LOCUS       NM_001013380            4647 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus dynein, cytoplasmic 1 light intermediate chain 2
            (Dync1li2), mRNA.
ACCESSION   NM_001013380 XM_134573
VERSION     NM_001013380.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4647)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4647)
  AUTHORS   He,S., Gillies,J.P., Zang,J.L., Cordoba-Beldad,C.M., Yamamoto,I.,
            Fujiwara,Y., Grantham,J., DeSantis,M.E. and Shibuya,H.
  TITLE     Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate
            mitotic and male meiotic spindle bipolarity
  JOURNAL   Nat Commun 14 (1), 1715 (2023)
   PUBMED   36973253
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4647)
  AUTHORS   Leca,I., Phillips,A.W., Hofer,I., Landler,L., Ushakova,L.,
            Cushion,T.D., Durnberger,G., Stejskal,K., Mechtler,K. and
            Keays,D.A.
  TITLE     A proteomic survey of microtubule-associated proteins in a R402H
            TUBA1A mutant mouse
  JOURNAL   PLoS Genet 16 (11), e1009104 (2020)
   PUBMED   33137126
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4647)
  AUTHORS   Kong,S., Du,X., Peng,C., Wu,Y., Li,H., Jin,X., Hou,L., Deng,K.,
            Xu,T. and Tao,W.
  TITLE     Dlic1 deficiency impairs ciliogenesis of photoreceptors by
            destabilizing dynein
  JOURNAL   Cell Res 23 (6), 835-850 (2013)
   PUBMED   23628724
  REMARK    Erratum:[Cell Res. 2013 Jul;23(7):972. Du, Xinrong [corrected to
            Du, Xingrong]]
REFERENCE   5  (bases 1 to 4647)
  AUTHORS   Schmoranzer,J., Fawcett,J.P., Segura,M., Tan,S., Vallee,R.B.,
            Pawson,T. and Gundersen,G.G.
  TITLE     Par3 and dynein associate to regulate local microtubule dynamics
            and centrosome orientation during migration
  JOURNAL   Curr Biol 19 (13), 1065-1074 (2009)
   PUBMED   19540120
  REMARK    GeneRIF: Results suggest that Par3 acts as a cortical factor that
            tethers microtubules through its association with LIC2 dynein.
REFERENCE   6  (bases 1 to 4647)
  AUTHORS   Pfister,K.K., Fisher,E.M., Gibbons,I.R., Hays,T.S., Holzbaur,E.L.,
            McIntosh,J.R., Porter,M.E., Schroer,T.A., Vaughan,K.T.,
            Witman,G.B., King,S.M. and Vallee,R.B.
  TITLE     Cytoplasmic dynein nomenclature
  JOURNAL   J Cell Biol 171 (3), 411-413 (2005)
   PUBMED   16260502
REFERENCE   7  (bases 1 to 4647)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 4647)
  AUTHORS   Grissom,P.M., Vaisberg,E.A. and McIntosh,J.R.
  TITLE     Identification of a novel light intermediate chain (D2LIC) for
            mammalian cytoplasmic dynein 2
  JOURNAL   Mol Biol Cell 13 (3), 817-829 (2002)
   PUBMED   11907264
  REMARK    GeneRIF: Results suggest that dynein 2 light intermediate chain
            (D2LIC) is a bona fide subunit of cytoplasmic dynein 2 that may
            play a role in maintaining Golgi organization by binding
            cytoplasmic dynein 2 to its Golgi-associated cargo.
REFERENCE   9  (bases 1 to 4647)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 4647)
  AUTHORS   Vaughan,K.T., Mikami,A., Paschal,B.M., Holzbaur,E.L., Hughes,S.M.,
            Echeverri,C.J., Moore,K.J., Gilbert,D.J., Copeland,N.G.,
            Jenkins,N.A. and Vallee,R.B.
  TITLE     Multiple mouse chromosomal loci for dynein-based motility
  JOURNAL   Genomics 36 (1), 29-38 (1996)
   PUBMED   8812413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY290848.1, AK147899.1, CD351101.1, AK140743.1 and BU850577.1.
