LOCUS       NM_146039               3725 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus dynein 2 intermediate chain 1 (Dync2i1), mRNA.
ACCESSION   NM_146039
VERSION     NM_146039.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3725)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3725)
  AUTHORS   Yan,L., Yin,H., Mi,Y., Wu,Y. and Zheng,Y.
  TITLE     Deficiency of Wdr60 and Wdr34 cause distinct neural tube
            malformation phenotypes in early embryos
  JOURNAL   Front Cell Dev Biol 11, 1084245 (2023)
   PUBMED   37228654
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3725)
  AUTHORS   Li,C., Zheng,Y., Zheng,Y. and Xu,Z.
  TITLE     SRPS associated protein WDR60 regulates the multipolar-to-bipolar
            transition of migrating neurons during cortical development
  JOURNAL   Cell Death Dis 12 (1), 75 (2021)
   PUBMED   33436552
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3725)
  AUTHORS   Ishikawa,H., Thompson,J., Yates,J.R. 3rd and Marshall,W.F.
  TITLE     Proteomic analysis of mammalian primary cilia
  JOURNAL   Curr Biol 22 (5), 414-419 (2012)
   PUBMED   22326026
REFERENCE   5  (bases 1 to 3725)
  AUTHORS   Ding,S., Wu,X., Li,G., Han,M., Zhuang,Y. and Xu,T.
  TITLE     Efficient transposition of the piggyBac (PB) transposon in
            mammalian cells and mice
  JOURNAL   Cell 122 (3), 473-483 (2005)
   PUBMED   16096065
REFERENCE   6  (bases 1 to 3725)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ150229.1, AK052482.1 and AK144444.1.
            
            On Aug 25, 2006 this sequence version replaced NM_146039.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144138.1, SRR1660817.241201.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                CJ150229.1         1-37
            38-3217             AK052482.1         2-3181
            3218-3725           AK144444.1         772-1279
FEATURES             Location/Qualifiers
     source          1..3725
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 62.65 cM"
     gene            1..3725
                     /gene="Dync2i1"
                     /gene_synonym="D430033N04Rik; Dync2l1; Wdr60"
                     /note="dynein 2 intermediate chain 1"
                     /db_xref="GeneID:217935"
                     /db_xref="MGI:MGI:2445085"
     exon            1..175
                     /gene="Dync2i1"
                     /gene_synonym="D430033N04Rik; Dync2l1; Wdr60"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..3160
                     /gene="Dync2i1"
                     /gene_synonym="D430033N04Rik; Dync2l1; Wdr60"
                     /note="WD repeat-containing protein 60; WD repeat domain
                     60"
                     /codon_start=1
                     /product="cytoplasmic dynein 2 intermediate chain 1"
                     /protein_id="NP_666151.3"
                     /db_xref="CCDS:CCDS36575.1"
                     /db_xref="GeneID:217935"
                     /db_xref="MGI:MGI:2445085"
                     /translation="MEPGKRRTKDDTWKADDLRKHLKVQSGSPKEEKKLREKKAHKDS
                     ESAAPEYREHKSRDPDREARHKEKTAERDLYTSTEHPRGERDRERHKERRKDAKDREK
                     DKLKERHRDQEAEKAHSRGKDREREKDRRARKEEIRQSMAYHDLLSRDMRGRQMAEKV
                     EKKASKIRTEERERRDEDSERIDEDRERRYRERKLQYGDSKEHPLSYWLYKEDGEKKH
