LOCUS       NM_001008498            1812 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus dynein 2 intermediate chain 2 (Dync2i2), mRNA.
ACCESSION   NM_001008498 XM_130136 XM_207084
VERSION     NM_001008498.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1812)
  AUTHORS   Yan,L., Yin,H., Mi,Y., Wu,Y. and Zheng,Y.
  TITLE     Deficiency of Wdr60 and Wdr34 cause distinct neural tube
            malformation phenotypes in early embryos
  JOURNAL   Front Cell Dev Biol 11, 1084245 (2023)
   PUBMED   37228654
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1812)
  AUTHORS   Wu,C., Li,J., Peterson,A., Tao,K. and Wang,B.
  TITLE     Loss of dynein-2 intermediate chain Wdr34 results in defects in
            retrograde ciliary protein trafficking and Hedgehog signaling in
            the mouse
  JOURNAL   Hum Mol Genet 26 (13), 2386-2397 (2017)
   PUBMED   28379358
REFERENCE   3  (bases 1 to 1812)
  AUTHORS   Pan,J., Mor,G., Ju,W., Zhong,J., Luo,X., Aldo,P.B., Zhong,M.,
            Yu,Y., Jenkins,E.C., Brown,W.T. and Zhong,N.
  TITLE     Viral Infection-Induced Differential Expression of LncRNAs
            Associated with Collagen in Mouse Placentas and Amniotic Sacs
  JOURNAL   Am J Reprod Immunol 74 (3), 237-257 (2015)
   PUBMED   26073538
REFERENCE   4  (bases 1 to 1812)
  AUTHORS   Goggolidou,P., Stevens,J.L., Agueci,F., Keynton,J., Wheway,G.,
            Grimes,D.T., Patel,S.H., Hilton,H., Morthorst,S.K., DiPaolo,A.,
            Williams,D.J., Sanderson,J., Khoronenkova,S.V., Powles-Glover,N.,
            Ermakov,A., Esapa,C.T., Romero,R., Dianov,G.L., Briscoe,J.,
            Johnson,C.A., Pedersen,L.B. and Norris,D.P.
  TITLE     ATMIN is a transcriptional regulator of both lung morphogenesis and
            ciliogenesis
  JOURNAL   Development 141 (20), 3966-3977 (2014)
   PUBMED   25294941
REFERENCE   5  (bases 1 to 1812)
  AUTHORS   Schmidts,M., Vodopiutz,J., Christou-Savina,S., Cortes,C.R.,
            McInerney-Leo,A.M., Emes,R.D., Arts,H.H., Tuysuz,B., D'Silva,J.,
            Leo,P.J., Giles,T.C., Oud,M.M., Harris,J.A., Koopmans,M.,
            Marshall,M., Elcioglu,N., Kuechler,A., Bockenhauer,D., Moore,A.T.,
            Wilson,L.C., Janecke,A.R., Hurles,M.E., Emmet,W., Gardiner,B.,
            Streubel,B., Dopita,B., Zankl,A., Kayserili,H., Scambler,P.J.,
            Brown,M.A., Beales,P.L., Wicking,C., Duncan,E.L. and Mitchison,H.M.
  CONSRTM   UK10K
  TITLE     Mutations in the gene encoding IFT dynein complex component WDR34
            cause Jeune asphyxiating thoracic dystrophy
  JOURNAL   Am J Hum Genet 93 (5), 932-944 (2013)
   PUBMED   24183451
REFERENCE   6  (bases 1 to 1812)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   7  (bases 1 to 1812)
  AUTHORS   Ding,S., Wu,X., Li,G., Han,M., Zhuang,Y. and Xu,T.
  TITLE     Efficient transposition of the piggyBac (PB) transposon in
            mammalian cells and mice
  JOURNAL   Cell 122 (3), 473-483 (2005)
   PUBMED   16096065
REFERENCE   8  (bases 1 to 1812)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX005298.9 and BC085113.1.