            
            On Mar 21, 2009 this sequence version replaced NM_001013380.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.39314.1, AK140743.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-234               BY290848.1         1-234
            235-2990            AK147899.1         2-2757
            2991-3443           CD351101.1         117-569
            3444-4623           AK140743.1         3212-4391
            4624-4647           BU850577.1         163-186
FEATURES             Location/Qualifiers
     source          1..4647
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..4647
                     /gene="Dync1li2"
                     /gene_synonym="C920003I06; Dlic2; Dncli2; Dnclic2; LIC2"
                     /note="dynein, cytoplasmic 1 light intermediate chain 2"
                     /db_xref="GeneID:234663"
                     /db_xref="MGI:MGI:107738"
     exon            1..353
                     /gene="Dync1li2"
                     /gene_synonym="C920003I06; Dlic2; Dncli2; Dnclic2; LIC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..1725
                     /gene="Dync1li2"
                     /gene_synonym="C920003I06; Dlic2; Dncli2; Dnclic2; LIC2"
                     /note="dynein, cytoplasmic, light intermediate polypeptide
                     2; dynein, cytoplasmic, light intermediate chain 2; dynein
                     light intermediate chain 2, cytosolic"
                     /codon_start=1
                     /product="cytoplasmic dynein 1 light intermediate chain 2"
                     /protein_id="NP_001013398.2"
                     /db_xref="CCDS:CCDS22579.1"
                     /db_xref="GeneID:234663"
                     /db_xref="MGI:MGI:107738"
                     /translation="MAPVGVEKKLLLGPNGPAVAAAGDLTSEEEEGQSLWSSILSEVS
                     TRARSKLPSGKNILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHT
                     RCNVWILDGDLYHKGLLKFAVSAESLRETLVIFVADMSRPWTIMESLQKWASVLREHI
                     DKMKIPPEEMRDLERKFMKEFQDYIEPEEGCQGSPQRRGPLTSGSDEDSVALPLGDNV
                     LTHNLGIPVLVVCTKCDAMSVLEKEHDYRDEHLDFIQAHLRRFCLQYGAALIYTSVKE
                     EKNLDLLYKYIVHKTYGFHFTIPALVVEKDAVFIPAGWDNEKKIAILHENFTTVKPED
                     AYEDFIVKPPVRKLVHDKELAAEDEQVFLMKQQSLLAKQPATPTRTSESPARGPSGSP
                     RTQGRGGPASVPSASPGTSVKKPDPNIKNNAASEGVLASFFNSLLSKKTGSPGSPSAG
                     GVQSTAKKSGQKTVLSNVQEELDRMTRKPDSMVTNSSTENEA"
     exon            354..427
                     /gene="Dync1li2"
                     /gene_synonym="C920003I06; Dlic2; Dncli2; Dnclic2; LIC2"
                     /inference="alignment:Splign:2.1.0"
     exon            428..544
                     /gene="Dync1li2"
                     /gene_synonym="C920003I06; Dlic2; Dncli2; Dnclic2; LIC2"
                     /inference="alignment:Splign:2.1.0"
     exon            545..775
                     /gene="Dync1li2"
                     /gene_synonym="C920003I06; Dlic2; Dncli2; Dnclic2; LIC2"
                     /inference="alignment:Splign:2.1.0"
     exon            776..945
                     /gene="Dync1li2"
                     /gene_synonym="C920003I06; Dlic2; Dncli2; Dnclic2; LIC2"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1039
                     /gene="Dync1li2"
                     /gene_synonym="C920003I06; Dlic2; Dncli2; Dnclic2; LIC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1175
                     /gene="Dync1li2"
                     /gene_synonym="C920003I06; Dlic2; Dncli2; Dnclic2; LIC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1287
                     /gene="Dync1li2"
                     /gene_synonym="C920003I06; Dlic2; Dncli2; Dnclic2; LIC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1347