                     RKAKDADREKRLREKSSMREKRERHAREKGSSLSDREVEDRHREKRHKEGLHYDDERR
                     RSHADKKERSSKEEHKKRELKELEKEDNDLEATGPDEYLPNLEDDFVDYEDDFEVCDG
                     DDDSNNEHEAREKAEELPLAQKREIQEIQKAISAENERVGELSLKMFQKQGWTEYTKE
                     PWTDANDSPSRTPVCGIFVDFATASHRQKSRSQALKQKTRSSKLLRLIDLDFSFTFSL
                     LDLPPVNEYDMYIRNFGKKNTKQAYVQYNEDNVERDIQTEDIETREVWTQHPGEGTAV
                     SGGSEEKDFSDVTVVPKIDTPRLANFLRAACQVVAVLLEEDRLAAGPSWIPRAQDKAL
                     NISDSSSQLNTSLPFLQSRKVSCLHASRVQRQTVVSVHDLPEKAFAPSLDSRHLLCVW
                     DIWQPSGPQKVLICESKVTCCCFSPLKAFLLFAGTVHGSVVVWDLREDSRIHHYVRLS
                     NCFWAFRTPTFSTDGILTSVNHRSPLQAIEPVATSAYKKQSFVLSPFSTQEEMAGLSF
                     HIASLDETGVLNVWVVVELPKADISGSMSDLGLIPGGRIKLVHSTVIQLGNSLSHKDS
                     ELWGSTQTLSVKFLPSDPNHFVVGTDMGLISHSTRQDWRVSPRVFKPEQHGVRPIKVN
                     VIDFSPFEETVFLAGCSDGSIRLHQLTSERPIMQWDNSTSGHAVTSLQWSPTRPAVFL
                     VQDDASRIYVWDLLENDLGPVAQQPISPDKLVAMTIVGEPEKTSGSFVALVLARTSGT
                     VDVQNLKRRWTTPAVDEHSQLRLLLQK"
     exon            176..229
                     /gene="Dync2i1"
                     /gene_synonym="D430033N04Rik; Dync2l1; Wdr60"
                     /inference="alignment:Splign:2.1.0"
     exon            230..650
                     /gene="Dync2i1"
                     /gene_synonym="D430033N04Rik; Dync2l1; Wdr60"
                     /inference="alignment:Splign:2.1.0"
     exon            651..742
                     /gene="Dync2i1"
                     /gene_synonym="D430033N04Rik; Dync2l1; Wdr60"
                     /inference="alignment:Splign:2.1.0"
     exon            743..1051
                     /gene="Dync2i1"
                     /gene_synonym="D430033N04Rik; Dync2l1; Wdr60"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1129
                     /gene="Dync2i1"
                     /gene_synonym="D430033N04Rik; Dync2l1; Wdr60"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1346
                     /gene="Dync2i1"
                     /gene_synonym="D430033N04Rik; Dync2l1; Wdr60"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1449
                     /gene="Dync2i1"
                     /gene_synonym="D430033N04Rik; Dync2l1; Wdr60"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1579
                     /gene="Dync2i1"
                     /gene_synonym="D430033N04Rik; Dync2l1; Wdr60"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1691
                     /gene="Dync2i1"
                     /gene_synonym="D430033N04Rik; Dync2l1; Wdr60"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1780
                     /gene="Dync2i1"
                     /gene_synonym="D430033N04Rik; Dync2l1; Wdr60"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1910
                     /gene="Dync2i1"
                     /gene_synonym="D430033N04Rik; Dync2l1; Wdr60"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2083
                     /gene="Dync2i1"
                     /gene_synonym="D430033N04Rik; Dync2l1; Wdr60"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2246
                     /gene="Dync2i1"
                     /gene_synonym="D430033N04Rik; Dync2l1; Wdr60"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2360
                     /gene="Dync2i1"
