087            AC132353.3         11344-11436         c
            1088-1355           AC132353.3         5577-5844           c
FEATURES             Location/Qualifiers
     source          1..1355
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 55.02 cM"
     gene            1..1355
                     /gene="Dync2li1"
                     /gene_synonym="4933404O11Rik; CGI-60; D2lic; LIC3; mD2LIC"
                     /note="dynein cytoplasmic 2 light intermediate chain 1"
                     /db_xref="GeneID:213575"
                     /db_xref="MGI:MGI:1913996"
     exon            1..102
                     /gene="Dync2li1"
                     /gene_synonym="4933404O11Rik; CGI-60; D2lic; LIC3; mD2LIC"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1150
                     /gene="Dync2li1"
                     /gene_synonym="4933404O11Rik; CGI-60; D2lic; LIC3; mD2LIC"
                     /note="dynein 2 light intermediate chain"
                     /codon_start=1
                     /product="cytoplasmic dynein 2 light intermediate chain 1"
                     /protein_id="NP_758460.1"
                     /db_xref="CCDS:CCDS29000.1"
                     /db_xref="GeneID:213575"
                     /db_xref="MGI:MGI:1913996"
                     /translation="MPSETLWEIAKAEVEKRRSHGSEGDGAEIGEKSVFFIGSKNGGK
                     TTIILRCLDRDESAKPTLALEYTYGRKTKGHNTPKDIAHFWELGGGTSLLDLISIPIT
                     VDTLRTFSIVLVLDLSKPNDLWSTMENLLQATKSHVDKVIMKLGKTSSKASAEMRQRM
                     WSVVQKDHPDRELIDPFPIPLVIIGSKYDIFQDFDPEKRKVICKTLRFVAHYYGASLM
                     FTSKSEALLLKIRGVINQLAFGIDKSKSICVDQNKPLFITAGLDSLCQIGSPPVPDSD
                     IGKLQAHSPMELWKKVYDKLFPPKSTGTLKAVQDPARDPQYAESEVDEMRVQKDQELE
                     HYKRSSSKTWKQIELDS"
     exon            103..220
                     /gene="Dync2li1"
                     /gene_synonym="4933404O11Rik; CGI-60; D2lic; LIC3; mD2LIC"
                     /inference="alignment:Splign:2.1.0"
     exon            221..255
                     /gene="Dync2li1"
                     /gene_synonym="4933404O11Rik; CGI-60; D2lic; LIC3; mD2LIC"
                     /inference="alignment:Splign:2.1.0"
     exon            256..325
                     /gene="Dync2li1"
                     /gene_synonym="4933404O11Rik; CGI-60; D2lic; LIC3; mD2LIC"
                     /inference="alignment:Splign:2.1.0"
     exon            326..414
                     /gene="Dync2li1"
                     /gene_synonym="4933404O11Rik; CGI-60; D2lic; LIC3; mD2LIC"
                     /inference="alignment:Splign:2.1.0"
     exon            415..601
                     /gene="Dync2li1"
                     /gene_synonym="4933404O11Rik; CGI-60; D2lic; LIC3; mD2LIC"
                     /inference="alignment:Splign:2.1.0"
     exon            602..670
                     /gene="Dync2li1"
                     /gene_synonym="4933404O11Rik; CGI-60; D2lic; LIC3; mD2LIC"
                     /inference="alignment:Splign:2.1.0"
     exon            671..748
                     /gene="Dync2li1"
                     /gene_synonym="4933404O11Rik; CGI-60; D2lic; LIC3; mD2LIC"
                     /inference="alignment:Splign:2.1.0"
     exon            749..825
                     /gene="Dync2li1"
                     /gene_synonym="4933404O11Rik; CGI-60; D2lic; LIC3; mD2LIC"
                     /inference="alignment:Splign:2.1.0"
     exon            826..896
                     /gene="Dync2li1"
                     /gene_synonym="4933404O11Rik; CGI-60; D2lic; LIC3; mD2LIC"
                     /inference="alignment:Splign:2.1.0"
     exon            897..994
                     /gene="Dync2li1"
                     /gene_synonym="4933404O11Rik; CGI-60; D2lic; LIC3; mD2LIC"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1087
                     /gene="Dync2li1"
                     /gene_synonym="4933404O11Rik; CGI-60; D2lic; LIC3; mD2LIC"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1355
                     /gene="Dync2li1"
                     /gene_synonym="4933404O11Rik; CGI-60; D2lic; LIC3; mD2LIC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcattctc tggcccaact aggtgtttgc agcctgcctg ggtcagggtt gttcctcacg
       61 cggagcccag gaactctggg gcggcgcagc caccatgccc agtgaaactc tctgggaaat
      121 cgcaaaagct gaggtagaga aacggagaag tcatgggagc gaaggggacg gagctgaaat
      181 cggagaaaaa tctgttttct tcattggcag taaaaacggg ggaaagacaa ccattatcct
      241 aaggtgtctt gacagggatg agtcagcaaa gccgacctta gcgttggagt acacgtacgg
      301 aaggaagacc aaggggcaca acacgccaaa agacattgct cacttttggg aactgggtgg
      361 aggaacctcc ttgctggact taatcagcat accaatcaca gtcgacacct taaggacatt
      421 ttctattgtt cttgttttgg atctttccaa acctaatgat ctttggtcaa ccatggaaaa
      481 tctgttgcaa gccacaaaaa gccatgtaga caaggtgata atgaagctgg gcaagacaag
      541 ctccaaggct tcggccgaga tgcggcaacg aatgtggagc gtggtgcaga aggaccatcc
      601 ggaccgggaa ttaattgacc catttccaat acctctggtc attattggaa gtaaatatga
      661 tattttccag gattttgatc ctgagaagag aaaggtgata tgtaagaccc tgcgctttgt
      721 ggcacattac tacggagcct cgctgatgtt taccagcaag tcagaagctc tgttactgaa
      781 gatacgcggt gttatcaacc agttggcatt cggtattgat aaaagcaaat caatatgtgt
      841 ggatcaaaat aagccactgt ttatcacagc aggactggat tctttatgtc agatagggtc
      901 tcctcctgtt cctgacagtg acattggaaa acttcaggcc cactcaccta tggagctgtg
      961 gaaaaaggtg tatgacaagc tcttcccacc aaagagtacc ggcaccctga aggcggtcca
     1021 ggacccagcc cgagacccgc agtatgcaga aagcgaagtc gatgagatga gggttcagaa
     1081 ggaccaggaa ctagaacact acaagagaag ctcctctaag acctggaagc aaatcgagct
     1141 ggactcctga cccgcttccc tgctgtgggc atggcttcct tcccaatcga ggaagattat
     1201 tttcttacct tctgtggcaa catgtgaaga aagttgagca tataacctgt tagggaaaat
     1261 ctgtttcttg ttctgttaca actttctgaa tgttctgaag tcttttagaa ggaaaatatt
     1321 cactatatgt ctgtcattct ttttcaaata aaaaa
//