                     /gene="Dync1li2"
                     /gene_synonym="C920003I06; Dlic2; Dncli2; Dnclic2; LIC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1389
                     /gene="Dync1li2"
                     /gene_synonym="C920003I06; Dlic2; Dncli2; Dnclic2; LIC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1507
                     /gene="Dync1li2"
                     /gene_synonym="C920003I06; Dlic2; Dncli2; Dnclic2; LIC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1624
                     /gene="Dync1li2"
                     /gene_synonym="C920003I06; Dlic2; Dncli2; Dnclic2; LIC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..4633
                     /gene="Dync1li2"
                     /gene_synonym="C920003I06; Dlic2; Dncli2; Dnclic2; LIC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3352..3357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dync1li2"
                     /gene_synonym="C920003I06; Dlic2; Dncli2; Dnclic2; LIC2"
                     /note="hexamer: AATATA"
     polyA_site      3377
                     /gene="Dync1li2"
                     /gene_synonym="C920003I06; Dlic2; Dncli2; Dnclic2; LIC2"
     regulatory      4607..4612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dync1li2"
                     /gene_synonym="C920003I06; Dlic2; Dncli2; Dnclic2; LIC2"
                     /note="hexamer: AACAAG"
     polyA_site      4627
                     /gene="Dync1li2"
                     /gene_synonym="C920003I06; Dlic2; Dncli2; Dnclic2; LIC2"
                     /note="major polyA site"
ORIGIN      
        1 ggtctggtgg cgtccgcggc tccacctccc gcgtaaggct gtccggctgg ctgcctgacc
       61 cagcaacgtc cctagctgcg gcgatcccac gtcccgcaga cgcacgagga caccgcgggc
      121 ccgtcgggac gcgctggata acggagcttc tgcggcgttg cgggcgggca gcgcggcccg
      181 gccggggtcc ttgcgggtcc tcggcgggcc cgggggaggg ccctctttgt ggctgcagtt
      241 ggcaagatgg cgccggtggg ggtggagaag aagctgctgc tgggtcccaa cgggcccgca
      301 gtggcggccg ccggcgacct gacaagtgaa gaggaggaag gccagagtct atggtcttcg
      361 atcttgagcg aagtgtccac ccgtgccagg tccaagctgc cgtccggcaa aaacattctg
      421 gtgttcggtg aagatggttc tggtaagaca actctcatga ccaaactcca aggagcagaa
      481 cacggcaaaa aaggaagagg cttagagtat ctttacctca gcgttcatga tgaggaccgg
      541 gacgatcaca cacgctgcaa tgtgtggatt ttagatggag acctctacca taaaggcctg
      601 ctgaaatttg cagtttcagc tgagtctctg cgggagaccc tggtcatttt tgttgccgac
      661 atgtctcgac cttggacgat aatggagtct ctgcagaagt gggctagtgt tttacgggag
      721 cacattgaca agatgaagat tccaccggag gagatgcggg atctggaacg gaaatttatg
      781 aaagagtttc aagattatat cgagcctgaa gaaggttgtc agggttcccc acagagaaga
      841 gggcctctga cctcaggctc agacgaagac agtgttgccc tccctctggg tgacaacgtg
      901 ctgactcata acctggggat cccagtgttg gtggtgtgca caaagtgtga tgccatgagc
      961 gtcttggaga aggagcacga ttacagggac gagcacctgg acttcatcca ggcgcacctg
     1021 cggagattct gcctccagta tggagcagcc ttgatttaca cctcagtgaa ggaagagaaa
     1081 aaccttgact tgctgtataa gtacattgtt cataaaacct atggcttcca ctttaccata
     1141 cccgccttag ttgtggaaaa ggacgcggtt tttatacctg caggctggga caatgaaaag
     1201 aaaatagcta ttttacatga aaattttaca accgtgaagc cagaagacgc gtatgaagat
     1261 tttattgtaa agccgcctgt gagaaagctg gtccatgaca aagagttggc agcggaggat
     1321 gagcaggtgt tcctaatgaa gcaacagtca ctccttgcca agcagcctgc cacgcccaca
     1381 agaacctccg aatcccctgc cagaggaccc tctggctctc caaggacgca gggtcggggt
     1441 ggaccagcta gtgtaccaag tgcctccccc ggaacttcag taaagaagcc agatccaaac
     1501 atcaaaaata atgcggcaag tgaaggggta ttggccagct tcttcaatag tctgttgagt
     1561 aaaaaaacag gctctcccgg aagtcctagt gctggtggag tgcagagcac agccaagaag
     1621 tcaggacaaa agactgtgtt gtcaaatgtt caggaagaac tggatagaat gactcgaaag