                     /gene_synonym="D430033N04Rik; Dync2l1; Wdr60"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2422
                     /gene="Dync2i1"
                     /gene_synonym="D430033N04Rik; Dync2l1; Wdr60"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..2474
                     /gene="Dync2i1"
                     /gene_synonym="D430033N04Rik; Dync2l1; Wdr60"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2535
                     /gene="Dync2i1"
                     /gene_synonym="D430033N04Rik; Dync2l1; Wdr60"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2635
                     /gene="Dync2i1"
                     /gene_synonym="D430033N04Rik; Dync2l1; Wdr60"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2767
                     /gene="Dync2i1"
                     /gene_synonym="D430033N04Rik; Dync2l1; Wdr60"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2991
                     /gene="Dync2i1"
                     /gene_synonym="D430033N04Rik; Dync2l1; Wdr60"
                     /inference="alignment:Splign:2.1.0"
     exon            2992..3725
                     /gene="Dync2i1"
                     /gene_synonym="D430033N04Rik; Dync2l1; Wdr60"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3200..3205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dync2i1"
                     /gene_synonym="D430033N04Rik; Dync2l1; Wdr60"
                     /note="hexamer: ATTACA"
     polyA_site      3219
                     /gene="Dync2i1"
                     /gene_synonym="D430033N04Rik; Dync2l1; Wdr60"
     regulatory      3309..3314
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dync2i1"
                     /gene_synonym="D430033N04Rik; Dync2l1; Wdr60"
                     /note="hexamer: AATAAA"
     polyA_site      3333
                     /gene="Dync2i1"
                     /gene_synonym="D430033N04Rik; Dync2l1; Wdr60"
                     /note="major polyA site"
ORIGIN      
        1 ttcggcccgt tgctaggagg cggggacgcc ggccctcctg ggacccaagt cgcagcaggc
       61 ctggctggct ggtagagctg agcgacggcg ggtttatctt cctccggtgg cccgcgcctg
      121 ctgggccgag gacacgcggc tgtcccggcc tcgaggagcg atggagcctg ggaagagaag
      181 aaccaaagat gatacttgga aagcagatga cctcagaaag cacctgaagg tgcagtcagg
      241 cagtcccaag gaggagaaga aactcagaga aaagaaggcg cacaaggact cagagtcggc
      301 cgctcctgaa tacagagaac acaagagcag ggacccagac cgagaggccc ggcacaagga
      361 gaagacagct gagagagacc tgtacacctc cacagaacat cctcgtgggg agagagaccg
      421 ggagaggcac aaggaaagga ggaaagatgc aaaagaccgt gagaaagaca agctaaaaga
      481 gagacatcga gaccaagaag cagagaaggc tcatagtcga ggcaaggaca gagagagaga
      541 gaaagacaga cgggccagga aagaagagat caggcagtcc atggcctacc atgacctctt
      601 gagtcgagat atgcgtggcc ggcagatggc agagaaagtg gaaaagaaag caagtaaaat
      661 acgaactgag gaaagagaaa ggagagatga agactctgaa agaatagatg aagatagaga
      721 aagaagatac cgagaaagaa agctgcagta tggagacagt aaggagcacc ccctcagcta
      781 ctggctgtac aaggaggacg gcgagaagaa gcacaggaaa gccaaagacg cagatcggga
      841 gaagaggctg agagagaaga gcagcatgag ggagaaaagg gagaggcacg caagggagaa
      901 ggggagctcg ctctccgaca gggaagtgga ggacagacac agagagaagc ggcacaaaga
      961 aggactgcac tatgatgacg agaggcgccg aagtcatgca gataaaaaag agagatcttc
     1021 gaaagaagag cacaagaaaa gggaattgaa ggaacttgaa aaagaagaca acgatttaga