            
            On Apr 4, 2007 this sequence version replaced NM_001008498.1.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is more supported by available transcript
            and homology data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085113.1, AK014304.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                BX005298.9         17837-17892         c
            57-1812             BC085113.1         13-1768
FEATURES             Location/Qualifiers
     source          1..1812
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 21.04 cM"
     gene            1..1812
                     /gene="Dync2i2"
                     /gene_synonym="3200002I06Rik; Wdr34"
                     /note="dynein 2 intermediate chain 2"
                     /db_xref="GeneID:71820"
                     /db_xref="MGI:MGI:1919070"
     exon            1..196
                     /gene="Dync2i2"
                     /gene_synonym="3200002I06Rik; Wdr34"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1624
                     /gene="Dync2i2"
                     /gene_synonym="3200002I06Rik; Wdr34"
                     /note="WD repeat-containing protein 34; WD repeat domain
                     34"
                     /codon_start=1
                     /product="cytoplasmic dynein 2 intermediate chain 2"
                     /protein_id="NP_001008498.2"
                     /db_xref="CCDS:CCDS15865.2"
                     /db_xref="GeneID:71820"
                     /db_xref="MGI:MGI:1919070"
                     /translation="MAMCASPRPFRRVGSAGAAALAAGGAGGAERRGRPAPLQDETLG
                     VASVPSQWRSVQGIRGETKSCQTAGIATAESSAQARTHADAQVQTEAPEEPAAMAPVS
                     QYDTLRLEAFLRRVEAMVIRELNNNWQSHAFDGYEVNWTEQQQTVSCLHTLVYPLAQG
                     QGLHVTGISWNSTGSVLACAYGRLDDGDWSTLKSYVCTWNLDRQGLNPQQPSVVVEVP
                     SAVMCLAFHPTQPSHIAGGLYSGEVLVWDMSRPEDPLLWRTGLTDDTHTDPVYQVLWL
                     PEPRHSHRFQVLSAATDGKVLLWRGSGAGQLRLTKGFALAVQQLPRSTKLKKPPRGET
                     EVGVTSVAFSSFDSSLFVLGTEGGFPLKCSLASEVAALTRMPSSVPLRAPVQFTFSPH
                     GGPVYSVSCSPFHRNLFLSAGTDGHVHLYSMLQAQPLTSLQLSHKYLFAVRWSPVRPL
                     VFAAASGEGDVQLFDLQKSSQKPTVSITQTQDGSPVYCLEFNSQQTQLLAAGDAKGMV
                     KVWQLSTAFTEQGPREVEDLDQLEAEITT"
     exon            197..448
                     /gene="Dync2i2"
                     /gene_synonym="3200002I06Rik; Wdr34"
                     /inference="alignment:Splign:2.1.0"
     exon            449..558
                     /gene="Dync2i2"
                     /gene_synonym="3200002I06Rik; Wdr34"
                     /inference="alignment:Splign:2.1.0"
     exon            559..716
                     /gene="Dync2i2"
                     /gene_synonym="3200002I06Rik; Wdr34"
                     /inference="alignment:Splign:2.1.0"
     exon            717..826
                     /gene="Dync2i2"
                     /gene_synonym="3200002I06Rik; Wdr34"
                     /inference="alignment:Splign:2.1.0"
     exon            827..994
                     /gene="Dync2i2"
                     /gene_synonym="3200002I06Rik; Wdr34"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1227
                     /gene="Dync2i2"
                     /gene_synonym="3200002I06Rik; Wdr34"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1385
                     /gene="Dync2i2"
                     /gene_synonym="3200002I06Rik; Wdr34"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1807
                     /gene="Dync2i2"
                     /gene_synonym="3200002I06Rik; Wdr34"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaccgtcgcc atggcaatgt gcgcgtcgcc caggcctttt cggcgcgttg gaagcgctgg
       61 agctgctgcc ctggctgctg gcggggctgg cggcgccgaa cggcgagggc ggcctgcgcc
      121 tcttcaggat gagaccctgg gcgtggcgtc cgtgccctcg cagtggagga gcgtccaggg
      181 gatccgcggg gagacgaaaa gttgccagac agcgggcatt gccacagccg agtcgtctgc
      241 ccaggcccgg acacatgcag atgcccaggt acagacagag gctcccgaag agccagcggc
      301 catggctcct gtttcccagt atgacaccct caggctggaa gcctttctcc ggagggtgga
      361 ggccatggtc atccgggagc tgaacaacaa ctggcagagt catgccttcg atggctatga
      421 ggtgaactgg actgagcagc agcagacggt gtcctgtctg cacaccctgg tctaccccct
      481 agcccaaggg cagggtctgc atgtgaccgg catttcctgg aactcgacag gctctgtgct
      541 ggcctgtgcc tatggtcggc tagatgatgg agactggagt acactcaagt cctacgtgtg
      601 tacttggaac ctggaccgcc aaggcctgaa tccccagcag ccatcagtag tggtggaggt
      661 gccgagtgct gtcatgtgcc tggcctttca tcccacacag ccctcccaca ttgccggggg
      721 gctgtatagc ggggaagtgc tggtgtggga catgagccga cctgaggacc cactgctttg
      781 gcgtacaggt ctgacagatg acactcacac agacccagtg tatcaggtgc tgtggttacc
      841 tgaaccccgg catagccacc gcttccaggt actgagtgcg gccacagatg gcaaggtgtt
      901 gctctggaga ggcagtgggg ccggtcagct gcggctcacc aagggctttg ccctggctgt
      961 gcagcagctg cctcggagca ccaagctgaa gaagccaccc cgtggagaga ctgaggtggg
     1021 ggtgacatca gtggccttct ccagctttga ctccagcctt ttcgttctgg gcacagaagg
     1081 tggcttcccc ctcaagtgtt ccctggcgtc agaggtagct gctctcactc ggatgcccag
     1141 ctctgtgccg ctgagggccc cggtgcagtt caccttctct ccccatggtg gccccgtgta
     1201 ttctgtgagc tgttccccct ttcacaggaa tctcttcctg agcgctggga ccgatggcca
     1261 cgtccacctg tactccatgc tgcaggctca gccccttacc tcactgcagc tctctcacaa
     1321 gtacctgttt gctgtgcgct ggtcccctgt gcgccccttg gtttttgctg ctgcttcagg
     1381 ggaaggtgat gtacaacttt ttgacctcca gaaaagctca cagaaaccca cagtttctat
     1441 aacacaaacc caagatggaa gtcctgtcta ctgtctcgag tttaacagcc agcagacaca
     1501 gctcttagcc gctggtgatg ctaagggcat ggtcaaagtg tggcagctga gcacagcctt
     1561 cacagaacaa gggccccggg aggtggagga cttggatcag ctagaagcag aaatcactac
     1621 ctgagggctg gtgagatggc tcagcgggta agagcactga ctactcttct gaaggtcctg
     1681 agttcaaatc ccagcaacca catggtggct cacaaccaac cgtaatgaga tctgatgccc
     1741 tcttctggtg tgtttgaaga cagctacagt gtacttacat ataataaata aatcttttaa
     1801 aaaaaaaaaa aa
//