     1681 ccagactcca tggtaacaaa ctcttcaaca gaaaatgaag cctgaccctc ctttgaaagt
     1741 gcatctgtca aatgaccaaa taactatgta tattcatctg ataagaccag gatttttctg
     1801 attcggcaca tgctgtcagt ttttgggggt aggggagatg aactttaaaa caatacatat
     1861 acttctttgg cttgtccgag tgtgagatgc acatttagga ggctccatgt caggcccctt
     1921 cttagggatg tcccttggac tcttgggctg cgattctctt gtgggaagca agtgcagctg
     1981 gccttgtaga gtggagaaag gaggcccact ttctatcagg gtggagcaaa ggagactagg
     2041 aaggcattgt tcagatggat ggttagtttg accagttgcg tgttagcaaa ttcacttgtt
     2101 cttgggaagc aggttaagta gctgacagtc caggaaagag aaaggttccg gagggacgag
     2161 agaagtgctg gtggggaagc cgaaggttga gggaggtgga ggaaggaagc gagtgagcgg
     2221 gcaggcagtg ttagtaagta caagctcggt agaaaccaga tagcaacagt taagacctaa
     2281 caattagaaa catttccaaa ctaagcacta aacagaatgg gagctgggct tgttctaaat
     2341 gatctttaag ttatgggaaa tgtgttttat gtagggtgct gagtaaggtg ggctgactca
     2401 gggctggtga agaccacagc tgcccccggg acccacatgc ttgacccagg ccatgtccct
     2461 tgtccttgga gagatgtcgg gctctatgca gatgtaacct ggggcaggca gtcgctgtgc
     2521 gttatgttca aagtcagcag atacaaaact agatatttta aatagttcct gttttgtgtt
     2581 gtttaattat ttttttaact accacaggct ggccaactaa tagaaaaagg gtgattgatt
     2641 tctcattttg taccatgttg gcaatgttct agggaaagtg tgggggaagt atttaatgtc
     2701 gttacactct ggttatttgg cttgtgccag gtcctgcctt agagcctgtg gtaaccctcc
     2761 ctgatacaga aaggttcttt ctgtagctcc ctggtcggat cattgctgtc agaccgacag
     2821 gtgggtgctt tccatggaga gtggaagtgg taggcttgtg ctttccatga aacgtagcac
     2881 ttcttctctt aaggaggtgc aagtcttctg tgtcttccat caggggcatg ttcatgaaca
     2941 ctgtcatgtc acaccaccat gctgaagata acttctgtgg atttgaaatg gcactttgag
     3001 tttctgtgtg acacagcaca tgtaaatgca agcactacca tgactttaat gtataaaatc
     3061 tttgttatcc aaaccaaggg gaaaaccaca gttcacttcc gtggagttta ctcttttttt
     3121 atatgaatgt ttgttactgt gtctcggcat agtgttccta atgttgttac atacatgcca
     3181 gatttgacta accactaatg tagttgcgta agttaacatc tagttacatg acaaggctgc
     3241 tcaactgtcg agtggctttg taaaggtctg aacactgtta aggggaaagc tgagtgcttg
     3301 cttgcctctc taacaacaaa aagatgtgtc ttgtgccggt tgtactattg aaatatattt
     3361 tttccttttt taattcagtt ttttttgttg ttgttatttt ggttttgttt tgttttgttt
     3421 tttaaacatg cattgtggct tcaaatgacc aggttgtcca ggcgatgaca gcaaactggc
     3481 tggagtggaa accatgatgg agggtcaact gatctccgta gcagccaggg caaagtgaat
     3541 gacctcagaa actaggaatt cttgcaaaga cactgcctaa tagtgtgatt ttgaaacctt
     3601 gatacaaaag ttaaagtgta tcactggaac gggtaggcac tttttgtgtt gatgtcaagt
     3661 gtgctctaac caactgagga aatgctgagg tcggagtggg agggaggctt ggagaccatt
     3721 gtgttattcc tttgatactt ggatgcgcct agtttcagaa gaaactgatg cgtgttgtca
     3781 tgtgctcagt agttgccaaa gtccaccagc tttgcggagc ttcagggttt tttgggggtt
     3841 tgaggagatg aggtaatttt tattatttta ggagtttcaa gcattggaac caaaggccaa
     3901 ataataaaca gcctttactt tttagagtaa aattaattct atttgcaaga atacacttgc
     3961 atggtagact ataaaagaca attttatgac tatttataca cattataatg attacctctg
     4021 tttgtcttta aatggataat tttaagtaag cccagcctaa aaattatagc ccacatgagg
     4081 gctgtgaatt ggtctttcct aaaaatccaa catatatgct gctagattat tttattttat
     4141 ttgcattttt tttaataaca gggagggttt ctttgtattg ccctggctgt cctggaactc
     4201 actctgtaga acaggctggc ctccagagat ctgcctgcct ctgcctccca agtgctagga
     4261 ttggtgtgtg ctacagtgcc cgattgcacc ttttttttca tttttacttt ttttgttgtt
     4321 gttggcattt taaaaccagt gtttaaactg aagagactgt tgtcttgatg agggtgagag
     4381 cgactgctct gtacatcacg accttaacaa tgttgatgct gtaagtggaa gttcactgtt
     4441 gtctctctgc tgagttcatt ggtgttttta acttcgaatt aggactgcgg acgatctccc
     4501 gtcagcctca gtccagggtg tggctctgtc tgggtgcagt atgcagtcat gtggaacctt
     4561 gctttctagt gctgggggaa gagatgtcta attactggct tcaataaaca agaatccaga
     4621 ctgctaagag gttaaaaaaa aaaaaaa
//