     1081 ggctactggg cctgatgaat atctgcccaa cttagaagat gattttgtgg attatgaaga
     1141 tgactttgag gtttgcgatg gagacgatga cagcaataat gagcatgaag ctagagaaaa
     1201 ggccgaagaa cttcctctgg cccagaaaag ggaaatacag gaaattcaaa aggcgatcag
     1261 tgcagagaat gaaagggttg gcgagttatc tttgaaaatg tttcagaagc aaggttggac
     1321 ggagtataca aaggagccct ggacagatgc aaatgattcc ccttctagaa cccctgtttg
     1381 tggaattttt gtggattttg caacagcctc acatcgtcag aagagtcgga gtcaggccct
     1441 caagcaaaag acacgaagtt caaaactgct ccggcttatt gacttagact tttcgttcac
     1501 attttctctc ctggatctac caccagtaaa tgagtatgac atgtacatta ggaactttgg
     1561 gaaaaaaaat accaagcagg cgtatgttca gtacaatgaa gataatgttg agagagacat
     1621 tcagactgaa gatatagaaa ccagggaagt atggacccaa cacccaggag aaggcacggc
     1681 tgtatctgga ggtagcgaag aaaaagactt ctctgatgtc acagttgtac cgaagatcga
     1741 cactccgagg ttggctaact ttctccgggc agcgtgccag gtggttgctg tattgcttga
     1801 agaggaccgt ttggcagctg gacccagctg gattccccgg gctcaagaca aagctctcaa
     1861 catcagtgac agctcatctc aactgaacac aagcctaccg tttcttcaga gtcggaaagt
     1921 atcctgcttg catgcatctc gagttcagag gcagaccgtg gtctctgttc atgacctacc
     1981 tgaaaaggct tttgccccat cgctggatag caggcacctc ctctgtgtgt gggatatttg
     2041 gcagccttca gggccccaga aggttctgat atgtgagtca aaggtcacat gctgctgctt
     2101 tagcccttta aaagcatttt tgctgtttgc gggaacagta catggctctg tggttgtatg
     2161 ggacttaaga gaagactcca ggatccacca ttatgtgaga ctgagcaatt gtttctgggc
     2221 tttcaggacc ccgacattct ccactgatgg aatcctcaca tcagtgaacc accgaagccc
     2281 tcttcaagcc atagagccag ttgctacttc tgcctacaaa aaacagagct tcgtgctttc
     2341 acccttttct actcaagaag aaatggcagg cttgtcattt catattgctt ccctggacga
     2401 gactggggtt ctcaatgtgt gggtggttgt tgaattacca aaagcagata tctcaggttc
     2461 aatgagtgat ttaggtctga tacctggagg aaggatcaag ttggtacaca gtactgtaat
     2521 ccagttgggt aacagtcttt ctcataaaga tagtgaactg tgggggtcga cacaaacact
     2581 gagtgtcaaa ttcctgcctt cagatcctaa tcactttgtt gtcggcaccg acatgggact
     2641 tataagccac agtaccaggc aagattggag agtatctccc agggtgttca aacctgagca
     2701 acacggtgtc agacccataa aagttaatgt gattgacttt tcaccatttg aagaaacagt
     2761 attcttggct ggctgttcag atggaagcat caggctgcac cagctgacgt ctgagaggcc
     2821 catcatgcag tgggacaaca gcaccagtgg ccatgctgtt actagtctgc agtggtcccc
     2881 aacaaggcct gcagtgttcc tggtccagga cgatgcgtct aggatctatg tctgggatct
     2941 tcttgagaat gacctgggtc ctgtggccca gcagcccatc tctccagata agcttgtggc
     3001 tatgactatc gtgggggaac cggagaagac cagtggtagt tttgtggccc tggtgttggc
     3061 caggacctct ggcacagtcg acgtccagaa cctgaagagg cggtggacca ccccagcagt
     3121 agacgagcat agccagctgc gcctgcttct tcagaaatga agacttggtg tcgggagaat
     3181 gatgggtaca tgagacttga ttacagatgg atcccttaac tctgtgttca tgtgattctg
     3241 tgtacataga atatgtatat tctgtacata atttgtttta gaagaacatt actttggtat
     3301 tcctaggaaa taaatcacta tttttaatgg aaacagtgaa cattttagtg tatactaaaa
     3361 cttcaaaggg aatatcaagt gatgtccaga aagctcttcc aagagtgttt ccagttattt
     3421 ttggaactat ttaaaaatac tgtcacattt attactgaat tttaaacagt ccaccatgaa
     3481 aaagcacttt aatggactat tttttaagcc atgcataaaa tgatgtacat atatctgaag
     3541 taagagaaat tgctcacttt ggaggtggcc tccatcagcc ttctgttttt acggttttct
     3601 tgaacagctt ttggtatgct ttcaatgaca ctcatagaat tgagtcagac acattcactg
     3661 tgtgacttag tgtgaaaacc atcttcatgt agaaataata caagtaaata cattttttga
     3721 gaatg
//
